Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4'-epidoxorubicin
go back to main search page
Accession:CHEBI:47898 term browser browse the term
Definition:An anthracycline that is the 4'-epi-isomer of doxorubicin.
Synonyms:exact_synonym: (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
 related_synonym: 4'-Epiadriamycin;   Epiadriamycin;   Formula=C27H29NO11;   InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1;   InChIKey=AOJJSUZBOXZQNB-VTZDEGQISA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO;   epirubicin;   epirubicina;   epirubicine;   epirubicinum;   pidorubicina;   pidorubicine;   pidorubicinum
 xref: Beilstein:1445812;   CAS:56420-45-2;   DrugBank:DB00445;   Drug_Central:1030;   KEGG:C11230;   KEGG:D07901;   LINCS:LSM-2078
 xref_mesh: MESH:D015251
 xref: PDBeChem:DM6;   PMID:11432615;   PMID:15821120;   PMID:16005104;   PMID:17604344;   PMID:18838875;   Patent:DE2510866;   Patent:US4058519;   Reaxys:1445812
 cyclic_relationship: is_conjugate_acid_of CHEBI:41983


show annotations for term's descendants           Sort by:
 
4'-epidoxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of ABCB1 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]
[Diethylnitrosamine co-treated with Epirubicin] results in increased expression of ABCB1 protein
Epirubicin analog results in increased expression of ABCB1 mRNA; Epirubicin results in increased expression of ABCB1 mRNA
CTD PMID:11818250, PMID:12576456, PMID:22914566, PMID:23867903, PMID:26335193 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
decreases response to substance
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]; ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]
Epirubicin analog results in increased expression of ABCC1 mRNA; Epirubicin results in increased expression of ABCC1 mRNA
ABCC1 protein results in decreased susceptibility to Epirubicin
CTD PMID:7954421, PMID:12576456, PMID:12657726, PMID:22914566, PMID:23867903, PMID:26335193 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
Epirubicin analog results in increased expression of ABCC2 mRNA; Epirubicin results in increased expression of ABCC2 mRNA
CTD PMID:22914566, PMID:23867903, PMID:26335193 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases response to substance
ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCG2 protein results in decreased susceptibility to Epirubicin
CTD PMID:10606239, PMID:12576456 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:26646421, PMID:29505745 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ar androgen receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of AR protein; Epirubicin binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of ATG5 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]
CTD PMID:29505745 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BAX mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of BAX mRNA]; formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
paeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein]
CTD PMID:22914566, PMID:23867903, PMID:26335193, PMID:26646421, PMID:29505745 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO Epirubicin analog results in increased expression of BCL2 mRNA; Epirubicin results in increased expression of BCL2 mRNA
paeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]
[Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BCL2 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of BCL2 mRNA
CTD PMID:14503796, PMID:23867903, PMID:26335193, PMID:26646421, PMID:29505745 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of BECN1 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]
CTD PMID:29505745 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance ISO BIRC5 protein results in decreased susceptibility to Epirubicin CTD PMID:16188142 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 decreases response to substance ISO BIRC6 results in decreased susceptibility to Epirubicin CTD PMID:21542283 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Epirubicin CTD PMID:9491796 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP3 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin results in increased activity of and affects the localization of CASP3 protein; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
paeonol inhibits the reaction [Epirubicin results in increased cleavage of CASP3 protein]
CTD PMID:14503796, PMID:15996160, PMID:22914566, PMID:23867903, PMID:26335193, PMID:26646421, PMID:29505745 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] CTD PMID:23867903 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP9 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA] CTD PMID:22914566, PMID:23867903, PMID:26335193 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO Epirubicin results in decreased activity of CAT protein
paeonol inhibits the reaction [Epirubicin results in decreased activity of CAT protein]
CTD PMID:26646421 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
ISO Epirubicin results in increased expression of CCN2 mRNA
Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA]
CTD PMID:22712078 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin] CTD PMID:16646564 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16446318, PMID:16682728, PMID:18768436 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO ERBB3 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Epirubicin results in increased expression of FAS protein CTD PMID:19429229 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression EXP Epirubicin results in increased expression of FASLG protein; Epirubicin results in increased expression of FASLG protein modified form CTD PMID:19429229 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Epirubicin results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,411,890...4,413,360
Ensembl chr20:4,411,876...4,413,366
JBrowse link
G Il2 interleukin 2 increases expression
multiple interactions
ISO Epirubicin results in increased expression of IL2 mRNA; Epirubicin results in increased expression of IL2 protein
paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 protein]
CTD PMID:26646421, PMID:29505745 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Epirubicin results in increased expression of IL6 protein
Epirubicin results in increased expression of IL6 mRNA
paeonol inhibits the reaction [Epirubicin results in increased expression of IL6 mRNA]
CTD PMID:17914082, PMID:19060235, PMID:26646421 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Epirubicin results in increased expression of IL6R protein CTD PMID:19060235 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Mir1 microRNA 1 decreases expression
multiple interactions
EXP Epirubicin results in decreased expression of MIR1 mRNA
paeonol inhibits the reaction [Epirubicin results in decreased expression of MIR1 mRNA]
CTD PMID:29505745 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
EXP Epirubicin results in increased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]
CTD PMID:29505745 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein; paeonol inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29505745 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppa natriuretic peptide A increases expression ISO Epirubicin results in increased expression of NPPA protein CTD PMID:1831809 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Epirubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Epirubicin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Epirubicin results in increased cleavage of PARP1 protein
paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein]
CTD PMID:26646421 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases response to substance ISO PHLDA2 results in increased susceptibility to Epirubicin CTD PMID:22021909 NCBI chr 1:216,701,345...216,704,479
Ensembl chr 1:216,702,319...216,703,534
JBrowse link
G Pml PML nuclear body scaffold affects mutagenesis ISO Epirubicin affects the mutagenesis of PML gene CTD PMID:19884644 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Rara retinoic acid receptor, alpha affects mutagenesis ISO Epirubicin affects the mutagenesis of RARA gene CTD PMID:19884644 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
EXP paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein] CTD PMID:29505745 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance ISO SOD2 protein affects the susceptibility to Epirubicin CTD PMID:9569045 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
EXP paeonol inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein] CTD PMID:29505745 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Epirubicin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Epirubicin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Epirubicin results in increased expression of TNF mRNA; Epirubicin results in increased expression of TNF protein
paeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]
CTD PMID:26646421, PMID:29505745 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil]; TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728, PMID:18465341 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of TP53 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of TP53 mRNA] CTD PMID:22914566, PMID:26335193 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [Epirubicin co-treated with Cyclophosphamide] results in increased expression of TYMP protein CTD PMID:15150550 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO VEGFC mRNA results in increased susceptibility to [Paclitaxel co-treated with Epirubicin co-treated with CMF regimen] CTD PMID:23146280 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          4'-epidoxorubicin 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxyketone 8629
                                          alpha-oxyketone 8629
                                            alpha-hydroxy ketone 8629
                                              primary alpha-hydroxy ketone 7514
                                                doxorubicin 7338
                                                  4'-epidoxorubicin 52
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.