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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:D-glucopyranuronic acid
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Accession:CHEBI:47952 term browser browse the term
Definition:A D-glucuronic acid in cyclic pyranose form.
Synonyms:related_synonym: D-glucuronic acid;   Formula=C6H10O7;   Glucuronate;   Glucuronic acid;   InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6?/m0/s1;   InChIKey=AEMOLEFTQBMNLQ-AQKNRBDQSA-N;   SMILES=OC1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
 xref: Beilstein:1427741;   CAS:528-16-5;   CAS:6556-12-3;   DrugBank:DB03156;   ECMDB:ECMDB04073;   Gmelin:397418;   HMDB:HMDB0000127;   KEGG:C00191;   KNApSAcK:C00001123;   MetaCyc:D-Glucopyranuronate;   PMID:1276;   PMID:16658890;   PMID:17440709;   PMID:19093370;   PMID:6814425;   PMID:6838587;   PMID:7504304;   PMID:7540499;   PMID:8049386;   PMID:8111290;   Reaxys:1427741
 cyclic_relationship: is_conjugate_acid_of CHEBI:58720;   is_enantiomer_of CHEBI:79049


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
affects export
multiple interactions
ISO
EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD PMID:16250050 PMID:16554369 PMID:17569508 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ins2 insulin 2 increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions
ISO B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]
CTD PMID:11986319 NCBI chr 1:205,817,374...205,823,928 JBrowse link
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:653,740...731,121
Ensembl chr 9:653,659...756,334
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              algal metabolite 13939
                D-glucopyranuronic acid 10
                  1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                  4-O-methyl-alpha-D-glucuronoside ester 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                  alpha-D-glucuronic acid + 6
                  beta-D-Xylp-(1->2)-D-GlcpA + 0
                  beta-D-glucuronic acid + 4
                  glycosylglucopyranuronic acid + 0
                  heparosan D-glucuronic acid 0
                  heparosan-N-sulfate D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          uronic acid 14
                                            hexuronic acid 14
                                              glucuronic acids 13
                                                glucuronic acid 11
                                                  D-glucuronic acid 10
                                                    D-glucopyranuronic acid 10
                                                      1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                                                      4-O-methyl-alpha-D-glucuronoside ester 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                                                      alpha-D-glucuronic acid + 6
                                                      beta-D-Xylp-(1->2)-D-GlcpA + 0
                                                      beta-D-glucuronic acid + 4
                                                      glycosylglucopyranuronic acid + 0
                                                      heparosan D-glucuronic acid 0
                                                      heparosan-N-sulfate D-glucuronic acid 0
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