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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:D-glucopyranuronic acid
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Accession:CHEBI:47952 term browser browse the term
Definition:A D-glucuronic acid in cyclic pyranose form.
Synonyms:related_synonym: D-glucuronic acid;   Formula=C6H10O7;   Glucuronate;   Glucuronic acid;   InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6?/m0/s1;   InChIKey=AEMOLEFTQBMNLQ-AQKNRBDQSA-N;   SMILES=OC1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
 xref: Beilstein:1427741;   CAS:528-16-5;   CAS:6556-12-3;   DrugBank:DB03156;   ECMDB:ECMDB04073;   Gmelin:397418;   HMDB:HMDB0000127;   KEGG:C00191;   KNApSAcK:C00001123;   MetaCyc:D-Glucopyranuronate;   PMID:1276;   PMID:16658890;   PMID:17440709;   PMID:19093370;   PMID:6814425;   PMID:6838587;   PMID:7504304;   PMID:7540499;   PMID:8049386;   PMID:8111290;   Reaxys:1427741
 cyclic_relationship: is_conjugate_acid_of CHEBI:58720;   is_enantiomer_of CHEBI:79049


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
affects export
multiple interactions
ISO
EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD PMID:16250050, PMID:16554369, PMID:17569508 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ins2 insulin 2 increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions
ISO B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]
CTD PMID:11986319 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579
JBrowse link
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        biochemical role 19222
          metabolite 19199
            eukaryotic metabolite 18817
              algal metabolite 13483
                D-glucopyranuronic acid 10
                  1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                  alpha-D-glucuronic acid + 6
                  beta-D-Xylp-(1->2)-D-GlcpA + 0
                  beta-D-glucuronic acid + 4
                  glycosylglucopyranuronic acid + 0
                  heparosan D-glucuronic acid 0
                  heparosan-N-sulfate D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        monocarboxylic acid 17396
                                          uronic acid 14
                                            hexuronic acid 14
                                              glucuronic acids 13
                                                glucuronic acid 11
                                                  D-glucuronic acid 10
                                                    D-glucopyranuronic acid 10
                                                      1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                                                      alpha-D-glucuronic acid + 6
                                                      beta-D-Xylp-(1->2)-D-GlcpA + 0
                                                      beta-D-glucuronic acid + 4
                                                      glycosylglucopyranuronic acid + 0
                                                      heparosan D-glucuronic acid 0
                                                      heparosan-N-sulfate D-glucuronic acid 0
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