Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic polypyrrole
go back to main search page
Accession:CHEBI:47882 term browser browse the term
Synonyms:exact_synonym: macrocyclic polypyrroles
 related_synonym: cyclic polypyrroles;   polypyrrole macrocycles


show annotations for term's descendants           Sort by:
 
cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
coproporphyrinogen III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase decreases carboxylation
multiple interactions
ISO CPOX protein results in decreased carboxylation of coproporphyrinogen III
Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]
CTD PMID:19339664 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO Vitamin B 12 results in decreased expression of ABCB1 mRNA; Vitamin B 12 results in decreased expression of ABCB1 protein
Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA]
CTD PMID:17982279 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 affects metabolic processing ISO ABCD4 protein affects the metabolism of Vitamin B 12 CTD PMID:22922874 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA] CTD PMID:18239293 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G As3mt arsenite methyltransferase multiple interactions ISO Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]; Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic] CTD PMID:20049124 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Axin1 axin 1 multiple interactions ISO [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943
G Casp3 caspase 3 multiple interactions EXP Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA] CTD PMID:23935743 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA] CTD PMID:23935743 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO
EXP
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]]
CTD PMID:16214333 PMID:20118189 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA CTD PMID:25003120 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of CD40 mRNA CTD PMID:30116142 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein CTD PMID:16517955 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:20118189 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein; Folic Acid inhibits the reaction [[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA]; Folic Acid promotes the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein]; Vitamin B 12 deficiency promotes the reaction [Folic Acid results in increased activity of FADS1 protein] CTD PMID:22133376 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions EXP [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein; [Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein] CTD PMID:22133376 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO Vitamin B 12 affects the reaction [FOLH1 gene SNP affects the susceptibility to and affects the metabolism of Arsenic] CTD PMID:29459232 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
G Fut2 fucosyltransferase 2 affects abundance ISO FUT2 gene polymorphism affects the abundance of Vitamin B 12 CTD PMID:18776911 NCBI chr 1:101,631,633...101,651,668
Ensembl chr 1:101,631,635...101,651,668
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects expression
affects glycosylation
ISO Vitamin B 12 affects the expression of HBA1 protein modified form
Vitamin B 12 affects the glycosylation of HBA1 protein
CTD PMID:2299304 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Il1b interleukin 1 beta increases methylation
multiple interactions
ISO Vitamin B 12 results in increased methylation of IL1B gene
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene
CTD PMID:30116142 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of IL6 protein] CTD PMID:16214333 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Vitamin B 12 results in decreased activity of MAOB protein CTD PMID:7430361 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mat2a methionine adenosyltransferase 2A multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; Fatty Acids, Omega-3 promotes the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA] CTD PMID:25003120 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mmachc metabolism of cobalamin associated C increases metabolic processing
affects binding
decreases metabolic processing
ISO MMACHC protein results in increased metabolism of Vitamin B 12
Vitamin B 12 analog binds to MMACHC protein; Vitamin B 12 binds to MMACHC protein
MMACHC protein mutant form results in decreased metabolism of Vitamin B 12
CTD PMID:19700356 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
JBrowse link
G Mthfr methylenetetrahydrofolate reductase decreases expression
multiple interactions
EXP Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA
[Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Fatty Acids, Omega-3 inhibits the reaction [Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA]
CTD PMID:25003120 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
increases activity
ISO
EXP
Vitamin B 12 binds to MTR protein
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of MTR mRNA; Fatty Acids, Omega-3 promotes the reaction [Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]]; Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]
Vitamin B 12 results in increased activity of MTR protein
CTD PMID:17477549 PMID:17982279 PMID:25003120 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA] CTD PMID:25003120 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein CTD PMID:20118189 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]; Vitamin B 12 inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA] CTD PMID:23935743 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases methylation
ISO [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene
Vitamin B 12 results in increased methylation of SERPINE1 gene
CTD PMID:30116142 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of SERPINH1 mRNA] CTD PMID:18239293 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Tcn2 transcobalamin 2 multiple interactions ISO TCN2 protein binds to and results in increased uptake of Vitamin B 12 CTD PMID:14632784 NCBI chr14:84,173,992...84,189,299
Ensembl chr14:84,174,138...84,189,266
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of TNF protein]
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein
CTD PMID:16214333 PMID:30116142 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
multiple interactions
ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]
CTD PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:64,600,968...64,714,114
Ensembl chr11:64,601,029...64,714,252
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083
JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions
EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA
CTD PMID:15539406 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:86,852,682...86,885,233
Ensembl chr11:86,852,711...86,885,224
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:63,268,106...63,291,125
Ensembl chr  X:63,268,037...63,292,092
JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions
ISO Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]
CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA
CTD PMID:15539406 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:23,818,370...23,924,393
Ensembl chr17:23,823,632...23,923,792
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:110,042,853...110,140,756
Ensembl chr 3:110,042,853...110,140,756
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP
Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
CTD PMID:19466990 PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:135,860,578...135,870,535
Ensembl chr 5:135,860,675...135,868,495
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:10,134,726...10,152,976
Ensembl chr17:10,137,974...10,152,956
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression
ISO
EXP
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 PMID:15242350 PMID:16959961 PMID:17156779 PMID:17292349 PMID:18178725 PMID:19039664 PMID:19136476 PMID:19191707 PMID:19952508 PMID:20638379 PMID:22859313 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin multiple interactions
affects binding
ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein
CTD PMID:11076874 PMID:23355332 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:89,919,570...89,929,774
Ensembl chr13:89,919,667...89,929,770
JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045
JBrowse link
G Lep leptin multiple interactions
increases abundance
ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like decreases expression ISO Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion
ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions
EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]
CTD PMID:15539406 NCBI chr13:91,772,927...91,827,231
Ensembl chr13:91,773,004...91,776,397
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme
CTD PMID:11213479 PMID:11878821 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:125,124,743...125,175,857
Ensembl chr 1:125,124,743...125,175,857
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:126,254,090...126,259,204
Ensembl chr 5:126,254,142...126,259,200
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:91,451,890...91,500,675
Ensembl chr10:91,451,865...91,500,661
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:198,112,104...198,120,202
Ensembl chr 2:198,112,076...198,120,120
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:140,822,141...140,835,244
Ensembl chr 5:140,822,141...140,834,959
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:74,173,809...74,291,188
Ensembl chr18:74,174,936...74,292,921
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:135,348,799...135,360,204
Ensembl chr  X:135,348,436...135,360,203
JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639
JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:111,565,646...111,587,184
Ensembl chr 3:111,565,650...111,587,151
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake
ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme
CTD PMID:17156779 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein
CTD PMID:11076874 PMID:23355332 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366
JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188
JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542
JBrowse link
glutathionylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
decreases expression
ISO MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein] CTD PMID:21659532 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein] CTD PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:64,600,968...64,714,114
Ensembl chr11:64,601,029...64,714,252
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083
JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions
EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA
CTD PMID:15539406 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:86,852,682...86,885,233
Ensembl chr11:86,852,711...86,885,224
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:63,268,106...63,291,125
Ensembl chr  X:63,268,037...63,292,092
JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression
multiple interactions
EXP Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
CTD PMID:15539406 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:23,818,370...23,924,393
Ensembl chr17:23,823,632...23,923,792
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:110,042,853...110,140,756
Ensembl chr 3:110,042,853...110,140,756
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP
Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
CTD PMID:19466990 PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:135,860,578...135,870,535
Ensembl chr 5:135,860,675...135,868,495
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:10,134,726...10,152,976
Ensembl chr17:10,137,974...10,152,956
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression
ISO
EXP
Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 PMID:15242350 PMID:16959961 PMID:17156779 PMID:17292349 PMID:18178725 PMID:19039664 PMID:19136476 PMID:19191707 PMID:19952508 PMID:20638379 PMID:22859313 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin multiple interactions
affects binding
ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein
CTD PMID:11076874 PMID:23355332 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:89,919,570...89,929,774
Ensembl chr13:89,919,667...89,929,770
JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045
JBrowse link
G Lep leptin multiple interactions
increases abundance
ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like decreases expression ISO Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Lyz2 lysozyme 2 increases secretion
multiple interactions
ISO Heme analog results in increased secretion of LYZ protein
SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]
CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions
EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]
CTD PMID:15539406 NCBI chr13:91,772,927...91,827,231
Ensembl chr13:91,773,004...91,776,397
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme
CTD PMID:11213479 PMID:11878821 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:125,124,743...125,175,857
Ensembl chr 1:125,124,743...125,175,857
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:126,254,090...126,259,204
Ensembl chr 5:126,254,142...126,259,200
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:91,451,890...91,500,675
Ensembl chr10:91,451,865...91,500,661
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:198,112,104...198,120,202
Ensembl chr 2:198,112,076...198,120,120
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:140,822,141...140,835,244
Ensembl chr 5:140,822,141...140,834,959
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:74,173,809...74,291,188
Ensembl chr18:74,174,936...74,292,921
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:135,348,799...135,360,204
Ensembl chr  X:135,348,436...135,360,203
JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639
JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:111,565,646...111,587,184
Ensembl chr 3:111,565,650...111,587,151
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake
ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme
CTD PMID:17156779 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein
CTD PMID:11076874 PMID:23355332 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366
JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188
JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542
JBrowse link
hemin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 decreases activity EXP Hemin results in decreased activity of ACO1 protein CTD PMID:16568477 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 increases expression EXP Hemin results in increased expression of ACO2 protein CTD PMID:16568477 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion EXP Hemin results in increased secretion of ADIPOQ protein CTD PMID:20016031 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression
multiple interactions
ISO Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]
CTD PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin affects binding ISO Hemin binds to ALB protein CTD PMID:10506189 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] CTD PMID:17541025 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 increases expression ISO Hemin results in increased expression of ARL6IP5 protein CTD PMID:16430862 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO Hemin results in decreased localization of and results in decreased activity of BACH1 protein CTD PMID:18550526 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein
CTD PMID:27815112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Hemin results in decreased expression of BCL2 protein CTD PMID:27815112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Hemin results in increased expression of BIRC2 protein CTD PMID:14647439 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased cleavage of CASP3 protein
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 PMID:27815112 PMID:31054940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:19150641 PMID:27815112 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA CTD PMID:29269057 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]
CTD PMID:14647439 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases degradation ISO Hemin results in decreased degradation of CDKN1B protein CTD PMID:17283133 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA] CTD PMID:29749404 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Crh corticotropin releasing hormone increases secretion
multiple interactions
ISO Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]
CTD PMID:11232018 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]] CTD PMID:23272707 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]
CTD PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]] CTD PMID:22159698 PMID:26747958 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO Hemin results in increased expression of CYP2A5 mRNA; Hemin results in increased expression of CYP2A5 protein
[tin protoporphyrin IX co-treated with Hemin] affects the localization of CYP2A5 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of CYP2A5 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP2B1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP2B1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP2B1 protein] CTD PMID:26747958 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] CTD PMID:11368792 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
CTD PMID:19325051 PMID:26747958 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]
Hemin results in increased expression of DDIT3 mRNA
CTD PMID:26747958 PMID:29749404 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA CTD PMID:32198055 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]; KN 62 inhibits the reaction [Hemin results in increased expression of FOS mRNA]; staurosporine aglycone inhibits the reaction [Hemin results in increased expression of FOS mRNA] CTD PMID:10381381 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression ISO Hemin results in decreased expression of FOSL1 protein CTD PMID:20006635 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP
ISO
Hemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 protein CTD PMID:15893546 PMID:16568477 PMID:17469137 PMID:29749404 PMID:31054940 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO
EXP
[Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA
Hemin results in increased expression of FTL1 mRNA
Hemin results in increased expression of FTL mRNA; Hemin results in increased expression of FTL1 protein
CTD PMID:12393473 PMID:15893546 PMID:16568477 PMID:29749404 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gata1 GATA binding protein 1 increases expression
multiple interactions
ISO Hemin results in increased expression of GATA1 mRNA
catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]
CTD PMID:21414390 PMID:23973255 PMID:28552822 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions
ISO Hemin results in decreased expression of GATA2 mRNA
hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]
CTD PMID:21414390 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Hemin results in increased expression of GCLC mRNA CTD PMID:16631525 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hemin results in increased stability of and results in increased expression of GSTP1 mRNA CTD PMID:15313425 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases activity ISO Hemin results in decreased activity of GSTZ1 protein CTD PMID:1846734 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
decreases response to substance
ISO Hemin results in increased expression of HAMP mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA; [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]; necrostatin-1 promotes the reaction [HAMP mRNA results in decreased susceptibility to Hemin]
CTD PMID:29749404 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
increases expression
ISO [catechol co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]; trichostatin A inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 PMID:30327826 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA
Hemin results in decreased expression of HIF1A mRNA
CTD PMID:12393473 PMID:29749404 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
increases expression
ISO [catechol co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
increases activity
decreases response to substance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased activity of HMOX1 protein] which results in decreased chemical synthesis of Reactive Oxygen Species; [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Genistein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
Hemin results in increased expression of HMOX1 mRNA; Hemin results in increased expression of HMOX1 protein
Hemin results in decreased expression of HMOX1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Hemin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; Hemin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Hemin
CTD PMID:3343248 PMID:8764571 PMID:9337616 PMID:9722676 PMID:10349844 PMID:10473555 PMID:11232018 PMID:12051994 PMID:12393473 PMID:12690112 PMID:14563492 PMID:14647439 PMID:14871405 PMID:15316927 PMID:15589375 PMID:16109301 PMID:16462769 PMID:16631525 PMID:16647178 PMID:16839318 PMID:16959797 PMID:17173083 PMID:17204476 PMID:17275847 PMID:17420286 PMID:17464175 PMID:17541025 PMID:17979934 PMID:18206168 PMID:18215737 PMID:18357586 PMID:18550526 PMID:18845130 PMID:19080378 PMID:19136476 PMID:19190261 PMID:19520142 PMID:20016031 PMID:20638379 PMID:20961405 PMID:21525764 PMID:22859313 PMID:23272707 PMID:23942037 PMID:24095726 PMID:25268984 PMID:25449124 PMID:25824035 PMID:26747958 PMID:27777014 PMID:27815112 PMID:27830717 PMID:29086419 PMID:29749404 PMID:30040983 PMID:31054940 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 decreases response to substance ISO HMOX2 protein results in decreased susceptibility to Hemin CTD PMID:15589375 PMID:16459095 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA CTD PMID:12393473 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA] CTD PMID:10349844 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Hemin results in increased expression of IL6 mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA
CTD PMID:29749404 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Hemin inhibits the reaction [Fructose results in increased expression of INS protein] CTD PMID:25268984 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions EXP Hemin results in decreased expression of and results in decreased activity of IREB2 protein CTD PMID:16568477 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Ivl involucrin decreases expression ISO Hemin results in decreased expression of IVL mRNA CTD PMID:20006635 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
[Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Hemin results in decreased expression of JUN mRNA
Hemin promotes the reaction [Paraquat results in increased phosphorylation of JUN protein]
CTD PMID:12393473 PMID:19080378 PMID:20016031 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Hemin results in increased phosphorylation of MAPK1 protein
diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK1 protein]
CTD PMID:16959797 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein] CTD PMID:18215737 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein] CTD PMID:18215737 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK3 protein] CTD PMID:16959797 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein] CTD PMID:19080378 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
Hemin results in decreased expression of MAPK9 mRNA
CTD PMID:19190261 PMID:20016031 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]] CTD PMID:27830717 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:19111564 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mir486 microRNA 486 increases expression
multiple interactions
ISO Hemin results in increased expression of MIR486-1 mRNA
[Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]
CTD PMID:32198055 Ensembl chr16:73,680,363...73,680,490 JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Hemin results in increased expression of MMP1 protein CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:17979934 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression
multiple interactions
ISO Hemin results in increased expression of NFE2 mRNA
catechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]
CTD PMID:21414390 PMID:28552822 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
affects localization
decreases expression
ISO
EXP
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]
CTD PMID:10473555 PMID:16959797 PMID:21464371 PMID:21525764 PMID:22859313 PMID:23272707 PMID:25824035 PMID:26747958 PMID:27777014 PMID:31054940 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Hemin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; Hemin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]
CTD PMID:14563492 PMID:15316927 PMID:26747958 PMID:27815112 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA CTD PMID:17541025 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Hemin results in increased expression of NQO1 mRNA; Hemin results in increased expression of NQO1 protein
Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]
CTD PMID:21464371 PMID:31054940 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of NRF1 protein] CTD PMID:30040983 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Hemin results in decreased expression of PDE5A protein CTD PMID:16839318 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA CTD PMID:32198055 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein] CTD PMID:11368792 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of PPARGC1A protein] CTD PMID:30040983 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases response to substance ISO PTGER2 gene mutant form results in increased susceptibility to Hemin CTD PMID:25451967 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein] CTD PMID:32198055 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] CTD PMID:32198055 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Rassf5 Ras association domain family member 5 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr13:47,956,754...48,022,333
Ensembl chr13:47,956,790...48,022,333
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
Hemin results in decreased expression of RELA mRNA
CTD PMID:19190261 PMID:20016031 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
affects response to substance
ISO [SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]
CTD PMID:31054940 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:19190261 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein] CTD PMID:12051994 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression EXP Hemin results in decreased expression of TFAP2C mRNA CTD PMID:20016031 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
EXP
ISO
Hemin results in decreased expression of TFRC protein
Hemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC protein
[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]
CTD PMID:12393473 PMID:16568477 PMID:16760464 PMID:21414390 PMID:25576684 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO [Hemin co-treated with Tretinoin] affects the localization of TGM2 protein CTD PMID:15556610 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of TNF mRNA; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Hemin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:17173083 PMID:19150641 PMID:26747958 PMID:27815112 PMID:29269057 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein] CTD PMID:17541025 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression
ISO zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA] CTD PMID:24095726 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
hydroxocobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Mmachc metabolism of cobalamin associated C affects binding ISO Hydroxocobalamin binds to MMACHC protein CTD PMID:19700356 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tetra(4-N-methylpyridyl)porphine binds to and affects the folding of MYC gene CTD PMID:15740131 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
mesoporphyrin IX term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions ISO mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein] CTD PMID:11232018 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
methylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein] CTD PMID:21237187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein] CTD PMID:21237187 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions
increases activity
ISO Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
motexafin gadolinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
motexafin gadolinium results in decreased expression of AGL mRNA
CTD PMID:16357179 NCBI chr 2:219,788,234...219,843,189
Ensembl chr 2:219,788,234...219,842,986
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]
motexafin gadolinium results in increased expression of ALDH5A1 mRNA
CTD PMID:16357179 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of ALDH6A1 mRNA
Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]
CTD PMID:16357179 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Arhgap17 Rho GTPase activating protein 17 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of ARHGAP17 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA
CTD PMID:16357179 NCBI chr 1:193,239,036...193,328,425
Ensembl chr 1:193,239,040...193,328,371
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]
motexafin gadolinium results in increased expression of ATF3 mRNA
CTD PMID:16357179 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]
motexafin gadolinium results in increased expression of ATM mRNA
CTD PMID:16357179 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of ATR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA
CTD PMID:16357179 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bach1 BTB domain and CNC homolog 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of BACH1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA
CTD PMID:16357179 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]
motexafin gadolinium results in increased expression of BAG3 mRNA
CTD PMID:16357179 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein] CTD PMID:20530418 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]
motexafin gadolinium results in increased expression of BIRC5 mRNA
CTD PMID:16357179 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmt2 base methyltransferase of 25S rRNA 2 homolog multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BMT2 mRNA
motexafin gadolinium results in increased expression of BMT2 mRNA
CTD PMID:16357179 NCBI chr 4:40,064,131...40,136,074
Ensembl chr 4:40,063,932...40,136,061
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of BNIP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA
CTD PMID:16357179 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of BNIP3L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA
CTD PMID:16357179 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Canx calnexin increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA
CTD PMID:16357179 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA
CTD PMID:16357179 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cbfb core-binding factor subunit beta increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA
CTD PMID:16357179 NCBI chr19:37,127,508...37,171,075
Ensembl chr19:37,127,508...37,171,069
JBrowse link
G Ccnj cyclin J multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
motexafin gadolinium results in decreased expression of CCNJ mRNA
CTD PMID:16357179 NCBI chr 1:259,926,537...259,944,275
Ensembl chr 1:260,093,641...260,111,254
Ensembl chr 1:260,093,641...260,111,254
JBrowse link
G Cdc16 cell division cycle 16 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of CDC16 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA
CTD PMID:16357179 NCBI chr16:81,493,355...81,516,493
Ensembl chr16:81,493,355...81,516,493
JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CDC25C mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA
CTD PMID:16357179 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc27 cell division cycle 27 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA
CTD PMID:16357179 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cdc5l cell division cycle 5-like decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA
CTD PMID:16357179 NCBI chr 9:17,949,764...17,988,514
Ensembl chr 9:17,949,764...17,988,509
JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of CDCA2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA
CTD PMID:16357179 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdk19 cyclin-dependent kinase 19 increases expression ISO motexafin gadolinium results in increased expression of CDK19 mRNA CTD PMID:16357179 NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]
motexafin gadolinium results in increased expression of CDK2 mRNA
CTD PMID:16357179 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA] CTD PMID:20530418 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CDKN1B mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA
CTD PMID:16357179 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cth cystathionine gamma-lyase increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA
CTD PMID:16357179 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cul3 cullin 3 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of CUL3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA
CTD PMID:16357179 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA
motexafin gadolinium results in increased expression of CYB5R1 mRNA
CTD PMID:16357179 NCBI chr13:51,229,697...51,236,447
Ensembl chr13:51,229,890...51,236,463
JBrowse link
G Dapk3 death-associated protein kinase 3 multiple interactions
decreases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]
motexafin gadolinium results in decreased expression of DAPK3 mRNA
CTD PMID:16357179 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]
motexafin gadolinium results in increased expression of DDIT3 mRNA
CTD PMID:16357179 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of DDIT4 mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]
CTD PMID:16357179 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dedd2 death effector domain containing 2 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]
motexafin gadolinium results in increased expression of DEDD2 mRNA
CTD PMID:16357179 NCBI chr 1:82,073,024...82,089,028
Ensembl chr 1:82,072,544...82,088,275
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of DFFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA
CTD PMID:16357179 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO motexafin gadolinium results in decreased expression of DHCR7 mRNA CTD PMID:16357179 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]
motexafin gadolinium results in increased expression of DNAJB1 mRNA
CTD PMID:16357179 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of DNAJB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA
CTD PMID:16357179 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of DNAJB6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA
CTD PMID:16357179 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]
motexafin gadolinium results in increased expression of DNAJC3 mRNA
CTD PMID:16357179 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA
motexafin gadolinium results in increased expression of E2F1 mRNA
CTD PMID:16357179 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of E2F3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA
CTD PMID:16357179 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA
CTD PMID:16357179 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of ELP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA
CTD PMID:16357179 NCBI chr 5:73,503,406...73,552,798
Ensembl chr 5:73,503,407...73,552,798
JBrowse link
G Eno1 enolase 1 increases expression ISO motexafin gadolinium results in increased expression of ENO1 mRNA CTD PMID:16357179 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Fadd Fas associated via death domain decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of FADD mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA
CTD PMID:16357179 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faim Fas apoptotic inhibitory molecule decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of FAIM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA
CTD PMID:16357179 NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224
Ensembl chr 8:107,225,212...107,241,224
JBrowse link
G Fam162a family with sequence similarity 162, member A increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of FAM162A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA
CTD PMID:16357179 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Fasn fatty acid synthase decreases expression ISO motexafin gadolinium results in decreased expression of FASN mRNA CTD PMID:16357179 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Foxo3 forkhead box O3 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of FOXO3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA
CTD PMID:16357179 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA
motexafin gadolinium results in increased expression of GCLM mRNA
CTD PMID:16357179 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gls glutaminase decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of GLS mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA
CTD PMID:16357179 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gpr146 G protein-coupled receptor 146 increases expression ISO motexafin gadolinium results in increased expression of GPR146 mRNA CTD PMID:16357179 NCBI chr12:17,343,396...17,358,631
Ensembl chr12:17,345,510...17,358,617
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO motexafin gadolinium results in increased expression of GPT2 mRNA CTD PMID:16357179 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA] CTD PMID:20530418 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of GSR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA
CTD PMID:16357179 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gtf3c2 general transcription factor IIIC subunit 2 increases expression ISO motexafin gadolinium results in increased expression of GTF3C2 mRNA CTD PMID:16357179 NCBI chr 6:26,560,601...26,584,533
Ensembl chr 6:26,560,601...26,584,535
JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA
motexafin gadolinium results in increased expression of HBP1 mRNA
CTD PMID:16357179 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO [motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
motexafin gadolinium results in increased expression of HIF1A protein
CTD PMID:16357179 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of HILPDA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA
CTD PMID:16357179 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]
motexafin gadolinium results in increased expression of HIPK1 mRNA
CTD PMID:16357179 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Hltf helicase-like transcription factor multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
motexafin gadolinium results in decreased expression of HLTF mRNA
CTD PMID:16357179 NCBI chr 2:104,854,571...104,914,338
Ensembl chr 2:104,854,572...104,914,173
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
motexafin gadolinium results in increased expression of HMOX1 mRNA
CTD PMID:16357179 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA
motexafin gadolinium results in increased expression of HRK mRNA
CTD PMID:16357179 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
motexafin gadolinium results in increased expression of HSP90AB1 mRNA
CTD PMID:16357179 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA] CTD PMID:16357179 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA] CTD PMID:16357179 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of HSPA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA
CTD PMID:16357179 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of HSPA4L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA
CTD PMID:16357179 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]
motexafin gadolinium results in increased expression of HSPB1 mRNA
CTD PMID:16357179 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]
motexafin gadolinium results in increased expression of HSPD1 mRNA
CTD PMID:16357179 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of HSPH1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]
CTD PMID:16357179 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of ID2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA
CTD PMID:16357179 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of IKBKE mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA
CTD PMID:16357179 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of IRF2BP2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA
CTD PMID:16357179 NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of JUND mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA
CTD PMID:16357179 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kdm3a lysine demethylase 3A increases expression ISO motexafin gadolinium results in increased expression of KDM3A mRNA CTD PMID:16357179 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of MDM2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]
CTD PMID:16357179 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mob1a MOB kinase activator 1A increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]
CTD PMID:16357179 NCBI chr 4:115,024,927...115,041,904
Ensembl chr 4:115,024,927...115,041,899
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA CTD PMID:15867382 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]
motexafin gadolinium results in increased expression of MT2A mRNA
CTD PMID:15867382 PMID:16357179 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA
motexafin gadolinium results in decreased expression of MYD88 mRNA
CTD PMID:16357179 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nadk NAD kinase increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of NADK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA
CTD PMID:16357179 NCBI chr 5:172,984,930...173,015,505
Ensembl chr 5:172,986,291...173,015,494
JBrowse link
G Nf1 neurofibromin 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA
motexafin gadolinium results in increased expression of NF1 mRNA
CTD PMID:16357179 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nisch nischarin decreases expression ISO motexafin gadolinium results in decreased expression of NISCH mRNA CTD PMID:16357179 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of NR1D2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]
CTD PMID:16357179 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]
motexafin gadolinium results in increased expression of P4HB mRNA
CTD PMID:16357179 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pdcd11 programmed cell death 11 decreases expression ISO motexafin gadolinium results in decreased expression of PDCD11 mRNA CTD PMID:16357179 NCBI chr 1:266,866,931...266,908,042
Ensembl chr 1:266,866,931...266,908,042
JBrowse link
G Pdcd4 programmed cell death 4 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of PDCD4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA
CTD PMID:16357179 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdcd5 programmed cell death 5 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of PDCD5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA
CTD PMID:16357179 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of PFKFB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA
CTD PMID:16357179 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of PFKFB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA
CTD PMID:16357179 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]
CTD PMID:16357179 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]
motexafin gadolinium results in increased expression of PHTF2 mRNA
CTD PMID:16357179 NCBI chr 4:10,823,191...10,938,273
Ensembl chr 4:10,823,281...10,938,318
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]
motexafin gadolinium results in increased expression of PIAS1 mRNA
CTD PMID:16357179 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of PIK3IP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA
CTD PMID:16357179 NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA
motexafin gadolinium results in increased expression of PMAIP1 mRNA
CTD PMID:16357179 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
motexafin gadolinium results in increased expression of PRKACB mRNA
CTD PMID:16357179 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO motexafin gadolinium results in decreased expression of PRKCD mRNA CTD PMID:16357179 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkd2 protein kinase D2 decreases expression ISO motexafin gadolinium results in decreased expression of PRKD2 mRNA CTD PMID:16357179 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO motexafin gadolinium results in increased expression of PRKDC mRNA CTD PMID:16357179 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of PTRH2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA
CTD PMID:16357179 NCBI chr10:74,002,151...74,012,182
Ensembl chr10:74,002,151...74,012,159
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of RB1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA
CTD PMID:16357179 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
motexafin gadolinium results in decreased expression of RCBTB2 mRNA
CTD PMID:16357179 NCBI chr15:55,029,388...55,074,728
Ensembl chr15:55,034,033...55,073,437
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of RELB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA
CTD PMID:16357179 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Rnf19b ring finger protein 19B increases expression ISO motexafin gadolinium results in increased expression of RNF19B mRNA CTD PMID:15867382 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
JBrowse link
G Selenow selenoprotein W multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
motexafin gadolinium results in increased expression of SELENOW mRNA
CTD PMID:16357179 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681
JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
motexafin gadolinium results in increased expression of SESN2 mRNA
CTD PMID:16357179 PMID:20530418 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]
motexafin gadolinium results in increased expression of SLC16A1 mRNA
CTD PMID:16357179 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc16a6 solute carrier family 16, member 6 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA
motexafin gadolinium results in increased expression of SLC16A6 mRNA
CTD PMID:16357179 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a4 solute carrier family 1 member 4 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]
motexafin gadolinium results in increased expression of SLC1A4 mRNA
CTD PMID:16357179 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression
ISO [Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA] CTD PMID:15867382 PMID:16357179 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA] CTD PMID:16357179 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions
affects expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA
motexafin gadolinium affects the expression of SLC39A10 mRNA
CTD PMID:16357179 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of SLC39A14 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA
CTD PMID:16357179 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc39a9 solute carrier family 39, member 9 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of SLC39A9 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA
CTD PMID:16357179 NCBI chr 6:104,291,001...104,326,553
Ensembl chr 6:104,291,071...104,329,872
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
motexafin gadolinium results in increased expression of SLC3A2 mRNA
CTD PMID:16357179 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc43a1 solute carrier family 43 member 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
motexafin gadolinium results in increased expression of SLC43A1 mRNA
CTD PMID:16357179 NCBI chr 3:72,238,796...72,265,023
Ensembl chr 3:72,238,981...72,264,466
JBrowse link
G Slc7a1 solute carrier family 7 member 1 multiple interactions
increases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
motexafin gadolinium results in increased expression of SLC7A1 mRNA
CTD PMID:16357179 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of SLC7A11 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA
CTD PMID:16357179 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of SMARCA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA
CTD PMID:16357179 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of SMARCA5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA
CTD PMID:16357179 NCBI chr19:30,936,703...30,969,454
Ensembl chr19:30,936,703...30,969,454
JBrowse link
G Tagap T-cell activation RhoGTPase activating protein increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of TAGAP mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA
CTD PMID:16357179 NCBI chr 1:47,493,990...47,503,492
Ensembl chr 1:47,493,994...47,502,952
JBrowse link
G Tfrc transferrin receptor multiple interactions
increases expression
ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]
motexafin gadolinium results in increased expression of TFRC mRNA
CTD PMID:16357179 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression
multiple interactions
ISO motexafin gadolinium results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA
CTD PMID:16357179 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions
decreases expression
ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
motexafin gadolinium results in decreased expression of TNFRSF17 mRNA
CTD PMID:16357179 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA
CTD PMID:16357179 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]
motexafin gadolinium results in increased expression of TNFSF8 mRNA
CTD PMID:16357179 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 decreases expression ISO motexafin gadolinium results in decreased expression of TNIP2 mRNA CTD PMID:16357179 NCBI chr14:81,487,934...81,505,889
Ensembl chr14:81,488,008...81,504,686
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein] CTD PMID:20530418 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of TRIB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA
CTD PMID:16357179 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of TXNRD1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA
CTD PMID:16357179 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO motexafin gadolinium results in increased expression of VEGFA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA
CTD PMID:16357179 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions
increases expression
ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]
motexafin gadolinium results in increased expression of VHL mRNA
CTD PMID:16357179 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
pheophorbide a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO ABCG2 protein affects the reaction [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased transport of pheophorbide a]; ABCG2 protein affects the reaction [Mifepristone results in decreased transport of pheophorbide a] CTD PMID:30217652 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
porphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anpep alanyl aminopeptidase, membrane decreases activity ISO Porphyrins analog results in decreased activity of ANPEP protein CTD PMID:19189318 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Porphyrins results in increased expression of BAX mRNA CTD PMID:26468117 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Porphyrins results in increased expression of BCL2 mRNA CTD PMID:26468117 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression ISO Porphyrins results in increased expression of CASP3 mRNA CTD PMID:26468117 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases expression ISO Porphyrins results in increased expression of CASP8 mRNA CTD PMID:26468117 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase decreases expression
increases expression
ISO Porphyrins results in decreased expression of CAT protein
Porphyrins results in increased expression of CAT mRNA
CTD PMID:26468117 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Porphyrins results in decreased expression of GPX1 mRNA CTD PMID:26468117 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Porphyrins results in increased expression of NFE2L2 mRNA CTD PMID:31385236 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression
ISO Porphyrins results in increased expression of SOD1 mRNA
Porphyrins results in decreased expression of SOD1 protein
CTD PMID:26468117 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression
ISO Porphyrins results in increased expression of SOD2 mRNA
Porphyrins results in decreased expression of SOD2 protein
CTD PMID:26468117 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tspo translocator protein affects transport EXP TSPO protein affects the transport of Porphyrins CTD PMID:11020479 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase copper transporting beta multiple interactions
decreases chemical synthesis
ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of protoporphyrin IX]
ATP7B gene mutant form results in decreased chemical synthesis of protoporphyrin IX
CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
EXP
ISO
Doxorubicin promotes the reaction [protoporphyrin IX results in increased activity of CASP3 protein]
protoporphyrin IX results in decreased activity of CASP3 protein
CTD PMID:16051694 PMID:18845130 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases activity ISO protoporphyrin IX results in decreased activity of CASP8 protein CTD PMID:16051694 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP protoporphyrin IX affects the localization of CYCS protein CTD PMID:18845130 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO protoporphyrin IX results in decreased expression of EGFR protein CTD PMID:23624237 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Epas1 endothelial PAS domain protein 1 affects localization ISO protoporphyrin IX affects the localization of EPAS1 protein CTD PMID:23624237 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of protoporphyrin IX CTD PMID:29906468 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO protoporphyrin IX results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects localization
increases degradation
decreases activity
ISO Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein]
protoporphyrin IX affects the localization of HIF1A protein
protoporphyrin IX results in increased degradation of HIF1A protein
CTD PMID:23624237 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases activity
EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
protoporphyrin IX results in decreased activity of HMOX1 protein
CTD PMID:18845130 PMID:19234301 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases response to substance ISO HSP90AA1 protein results in decreased susceptibility to protoporphyrin IX CTD PMID:23624237 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO protoporphyrin IX results in decreased expression of MMP2 mRNA; protoporphyrin IX results in decreased expression of MMP2 protein CTD PMID:23624237 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:21827494 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO protoporphyrin IX results in decreased expression of NOS3 protein CTD PMID:23624237 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [oxadiazon results in increased abundance of protoporphyrin IX] CTD PMID:26710982 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO protoporphyrin IX results in decreased expression of NR3C1 protein CTD PMID:23624237 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO protoporphyrin IX results in decreased expression of PLAT protein CTD PMID:23624237 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:21827494 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO protoporphyrin IX results in decreased expression of SLC2A1 mRNA CTD PMID:23624237 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tspo translocator protein decreases abundance EXP TSPO protein results in decreased abundance of protoporphyrin IX CTD PMID:11020479 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
protoporphyrinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase increases chemical synthesis
multiple interactions
ISO CPOX protein results in increased chemical synthesis of protoporphyrinogen
Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]; TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]
CTD PMID:11248690 PMID:19339664 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen] CTD PMID:11248690 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
protoporphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin increases expression ISO Protoporphyrins results in increased expression of AREG protein CTD PMID:19267999 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin increases expression ISO Protoporphyrins results in increased expression of BTC protein CTD PMID:19267999 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Ereg epiregulin increases expression ISO Protoporphyrins results in increased expression of EREG protein CTD PMID:19267999 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 multiple interactions
decreases expression
ISO verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]
verteporfin results in decreased expression of ANKRD1 mRNA
CTD PMID:29725256 PMID:29893953 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA
CTD PMID:29725256 PMID:29893953 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of CCN2 mRNA
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
CTD PMID:29725256 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cma1 chymase 1 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
CTD PMID:31812773 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases expression
ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein
Verteporfin results in decreased expression of JAK1 protein
CTD PMID:31812773 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of JAK2 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
CTD PMID:31812773 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:31812773 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]
Verteporfin results in decreased expression of STAT3 protein
CTD PMID:31812773 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:31812773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin results in decreased expression of YAP1 protein
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
CTD PMID:29725256 PMID:29893953 PMID:31494105 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:20052772 PMID:20861358 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen multiple interactions ISO [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20523338 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein] CTD PMID:19387321 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase affects abundance ISO ALAD gene SNP affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]
CTD PMID:19376148 PMID:21163135 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA CTD PMID:22839698 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA CTD PMID:22839698 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA CTD PMID:22839698 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984
JBrowse link
G Asf1a anti-silencing function 1A histone chaperone multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA CTD PMID:22839698 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
CTD PMID:22763982 PMID:27523796 PMID:32621855 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
EXP
ISO
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein
CTD PMID:20357190 PMID:27829220 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO zinc protoporphyrin results in increased expression of BCL2L11 protein CTD PMID:27829220 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein] CTD PMID:18508827 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA] CTD PMID:11738242 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cand1 cullin-associated and neddylation-dissociated 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA CTD PMID:22839698 NCBI chr 7:62,124,362...62,162,451
Ensembl chr 7:62,124,362...62,162,453
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity
ISO
EXP
zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein
CTD PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 PMID:25003661 PMID:26747958 PMID:27375190 PMID:27815112 PMID:28025122 PMID:29432840 PMID:30261164 PMID:32621855 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] CTD PMID:16051694 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106