CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: enflurane
Accession: CHEBI:4792
browse the term
Definition: An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.
Synonyms: exact_synonym: 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
related_synonym: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; Alyrane; Efrane; Ethrane; Formula=C3H2ClF5O; InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H; InChIKey=JPGQOUSTVILISH-UHFFFAOYSA-N; Methylflurether; SMILES=FC(F)OC(F)(F)C(F)Cl
xref: Beilstein:1903921; CAS:13838-16-9; DrugBank:DB00228; Drug_Central:1009; HMDB:HMDB0014373; KEGG:C07516; KEGG:D00543
xref_mesh: MESH:D004737
xref: PMID:23934553; PMID:25386744; PMID:7457058; Patent:AU2014277860; Patent:US5783199; Reaxys:1903921; Wikipedia:Enflurane
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Alad
aminolevulinate dehydratase
increases activity increases expression
ISO
Enflurane results in increased activity of ALAD protein Enflurane results in increased expression of ALAD mRNA
CTD
PMID:16309571
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Cacna1i
calcium voltage-gated channel subunit alpha1 I
affects response to substance
EXP
CACNA1I protein affects the susceptibility to Enflurane
CTD
PMID:15644869
NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
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Cxcl2
C-X-C motif chemokine ligand 2
increases expression
EXP
Enflurane results in increased expression of CXCL2 mRNA
CTD
PMID:10422944
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
multiple interactions
ISO
Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]
CTD
PMID:10683198
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]
CTD
PMID:10825391
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
ISO
Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
multiple interactions
ISO
Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198 PMID:10825391
NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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Glra1
glycine receptor, alpha 1
multiple interactions
ISO
Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]
CTD
PMID:10683198 PMID:10825391
NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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Hmox1
heme oxygenase 1
increases activity increases expression
ISO
Enflurane results in increased activity of HMOX1 protein Enflurane results in increased expression of HMOX1 mRNA
CTD
PMID:16309571
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
increases expression
EXP
Enflurane results in increased expression of IFNG mRNA
CTD
PMID:10422944
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
increases expression
EXP
Enflurane results in increased expression of IL1B mRNA
CTD
PMID:10422944
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Tnf
tumor necrosis factor
increases expression
EXP
Enflurane results in increased expression of TNF mRNA
CTD
PMID:10422944
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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