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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkanethiol
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Accession:CHEBI:47908 term browser browse the term
Definition:An alkanethiol is a compound in which a sulfanyl group, -SH, is attached to an alkyl group.
Synonyms:related_synonym: Alkyl thiol;   Formula=HSR;   SMILES=*S;   alkanethiols;   alkyl thiols;   an alkyl thiol
 alt_id: CHEBI:13812;   CHEBI:22328;   CHEBI:2585
 xref: KEGG:C00812


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captopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity
EXP
ISO
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Captopril results in decreased activity of ACE protein
CTD PMID:26851370 PMID:31629013 PMID:33007385 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases response to substance
multiple interactions
ISO
EXP
ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
CTD PMID:17473847 PMID:31629013 PMID:33007385 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:31181250 PMID:33007385 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
CTD PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
CTD PMID:28130181 PMID:31629013 PMID:33007385 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] CTD PMID:28130181 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] CTD PMID:28130181 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] CTD PMID:28130181 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
CTD PMID:31181250 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
CTD PMID:31181250 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
CTD PMID:31181250 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Lepr leptin receptor multiple interactions
affects response to substance
ISO Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril
CTD PMID:28130181 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]
CTD PMID:31629013 PMID:33007385 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] CTD PMID:28130181 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] CTD PMID:31629013 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]
CTD PMID:31181250 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Pth parathyroid hormone multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] CTD PMID:28130181 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] CTD PMID:28130181 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]
CTD PMID:31181250 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
CTD PMID:31181250 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] CTD PMID:28130181 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] CTD PMID:28130181 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
demeton-S-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO demeton-S-methyl results in decreased activity of ACHE protein CTD PMID:16766477 PMID:21238577 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO demeton-S-methyl results in decreased activity of BCHE protein CTD PMID:21238577 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
mercaptoethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Mercaptoethanol co-treated with Ascorbic Acid] results in increased expression of ACTA2 protein CTD PMID:17053324 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein] CTD PMID:24028651 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp11 aquaporin 11 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]] CTD PMID:21251984 NCBI chr 1:162,703,394...162,713,560
Ensembl chr 1:162,703,442...162,713,610
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]] CTD PMID:9124401 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Aqp7 aquaporin 7 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein] CTD PMID:10777495 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mercaptoethanol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Mercaptoethanol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein] CTD PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Mercaptoethanol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L affects response to substance ISO PIGL protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr10:48,774,018...48,831,848
Ensembl chr10:48,773,828...48,831,855
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity ISO Mercaptoethanol results in increased activity of RELA protein CTD PMID:7491977 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase affects response to substance ISO RFFL protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [[cinnamic aldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein] CTD PMID:20955755 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions EXP Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc] CTD PMID:16804107 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Mercaptoethanol promotes the reaction [Mercuric Chloride inhibits the reaction [SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins]] CTD PMID:9761775 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]; Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein] CTD PMID:18951995 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases oxidation
ISO Mercaptoethanol inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] promotes the reaction [SOD1 protein binds to SOD1 protein]]
Mercaptoethanol results in increased oxidation of SOD1 protein
CTD PMID:15096637 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 affects response to substance ISO TIAM1 protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr11:29,931,083...30,061,173
Ensembl chr11:29,933,163...30,051,103
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
methanethiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Selenbp1 selenium binding protein 1 increases metabolic processing ISO SELENBP1 protein results in increased metabolism of methylmercaptan CTD PMID:29255262 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
phorate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
Phorate metabolite results in decreased activity of ACHE protein; Phorate results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33720374 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin decreases expression EXP Phorate results in decreased expression of ALB protein CTD PMID:23280859 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP Phorate results in decreased expression of BCHE protein CTD PMID:23280859 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 increases expression EXP Phorate results in increased expression of CASP3 mRNA; Phorate results in increased expression of CASP3 protein CTD PMID:22197610 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression EXP Phorate results in increased expression of CASP9 mRNA; Phorate results in increased expression of CASP9 protein CTD PMID:22197610 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
Phorate results in decreased activity of CAT protein
CTD PMID:22034174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Phorate results in increased expression of GPT protein CTD PMID:23280859 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Phorate results in increased expression of TP53 mRNA; Phorate results in increased expression of TP53 protein CTD PMID:22197610 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
propane-1-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 multiple interactions ISO propanethiol promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein] CTD PMID:11049924 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions ISO propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
S-methyl methanethiosulfonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [NR3C1 protein binds to dexamethasone oxetanone] CTD PMID:1597467 PMID:2226332 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Pgr progesterone receptor decreases activity ISO methyl methanethiosulfonate results in decreased activity of PGR protein CTD PMID:9879984 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
thioridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Thioridazine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thioridazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Casp3 caspase 3 increases activity ISO Thioridazine results in increased activity of CASP3 protein CTD PMID:21035837 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thioridazine results in decreased expression of CCND1 protein CTD PMID:21035837 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25a cell division cycle 25A increases phosphorylation ISO Thioridazine results in increased phosphorylation of CDC25A protein CTD PMID:21035837 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thioridazine results in increased expression of CDKN1A protein CTD PMID:21035837 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Thioridazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein
CTD PMID:15135088 PMID:23397584 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Thioridazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Thioridazine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Thioridazine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21035837 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Thioridazine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Thioridazine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:26,387,284...26,389,524 JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Thioridazine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Hpn hepsin increases expression ISO Thioridazine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Thioridazine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein
CTD PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Thioridazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G Lss lanosterol synthase increases expression ISO Thioridazine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Thioridazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Thioridazine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Thioridazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Prl prolactin increases expression ISO Thioridazine results in increased expression of PRL protein CTD PMID:4065553 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Thioridazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Tagln transgelin decreases expression ISO Thioridazine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Thioridazine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
WR-1065 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO WR 1065 results in increased expression of CAT protein CTD PMID:17388698 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO WR 1065 results in increased expression of CCL5 mRNA CTD PMID:12007958 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO WR 1065 results in decreased expression of GSTP1 mRNA CTD PMID:12007958 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO WR 1065 results in increased expression of IL2RA mRNA CTD PMID:12007958 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO WR 1065 results in increased expression of MYB mRNA CTD PMID:12007958 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO WR 1065 results in decreased expression of MYC mRNA CTD PMID:12007958 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
increases activity
multiple interactions
ISO WR 1065 results in increased expression of SOD2 mRNA; WR 1065 results in increased expression of SOD2 protein
WR 1065 results in increased activity of SOD2
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]
helenalin inhibits the reaction [WR 1065 results in increased expression of SOD2 protein]; WR 1065 results in increased expression of and results in increased activity of SOD2 protein
CTD PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 PMID:21945096 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    chemical entity 19786
      group 19705
        inorganic group 19196
          thiol group 1952
            thiol 1952
              alkanethiol 101
                (2S)-2-\{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino\}propane-1-thiol 0
                (ethylsulfanyl)methanethiol + 8
                1,6-Hexanedithiol 0
                1,8-Octanedithiol 0
                1,9-Nonanedithiol 0
                1-Hexanethiol 0
                1-Pentanethiol 0
                2-(ethylsulfanyl)ethanethiol + 2
                2-Ethyl-1-hexanethiol 0
                2-Heptanethiol 0
                2-Methyl-1-butanethiol 0
                2-Methyl-1-propenethiol 0
                2-Pentanethiol 0
                2-Propene-1-thiol 0
                2-methyl-3-sulfanylbutan-1-ol 0
                3-Mercapto-2-methylpentanal 0
                3-Methyl-2-butanethiol 0
                3-Methyl-2-butene-1-thiol 0
                3-mercaptohexanol + 0
                3-mercaptohexyl acetate 0
                3-mercaptopentanol 0
                3-methyl-3-sulfanylbutan-1-ol 0
                4-mercapto-4-methylpentan-2-one 0
                Cyclopentanethiol 0
                Heptane-1-thiol 0
                Isopentyl mercaptan 0
                WR-1065 11
                [(1R,2S)-2-hydroxy-1-thiopropyl]phosphonic acid 0
                captopril + 26
                ethanethiol 0
                mercaptoethanol + 23
                methanethiol + 37
                propane-1-thiol 2
                propane-2-thiol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19443
                        hydrogen molecular entity 19439
                          hydrides 18763
                            inorganic hydride 17484
                              chalcogen hydride 2453
                                sulfur hydride 2066
                                  hydrogen sulfide 2066
                                    thiol group 1952
                                      thiol 1952
                                        alkanethiol 101
                                          (2S)-2-\{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino\}propane-1-thiol 0
                                          (ethylsulfanyl)methanethiol + 8
                                          1,6-Hexanedithiol 0
                                          1,8-Octanedithiol 0
                                          1,9-Nonanedithiol 0
                                          1-Hexanethiol 0
                                          1-Pentanethiol 0
                                          2-(ethylsulfanyl)ethanethiol + 2
                                          2-Ethyl-1-hexanethiol 0
                                          2-Heptanethiol 0
                                          2-Methyl-1-butanethiol 0
                                          2-Methyl-1-propenethiol 0
                                          2-Pentanethiol 0
                                          2-Propene-1-thiol 0
                                          2-methyl-3-sulfanylbutan-1-ol 0
                                          3-Mercapto-2-methylpentanal 0
                                          3-Methyl-2-butanethiol 0
                                          3-Methyl-2-butene-1-thiol 0
                                          3-mercaptohexanol + 0
                                          3-mercaptohexyl acetate 0
                                          3-mercaptopentanol 0
                                          3-methyl-3-sulfanylbutan-1-ol 0
                                          4-mercapto-4-methylpentan-2-one 0
                                          Cyclopentanethiol 0
                                          Heptane-1-thiol 0
                                          Isopentyl mercaptan 0
                                          WR-1065 11
                                          [(1R,2S)-2-hydroxy-1-thiopropyl]phosphonic acid 0
                                          captopril + 26
                                          ethanethiol 0
                                          mercaptoethanol + 23
                                          methanethiol + 37
                                          propane-1-thiol 2
                                          propane-2-thiol 0
paths to the root