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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:citronellal
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Accession:CHEBI:47856 term browser browse the term
Definition:A monoterpenoid, the main component of citronella oil which gives it its distinctive lemon aroma.
Synonyms:exact_synonym: 3,7-dimethyloct-6-enal
 related_synonym: 2,3-dihydrocitral;   3,7-dimethyl-6-octen-1-al;   3,7-dimethyl-6-octenal;   Formula=C10H18O;   InChI=1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,8,10H,4,6-7H2,1-3H3;   InChIKey=NEHNMFOYXAPHSD-UHFFFAOYSA-N;   SMILES=[H]C(=O)CC(C)CCC=C(C)C;   beta-citronellal
 xref: Beilstein:1209447;   Beilstein:1720789;   CAS:106-23-0;   Gmelin:1521962;   KEGG:C17384
 xref_mesh: MESH:C108217
 xref: PMID:10771133;   PMID:22382815;   PMID:22559719;   PMID:22972327;   PMID:23047114;   PMID:23064632;   PMID:23065287;   PMID:23071142;   PMID:9540973;   Wikipedia:Citronellal


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citronellal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO citronellal results in decreased activity of ABCB1 protein
[citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
CTD PMID:15890377, PMID:16904803 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO citronellal results in decreased activity of ALAD protein CTD PMID:25218989 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP citronellal results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Gcg glucagon increases secretion ISO citronellal results in increased secretion of GCG protein CTD PMID:29070885 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gna15 G protein subunit alpha 15 multiple interactions
increases response to substance
ISO [GNA15 protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein CTD PMID:9875846 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251
JBrowse link
G Gnal G protein subunit alpha L multiple interactions
increases response to substance
ISO [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein] which results in increased abundance of Cyclic AMP; [GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein; Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to citronellal] CTD PMID:15598656 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Gnas GNAS complex locus increases response to substance
multiple interactions
ISO GNAS protein results in increased susceptibility to citronellal
[[GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein] which results in increased abundance of Cyclic AMP; [GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein; Egtazic Acid inhibits the reaction [[GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to citronellal]
CTD PMID:15598656 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G LOC100909683 olfactory receptor 63-like increases activity ISO citronellal results in increased activity of OLFR63 protein CTD PMID:15598656 NCBI chr 7:15,722,054...15,723,428
Ensembl chr 7:15,722,177...15,723,127
JBrowse link
G Olr1513 olfactory receptor 1513 affects binding
increases activity
ISO citronellal binds to OR1A1 protein; OR1A1 protein binds to citronellal
OLFR43 protein binds to citronellal
citronellal results in increased activity of OLFR43 protein
CTD PMID:15598656, PMID:17601748, PMID:17681278 NCBI chr10:61,033,113...61,034,051
Ensembl chr10:61,033,113...61,034,051
JBrowse link
G Olr1514 olfactory receptor 1514 affects binding
increases expression
ISO citronellal binds to OR1A2 protein; OR1A2 protein binds to citronellal
citronellal results in increased expression of OR1A2 mRNA; citronellal results in increased expression of OR1A2 protein
CTD PMID:17601748, PMID:17681278, PMID:25513961 NCBI chr10:61,044,411...61,045,355
Ensembl chr10:61,044,411...61,045,355
JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 decreases activity ISO citronellal analog results in decreased activity of TDP1 protein CTD PMID:29248742 NCBI chr 6:123,895,860...123,963,688
Ensembl chr 6:123,897,956...123,963,675
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO citronellal results in increased activity of TRPA1 protein CTD PMID:26447139 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
hydroxycitronellal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO hydroxycitronellal results in increased expression of CCR7 mRNA CTD PMID:17936526 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd80 Cd80 molecule increases expression ISO hydroxycitronellal results in increased expression of CD80 mRNA CTD PMID:17936526 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression ISO hydroxycitronellal results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxycitronellal results in increased expression of HMOX1 mRNA CTD PMID:20491607 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO hydroxycitronellal results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mt1 metallothionein 1 increases expression ISO hydroxycitronellal results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO hydroxycitronellal results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO hydroxycitronellal results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO hydroxycitronellal results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO hydroxycitronellal results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            citronellal 22
              (R)-(+)-citronellal 0
              (S)-(-)-citronellal + 0
              citronellic acid + 0
              hydroxycitronellal 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            formyl group 7845
                                              aldehyde 7845
                                                citronellal 22
                                                  (R)-(+)-citronellal 0
                                                  (S)-(-)-citronellal + 0
                                                  citronellic acid + 0
                                                  hydroxycitronellal 10
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