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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-substituted L-cysteine
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Accession:CHEBI:47910 term browser browse the term
Synonyms:related_synonym: Formula=C3H6NO2SR;   R-S-Cysteine;   S-substituted L-cysteines;   SMILES=N[C@@H](CS[*])C(O)=O
 alt_id: CHEBI:13794;   CHEBI:8969
 xref: KEGG:C05726
 cyclic_relationship: is_tautomer_of CHEBI:58717

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lactacystin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] CTD PMID:18487452 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization		 ISO
EXP		 lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
lactacystin affects the localization of AHR protein		 CTD PMID:10722677 PMID:12237327 PMID:17445780 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization
affects localization
multiple interactions		 ISO lactacystin results in increased localization of AIFM1 protein
lactacystin affects the localization of AIFM1 protein
ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein]; U 0126 inhibits the reaction [lactacystin results in increased localization of AIFM1 protein]		 CTD PMID:16860906 PMID:21683092 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Apob apolipoprotein B multiple interactions
increases secretion
increases expression		 ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]; lactacystin results in increased expression of and results in increased secretion of APOB protein CTD PMID:15618547 PMID:19383982 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein] CTD PMID:16162502 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] CTD PMID:10506578 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Atrn attractin multiple interactions
decreases response to substance		 ISO ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein]
ATRN protein results in decreased susceptibility to lactacystin		 CTD PMID:16860906 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 lactacystin results in decreased expression of BCL2 protein
lactacystin inhibits the reaction [sodium bichromate results in decreased expression of BCL2 protein]
lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; Sirolimus inhibits the reaction [lactacystin results in decreased expression of BCL2 protein]		 CTD PMID:18544562 PMID:18640276 PMID:19361538 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO lactacystin inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein] CTD PMID:15673306 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions		 EXP
ISO		 lactacystin results in increased activity of CASP3 protein
lactacystin results in increased expression of CASP3 protein modified form
[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]		 CTD PMID:15618349 PMID:20649845 PMID:21683092 PMID:29944914 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] CTD PMID:20671745 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein] CTD PMID:18156803 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] CTD PMID:18156803 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO
EXP		 lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]
lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]		 CTD PMID:12832419 PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 ISO lactacystin results in increased expression of CDKN1B protein
lactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]		 CTD PMID:12149143 PMID:17283133 PMID:23029392 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO lactacystin results in increased expression of CEBPB protein CTD PMID:11779194 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO lactacystin results in increased expression of CEBPD protein CTD PMID:11779194 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein] CTD PMID:17138778 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cp ceruloplasmin decreases degradation ISO lactacystin results in decreased degradation of CP protein CTD PMID:16405854 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO lactacystin inhibits the reaction [Indomethacin results in decreased expression of CTNNB1 protein]; lactacystin inhibits the reaction [resveratrol results in increased degradation of CTNNB1 protein] CTD PMID:11756231 PMID:26040106 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10722677 PMID:10777561 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:24792400 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA] CTD PMID:24224465 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP lactacystin inhibits the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 protein] CTD PMID:17083955 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] CTD PMID:24224465 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO lactacystin results in increased expression of DDIT3 mRNA CTD PMID:19135031 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin results in increased expression of and results in increased activity of DIO2 protein CTD PMID:11425850 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO lactacystin inhibits the reaction [Dronabinol results in decreased expression of ERBB2 protein] CTD PMID:30733293 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 multiple interactions ISO lactacystin inhibits the reaction [Estradiol affects the localization of FZR1 protein] CTD PMID:23029392 NCBI chr 7:11,201,690...11,213,614
Ensembl chr 7:11,201,690...11,213,613 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gls glutaminase multiple interactions ISO lactacystin inhibits the reaction [diphenylarsinic acid results in increased degradation of GLS protein alternative form] CTD PMID:22493432 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases localization EXP lactacystin results in increased localization of GRIA1 protein CTD PMID:19674091 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases localization EXP lactacystin results in increased localization of GRIA2 protein CTD PMID:19674091 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO lactacystin results in increased expression of GSTA2 mRNA CTD PMID:12446695 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] CTD PMID:11980636 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]
lactacystin results in increased expression of HMOX1 mRNA		 CTD PMID:12441344 PMID:21384399 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpx hemopexin multiple interactions ISO lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO lactacystin results in increased activity of HSF1 protein CTD PMID:11893605 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hsf2 heat shock transcription factor 2 increases activity ISO lactacystin results in increased activity of HSF2 protein CTD PMID:11893605 NCBI chr20:38,935,820...38,963,444
Ensembl chr20:38,935,820...38,963,309 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein] CTD PMID:15618547 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Ifng interferon gamma multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]		 CTD PMID:22398747 PMID:25766886 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA] CTD PMID:22398747 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] CTD PMID:25766886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA] CTD PMID:22398747 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA] CTD PMID:22398747 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA] CTD PMID:22398747 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO lactacystin results in increased expression of IL6 mRNA; lactacystin results in increased expression of IL6 protein
Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 protein]		 CTD PMID:11893605 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO lactacystin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions ISO lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions		 ISO lactacystin results in increased activity of MAPK1 protein
U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK1 protein]		 CTD PMID:21683092 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions		 ISO lactacystin results in increased activity of MAPK3 protein
U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK3 protein]		 CTD PMID:21683092 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
increases phosphorylation		 ISO
EXP		 lactacystin results in increased activity of MAPK8 protein
lactacystin results in increased phosphorylation of MAPK8 protein		 CTD PMID:15618349 PMID:18463101 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO
EXP		 lactacystin results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases ubiquitination ISO lactacystin results in increased ubiquitination of MTTP protein CTD PMID:17405876 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
decreases degradation
multiple interactions		 ISO
EXP		 lactacystin results in increased expression of NFE2L2 protein
lactacystin results in decreased degradation of NFE2L2 protein
lactacystin promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]
lactacystin promotes the reaction [manganese chloride affects the localization of and results in increased activity of NFE2L2 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]		 CTD PMID:12441344 PMID:12446695 PMID:15322212 PMID:21384399 PMID:26598004 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lactacystin promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] CTD PMID:17644113 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nol3 nucleolar protein 3 multiple interactions EXP lactacystin affects the reaction [Doxorubicin results in increased degradation of NOL3 protein] CTD PMID:19139834 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lactacystin inhibits the reaction [GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [deoxynivalenol results in increased degradation of NOS2 protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]		 CTD PMID:17891158 PMID:19376148 PMID:25766886 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity
multiple interactions		 ISO lactacystin results in decreased activity of NR1I3 protein
lactacystin inhibits the reaction [Phenobarbital affects the localization of NR1I3 protein]		 CTD PMID:24224465 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Optn optineurin increases expression
multiple interactions		 EXP
ISO		 lactacystin results in increased expression of OPTN protein
lactacystin results in increased expression of and results in increased ubiquitination of OPTN protein		 CTD PMID:21059646 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions
decreases metabolic processing		 ISO lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein]
lactacystin results in decreased metabolism of OTC protein		 CTD PMID:11161710 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases response to substance ISO PARK7 protein results in decreased susceptibility to lactacystin CTD PMID:18331584 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 increases expression ISO lactacystin results in increased expression of PDIA2 mRNA; lactacystin results in increased expression of PDIA2 protein CTD PMID:15353226
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression EXP lactacystin results in increased expression of PFKFB3 protein CTD PMID:19448625 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO lactacystin results in increased expression of PPP1R15A mRNA CTD PMID:19135031 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO lactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] CTD PMID:17644113 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Psmb10 proteasome 20S subunit beta 10 multiple interactions ISO [PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin CTD PMID:22398747 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 multiple interactions ISO [PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin CTD PMID:22398747 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769 		JBrowse link
G Psmd4 proteasome 26S subunit, non-ATPase 4 multiple interactions ISO lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] CTD PMID:15362974 NCBI chr 2:196,198,303...196,207,569
Ensembl chr 2:196,198,038...196,207,560 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO lactacystin results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] CTD PMID:17644113 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] CTD PMID:18344023 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions
decreases expression		 ISO lactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]
lactacystin results in decreased expression of SKP2 protein		 CTD PMID:23029392 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO lactacystin inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein] CTD PMID:24498857 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO lactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions EXP lactacystin inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366 		JBrowse link
G Snca synuclein alpha multiple interactions
decreases expression		 ISO
EXP		 lactacystin promotes the reaction [SNCA protein mutant form binds to SNCA protein mutant form]
lactacystin results in decreased expression of SNCA protein		 CTD PMID:16584840 PMID:18818210 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects localization		 ISO lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]
lactacystin affects the localization of SOD1 protein mutant form
Copper promotes the reaction [lactacystin affects the localization of SOD1 protein mutant form]; Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form]		 CTD PMID:15034941 PMID:17309078 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage		 ISO [lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein] CTD PMID:21683092 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein] CTD PMID:21191146 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513 		JBrowse link
G Syp synaptophysin multiple interactions EXP lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] CTD PMID:18487452 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA] CTD PMID:22398747 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] CTD PMID:18344023 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF mRNA]; lactacystin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:17138778 PMID:18809656 PMID:22398747 PMID:25766886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 affects localization ISO lactacystin affects the localization of TOMM20 protein CTD PMID:11161710 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases ubiquitination		 EXP lactacystin inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; lactacystin results in increased phosphorylation of and results in increased expression of TP53 protein
lactacystin results in increased ubiquitination of TP53 protein		 CTD PMID:16330492 PMID:18463101 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp63 tumor protein p63 multiple interactions ISO lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]; lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form] CTD PMID:21191146 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] CTD PMID:20671745 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906 		JBrowse link
G Ubxn1 UBX domain protein 1 multiple interactions ISO lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] CTD PMID:15362974 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein] CTD PMID:19361538 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Vcp valosin-containing protein multiple interactions
increases expression		 ISO lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]
lactacystin results in increased expression of VCP protein		 CTD PMID:15362974 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953 		JBrowse link
G Vdr vitamin D receptor decreases degradation ISO lactacystin results in decreased degradation of VDR protein CTD PMID:24792400 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Xbp1 X-box binding protein 1 decreases response to substance ISO XBP1 protein results in decreased susceptibility to lactacystin CTD PMID:19135031 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
leukotriene E4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4		 CTD PMID:8621850 PMID:10764316 PMID:12794006 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 affects binding
multiple interactions		 ISO Leukotriene E4 binds to CYSLTR1 protein
[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]		 CTD PMID:8384568 PMID:9620942 PMID:10462554 PMID:11705452 PMID:12853847 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity		 ISO [Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239 PMID:11093801 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Leukotriene E4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G Il13 interleukin 13 increases abundance EXP IL13 protein results in increased abundance of Leukotriene E4 CTD PMID:12654629 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene E4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression EXP Leukotriene E4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4] CTD PMID:25432964 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
S-(1,2-dichlorovinyl)-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of APAF1 protein CTD PMID:15967204 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of BAX protein CTD PMID:15967204 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of BCL2 protein CTD PMID:15967204 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein] CTD PMID:29129777 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein
alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]		 CTD PMID:29129777 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity ISO S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP8 protein CTD PMID:29129777 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity		 ISO S-(1,2-dichlorovinyl)cysteine results in increased cleavage of CASP9 protein
S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP9 protein		 CTD PMID:15967204 PMID:29129777 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CCND1 protein CTD PMID:16495211 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CDK4 protein CTD PMID:16495211 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of CDK6 protein CTD PMID:16495211 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO S-(1,2-dichlorovinyl)cysteine results in decreased expression of CDKN2A protein CTD PMID:16495211 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions
decreases activity		 EXP Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein] CTD PMID:2360207 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP S-(1,2-dichlorovinyl)cysteine results in decreased activity of GSR protein CTD PMID:2360207 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of JUN protein CTD PMID:15967204 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO S-(1,2-dichlorovinyl)cysteine results in increased cleavage of PARP1 protein CTD PMID:15967204 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases phosphorylation
decreases expression		 ISO S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of PPP1CA protein
S-(1,2-dichlorovinyl)cysteine results in decreased expression of PPP1CA protein		 CTD PMID:16495211 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of RB1 protein CTD PMID:16495211 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of RELA protein CTD PMID:15967204 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc25a10 solute carrier family 25 member 10 multiple interactions EXP [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine CTD PMID:12388626 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO S-(1,2-dichlorovinyl)cysteine results in increased expression of TP53 protein CTD PMID:15967204 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vim vimentin increases expression EXP S-(1,2-dichlorovinyl)cysteine results in increased expression of VIM mRNA CTD PMID:10996665 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
S-allylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 ISO dorsomorphin inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; S-allylcysteine promotes the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of ACACA protein]; sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; STO 609 inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]
S-allylcysteine results in decreased expression of BCL2 protein		 CTD PMID:16030430 PMID:17155983 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases phosphorylation ISO S-allylcysteine results in increased phosphorylation of CAMK2A protein CTD PMID:23465592 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP1 protein] CTD PMID:32453893 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO
EXP		 S-allylcysteine results in increased cleavage of CASP3 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP3 protein]
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]		 CTD PMID:16030430 PMID:17155983 PMID:22033380 PMID:32453893 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 EXP
ISO		 [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
S-allylcysteine results in increased activity of CASP8 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine results in decreased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]		 CTD PMID:16030430 PMID:22033380 PMID:31067004 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [lead acetate results in decreased activity of CAT protein]		 CTD PMID:18548744 PMID:19391111 PMID:20951120 PMID:22033380 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO S-allylcysteine results in increased expression of CDH1 protein CTD PMID:17155983 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP S-allylcysteine results in increased expression of CYP3A2 protein CTD PMID:16000231 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions		 ISO S-allylcysteine results in increased expression of FADD protein
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]		 CTD PMID:31067004 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; S-allylcysteine promotes the reaction [FAS protein binds to FAS protein]; S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]		 CTD PMID:22033380 PMID:31067004 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]
S-allylcysteine results in increased expression of FASLG protein		 CTD PMID:31067004 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of FASN mRNA] CTD PMID:23465592 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA] CTD PMID:17182065 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein] CTD PMID:22033380 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP		 [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]
S-allylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]		 CTD PMID:19391111 PMID:22033380 PMID:32453893 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] CTD PMID:16757080 PMID:19391111 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] CTD PMID:17182065 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein] CTD PMID:32453893 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:32453893 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jup junction plakoglobin increases expression ISO S-allylcysteine results in increased expression of JUP protein CTD PMID:17155983 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of KCNN4 protein] CTD PMID:22033380 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996 		JBrowse link
G Klk1 kallikrein 1 decreases expression ISO S-allylcysteine results in decreased expression of KLK3 protein CTD PMID:17155983 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of MMP2 protein] CTD PMID:19391111 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of MPO protein] CTD PMID:32453893 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP S-allylcysteine promotes the reaction [Potassium Dichromate results in increased expression of NFE2L2 protein] CTD PMID:18548744 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein] CTD PMID:32453893 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2]; S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of NOS2 protein] CTD PMID:16614485 PMID:19391111 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in decreased expression of OGDH mRNA] CTD PMID:17182065 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327 		JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; S-allylcysteine inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] CTD PMID:22033380 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PTGS2 protein] CTD PMID:32453893 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of RELA protein] CTD PMID:19391111 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of SMPD1 protein] CTD PMID:22033380 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]; sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:16614485 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TLR4 protein] CTD PMID:32453893 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:32453893 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation		 ISO SB 203580 inhibits the reaction [S-allylcysteine results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with S-allylcysteine] results in increased phosphorylation of TRP53 protein		 CTD PMID:31067004 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Upk2 uroplakin 2 multiple interactions ISO S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 mRNA]; S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 protein] CTD PMID:27234646 NCBI chr 8:48,772,906...48,774,898
Ensembl chr 8:48,772,906...48,774,898 		JBrowse link
S-methylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msra methionine sulfoxide reductase A multiple interactions ISO S-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T] CTD PMID:19085252 NCBI chr15:47,488,333...47,800,662
Ensembl chr15:47,488,894...47,800,024 		JBrowse link
G Pah phenylalanine hydroxylase increases oxidation ISO PAH protein results in increased oxidation of S-methylcysteine CTD PMID:19367645 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        food additive 14758
          flour treatment agent 5585
            L-cysteine 1141
              L-cysteine derivative 1130
                S-substituted L-cysteine 148
                  (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                  (8S)-cystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 0
                  16(S)-cystein-S-yl,17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid 0
                  3-[(2-hydroxyethyl)disulfanyl]-L-alanine 0
                  3-disulfanyl-L-alanine + 0
                  3-sulfino-L-alanine + 0
                  L-cysteine thioether + 66
                  L-thialysinium + 0
                  S-(acetaldehyde)-L-cysteine zwitterion 0
                  S-[9-(methylthio)nonylhydroximoyl]-L-cysteine 0
                  S-nitrosyl-L-cysteine 0
                  S-organyl-L-cysteine + 43
                  S-phospho-L-cysteine + 0
                  S-selenyl-L-cysteine 0
                  S-sulfo-L-cysteine 0
                  lactacystin + 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        amino acid 14125
                                          alpha-amino acid 11602
                                            L-alpha-amino acid 11439
                                              serine family amino acid 2059
                                                L-cysteine 1141
                                                  L-cysteine derivative 1130
                                                    S-substituted L-cysteine 148
                                                      (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                                                      (8S)-cystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid 0
                                                      16(S)-cystein-S-yl,17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid 0
                                                      3-[(2-hydroxyethyl)disulfanyl]-L-alanine 0
                                                      3-disulfanyl-L-alanine + 0
                                                      3-sulfino-L-alanine + 0
                                                      L-cysteine thioether + 66
                                                      L-thialysinium + 0
                                                      S-(acetaldehyde)-L-cysteine zwitterion 0
                                                      S-[9-(methylthio)nonylhydroximoyl]-L-cysteine 0
                                                      S-nitrosyl-L-cysteine 0
                                                      S-organyl-L-cysteine + 43
                                                      S-phospho-L-cysteine + 0
                                                      S-selenyl-L-cysteine 0
                                                      S-sulfo-L-cysteine 0
                                                      lactacystin + 95
paths to the root