|
G
|
Abcc4
|
ATP binding cassette subfamily C member 4
|
increases transport
|
ISO
|
ABCC4 protein results in increased transport of Enalapril
|
CTD |
PMID:17939016 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
|
|
G
|
Ace
|
angiotensin I converting enzyme
|
decreases activity multiple interactions increases expression
|
ISO EXP
|
Enalapril results in decreased activity of ACE protein Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of ACE protein] ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] Enalapril results in increased expression of ACE mRNA Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]
|
CTD |
PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 PMID:28973481 PMID:30940551 PMID:36706861 More...
|
|
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of ACTA2 protein
|
CTD |
PMID:19349682 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Acvrl1
|
activin A receptor like type 1
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of ACVRL1 protein
|
CTD |
PMID:12883979 |
|
NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305
|
|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
increases expression
|
ISO
|
Enalapril results in increased expression of ADIPOQ protein
|
CTD |
PMID:25037058 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
|
|
G
|
Adrb1
|
adrenoceptor beta 1
|
increases expression
|
EXP
|
Enalapril results in increased expression of ADRB1 protein
|
CTD |
PMID:7586371 |
|
NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237
|
|
G
|
Agt
|
angiotensinogen
|
decreases activity affects response to substance increases expression decreases response to substance multiple interactions decreases expression
|
EXP ISO
|
Enalapril results in decreased activity of AGT protein modified form AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril Enalapril results in increased expression of AGT mRNA Enalapril results in decreased susceptibility to AGT protein modified form Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein] Enalapril results in decreased expression of AGT protein modified form [Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] Enalapril results in decreased expression of AGT mRNA
|
CTD |
PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 PMID:14659064 PMID:16685205 PMID:18300870 PMID:18679781 PMID:18796534 PMID:19114890 PMID:20829712 PMID:21602471 More...
|
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
|
|
G
|
Agtr1a
|
angiotensin II receptor, type 1a
|
increases expression multiple interactions decreases expression affects expression
|
EXP ISO
|
Enalapril results in increased expression of AGTR1A mRNA Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of AGTR1 protein] Enalapril results in decreased expression of AGTR1A mRNA Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA] Enalapril affects the expression of AGTR1A mRNA
|
CTD |
PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 PMID:36706861 More...
|
|
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
|
|
G
|
Agtr2
|
angiotensin II receptor, type 2
|
increases expression decreases expression
|
EXP
|
Enalapril results in increased expression of AGTR2 mRNA Enalapril results in decreased expression of AGTR2 mRNA
|
CTD |
PMID:9740612 PMID:18403896 PMID:18765277 |
|
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions
|
EXP
|
Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:18806606 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA]
|
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
|
|
G
|
Ang
|
angiogenin
|
decreases expression
|
ISO
|
Enalapril results in decreased expression of ANG protein
|
CTD |
PMID:3038326 |
|
NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106
|
|
G
|
Angpt2
|
angiopoietin 2
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA]
|
CTD |
PMID:19958114 |
|
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:77,790,563...77,841,239
|
|
G
|
Apoe
|
apolipoprotein E
|
multiple interactions
|
ISO
|
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
|
CTD |
PMID:19603250 PMID:25037058 |
|
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
|
|
G
|
Atf2
|
activating transcription factor 2
|
increases expression
|
EXP
|
Enalapril results in increased expression of ATF2 protein
|
CTD |
PMID:15531746 |
|
NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745
|
|
G
|
Atp1a2
|
ATPase Na+/K+ transporting subunit alpha 2
|
increases expression
|
EXP
|
Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein
|
CTD |
PMID:18418421 |
|
NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911
|
|
G
|
Atp1a3
|
ATPase Na+/K+ transporting subunit alpha 3
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein
|
CTD |
PMID:18418421 |
|
NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825
|
|
G
|
Avp
|
arginine vasopressin
|
multiple interactions
|
EXP
|
Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein]
|
CTD |
PMID:3346065 |
|
NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of BAX protein
|
CTD |
PMID:21153712 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
increases expression multiple interactions
|
EXP
|
Enalapril results in increased expression of BCL2 protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
|
CTD |
PMID:21153712 PMID:30623541 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bdkrb1
|
bradykinin receptor B1
|
increases expression multiple interactions
|
EXP
|
Enalapril results in increased expression of BDKRB1 mRNA [kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril
|
CTD |
PMID:18796534 PMID:21430409 |
|
NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973
|
|
G
|
Bdkrb2
|
bradykinin receptor B2
|
increases expression
|
EXP
|
Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein
|
CTD |
PMID:18190998 |
|
NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209
|
|
G
|
Becn1
|
beclin 1
|
increases expression
|
EXP
|
Enalapril results in increased expression of BECN1 protein
|
CTD |
PMID:30563025 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
|
|
G
|
Bglap
|
bone gamma-carboxyglutamate protein
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA]
|
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
|
|
G
|
Car2
|
carbonic anhydrase 2
|
decreases activity
|
ISO
|
Enalapril results in decreased activity of CA2 protein
|
CTD |
PMID:28126276 |
|
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
|
|
G
|
Casp3
|
caspase 3
|
decreases activity multiple interactions
|
EXP
|
Enalapril results in decreased activity of CASP3 protein Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]
|
CTD |
PMID:21153712 PMID:30623541 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp9
|
caspase 9
|
decreases activity
|
EXP
|
Enalapril results in decreased activity of CASP9 protein
|
CTD |
PMID:21153712 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
increases activity multiple interactions
|
EXP
|
Enalapril results in increased activity of CAT protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
|
CTD |
PMID:12124199 PMID:30623541 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions decreases expression
|
EXP ISO
|
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein] Enalapril results in decreased expression of CCL2 protein Enalapril results in decreased expression of CCL2 mRNA
|
CTD |
PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 PMID:28973481 More...
|
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Ccn2
|
cellular communication network factor 2
|
decreases expression multiple interactions
|
EXP ISO
|
Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
|
CTD |
PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 |
|
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
|
|
G
|
Cela2a
|
chymotrypsin like elastase 2A
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of CELA2A mRNA
|
CTD |
PMID:21602471 |
|
NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:159,409,899...159,426,208
|
|
G
|
Cltrn
|
collectrin, amino acid transport regulator
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein
|
CTD |
PMID:12887829 |
|
NCBI chr X:30,361,967...30,395,264
Ensembl chr X:33,993,825...34,027,181
|
|
G
|
Clu
|
clusterin
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of CLU protein
|
CTD |
PMID:12193663 |
|
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860
|
|
G
|
Cma1
|
chymase 1
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of CMA1 mRNA
|
CTD |
PMID:18796534 |
|
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:33,387,351...33,390,133
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
|
CTD |
PMID:12003776 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
|
|
G
|
Col3a1
|
collagen type III alpha 1 chain
|
decreases expression increases expression
|
EXP ISO
|
Enalapril results in decreased expression of COL3A1 mRNA Enalapril results in increased expression of COL3A1 mRNA
|
CTD |
PMID:17164399 PMID:25037058 |
|
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
|
|
G
|
Col4a1
|
collagen type IV alpha 1 chain
|
multiple interactions decreases expression
|
EXP
|
[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein
|
CTD |
PMID:9175058 PMID:18682491 |
|
NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482
|
|
G
|
Cs
|
citrate synthase
|
increases activity
|
EXP
|
Enalapril results in increased activity of CS protein
|
CTD |
PMID:30563025 |
|
NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938
|
|
G
|
Cyba
|
cytochrome b-245 alpha chain
|
multiple interactions decreases expression
|
ISO
|
[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein Enalapril results in decreased expression of CYBA protein
|
CTD |
PMID:20720404 PMID:25037058 |
|
NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214
|
|
G
|
Cycs
|
cytochrome c, somatic
|
affects localization
|
EXP
|
Enalapril affects the localization of CYCS protein
|
CTD |
PMID:21153712 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
|
CTD |
PMID:19299527 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
|
|
G
|
Edn1
|
endothelin 1
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]
|
CTD |
PMID:9175058 |
|
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
|
|
G
|
Eng
|
endoglin
|
multiple interactions
|
ISO
|
[Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933
|
|
G
|
Epo
|
erythropoietin
|
decreases expression multiple interactions
|
ISO EXP
|
Enalapril results in decreased expression of EPO protein Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]
|
CTD |
PMID:2474097 PMID:9434678 PMID:19958114 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
|
|
G
|
Epor
|
erythropoietin receptor
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein]
|
CTD |
PMID:19958114 |
|
NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322
|
|
G
|
F3
|
coagulation factor III, tissue factor
|
decreases expression multiple interactions
|
ISO
|
Enalapril results in decreased expression of F3 protein Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]
|
CTD |
PMID:18060435 PMID:22188725 |
|
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
|
|
G
|
Faslg
|
Fas ligand
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of FASLG mRNA
|
CTD |
PMID:10925121 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
|
|
G
|
Gh1
|
growth hormone 1
|
increases response to substance
|
ISO
|
GH1 protein results in increased susceptibility to Enalapril
|
CTD |
PMID:12883983 |
|
NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859
|
|
G
|
Gja5
|
gap junction protein, alpha 5
|
multiple interactions
|
ISO
|
GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]
|
CTD |
PMID:19109587 |
|
NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512
|
|
G
|
Gjc1
|
gap junction protein, gamma 1
|
multiple interactions
|
ISO
|
GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]
|
CTD |
PMID:19109587 |
|
NCBI chr10:87,758,192...87,785,443
Ensembl chr10:88,249,489...88,285,853
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:18806606 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Has2
|
hyaluronan synthase 2
|
increases expression
|
EXP
|
Enalapril results in increased expression of HAS2 mRNA
|
CTD |
PMID:20933085 |
|
NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535
|
|
G
|
Hmgb1
|
high mobility group box 1
|
multiple interactions
|
EXP ISO
|
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]
|
CTD |
PMID:19114890 |
|
NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
|
|
G
|
Hmox1
|
heme oxygenase 1
|
increases expression
|
EXP
|
Enalapril results in increased expression of HMOX1 protein
|
CTD |
PMID:21263376 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Hyal1
|
hyaluronidase 1
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein
|
CTD |
PMID:20933085 |
|
NCBI chr 8:117,129,311...117,133,162
Ensembl chr 8:117,129,277...117,133,146
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
decreases expression multiple interactions
|
EXP ISO
|
Enalapril results in decreased expression of ICAM1 protein Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form] [Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA Enalapril results in decreased expression of ICAM1 protein modified form
|
CTD |
PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
|
|
G
|
Igf1
|
insulin-like growth factor 1
|
affects expression decreases expression
|
EXP
|
Enalapril affects the expression of IGF1 protein Enalapril results in decreased expression of IGF1 mRNA
|
CTD |
PMID:12883983 |
|
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
|
|
G
|
Igfbp1
|
insulin-like growth factor binding protein 1
|
increases expression
|
EXP
|
Enalapril results in increased expression of IGFBP1 mRNA
|
CTD |
PMID:12883983 |
|
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
|
|
G
|
Il1a
|
interleukin 1 alpha
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
|
CTD |
PMID:17299153 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions decreases expression
|
EXP ISO
|
Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA] Enalapril results in decreased expression of IL1B mRNA
|
CTD |
PMID:17167242 PMID:21265103 PMID:25037058 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions affects response to substance
|
EXP ISO
|
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA] Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein] IL6 gene polymorphism affects the susceptibility to Enalapril
|
CTD |
PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Irak1
|
interleukin-1 receptor-associated kinase 1
|
multiple interactions
|
ISO
|
[Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA
|
CTD |
PMID:20524934 |
|
NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825
|
|
G
|
Itga2
|
integrin subunit alpha 2
|
decreases expression
|
ISO
|
Enalapril results in decreased expression of ITGA2 mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509
|
|
G
|
Kdr
|
kinase insert domain receptor
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]
|
CTD |
PMID:12110003 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
|
|
G
|
Kng1
|
kininogen 1
|
increases response to substance
|
EXP
|
Enalapril results in increased susceptibility to KNG1 protein modified form
|
CTD |
PMID:18190998 |
|
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148
|
|
G
|
Lamb1
|
laminin subunit beta 1
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]
|
CTD |
PMID:9175058 |
|
NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760
|
|
G
|
Lamb2
|
laminin subunit beta 2
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]
|
CTD |
PMID:9175058 |
|
NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:118,056,935...118,069,090
|
|
G
|
Lep
|
leptin
|
increases response to substance
|
ISO
|
LEP protein results in increased susceptibility to Enalapril
|
CTD |
PMID:20614101 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
increases expression increases phosphorylation
|
EXP
|
Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein Enalapril results in increased phosphorylation of MAPK9 protein
|
CTD |
PMID:15531746 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
|
|
G
|
Mfn2
|
mitofusin 2
|
increases expression
|
EXP
|
Enalapril results in increased expression of MFN2 protein
|
CTD |
PMID:30563025 |
|
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
|
|
G
|
Mir146a
|
microRNA 146a
|
multiple interactions
|
ISO
|
[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A
|
CTD |
PMID:20524934 |
|
NCBI chr10:28,349,996...28,350,090
|
|
G
|
Mir146b
|
microRNA 146b
|
multiple interactions
|
ISO
|
[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B
|
CTD |
PMID:20524934 |
|
NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:255,144,860...255,144,947
|
|
G
|
Mmp3
|
matrix metallopeptidase 3
|
decreases expression
|
ISO
|
Enalapril results in decreased expression of MMP3 mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein]
|
CTD |
PMID:19114890 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Myh6
|
myosin heavy chain 6
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein]
|
CTD |
PMID:15362513 |
|
NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333
|
|
G
|
Myh7
|
myosin heavy chain 7
|
decreases expression multiple interactions
|
EXP
|
Enalapril results in decreased expression of MYH7 mRNA Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]
|
CTD |
PMID:15362513 PMID:21423293 |
|
NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194
|
|
G
|
Ndst1
|
N-deacetylase and N-sulfotransferase 1
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein]
|
CTD |
PMID:15793251 |
|
NCBI chr18:56,407,308...56,470,007
Ensembl chr18:56,411,200...56,448,612
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of NFE2L2 mRNA
|
CTD |
PMID:18765277 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
decreases activity multiple interactions
|
EXP
|
Enalapril results in decreased activity of NFKB1 protein Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]
|
CTD |
PMID:19225048 PMID:21265102 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:19114890 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Noa1
|
nitric oxide associated 1
|
increases expression increases activity
|
EXP
|
Enalapril results in increased expression of NOA1 mRNA Enalapril results in increased activity of NOA1 protein
|
CTD |
PMID:14588141 |
|
NCBI chr14:31,189,570...31,205,600
Ensembl chr14:31,188,978...31,205,599
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
decreases expression multiple interactions
|
EXP ISO
|
Enalapril results in decreased expression of NOS2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
|
CTD |
PMID:20720404 PMID:21377515 PMID:25037058 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions increases expression affects expression
|
EXP ISO
|
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] Enalapril results in increased expression of NOS3 protein [paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]] Enalapril affects the expression of NOS3 mRNA
|
CTD |
PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 PMID:30940551 More...
|
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
|
|
G
|
Nppa
|
natriuretic peptide A
|
decreases expression
|
ISO EXP
|
Enalapril results in decreased expression of NPPA protein Enalapril results in decreased expression of NPPA mRNA
|
CTD |
PMID:2136812 PMID:8112904 PMID:21423293 |
|
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
|
|
G
|
Nppb
|
natriuretic peptide B
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]
|
CTD |
PMID:18806606 |
|
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
|
|
G
|
Nr3c2
|
nuclear receptor subfamily 3, group C, member 2
|
increases expression
|
EXP
|
Enalapril results in increased expression of NR3C2 mRNA
|
CTD |
PMID:18796534 |
|
NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
|
|
G
|
Nrf1
|
nuclear respiratory factor 1
|
increases expression
|
EXP
|
Enalapril results in increased expression of NRF1 mRNA
|
CTD |
PMID:18765277 |
|
NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353
|
|
G
|
Pdpn
|
podoplanin
|
increases expression
|
EXP
|
Enalapril results in increased expression of PDPN protein
|
CTD |
PMID:20933085 |
|
NCBI chr 5:160,884,995...160,919,112
Ensembl chr 5:160,884,993...160,925,637
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
ISO
|
[Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
|
CTD |
PMID:18812576 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
decreases expression multiple interactions
|
EXP
|
Enalapril results in decreased expression of PPARG protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
|
CTD |
PMID:19225048 PMID:30623541 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
increases expression
|
EXP
|
Enalapril results in increased expression of PPARGC1A mRNA
|
CTD |
PMID:18765277 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
G
|
Prdx3
|
peroxiredoxin 3
|
increases expression
|
EXP
|
Enalapril results in increased expression of PRDX3 protein
|
CTD |
PMID:30563025 |
|
NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
increases expression
|
ISO
|
Enalapril results in increased expression of PRKAA1 protein
|
CTD |
PMID:25037058 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
|
|
G
|
Prkca
|
protein kinase C, alpha
|
decreases expression
|
EXP
|
Enalapril results in decreased expression of PRKCA protein modified form
|
CTD |
PMID:21565836 |
|
NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
|
|
G
|
Ptgs1
|
prostaglandin-endoperoxide synthase 1
|
decreases expression
|
ISO
|
Enalapril results in decreased expression of PTGS1 mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
decreases expression multiple interactions
|
EXP ISO
|
Enalapril results in decreased expression of PTGS2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
|
CTD |
PMID:20720404 PMID:21377515 PMID:25037058 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Pth1r
|
parathyroid hormone 1 receptor
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]
|
CTD |
PMID:15728788 |
|
NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108
|
|
G
|
Pthlh
|
parathyroid hormone-like hormone
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]
|
CTD |
PMID:15728788 |
|
NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein]
|
CTD |
PMID:30623541 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Ren
|
renin
|
multiple interactions increases expression increases secretion decreases activity increases activity
|
ISO EXP
|
[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein Enalapril results in increased secretion of REN protein [Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein] Enalapril results in decreased activity of REN protein Enalapril results in increased activity of REN protein
|
CTD |
PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 PMID:17846348 PMID:18679781 PMID:18796534 PMID:19109587 PMID:19536436 PMID:19767874 PMID:21423293 PMID:21424707 More...
|
|
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
|
|
G
|
Runx2
|
RUNX family transcription factor 2
|
multiple interactions
|
EXP
|
Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA]
|
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
|
|
G
|
Sele
|
selectin E
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein]
|
CTD |
PMID:28973481 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
|
|
G
|
Sell
|
selectin L
|
multiple interactions
|
ISO
|
[Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
|
|
G
|
Selp
|
selectin P
|
multiple interactions decreases expression
|
EXP ISO
|
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein] Enalapril results in decreased expression of SELP mRNA
|
CTD |
PMID:14716214 PMID:25037058 |
|
NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987
|
|
G
|
Serpinb2
|
serpin family B member 2
|
decreases expression
|
ISO
|
Enalapril results in decreased expression of SERPINB2 mRNA
|
CTD |
PMID:25037058 |
|
NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031
|
|
G
|
Serpine1
|
serpin family E member 1
|
multiple interactions decreases expression
|
EXP
|
[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein] Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein
|
CTD |
PMID:18682491 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
|
|
G
|
Slc15a2
|
solute carrier family 15 member 2
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]
|
CTD |
PMID:18713951 |
|
NCBI chr11:77,519,565...77,548,609
Ensembl chr11:77,519,529...77,548,606
|
|
G
|
Slc22a12
|
solute carrier family 22 member 12
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]
|
CTD |
PMID:21272127 |
|
NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380
|
|
G
|
Slc22a7
|
solute carrier family 22 member 7
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
|
CTD |
PMID:12065749 |
|
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
|
|
G
|
Slc22a8
|
solute carrier family 22 member 8
|
multiple interactions
|
ISO
|
Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
|
CTD |
PMID:15100168 |
|
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
|
|
G
|
Smad2
|
SMAD family member 2
|
multiple interactions
|
EXP
|
Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]
|
CTD |
PMID:17513326 |
|
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
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G
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Smad7
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SMAD family member 7
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increases expression
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EXP
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Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein
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CTD |
PMID:19197123 PMID:19349682 |
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NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849
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G
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Sod1
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superoxide dismutase 1
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multiple interactions increases expression
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ISO
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[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein Enalapril results in increased expression of SOD1 protein
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CTD |
PMID:20720404 PMID:25037058 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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G
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Sod2
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superoxide dismutase 2
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decreases activity increases expression decreases expression multiple interactions
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EXP ISO
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Enalapril results in decreased activity of SOD2 protein Enalapril results in increased expression of SOD2 protein Enalapril results in decreased expression of SOD2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
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CTD |
PMID:18765277 PMID:20720404 PMID:25037058 PMID:30563025 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
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G
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Spp1
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secreted phosphoprotein 1
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multiple interactions
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ISO EXP
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[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]
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CTD |
PMID:25037058 PMID:30423288 PMID:31887396 |
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NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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G
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Sqstm1
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sequestosome 1
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increases expression
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EXP
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Enalapril results in increased expression of SQSTM1 protein
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CTD |
PMID:30563025 |
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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G
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Ssbp1
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single stranded DNA binding protein 1
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increases expression
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EXP
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Enalapril results in increased expression of SSBP1 mRNA
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CTD |
PMID:18765277 |
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NCBI chr 4:70,232,740...70,242,824
Ensembl chr 4:70,232,794...70,243,700
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G
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Stat3
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signal transducer and activator of transcription 3
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multiple interactions
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EXP
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Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein]
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CTD |
PMID:19958114 |
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NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
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G
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Tek
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TEK receptor tyrosine kinase
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multiple interactions
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EXP
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Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]
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CTD |
PMID:19958114 |
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NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:114,723,006...114,849,991
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G
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Tfam
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transcription factor A, mitochondrial
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increases expression
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EXP
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Enalapril results in increased expression of TFAM protein
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CTD |
PMID:30563025 |
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NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions decreases expression
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EXP
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[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein] Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein
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CTD |
PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 PMID:19197123 PMID:19349682 PMID:23733546 More...
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Tgfb2
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transforming growth factor, beta 2
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decreases expression
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EXP
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Enalapril results in decreased expression of TGFB2 mRNA
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CTD |
PMID:17164399 |
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NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
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G
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Tgfbi
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transforming growth factor, beta induced
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decreases secretion multiple interactions
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EXP
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Enalapril results in decreased secretion of TGFBI protein [eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
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CTD |
PMID:18682491 |
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NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471
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G
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Tgfbr1
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transforming growth factor, beta receptor 1
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decreases expression
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EXP
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Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein
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CTD |
PMID:12883979 |
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NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
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G
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Thbs4
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thrombospondin 4
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increases expression
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ISO
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Enalapril results in increased expression of THBS4 mRNA
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CTD |
PMID:25037058 |
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NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:25,718,219...25,761,369
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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ISO
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[Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein
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CTD |
PMID:20524934 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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G
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Tnf
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tumor necrosis factor
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decreases expression multiple interactions
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EXP ISO
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Enalapril results in decreased expression of TNF protein Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] [paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein] Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
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CTD |
PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 PMID:19114890 PMID:19225048 PMID:20720404 PMID:25037058 PMID:30623541 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
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Tomm20
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translocase of outer mitochondrial membrane 20
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decreases expression
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EXP
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Enalapril results in decreased expression of TOMM20 mRNA
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CTD |
PMID:18765277 |
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NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510
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G
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Traf6
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TNF receptor associated factor 6
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multiple interactions
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ISO
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[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA
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CTD |
PMID:20524934 |
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NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328
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G
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Vcam1
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vascular cell adhesion molecule 1
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affects expression decreases expression
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ISO
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Enalapril affects the expression of VCAM1 Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form
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CTD |
PMID:17347482 PMID:19939336 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
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G
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Vegfa
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vascular endothelial growth factor A
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multiple interactions increases expression
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EXP ISO
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Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein] Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA] Enalapril results in increased expression of VEGFA protein
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CTD |
PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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G
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Vwf
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von Willebrand factor
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decreases expression
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ISO
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Enalapril results in decreased expression of VWF mRNA
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CTD |
PMID:25037058 |
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NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757
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G
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Ace
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angiotensin I converting enzyme
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multiple interactions
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ISO
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Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein]
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CTD |
PMID:16452552 |
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NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
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G
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Adrb1
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adrenoceptor beta 1
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affects expression
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EXP
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Enalaprilat affects the expression of ADRB1 protein
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CTD |
PMID:9260993 |
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NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237
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G
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Adrb2
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adrenoceptor beta 2
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affects expression
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EXP
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Enalaprilat affects the expression of ADRB2 protein
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CTD |
PMID:9260993 |
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NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803
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G
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Agt
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angiotensinogen
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decreases expression multiple interactions
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EXP ISO
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Enalaprilat results in decreased expression of AGT protein modified form Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein]
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CTD |
PMID:16452552 PMID:21795644 |
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NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
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G
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Agtr1a
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angiotensin II receptor, type 1a
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multiple interactions
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ISO
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Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]
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CTD |
PMID:16452552 |
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NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
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G
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Bcl2
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BCL2, apoptosis regulator
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increases expression
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ISO
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Enalaprilat results in increased expression of BCL2 mRNA
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CTD |
PMID:17342403 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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G
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Bdkrb1
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bradykinin receptor B1
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multiple interactions increases activity
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ISO
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bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein]
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CTD |
PMID:11880373 |
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NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973
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G
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Edn1
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endothelin 1
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decreases secretion
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ISO
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Enalaprilat results in decreased secretion of EDN1 protein
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CTD |
PMID:19079593 |
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NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
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G
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Fn1
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fibronectin 1
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decreases expression multiple interactions
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EXP ISO
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Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]
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CTD |
PMID:14520012 PMID:21795644 |
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NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
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G
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Glud1
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glutamate dehydrogenase 1
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multiple interactions
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EXP
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Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA]
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CTD |
PMID:32494933 |
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NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210
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G
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Grm1
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glutamate metabotropic receptor 1
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multiple interactions
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EXP
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Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA]
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CTD |
PMID:32494933 |
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NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
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G
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Hmgb1
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high mobility group box 1
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multiple interactions
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EXP
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Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein]
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CTD |
PMID:32494933 |
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NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
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G
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Ins2
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insulin 2
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multiple interactions
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ISO
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Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein]
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CTD |
PMID:16452552 |
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
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G
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Ppard
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peroxisome proliferator-activated receptor delta
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multiple interactions
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EXP
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[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA
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CTD |
PMID:23834779 |
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NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
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G
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Ren
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renin
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increases expression
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EXP
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Enalaprilat results in increased expression of REN mRNA
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CTD |
PMID:21795644 |
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NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
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G
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Serpine1
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serpin family E member 1
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decreases expression
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EXP
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Enalaprilat results in decreased expression of SERPINE1 mRNA
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CTD |
PMID:21795644 |
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NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
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G
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Slc22a8
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solute carrier family 22 member 8
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multiple interactions increases uptake
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ISO
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verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat]
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CTD |
PMID:33007874 |
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NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
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G
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Tgfb1
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transforming growth factor, beta 1
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decreases expression
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EXP
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Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein
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CTD |
PMID:21795644 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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EXP
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Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA]
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CTD |
PMID:32494933 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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G
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Tnf
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tumor necrosis factor
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decreases expression
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ISO
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Enalaprilat results in decreased expression of TNF mRNA
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CTD |
PMID:17342403 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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