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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aurone
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Accession:CHEBI:47964 term browser browse the term
Definition:A simplest memebr of the class of aurones that is 1-benzofuran-3(2H)-one in which both hydrogens at position 2 are substituted by a benzylidene group (the Z-isomer).
Synonyms:exact_synonym: (2Z)-2-benzylidene-1-benzofuran-3(2H)-one
 related_synonym: Formula=C15H10O2;   InChI=1S/C15H10O2/c16-15-12-8-4-5-9-13(12)17-14(15)10-11-6-2-1-3-7-11/h1-10H/b14-10-;   InChIKey=OMUOMODZGKSORV-UVTDQMKNSA-N;   SMILES=O=C1c2ccccc2O\\C1=C/c1ccccc1
 xref: Wikipedia:Aurone


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aureusidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP aureusidin results in increased phosphorylation of AKT1 protein CTD PMID:31790703 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]
aureusidin results in increased expression of HMOX1 mRNA; aureusidin results in increased expression of HMOX1 protein
CTD PMID:31790703 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:31790703 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP aureusidin results in decreased expression of KEAP1 mRNA; aureusidin results in decreased expression of KEAP1 protein CTD PMID:31790703 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP aureusidin results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]
CTD PMID:31790703 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP aureusidin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK3 protein]
CTD PMID:31790703 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein] CTD PMID:31790703 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; aureusidin results in increased expression of and affects the localization of NFE2L2 protein; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]
aureusidin results in increased expression of NFE2L2 mRNA
CTD PMID:31790703 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31790703 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:31790703 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP aureusidin results in increased expression of NQO1 mRNA CTD PMID:31790703 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31790703 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of and affects the localization of RELA protein] CTD PMID:31790703 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31790703 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              flavonoids 11135
                aurones 14
                  aurone 14
                    (Z)-3',5'-dibromo-2',4,4',6'-tetrahydroxyaurone 0
                    3'-hydroxy-4,6,4'-trimethoxyaurone 0
                    4,5-methylenedioxy-6-hydroxyaurone 0
                    alphitonin 0
                    aureusidin + 14
                    furano[2'',3'':6,7]aurone 0
                    hispidol 0
                    leptosidin 0
                    maritimetin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          aurone 14
                                            (Z)-3',5'-dibromo-2',4,4',6'-tetrahydroxyaurone 0
                                            3'-hydroxy-4,6,4'-trimethoxyaurone 0
                                            4,5-methylenedioxy-6-hydroxyaurone 0
                                            alphitonin 0
                                            aureusidin + 14
                                            furano[2'',3'':6,7]aurone 0
                                            hispidol 0
                                            leptosidin 0
                                            maritimetin 0
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