Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclic polypyrrole
go back to main search page
Accession:CHEBI:47882 term browser browse the term
Synonyms:exact_synonym: macrocyclic polypyrroles
 related_synonym: cyclic polypyrroles;   polypyrrole macrocycles

show annotations for term's descendants           Sort by:
 
cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
coproporphyrinogen III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase decreases carboxylation
multiple interactions		 ISO CPOX protein results in decreased carboxylation of coproporphyrinogen III
Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]		 CTD PMID:19339664 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648 		JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions		 ISO Vitamin B 12 results in decreased expression of ABCB1 mRNA; Vitamin B 12 results in decreased expression of ABCB1 protein
Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA]		 CTD PMID:17982279 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 affects metabolic processing ISO ABCD4 protein affects the metabolism of Vitamin B 12 CTD PMID:22922874 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA] CTD PMID:18239293 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G As3mt arsenite methyltransferase multiple interactions ISO Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]; Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic] CTD PMID:20049124 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569 		JBrowse link
G Axin1 axin 1 multiple interactions ISO [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943
G Casp3 caspase 3 multiple interactions EXP Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA] CTD PMID:23935743 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA] CTD PMID:23935743 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]]		 CTD PMID:16214333 PMID:20118189 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cbs cystathionine beta synthase multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA CTD PMID:25003120 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of CD40 mRNA CTD PMID:30116142 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein CTD PMID:16517955 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:20118189 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein; Folic Acid inhibits the reaction [[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA]; Folic Acid promotes the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein]; Vitamin B 12 deficiency promotes the reaction [Folic Acid results in increased activity of FADS1 protein] CTD PMID:22133376 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138 		JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions EXP [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein; [Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein] CTD PMID:22133376 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO Vitamin B 12 affects the reaction [FOLH1 gene SNP affects the susceptibility to and affects the metabolism of Arsenic] CTD PMID:29459232 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415 		JBrowse link
G Fut2 fucosyltransferase 2 affects abundance ISO FUT2 gene polymorphism affects the abundance of Vitamin B 12 CTD PMID:18776911 NCBI chr 1:101,631,633...101,651,668
Ensembl chr 1:101,631,635...101,651,668 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects expression
affects glycosylation		 ISO Vitamin B 12 affects the expression of HBA1 protein modified form
Vitamin B 12 affects the glycosylation of HBA1 protein		 CTD PMID:2299304 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220 		JBrowse link
G Il1b interleukin 1 beta increases methylation
multiple interactions		 ISO Vitamin B 12 results in increased methylation of IL1B gene
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene		 CTD PMID:30116142 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of IL6 protein] CTD PMID:16214333 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO Vitamin B 12 results in decreased activity of MAOB protein CTD PMID:7430361 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Mat2a methionine adenosyltransferase 2A multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; Fatty Acids, Omega-3 promotes the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA] CTD PMID:25003120 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080 		JBrowse link
G Mmachc metabolism of cobalamin associated C increases metabolic processing
affects binding
decreases metabolic processing		 ISO MMACHC protein results in increased metabolism of Vitamin B 12
Vitamin B 12 analog binds to MMACHC protein; Vitamin B 12 binds to MMACHC protein
MMACHC protein mutant form results in decreased metabolism of Vitamin B 12		 CTD PMID:19700356 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase decreases expression
multiple interactions		 EXP Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA
[Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Fatty Acids, Omega-3 inhibits the reaction [Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA]		 CTD PMID:25003120 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
increases activity		 ISO
EXP		 Vitamin B 12 binds to MTR protein
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of MTR mRNA; Fatty Acids, Omega-3 promotes the reaction [Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]]; Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]
Vitamin B 12 results in increased activity of MTR protein		 CTD PMID:17477549 PMID:17982279 PMID:25003120 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA] CTD PMID:25003120 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein CTD PMID:20118189 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]; Vitamin B 12 inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA] CTD PMID:23935743 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases methylation		 ISO [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene
Vitamin B 12 results in increased methylation of SERPINE1 gene		 CTD PMID:30116142 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of SERPINH1 mRNA] CTD PMID:18239293 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317 		JBrowse link
G Tcn2 transcobalamin 2 multiple interactions ISO TCN2 protein binds to and results in increased uptake of Vitamin B 12 CTD PMID:14632784 NCBI chr14:84,173,992...84,189,299
Ensembl chr14:84,174,138...84,189,266 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of TNF protein]
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein		 CTD PMID:16214333 PMID:30116142 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272 		JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
multiple interactions		 ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]		 CTD PMID:21659532 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]		 CTD PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990 		JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions		 ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]		 CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:64,600,968...64,714,114
Ensembl chr11:64,601,029...64,714,252 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438 		JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression		 EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA		 CTD PMID:15539406 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404 		JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083 		JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions		 EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA		 CTD PMID:15539406 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339 		JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:86,852,682...86,885,233
Ensembl chr11:86,852,711...86,885,224 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099 		JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:63,268,106...63,291,125
Ensembl chr  X:63,268,037...63,292,092 		JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047 		JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions		 ISO Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]		 CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions
increases expression		 EXP [Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA		 CTD PMID:15539406 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295 		JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:23,818,370...23,924,393
Ensembl chr17:23,823,632...23,923,792 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233 		JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:110,042,853...110,140,756
Ensembl chr 3:110,042,853...110,140,756 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP		 Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:135,860,578...135,870,535
Ensembl chr 5:135,860,675...135,868,495 		JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:10,134,726...10,152,976
Ensembl chr17:10,137,974...10,152,956 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression		 ISO
EXP		 [HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]		 CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 PMID:15242350 PMID:16959961 PMID:17156779 PMID:17292349 PMID:18178725 PMID:19039664 PMID:19136476 PMID:19191707 PMID:19952508 PMID:20638379 PMID:22859313 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpx hemopexin multiple interactions
affects binding		 ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein		 CTD PMID:11076874 PMID:23355332 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198 		JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117 		JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:89,919,570...89,929,774
Ensembl chr13:89,919,667...89,929,770 		JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045 		JBrowse link
G Lep leptin multiple interactions
increases abundance		 ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like decreases expression ISO Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion		 ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions		 EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]		 CTD PMID:15539406 NCBI chr13:91,772,927...91,827,231
Ensembl chr13:91,773,004...91,776,397 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance		 ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme		 CTD PMID:11213479 PMID:11878821 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122 		JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:125,124,743...125,175,857
Ensembl chr 1:125,124,743...125,175,857 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:126,254,090...126,259,204
Ensembl chr 5:126,254,142...126,259,200 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:91,451,890...91,500,675
Ensembl chr10:91,451,865...91,500,661 		JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:198,112,104...198,120,202
Ensembl chr 2:198,112,076...198,120,120 		JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901 		JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:140,822,141...140,835,244
Ensembl chr 5:140,822,141...140,834,959 		JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:74,173,809...74,291,188
Ensembl chr18:74,174,936...74,292,921 		JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:135,348,799...135,360,204
Ensembl chr  X:135,348,436...135,360,203 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206 		JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654 		JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639 		JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:111,565,646...111,587,184
Ensembl chr 3:111,565,650...111,587,151 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127 		JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake		 ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme		 CTD PMID:17156779 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415 		JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein		 CTD PMID:11076874 PMID:23355332 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366 		JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987 		JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188 		JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542 		JBrowse link
glutathionylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272 		JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
decreases expression		 ISO MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein] CTD PMID:21659532 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein] CTD PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990 		JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions		 ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]		 CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:64,600,968...64,714,114
Ensembl chr11:64,601,029...64,714,252 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438 		JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression		 EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA		 CTD PMID:15539406 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404 		JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083 		JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions		 EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA		 CTD PMID:15539406 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339 		JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:86,852,682...86,885,233
Ensembl chr11:86,852,711...86,885,224 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099 		JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:63,268,106...63,291,125
Ensembl chr  X:63,268,037...63,292,092 		JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047 		JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression
multiple interactions		 EXP Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA		 CTD PMID:15539406 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295 		JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:23,818,370...23,924,393
Ensembl chr17:23,823,632...23,923,792 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233 		JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:110,042,853...110,140,756
Ensembl chr 3:110,042,853...110,140,756 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP		 Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:135,860,578...135,870,535
Ensembl chr 5:135,860,675...135,868,495 		JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:10,134,726...10,152,976
Ensembl chr17:10,137,974...10,152,956 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression		 ISO
EXP		 Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein		 CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 PMID:15242350 PMID:16959961 PMID:17156779 PMID:17292349 PMID:18178725 PMID:19039664 PMID:19136476 PMID:19191707 PMID:19952508 PMID:20638379 PMID:22859313 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpx hemopexin multiple interactions
affects binding		 ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein		 CTD PMID:11076874 PMID:23355332 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198 		JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117 		JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:89,919,570...89,929,774
Ensembl chr13:89,919,667...89,929,770 		JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045 		JBrowse link
G Lep leptin multiple interactions
increases abundance		 ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like decreases expression ISO Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G Lyz2 lysozyme 2 increases secretion
multiple interactions		 ISO Heme analog results in increased secretion of LYZ protein
SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]		 CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions		 EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]		 CTD PMID:15539406 NCBI chr13:91,772,927...91,827,231
Ensembl chr13:91,773,004...91,776,397 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance		 ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme		 CTD PMID:11213479 PMID:11878821 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122 		JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:125,124,743...125,175,857
Ensembl chr 1:125,124,743...125,175,857 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:126,254,090...126,259,204
Ensembl chr 5:126,254,142...126,259,200 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:91,451,890...91,500,675
Ensembl chr10:91,451,865...91,500,661 		JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:198,112,104...198,120,202
Ensembl chr 2:198,112,076...198,120,120 		JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901 		JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:140,822,141...140,835,244
Ensembl chr 5:140,822,141...140,834,959 		JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:74,173,809...74,291,188
Ensembl chr18:74,174,936...74,292,921 		JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:135,348,799...135,360,204
Ensembl chr  X:135,348,436...135,360,203 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206 		JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654 		JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639 		JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:111,565,646...111,587,184
Ensembl chr 3:111,565,650...111,587,151 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127 		JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake		 ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme		 CTD PMID:17156779 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415 		JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein		 CTD PMID:11076874 PMID:23355332 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366 		JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987 		JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188 		JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542 		JBrowse link
hemin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 decreases activity EXP Hemin results in decreased activity of ACO1 protein CTD PMID:16568477 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Aco2 aconitase 2 increases expression EXP Hemin results in increased expression of ACO2 protein CTD PMID:16568477 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion EXP Hemin results in increased secretion of ADIPOQ protein CTD PMID:20016031 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression
multiple interactions		 ISO Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]		 CTD PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G Alb albumin affects binding ISO Hemin binds to ALB protein CTD PMID:10506189 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] CTD PMID:17541025 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 increases expression ISO Hemin results in increased expression of ARL6IP5 protein CTD PMID:16430862 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO Hemin results in decreased localization of and results in decreased activity of BACH1 protein CTD PMID:18550526 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein		 CTD PMID:27815112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Hemin results in decreased expression of BCL2 protein CTD PMID:27815112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Hemin results in increased expression of BIRC2 protein CTD PMID:14647439 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 EXP
ISO		 [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased cleavage of CASP3 protein
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]		 CTD PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 PMID:27815112 PMID:31054940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:19150641 PMID:27815112 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA CTD PMID:29269057 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]		 CTD PMID:14647439 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases degradation ISO Hemin results in decreased degradation of CDKN1B protein CTD PMID:17283133 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA] CTD PMID:29749404 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Crh corticotropin releasing hormone increases secretion
multiple interactions		 ISO Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]		 CTD PMID:11232018 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]] CTD PMID:23272707 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]		 CTD PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]] CTD PMID:22159698 PMID:26747958 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions		 ISO Hemin results in increased expression of CYP2A5 mRNA; Hemin results in increased expression of CYP2A5 protein
[tin protoporphyrin IX co-treated with Hemin] affects the localization of CYP2A5 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of CYP2A5 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]		 CTD PMID:22859313 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP2B1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP2B1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP2B1 protein] CTD PMID:26747958 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] CTD PMID:11368792 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]		 CTD PMID:19325051 PMID:26747958 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 EXP
ISO		 Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]
Hemin results in increased expression of DDIT3 mRNA		 CTD PMID:26747958 PMID:29749404 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA CTD PMID:32198055 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]; KN 62 inhibits the reaction [Hemin results in increased expression of FOS mRNA]; staurosporine aglycone inhibits the reaction [Hemin results in increased expression of FOS mRNA] CTD PMID:10381381 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression ISO Hemin results in decreased expression of FOSL1 protein CTD PMID:20006635 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP
ISO		 Hemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 protein CTD PMID:15893546 PMID:16568477 PMID:17469137 PMID:29749404 PMID:31054940 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression		 ISO
EXP		 [Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA
Hemin results in increased expression of FTL1 mRNA
Hemin results in increased expression of FTL mRNA; Hemin results in increased expression of FTL1 protein		 CTD PMID:12393473 PMID:15893546 PMID:16568477 PMID:29749404 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829 		JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940 		JBrowse link
G Gata1 GATA binding protein 1 increases expression
multiple interactions		 ISO Hemin results in increased expression of GATA1 mRNA
catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]		 CTD PMID:21414390 PMID:23973255 PMID:28552822 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066 		JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions		 ISO Hemin results in decreased expression of GATA2 mRNA
hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]		 CTD PMID:21414390 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Hemin results in increased expression of GCLC mRNA CTD PMID:16631525 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hemin results in increased stability of and results in increased expression of GSTP1 mRNA CTD PMID:15313425 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases activity ISO Hemin results in decreased activity of GSTZ1 protein CTD PMID:1846734 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
decreases response to substance		 ISO Hemin results in increased expression of HAMP mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA; [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]; necrostatin-1 promotes the reaction [HAMP mRNA results in decreased susceptibility to Hemin]		 CTD PMID:29749404 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
increases expression		 ISO [catechol co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]; trichostatin A inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 PMID:30327826 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA
Hemin results in decreased expression of HIF1A mRNA		 CTD PMID:12393473 PMID:29749404 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
increases expression		 ISO [catechol co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
increases activity
decreases response to substance		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased activity of HMOX1 protein] which results in decreased chemical synthesis of Reactive Oxygen Species; [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Genistein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
Hemin results in increased expression of HMOX1 mRNA; Hemin results in increased expression of HMOX1 protein
Hemin results in decreased expression of HMOX1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Hemin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; Hemin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Hemin		 CTD PMID:3343248 PMID:8764571 PMID:9337616 PMID:9722676 PMID:10349844 PMID:10473555 PMID:11232018 PMID:12051994 PMID:12393473 PMID:12690112 PMID:14563492 PMID:14647439 PMID:14871405 PMID:15316927 PMID:15589375 PMID:16109301 PMID:16462769 PMID:16631525 PMID:16647178 PMID:16839318 PMID:16959797 PMID:17173083 PMID:17204476 PMID:17275847 PMID:17420286 PMID:17464175 PMID:17541025 PMID:17979934 PMID:18206168 PMID:18215737 PMID:18357586 PMID:18550526 PMID:18845130 PMID:19080378 PMID:19136476 PMID:19190261 PMID:19520142 PMID:20016031 PMID:20638379 PMID:20961405 PMID:21525764 PMID:22859313 PMID:23272707 PMID:23942037 PMID:24095726 PMID:25268984 PMID:25449124 PMID:25824035 PMID:26747958 PMID:27777014 PMID:27815112 PMID:27830717 PMID:29086419 PMID:29749404 PMID:30040983 PMID:31054940 PMID:32671443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hmox2 heme oxygenase 2 decreases response to substance ISO HMOX2 protein results in decreased susceptibility to Hemin CTD PMID:15589375 PMID:16459095 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA CTD PMID:12393473 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA] CTD PMID:10349844 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance		 ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Hemin results in increased expression of IL6 mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA		 CTD PMID:29749404 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Hemin inhibits the reaction [Fructose results in increased expression of INS protein] CTD PMID:25268984 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions EXP Hemin results in decreased expression of and results in decreased activity of IREB2 protein CTD PMID:16568477 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118 		JBrowse link
G Ivl involucrin decreases expression ISO Hemin results in decreased expression of IVL mRNA CTD PMID:20006635 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO
EXP		 [Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Hemin results in decreased expression of JUN mRNA
Hemin promotes the reaction [Paraquat results in increased phosphorylation of JUN protein]		 CTD PMID:12393473 PMID:19080378 PMID:20016031 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Hemin results in increased phosphorylation of MAPK1 protein
diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16959797 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein] CTD PMID:18215737 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein] CTD PMID:18215737 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK3 protein] CTD PMID:16959797 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein] CTD PMID:19080378 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
Hemin results in decreased expression of MAPK9 mRNA		 CTD PMID:19190261 PMID:20016031 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]] CTD PMID:27830717 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:19111564 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Mir486 microRNA 486 increases expression
multiple interactions		 ISO Hemin results in increased expression of MIR486-1 mRNA
[Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]		 CTD PMID:32198055 Ensembl chr16:73,680,363...73,680,490 JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Hemin results in increased expression of MMP1 protein CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:17979934 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression
multiple interactions		 ISO Hemin results in increased expression of NFE2 mRNA
catechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]		 CTD PMID:21414390 PMID:28552822 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
affects localization
decreases expression		 ISO
EXP		 [Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]		 CTD PMID:10473555 PMID:16959797 PMID:21464371 PMID:21525764 PMID:22859313 PMID:23272707 PMID:25824035 PMID:26747958 PMID:27777014 PMID:31054940 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Hemin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; Hemin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]		 CTD PMID:14563492 PMID:15316927 PMID:26747958 PMID:27815112 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA CTD PMID:17541025 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO Hemin results in increased expression of NQO1 mRNA; Hemin results in increased expression of NQO1 protein
Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]		 CTD PMID:21464371 PMID:31054940 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of NRF1 protein] CTD PMID:30040983 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908 		JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Hemin results in decreased expression of PDE5A protein CTD PMID:16839318 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA CTD PMID:32198055 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein] CTD PMID:11368792 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of PPARGC1A protein] CTD PMID:30040983 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptger2 prostaglandin E receptor 2 increases response to substance ISO PTGER2 gene mutant form results in increased susceptibility to Hemin CTD PMID:25451967 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein] CTD PMID:32198055 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] CTD PMID:32198055 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157 		JBrowse link
G Rassf5 Ras association domain family member 5 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr13:47,956,754...48,022,333
Ensembl chr13:47,956,790...48,022,333 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
Hemin results in decreased expression of RELA mRNA		 CTD PMID:19190261 PMID:20016031 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
affects response to substance		 ISO [SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]		 CTD PMID:31054940 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:19190261 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein] CTD PMID:12051994 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression EXP Hemin results in decreased expression of TFAP2C mRNA CTD PMID:20016031 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 EXP
ISO		 Hemin results in decreased expression of TFRC protein
Hemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC protein
[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]		 CTD PMID:12393473 PMID:16568477 PMID:16760464 PMID:21414390 PMID:25576684 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO [Hemin co-treated with Tretinoin] affects the localization of TGM2 protein CTD PMID:15556610 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of TNF mRNA; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Hemin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:17173083 PMID:19150641 PMID:26747958 PMID:27815112 PMID:29269057 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein] CTD PMID:17541025 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882 		JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression		 ISO zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA] CTD PMID:24095726 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569 		JBrowse link
hydroxocobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Mmachc metabolism of cobalamin associated C affects binding ISO Hydroxocobalamin binds to MMACHC protein CTD PMID:19700356 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tetra(4-N-methylpyridyl)porphine binds to and affects the folding of MYC gene CTD PMID:15740131 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
mesoporphyrin IX term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions ISO mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein] CTD PMID:11232018 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpx hemopexin multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
methylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein] CTD PMID:21237187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein] CTD PMID:21237187 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions
increases activity		 ISO Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
motexafin gadolinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
motexafin gadolinium results in decreased expression of AGL mRNA		 CTD PMID:16357179 NCBI chr 2:219,788,234...219,843,189
Ensembl chr 2:219,788,234...219,842,986 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]
motexafin gadolinium results in increased expression of ALDH5A1 mRNA		 CTD PMID:16357179 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of ALDH6A1 mRNA
Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]		 CTD PMID:16357179 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185 		JBrowse link
G Arhgap17 Rho GTPase activating protein 17 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of ARHGAP17 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA		 CTD PMID:16357179 NCBI chr 1:193,239,036...193,328,425
Ensembl chr 1:193,239,040...193,328,371 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]
motexafin gadolinium results in increased expression of ATF3 mRNA		 CTD PMID:16357179 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]
motexafin gadolinium results in increased expression of ATM mRNA		 CTD PMID:16357179 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of ATR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA		 CTD PMID:16357179 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of BACH1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA		 CTD PMID:16357179 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842 		JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]
motexafin gadolinium results in increased expression of BAG3 mRNA		 CTD PMID:16357179 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein] CTD PMID:20530418 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]
motexafin gadolinium results in increased expression of BIRC5 mRNA		 CTD PMID:16357179 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bmt2 base methyltransferase of 25S rRNA 2 homolog multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BMT2 mRNA
motexafin gadolinium results in increased expression of BMT2 mRNA		 CTD PMID:16357179 NCBI chr 4:40,064,131...40,136,074
Ensembl chr 4:40,063,932...40,136,061 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of BNIP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA		 CTD PMID:16357179 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of BNIP3L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA		 CTD PMID:16357179 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Canx calnexin increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA		 CTD PMID:16357179 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA		 CTD PMID:16357179 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cbfb core-binding factor subunit beta increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA		 CTD PMID:16357179 NCBI chr19:37,127,508...37,171,075
Ensembl chr19:37,127,508...37,171,069 		JBrowse link
G Ccnj cyclin J multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
motexafin gadolinium results in decreased expression of CCNJ mRNA		 CTD PMID:16357179 NCBI chr 1:259,926,537...259,944,275
Ensembl chr 1:260,093,641...260,111,254
Ensembl chr 1:260,093,641...260,111,254 		JBrowse link
G Cdc16 cell division cycle 16 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of CDC16 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA		 CTD PMID:16357179 NCBI chr16:81,493,355...81,516,493
Ensembl chr16:81,493,355...81,516,493 		JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CDC25C mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA		 CTD PMID:16357179 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdc27 cell division cycle 27 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA		 CTD PMID:16357179 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082 		JBrowse link
G Cdc5l cell division cycle 5-like decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA		 CTD PMID:16357179 NCBI chr 9:17,949,764...17,988,514
Ensembl chr 9:17,949,764...17,988,509 		JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of CDCA2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA		 CTD PMID:16357179 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004 		JBrowse link
G Cdk19 cyclin-dependent kinase 19 increases expression ISO motexafin gadolinium results in increased expression of CDK19 mRNA CTD PMID:16357179 NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]
motexafin gadolinium results in increased expression of CDK2 mRNA		 CTD PMID:16357179 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA] CTD PMID:20530418 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CDKN1B mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA		 CTD PMID:16357179 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cth cystathionine gamma-lyase increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA		 CTD PMID:16357179 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Cul3 cullin 3 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of CUL3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA		 CTD PMID:16357179 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA
motexafin gadolinium results in increased expression of CYB5R1 mRNA		 CTD PMID:16357179 NCBI chr13:51,229,697...51,236,447
Ensembl chr13:51,229,890...51,236,463 		JBrowse link
G Dapk3 death-associated protein kinase 3 multiple interactions
decreases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]
motexafin gadolinium results in decreased expression of DAPK3 mRNA		 CTD PMID:16357179 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]
motexafin gadolinium results in increased expression of DDIT3 mRNA		 CTD PMID:16357179 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of DDIT4 mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]		 CTD PMID:16357179 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Dedd2 death effector domain containing 2 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]
motexafin gadolinium results in increased expression of DEDD2 mRNA		 CTD PMID:16357179 NCBI chr 1:82,073,024...82,089,028
Ensembl chr 1:82,072,544...82,088,275 		JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of DFFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA		 CTD PMID:16357179 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO motexafin gadolinium results in decreased expression of DHCR7 mRNA CTD PMID:16357179 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]
motexafin gadolinium results in increased expression of DNAJB1 mRNA		 CTD PMID:16357179 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of DNAJB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA		 CTD PMID:16357179 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of DNAJB6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA		 CTD PMID:16357179 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]
motexafin gadolinium results in increased expression of DNAJC3 mRNA		 CTD PMID:16357179 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA
motexafin gadolinium results in increased expression of E2F1 mRNA		 CTD PMID:16357179 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f3 E2F transcription factor 3 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of E2F3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA		 CTD PMID:16357179 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA		 CTD PMID:16357179 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113 		JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of ELP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA		 CTD PMID:16357179 NCBI chr 5:73,503,406...73,552,798
Ensembl chr 5:73,503,407...73,552,798 		JBrowse link
G Eno1 enolase 1 increases expression ISO motexafin gadolinium results in increased expression of ENO1 mRNA CTD PMID:16357179 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Fadd Fas associated via death domain decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of FADD mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA		 CTD PMID:16357179 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Faim Fas apoptotic inhibitory molecule decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of FAIM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA		 CTD PMID:16357179 NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224
Ensembl chr 8:107,225,212...107,241,224 		JBrowse link
G Fam162a family with sequence similarity 162, member A increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of FAM162A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA		 CTD PMID:16357179 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO motexafin gadolinium results in decreased expression of FASN mRNA CTD PMID:16357179 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Foxo3 forkhead box O3 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of FOXO3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA		 CTD PMID:16357179 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA
motexafin gadolinium results in increased expression of GCLM mRNA		 CTD PMID:16357179 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gls glutaminase decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of GLS mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA		 CTD PMID:16357179 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872 		JBrowse link
G Gpr146 G protein-coupled receptor 146 increases expression ISO motexafin gadolinium results in increased expression of GPR146 mRNA CTD PMID:16357179 NCBI chr12:17,343,396...17,358,631
Ensembl chr12:17,345,510...17,358,617 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO motexafin gadolinium results in increased expression of GPT2 mRNA CTD PMID:16357179 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA] CTD PMID:20530418 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of GSR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA		 CTD PMID:16357179 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gtf3c2 general transcription factor IIIC subunit 2 increases expression ISO motexafin gadolinium results in increased expression of GTF3C2 mRNA CTD PMID:16357179 NCBI chr 6:26,560,601...26,584,533
Ensembl chr 6:26,560,601...26,584,535 		JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA
motexafin gadolinium results in increased expression of HBP1 mRNA		 CTD PMID:16357179 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO [motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
motexafin gadolinium results in increased expression of HIF1A protein		 CTD PMID:16357179 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of HILPDA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA		 CTD PMID:16357179 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]
motexafin gadolinium results in increased expression of HIPK1 mRNA		 CTD PMID:16357179 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079 		JBrowse link
G Hltf helicase-like transcription factor multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
motexafin gadolinium results in decreased expression of HLTF mRNA		 CTD PMID:16357179 NCBI chr 2:104,854,571...104,914,338
Ensembl chr 2:104,854,572...104,914,173 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
motexafin gadolinium results in increased expression of HMOX1 mRNA		 CTD PMID:16357179 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA
motexafin gadolinium results in increased expression of HRK mRNA		 CTD PMID:16357179 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
motexafin gadolinium results in increased expression of HSP90AB1 mRNA		 CTD PMID:16357179 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA] CTD PMID:16357179 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA] CTD PMID:16357179 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of HSPA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA		 CTD PMID:16357179 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of HSPA4L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA		 CTD PMID:16357179 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]
motexafin gadolinium results in increased expression of HSPB1 mRNA		 CTD PMID:16357179 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]
motexafin gadolinium results in increased expression of HSPD1 mRNA		 CTD PMID:16357179 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of HSPH1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]		 CTD PMID:16357179 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of ID2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA		 CTD PMID:16357179 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of IKBKE mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA		 CTD PMID:16357179 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394 		JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of IRF2BP2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA		 CTD PMID:16357179 NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of JUND mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA		 CTD PMID:16357179 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707 		JBrowse link
G Kdm3a lysine demethylase 3A increases expression ISO motexafin gadolinium results in increased expression of KDM3A mRNA CTD PMID:16357179 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of MDM2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]		 CTD PMID:16357179 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mob1a MOB kinase activator 1A increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]		 CTD PMID:16357179 NCBI chr 4:115,024,927...115,041,904
Ensembl chr 4:115,024,927...115,041,899 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA CTD PMID:15867382 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression		 ISO motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]
motexafin gadolinium results in increased expression of MT2A mRNA		 CTD PMID:15867382 PMID:16357179 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA
motexafin gadolinium results in decreased expression of MYD88 mRNA		 CTD PMID:16357179 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nadk NAD kinase increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of NADK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA		 CTD PMID:16357179 NCBI chr 5:172,984,930...173,015,505
Ensembl chr 5:172,986,291...173,015,494 		JBrowse link
G Nf1 neurofibromin 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA
motexafin gadolinium results in increased expression of NF1 mRNA		 CTD PMID:16357179 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903 		JBrowse link
G Nisch nischarin decreases expression ISO motexafin gadolinium results in decreased expression of NISCH mRNA CTD PMID:16357179 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of NR1D2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]		 CTD PMID:16357179 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]
motexafin gadolinium results in increased expression of P4HB mRNA		 CTD PMID:16357179 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987 		JBrowse link
G Pdcd11 programmed cell death 11 decreases expression ISO motexafin gadolinium results in decreased expression of PDCD11 mRNA CTD PMID:16357179 NCBI chr 1:266,866,931...266,908,042
Ensembl chr 1:266,866,931...266,908,042 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of PDCD4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA		 CTD PMID:16357179 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204 		JBrowse link
G Pdcd5 programmed cell death 5 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of PDCD5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA		 CTD PMID:16357179 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of PFKFB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA		 CTD PMID:16357179 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of PFKFB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA		 CTD PMID:16357179 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]		 CTD PMID:16357179 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367 		JBrowse link
G Phtf2 putative homeodomain transcription factor 2 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]
motexafin gadolinium results in increased expression of PHTF2 mRNA		 CTD PMID:16357179 NCBI chr 4:10,823,191...10,938,273
Ensembl chr 4:10,823,281...10,938,318 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]
motexafin gadolinium results in increased expression of PIAS1 mRNA		 CTD PMID:16357179 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of PIK3IP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA		 CTD PMID:16357179 NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA
motexafin gadolinium results in increased expression of PMAIP1 mRNA		 CTD PMID:16357179 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
motexafin gadolinium results in increased expression of PRKACB mRNA		 CTD PMID:16357179 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886 		JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO motexafin gadolinium results in decreased expression of PRKCD mRNA CTD PMID:16357179 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Prkd2 protein kinase D2 decreases expression ISO motexafin gadolinium results in decreased expression of PRKD2 mRNA CTD PMID:16357179 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO motexafin gadolinium results in increased expression of PRKDC mRNA CTD PMID:16357179 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of PTRH2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA		 CTD PMID:16357179 NCBI chr10:74,002,151...74,012,182
Ensembl chr10:74,002,151...74,012,159 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of RB1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA		 CTD PMID:16357179 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
motexafin gadolinium results in decreased expression of RCBTB2 mRNA		 CTD PMID:16357179 NCBI chr15:55,029,388...55,074,728
Ensembl chr15:55,034,033...55,073,437 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of RELB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA		 CTD PMID:16357179 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825 		JBrowse link
G Rnf19b ring finger protein 19B increases expression ISO motexafin gadolinium results in increased expression of RNF19B mRNA CTD PMID:15867382 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957 		JBrowse link
G Selenow selenoprotein W multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
motexafin gadolinium results in increased expression of SELENOW mRNA		 CTD PMID:16357179 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681 		JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression		 ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
motexafin gadolinium results in increased expression of SESN2 mRNA		 CTD PMID:16357179 PMID:20530418 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]
motexafin gadolinium results in increased expression of SLC16A1 mRNA		 CTD PMID:16357179 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA
motexafin gadolinium results in increased expression of SLC16A6 mRNA		 CTD PMID:16357179 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]
motexafin gadolinium results in increased expression of SLC1A4 mRNA		 CTD PMID:16357179 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression		 ISO [Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA] CTD PMID:15867382 PMID:16357179 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA] CTD PMID:16357179 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841 		JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions
affects expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA
motexafin gadolinium affects the expression of SLC39A10 mRNA		 CTD PMID:16357179 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of SLC39A14 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA		 CTD PMID:16357179 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816 		JBrowse link
G Slc39a9 solute carrier family 39, member 9 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of SLC39A9 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA		 CTD PMID:16357179 NCBI chr 6:104,291,001...104,326,553
Ensembl chr 6:104,291,071...104,329,872 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
motexafin gadolinium results in increased expression of SLC3A2 mRNA		 CTD PMID:16357179 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092 		JBrowse link
G Slc43a1 solute carrier family 43 member 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
motexafin gadolinium results in increased expression of SLC43A1 mRNA		 CTD PMID:16357179 NCBI chr 3:72,238,796...72,265,023
Ensembl chr 3:72,238,981...72,264,466 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 multiple interactions
increases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
motexafin gadolinium results in increased expression of SLC7A1 mRNA		 CTD PMID:16357179 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of SLC7A11 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA		 CTD PMID:16357179 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of SMARCA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA		 CTD PMID:16357179 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468 		JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of SMARCA5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA		 CTD PMID:16357179 NCBI chr19:30,936,703...30,969,454
Ensembl chr19:30,936,703...30,969,454 		JBrowse link
G Tagap T-cell activation RhoGTPase activating protein increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of TAGAP mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA		 CTD PMID:16357179 NCBI chr 1:47,493,990...47,503,492
Ensembl chr 1:47,493,994...47,502,952 		JBrowse link
G Tfrc transferrin receptor multiple interactions
increases expression		 ISO motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]
motexafin gadolinium results in increased expression of TFRC mRNA		 CTD PMID:16357179 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression
multiple interactions		 ISO motexafin gadolinium results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA		 CTD PMID:16357179 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914 		JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions
decreases expression		 ISO [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
motexafin gadolinium results in decreased expression of TNFRSF17 mRNA		 CTD PMID:16357179 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA		 CTD PMID:16357179 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]
motexafin gadolinium results in increased expression of TNFSF8 mRNA		 CTD PMID:16357179 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 decreases expression ISO motexafin gadolinium results in decreased expression of TNIP2 mRNA CTD PMID:16357179 NCBI chr14:81,487,934...81,505,889
Ensembl chr14:81,488,008...81,504,686 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein] CTD PMID:20530418 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of TRIB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA		 CTD PMID:16357179 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of TXNRD1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA		 CTD PMID:16357179 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO motexafin gadolinium results in increased expression of VEGFA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA		 CTD PMID:16357179 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions
increases expression		 ISO motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]
motexafin gadolinium results in increased expression of VHL mRNA		 CTD PMID:16357179 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845 		JBrowse link
pheophorbide a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO ABCG2 protein affects the reaction [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased transport of pheophorbide a]; ABCG2 protein affects the reaction [Mifepristone results in decreased transport of pheophorbide a] CTD PMID:30217652 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
porphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anpep alanyl aminopeptidase, membrane decreases activity ISO Porphyrins analog results in decreased activity of ANPEP protein CTD PMID:19189318 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Porphyrins results in increased expression of BAX mRNA CTD PMID:26468117 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Porphyrins results in increased expression of BCL2 mRNA CTD PMID:26468117 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases expression ISO Porphyrins results in increased expression of CASP3 mRNA CTD PMID:26468117 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases expression ISO Porphyrins results in increased expression of CASP8 mRNA CTD PMID:26468117 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase decreases expression
increases expression		 ISO Porphyrins results in decreased expression of CAT protein
Porphyrins results in increased expression of CAT mRNA		 CTD PMID:26468117 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Porphyrins results in decreased expression of GPX1 mRNA CTD PMID:26468117 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Porphyrins results in increased expression of NFE2L2 mRNA CTD PMID:31385236 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression		 ISO Porphyrins results in increased expression of SOD1 mRNA
Porphyrins results in decreased expression of SOD1 protein		 CTD PMID:26468117 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression		 ISO Porphyrins results in increased expression of SOD2 mRNA
Porphyrins results in decreased expression of SOD2 protein		 CTD PMID:26468117 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tspo translocator protein affects transport EXP TSPO protein affects the transport of Porphyrins CTD PMID:11020479 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609 		JBrowse link
protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase copper transporting beta multiple interactions
decreases chemical synthesis		 ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of protoporphyrin IX]
ATP7B gene mutant form results in decreased chemical synthesis of protoporphyrin IX		 CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity		 EXP
ISO		 Doxorubicin promotes the reaction [protoporphyrin IX results in increased activity of CASP3 protein]
protoporphyrin IX results in decreased activity of CASP3 protein		 CTD PMID:16051694 PMID:18845130 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 decreases activity ISO protoporphyrin IX results in decreased activity of CASP8 protein CTD PMID:16051694 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cycs cytochrome c, somatic affects localization EXP protoporphyrin IX affects the localization of CYCS protein CTD PMID:18845130 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO protoporphyrin IX results in decreased expression of EGFR protein CTD PMID:23624237 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects localization ISO protoporphyrin IX affects the localization of EPAS1 protein CTD PMID:23624237 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of protoporphyrin IX CTD PMID:29906468 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO protoporphyrin IX results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects localization
increases degradation
decreases activity		 ISO Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein]
protoporphyrin IX affects the localization of HIF1A protein
protoporphyrin IX results in increased degradation of HIF1A protein		 CTD PMID:23624237 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases activity		 EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
protoporphyrin IX results in decreased activity of HMOX1 protein		 CTD PMID:18845130 PMID:19234301 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases response to substance ISO HSP90AA1 protein results in decreased susceptibility to protoporphyrin IX CTD PMID:23624237 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO protoporphyrin IX results in decreased expression of MMP2 mRNA; protoporphyrin IX results in decreased expression of MMP2 protein CTD PMID:23624237 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:21827494 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO protoporphyrin IX results in decreased expression of NOS3 protein CTD PMID:23624237 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [oxadiazon results in increased abundance of protoporphyrin IX] CTD PMID:26710982 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO protoporphyrin IX results in decreased expression of NR3C1 protein CTD PMID:23624237 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO protoporphyrin IX results in decreased expression of PLAT protein CTD PMID:23624237 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:21827494 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO protoporphyrin IX results in decreased expression of SLC2A1 mRNA CTD PMID:23624237 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tspo translocator protein decreases abundance EXP TSPO protein results in decreased abundance of protoporphyrin IX CTD PMID:11020479 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
protoporphyrinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase increases chemical synthesis
multiple interactions		 ISO CPOX protein results in increased chemical synthesis of protoporphyrinogen
Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]; TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]		 CTD PMID:11248690 PMID:19339664 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen] CTD PMID:11248690 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
protoporphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin increases expression ISO Protoporphyrins results in increased expression of AREG protein CTD PMID:19267999 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Btc betacellulin increases expression ISO Protoporphyrins results in increased expression of BTC protein CTD PMID:19267999 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484 		JBrowse link
G Ereg epiregulin increases expression ISO Protoporphyrins results in increased expression of EREG protein CTD PMID:19267999 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 multiple interactions
decreases expression		 ISO verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]
verteporfin results in decreased expression of ANKRD1 mRNA		 CTD PMID:29725256 PMID:29893953 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA		 CTD PMID:29725256 PMID:29893953 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of CCN2 mRNA
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]		 CTD PMID:29725256 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cma1 chymase 1 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]		 CTD PMID:31812773 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases expression		 ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein
Verteporfin results in decreased expression of JAK1 protein		 CTD PMID:31812773 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904 		JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of JAK2 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein		 CTD PMID:31812773 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]		 CTD PMID:31812773 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]
Verteporfin results in decreased expression of STAT3 protein		 CTD PMID:31812773 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:31812773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin results in decreased expression of YAP1 protein
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]		 CTD PMID:29725256 PMID:29893953 PMID:31494105 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579 		JBrowse link
zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP		 zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]		 CTD PMID:20052772 PMID:20861358 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20523338 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein] CTD PMID:19387321 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alad aminolevulinate dehydratase affects abundance ISO ALAD gene SNP affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]		 CTD PMID:19376148 PMID:21163135 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA CTD PMID:22839698 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198 		JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA CTD PMID:22839698 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335 		JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA CTD PMID:22839698 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA CTD PMID:22839698 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]		 CTD PMID:22763982 PMID:27523796 PMID:32621855 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 EXP
ISO		 zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein		 CTD PMID:20357190 PMID:27829220 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO zinc protoporphyrin results in increased expression of BCL2L11 protein CTD PMID:27829220 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein] CTD PMID:18508827 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA] CTD PMID:11738242 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Cand1 cullin-associated and neddylation-dissociated 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA CTD PMID:22839698 NCBI chr 7:62,124,362...62,162,451
Ensembl chr 7:62,124,362...62,162,453 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity		 ISO
EXP		 zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein		 CTD PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 PMID:25003661 PMID:26747958 PMID:27375190 PMID:27815112 PMID:28025122 PMID:29432840 PMID:30261164 PMID:32621855 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] CTD PMID:16051694 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106