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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enflurane
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Accession:CHEBI:4792 term browser browse the term
Definition:An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.
Synonyms:exact_synonym: 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
 related_synonym: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether;   Alyrane;   Efrane;   Ethrane;   Formula=C3H2ClF5O;   InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H;   InChIKey=JPGQOUSTVILISH-UHFFFAOYSA-N;   Methylflurether;   SMILES=FC(F)OC(F)(F)C(F)Cl
 xref: Beilstein:1903921;   CAS:13838-16-9;   DrugBank:DB00228;   Drug_Central:1009;   HMDB:HMDB0014373;   KEGG:C07516;   KEGG:D00543
 xref_mesh: MESH:D004737
 xref: PMID:23934553;   PMID:25386744;   PMID:7457058;   Patent:AU2014277860;   Patent:US5783199;   Reaxys:1903921;   Wikipedia:Enflurane


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enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression
ISO Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:10825391 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 PMID:10825391 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA
CTD PMID:16309571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma increases expression EXP Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            anaesthetic 5311
              enflurane 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      chalcogen 19387
                        oxygen atom 19350
                          oxygen molecular entity 19350
                            hydroxides 19076
                              organic hydroxy compound 18659
                                alcohol 15025
                                  primary alcohol 13918
                                    ethanols 8172
                                      ethanol 8172
                                        methoxyethane 120
                                          enflurane 12
paths to the root