Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4'-epidoxorubicin
go back to main search page
Accession:CHEBI:47898 term browser browse the term
Definition:An anthracycline that is the 4'-epi-isomer of doxorubicin.
Synonyms:exact_synonym: (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
 related_synonym: 4'-Epiadriamycin;   Epiadriamycin;   Formula=C27H29NO11;   InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1;   InChIKey=AOJJSUZBOXZQNB-VTZDEGQISA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO;   epirubicin;   epirubicina;   epirubicine;   epirubicinum;   pidorubicina;   pidorubicine;   pidorubicinum
 xref: Beilstein:1445812;   CAS:56420-45-2;   DrugBank:DB00445;   Drug_Central:1030;   KEGG:C11230;   KEGG:D07901;   LINCS:LSM-2078
 xref_mesh: MESH:D015251
 xref: PDBeChem:DM6;   PMID:11432615;   PMID:15821120;   PMID:16005104;   PMID:17604344;   PMID:18838875;   Patent:DE2510866;   Patent:US4058519;   Reaxys:1445812
 cyclic_relationship: is_conjugate_acid_of CHEBI:41983



show annotations for term's descendants           Sort by:
 
4'-epidoxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of ABCB1 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]
[Diethylnitrosamine co-treated with Epirubicin] results in increased expression of ABCB1 protein
Epirubicin analog results in increased expression of ABCB1 mRNA; Epirubicin results in increased expression of ABCB1 mRNA
CTD PMID:11818250 PMID:12576456 PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
decreases response to substance
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]; ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]
Epirubicin analog results in increased expression of ABCC1 mRNA; Epirubicin results in increased expression of ABCC1 mRNA
ABCC1 protein results in decreased susceptibility to Epirubicin
CTD PMID:7954421 PMID:12576456 PMID:12657726 PMID:22914566 PMID:23867903 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
Epirubicin analog results in increased expression of ABCC2 mRNA; Epirubicin results in increased expression of ABCC2 mRNA
CTD PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases response to substance
ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCG2 protein results in decreased susceptibility to Epirubicin
CTD PMID:10606239 PMID:12576456 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:26646421 PMID:29505745 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ar androgen receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of AR protein; Epirubicin binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of ATG5 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]
CTD PMID:29505745 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BAX mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of BAX mRNA]; formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
paeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein]
CTD PMID:22914566 PMID:23867903 PMID:26335193 PMID:26646421 PMID:29505745 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO Epirubicin analog results in increased expression of BCL2 mRNA; Epirubicin results in increased expression of BCL2 mRNA
paeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]
[Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BCL2 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of BCL2 mRNA
CTD PMID:14503796 PMID:23867903 PMID:26335193 PMID:26646421 PMID:29505745 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of BECN1 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]
CTD PMID:29505745 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance ISO BIRC5 protein results in decreased susceptibility to Epirubicin CTD PMID:16188142 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 decreases response to substance ISO BIRC6 results in decreased susceptibility to Epirubicin CTD PMID:21542283 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Epirubicin CTD PMID:9491796 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP3 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin results in increased activity of and affects the localization of CASP3 protein; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
paeonol inhibits the reaction [Epirubicin results in increased cleavage of CASP3 protein]
CTD PMID:14503796 PMID:15996160 PMID:22914566 PMID:23867903 PMID:26335193 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] CTD PMID:23867903 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP9 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA] CTD PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO Epirubicin results in decreased activity of CAT protein
paeonol inhibits the reaction [Epirubicin results in decreased activity of CAT protein]
CTD PMID:26646421 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
ISO Epirubicin results in increased expression of CCN2 mRNA
Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA]
CTD PMID:22712078 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin] CTD PMID:16646564 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16446318 PMID:16682728 PMID:18768436 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO ERBB3 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Epirubicin results in increased expression of FAS protein CTD PMID:19429229 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression EXP Epirubicin results in increased expression of FASLG protein; Epirubicin results in increased expression of FASLG protein modified form CTD PMID:19429229 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Epirubicin results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368
JBrowse link
G Il2 interleukin 2 increases expression
multiple interactions
ISO Epirubicin results in increased expression of IL2 mRNA; Epirubicin results in increased expression of IL2 protein
paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 protein]
CTD PMID:26646421 PMID:29505745 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Epirubicin results in increased expression of IL6 protein
Epirubicin results in increased expression of IL6 mRNA
paeonol inhibits the reaction [Epirubicin results in increased expression of IL6 mRNA]
CTD PMID:17914082 PMID:19060235 PMID:26646421 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Epirubicin results in increased expression of IL6R protein CTD PMID:19060235 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Mir1 microRNA 1 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of MIR1 mRNA
paeonol inhibits the reaction [Epirubicin results in decreased expression of MIR1 mRNA]
CTD PMID:29505745 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
EXP Epirubicin results in increased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]
CTD PMID:29505745 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein; paeonol inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29505745 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nppa natriuretic peptide A increases expression ISO Epirubicin results in increased expression of NPPA protein CTD PMID:1831809 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Epirubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Epirubicin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Epirubicin results in increased cleavage of PARP1 protein
paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein]
CTD PMID:26646421 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases response to substance ISO PHLDA2 results in increased susceptibility to Epirubicin CTD PMID:22021909 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
JBrowse link
G Pml PML nuclear body scaffold affects mutagenesis ISO Epirubicin affects the mutagenesis of PML gene CTD PMID:19884644 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Rara retinoic acid receptor, alpha affects mutagenesis ISO Epirubicin affects the mutagenesis of RARA gene CTD PMID:19884644 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
EXP paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein] CTD PMID:29505745 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance ISO SOD2 protein affects the susceptibility to Epirubicin CTD PMID:9569045 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
EXP paeonol inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein] CTD PMID:29505745 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Epirubicin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Epirubicin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Epirubicin results in increased expression of TNF mRNA; Epirubicin results in increased expression of TNF protein
paeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]
CTD PMID:26646421 PMID:29505745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil]; TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 PMID:18465341 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of TP53 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of TP53 mRNA] CTD PMID:22914566 PMID:26335193 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [Epirubicin co-treated with Cyclophosphamide] results in increased expression of TYMP protein CTD PMID:15150550 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO VEGFC mRNA results in increased susceptibility to [Paclitaxel co-treated with Epirubicin co-treated with CMF regimen] CTD PMID:23146280 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        antimicrobial agent 17482
          4'-epidoxorubicin 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        oxyketone 8664
                                          alpha-oxyketone 8664
                                            alpha-hydroxy ketone 8664
                                              primary alpha-hydroxy ketone 7547
                                                doxorubicin 7362
                                                  4'-epidoxorubicin 52
paths to the root