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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diazepine
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Accession:CHEBI:47918 term browser browse the term
Synonyms:related_synonym: diazepines



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CX-5461 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated affects response to substance
multiple interactions
ISO BRCA2 protein affects the susceptibility to CX 5461
BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein]; BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]
CTD PMID:28211448 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK1 protein CTD PMID:28211448 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK2 protein CTD PMID:28211448 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G H2ax H2A.X variant histone increases expression ISO CX 5461 results in increased expression of H2AX protein CTD PMID:28211448 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO CX 5461 results in increased cleavage of PARP1 protein CTD PMID:32799625 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO CX 5461 results in increased expression of RAD51 protein CTD PMID:28211448 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation
multiple interactions
ISO CX 5461 results in increased phosphorylation of RPA2 protein
BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]
CTD PMID:28211448 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression
ISO BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein] CTD PMID:28211448 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
suvorexant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] CTD PMID:33609567 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression ISO suvorexant results in increased expression of GRIN2A protein CTD PMID:33609567 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] CTD PMID:33609567 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] CTD PMID:33609567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          nitrogen atom 18955
            nitrogen molecular entity 18955
              organonitrogen compound 18804
                organonitrogen heterocyclic compound 18148
                  diazepine 12
                    1-beta-D-ribofuranosyl-1,3-dihydro-2H-1,3-diazepin-2-one 0
                    4,5-dihydrothiazolo[2,3-d][1,5]benzodiazepin-11-ium-6-carboxaldehyde 0
                    6-epi-monanchorin 0
                    7-(2-chloro-6-fluorophenyl)-5-methyl-6,7-dihydro-1H-1,4-diazepine-2,3-dicarbonitrile 0
                    CX-5461 8
                    N-(2-furylmethyl)-3-[(2s,5as,8ar)-1-methyl-5-oxodecahydropyrrolo[3,2-e][1,4]diazepin-2-yl]propanamide 0
                    N-Benzyl-3-[(2S,5aS,8aR)-6-(1H-imidazol-2-ylmethyl)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide 0
                    homofenazine 0
                    suvorexant 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteromonocyclic compound 17794
                                    diazepine 12
                                      1-beta-D-ribofuranosyl-1,3-dihydro-2H-1,3-diazepin-2-one 0
                                      4,5-dihydrothiazolo[2,3-d][1,5]benzodiazepin-11-ium-6-carboxaldehyde 0
                                      6-epi-monanchorin 0
                                      7-(2-chloro-6-fluorophenyl)-5-methyl-6,7-dihydro-1H-1,4-diazepine-2,3-dicarbonitrile 0
                                      CX-5461 8
                                      N-(2-furylmethyl)-3-[(2s,5as,8ar)-1-methyl-5-oxodecahydropyrrolo[3,2-e][1,4]diazepin-2-yl]propanamide 0
                                      N-Benzyl-3-[(2S,5aS,8aR)-6-(1H-imidazol-2-ylmethyl)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide 0
                                      homofenazine 0
                                      suvorexant 4
paths to the root