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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:D-glucopyranuronic acid
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Accession:CHEBI:47952 term browser browse the term
Definition:A D-glucuronic acid in cyclic pyranose form.
Synonyms:related_synonym: Formula=C6H10O7;   Glucuronate;   Glucuronic acid;   InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6?/m0/s1;   InChIKey=AEMOLEFTQBMNLQ-AQKNRBDQSA-N;   SMILES=OC1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
 xref: Beilstein:1427741;   CAS:528-16-5;   CAS:6556-12-3;   DrugBank:DB03156;   ECMDB:ECMDB04073;   Gmelin:397418;   HMDB:HMDB0000127;   KEGG:C00191;   KNApSAcK:C00001123;   MetaCyc:D-Glucopyranuronate;   PMID:1276;   PMID:16658890;   PMID:17440709;   PMID:19093370;   PMID:6814425;   PMID:6838587;   PMID:7504304;   PMID:7540499;   PMID:8049386;   PMID:8111290;   Reaxys:1427741
 cyclic_relationship: is_conjugate_acid_of CHEBI:58720;   is_enantiomer_of CHEBI:79049


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
affects export
multiple interactions		 ISO
EXP		 acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]		 CTD PMID:16250050 PMID:16554369 PMID:17569508 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Ins2 insulin 2 increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]] CTD PMID:35101544 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions		 ISO B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]		 CTD PMID:11986319 NCBI chr 1:205,817,374...205,823,928
Ensembl chr 1:205,817,378...205,837,807 		JBrowse link
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A3 protein] results in increased metabolism of Lithocholic Acid CTD PMID:36473578 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased metabolism of hyodeoxycholic acid; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 PMID:36473578 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:653,740...731,121
Ensembl chr 9:653,659...756,334 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    role 19851
      biological role 19849
        biochemical role 19543
          metabolite 19529
            eukaryotic metabolite 19342
              algal metabolite 15263
                D-glucopyranuronic acid 12
                  1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                  4-O-methyl-alpha-D-glucuronoside ester 0
                  UDP-D-glucuronic acid + 8
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                  [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                  alpha-D-glucuronic acid + 8
                  beta-D-Xylp-(1->2)-D-GlcpA + 0
                  beta-D-glucuronic acid + 4
                  glycosylglucopyranuronic acid + 0
                  heparosan D-glucuronic acid 0
                  heparosan-N-sulfate D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  main group element atom 19821
                    p-block element atom 19821
                      carbon group element atom 19768
                        carbon atom 19764
                          organic molecular entity 19764
                            organic group 18962
                              organic divalent group 18943
                                organodiyl group 18915
                                  carbonyl group 18869
                                    carbonyl compound 18869
                                      carboxylic acid 18618
                                        monocarboxylic acid 17917
                                          uronic acid 16
                                            hexuronic acid 16
                                              glucuronic acids 15
                                                glucuronic acid 13
                                                  D-glucuronic acid 12
                                                    D-glucopyranuronic acid 12
                                                      1-O-(alpha-D-glucopyranuronosyl)-N-tetradecanoyldihydrosphingosine 0
                                                      4-O-methyl-alpha-D-glucuronoside ester 0
                                                      UDP-D-glucuronic acid + 8
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n 0
                                                      [4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n 0
                                                      alpha-D-glucuronic acid + 8
                                                      beta-D-Xylp-(1->2)-D-GlcpA + 0
                                                      beta-D-glucuronic acid + 4
                                                      glycosylglucopyranuronic acid + 0
                                                      heparosan D-glucuronic acid 0
                                                      heparosan-N-sulfate D-glucuronic acid 0
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