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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enflurane
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Accession:CHEBI:4792 term browser browse the term
Definition:An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.
Synonyms:exact_synonym: 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
 related_synonym: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether;   Alyrane;   Efrane;   Ethrane;   Formula=C3H2ClF5O;   InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H;   InChIKey=JPGQOUSTVILISH-UHFFFAOYSA-N;   Methylflurether;   SMILES=FC(F)OC(F)(F)C(F)Cl
 xref: Beilstein:1903921;   CAS:13838-16-9;   DrugBank:DB00228;   Drug_Central:1009;   HMDB:HMDB0014373;   KEGG:C07516;   KEGG:D00543
 xref_mesh: MESH:D004737
 xref: PMID:23934553;   PMID:25386744;   PMID:7457058;   Patent:AU2014277860;   Patent:US5783199;   Reaxys:1903921;   Wikipedia:Enflurane



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enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression
ISO Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:10825391 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 PMID:10825391 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA
CTD PMID:16309571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma increases expression EXP Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            anaesthetic 9351
              enflurane 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      chalcogen 19683
                        oxygen atom 19655
                          oxygen molecular entity 19655
                            hydroxides 19380
                              organic hydroxy compound 18898
                                alcohol 15184
                                  primary alcohol 14059
                                    ethanols 8198
                                      ethanol 8198
                                        methoxyethane 123
                                          enflurane 12
paths to the root