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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:enalapril
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Accession:CHEBI:4784 term browser browse the term
Definition:A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Synonyms:exact_synonym: N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
 related_synonym: (S)-1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline;   (S)-1-{(S)-2-[1-((S)-Ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid;   1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester;   Formula=C20H28N2O5;   InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1;   InChIKey=GBXSMTUPTTWBMN-XIRDDKMYSA-N;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O;   analapril;   enalaprila;   enalaprilum
 alt_id: CHEBI:116847
 xref: Beilstein:3657467;   CAS:75847-73-3;   Chemspider:4534998;   DrugBank:DB00584;   Drug_Central:1005;   HMDB:HMDB0014722;   KEGG:C06977;   KEGG:D07892;   LINCS:LSM-3282
 xref_mesh: MESH:D004656
 xref: MetaCyc:CPD0-2065;   PMID:10669559;   PMID:11523315;   PMID:12725609;   PMID:19019755;   PMID:19549507;   PMID:23030053;   PMID:23413003;   PMID:32835726;   PMID:33643971;   PMID:33881639;   PMID:33963573;   PMID:34020248;   PMID:34101308;   PMID:34412508;   PMID:34440064;   PMID:34533783;   Patent:EP12401;   Patent:US4374829;   Wikipedia:Enalapril


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enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) increases transport EXP ABCC4 protein results in increased transport of Enalapril CTD PMID:17939016 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ACE angiotensin I converting enzyme decreases activity
multiple interactions
increases expression		 EXP
ISO		 Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of ACE protein]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]
Enalapril results in increased expression of ACE mRNA		 CTD PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 More... NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression ISO Enalapril results in decreased expression of ACTA2 protein CTD PMID:19349682 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G ACVRL1 activin A receptor like type 1 decreases expression ISO Enalapril results in decreased expression of ACVRL1 protein CTD PMID:12883979 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO Enalapril results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADRB1 adrenoceptor beta 1 increases expression ISO Enalapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G AGT angiotensinogen decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression		 ISO
EXP		 Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA		 CTD PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 More... NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 affects expression
multiple interactions
decreases expression
increases expression		 ISO Enalapril affects the expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of AGTR1 protein]
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril results in increased expression of AGTR1A mRNA		 CTD PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 More... NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 increases expression
decreases expression		 ISO Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA		 CTD PMID:9740612 PMID:18403896 PMID:18765277 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:18806606 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions ISO Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G ANG angiogenin decreases expression EXP Enalapril results in decreased expression of ANG protein CTD PMID:3038326 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971 		JBrowse link
G ANGPT2 angiopoietin 2 multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] CTD PMID:19958114 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409 		JBrowse link
G APOE apolipoprotein E multiple interactions EXP
ISO		 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]		 CTD PMID:19603250 PMID:25037058 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G ATF2 activating transcription factor 2 increases expression ISO Enalapril results in increased expression of ATF2 protein CTD PMID:15531746 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 increases expression ISO Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression ISO Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497 		JBrowse link
G AVP arginine vasopressin multiple interactions ISO Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression ISO Enalapril results in decreased expression of BAX protein CTD PMID:21153712 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 ISO Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]		 CTD PMID:21153712 PMID:30623541 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDKRB1 bradykinin receptor B1 increases expression
multiple interactions		 ISO Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril		 CTD PMID:18796534 PMID:21430409 NCBI chr14:96,256,210...96,264,763
Ensembl chr14:96,256,210...96,268,967 		JBrowse link
G BDKRB2 bradykinin receptor B2 increases expression ISO Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein CTD PMID:18190998 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP Enalapril results in decreased activity of CA2 protein CTD PMID:28126276 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493 		JBrowse link
G CASP3 caspase 3 decreases activity
multiple interactions		 ISO Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]		 CTD PMID:21153712 PMID:30623541 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 decreases activity ISO Enalapril results in decreased activity of CASP9 protein CTD PMID:21153712 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase increases activity
multiple interactions		 ISO Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]		 CTD PMID:12124199 PMID:30623541 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO
EXP		 [paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 protein
Enalapril results in decreased expression of CCL2 mRNA		 CTD PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 More... NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCN2 cellular communication network factor 2 decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]		 CTD PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CELA2A chymotrypsin like elastase 2A decreases expression ISO Enalapril results in decreased expression of CELA2A mRNA CTD PMID:21602471 NCBI chr 1:15,456,732...15,472,091
Ensembl chr 1:15,456,728...15,472,091 		JBrowse link
G CLTRN collectrin, amino acid transport regulator decreases expression ISO Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein CTD PMID:12887829 NCBI chr  X:15,627,318...15,675,644
Ensembl chr  X:15,627,318...15,675,012 		JBrowse link
G CLU clusterin decreases expression ISO Enalapril results in decreased expression of CLU protein CTD PMID:12193663 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G CMA1 chymase 1 decreases expression ISO Enalapril results in decreased expression of CMA1 mRNA CTD PMID:18796534 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] CTD PMID:12003776 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression
increases expression		 ISO Enalapril results in decreased expression of COL3A1 mRNA
Enalapril results in increased expression of COL3A1 mRNA		 CTD PMID:17164399 PMID:25037058 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions
decreases expression		 ISO [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein		 CTD PMID:9175058 PMID:18682491 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CXCL8 protein] CTD PMID:28973481 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
Enalapril results in decreased expression of CYBA protein		 CTD PMID:20720404 PMID:25037058 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYCS cytochrome c, somatic affects localization ISO Enalapril affects the localization of CYCS protein CTD PMID:21153712 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G ENG endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,815,013...127,854,658 		JBrowse link
G EPO erythropoietin decreases expression
multiple interactions		 EXP
ISO		 Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]		 CTD PMID:2474097 PMID:9434678 PMID:19958114 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G EPOR erythropoietin receptor multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] CTD PMID:19958114 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 EXP Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]		 CTD PMID:18060435 PMID:22188725 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FASLG Fas ligand decreases expression ISO Enalapril results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GH1 growth hormone 1 increases response to substance EXP GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839 		JBrowse link
G GJA5 gap junction protein alpha 5 multiple interactions ISO GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJC1 gap junction protein gamma 1 multiple interactions ISO GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] CTD PMID:18806606 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HAS2 hyaluronan synthase 2 increases expression ISO Enalapril results in increased expression of HAS2 mRNA CTD PMID:20933085 NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]		 CTD PMID:19114890 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO Enalapril results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HYAL1 hyaluronidase 1 decreases expression ISO Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein CTD PMID:20933085 NCBI chr 3:50,299,893...50,312,381
Ensembl chr 3:50,299,890...50,312,381 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 ISO
EXP		 Enalapril results in decreased expression of ICAM1 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form		 CTD PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IGF1 insulin like growth factor 1 affects expression
decreases expression		 ISO Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA		 CTD PMID:12883983 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 increases expression ISO Enalapril results in increased expression of IGFBP1 mRNA CTD PMID:12883983 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] CTD PMID:17299153 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression		 ISO Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA		 CTD PMID:17167242 PMID:21265103 PMID:25037058 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions
affects response to substance		 ISO
EXP		 Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril		 CTD PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions EXP [Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G ITGA2 integrin subunit alpha 2 decreases expression ISO Enalapril results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G KDR kinase insert domain receptor multiple interactions ISO Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KNG1 kininogen 1 increases response to substance ISO Enalapril results in increased susceptibility to KNG1 protein modified form CTD PMID:18190998 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G LAMB1 laminin subunit beta 1 multiple interactions ISO Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:9175058 NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213 		JBrowse link
G LAMB2 laminin subunit beta 2 multiple interactions ISO Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:9175058 NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118 		JBrowse link
G LEP leptin increases response to substance ISO LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases expression
increases phosphorylation		 ISO Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein		 CTD PMID:15531746 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MIR146A microRNA 146a multiple interactions EXP [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR146B microRNA 146b multiple interactions EXP [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr10:102,436,512...102,436,584
Ensembl chr10:102,436,512...102,436,584 		JBrowse link
G MMP3 matrix metallopeptidase 3 decreases expression ISO Enalapril results in decreased expression of MMP3 mRNA CTD PMID:25037058 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] CTD PMID:19114890 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MYH6 myosin heavy chain 6 multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273 		JBrowse link
G MYH7 myosin heavy chain 7 decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]		 CTD PMID:15362513 PMID:21423293 NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660 		JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr 5:150,497,779...150,558,211
Ensembl chr 5:150,485,818...150,558,211 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression ISO Enalapril results in decreased expression of NFE2L2 mRNA CTD PMID:18765277 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases activity
multiple interactions		 ISO Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]		 CTD PMID:19225048 PMID:21265102 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:19114890 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOA1 nitric oxide associated 1 increases expression
increases activity		 ISO Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein		 CTD PMID:14588141 NCBI chr 4:56,963,350...56,977,606
Ensembl chr 4:56,963,350...56,977,606 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
Enalapril results in decreased expression of NOS2 protein		 CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression		 ISO [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
Enalapril results in increased expression of NOS3 protein
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril affects the expression of NOS3 mRNA		 CTD PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 More... NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPA natriuretic peptide A decreases expression EXP
ISO		 Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA		 CTD PMID:2136812 PMID:8112904 PMID:21423293 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:18806606 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 increases expression ISO Enalapril results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression ISO Enalapril results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082 		JBrowse link
G PDPN podoplanin increases expression ISO Enalapril results in increased expression of PDPN protein CTD PMID:20933085 NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]		 CTD PMID:19225048 PMID:30623541 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression ISO Enalapril results in increased expression of PPARGC1A mRNA CTD PMID:18765277 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO Enalapril results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKCA protein kinase C alpha decreases expression ISO Enalapril results in decreased expression of PRKCA protein modified form CTD PMID:21565836 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Enalapril results in decreased expression of PTGS1 mRNA CTD PMID:25037058 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein		 CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTH1R parathyroid hormone 1 receptor multiple interactions ISO Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799 		JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions ISO Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G REN renin multiple interactions
increases expression
increases secretion
decreases activity
increases activity		 EXP
ISO		 [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein		 CTD PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 More... NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions ISO Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SELE selectin E multiple interactions EXP Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SELL selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SELP selectin P multiple interactions
decreases expression		 ISO Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA		 CTD PMID:14716214 PMID:25037058 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SERPINB2 serpin family B member 2 decreases expression ISO Enalapril results in decreased expression of SERPINB2 mRNA CTD PMID:25037058 NCBI chr18:63,887,705...63,903,888
Ensembl chr18:63,871,692...63,903,888 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions
decreases expression		 ISO [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein		 CTD PMID:18682491 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SLC15A2 solute carrier family 15 member 2 multiple interactions EXP Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr 3:121,894,401...121,944,188
Ensembl chr 3:121,894,401...121,944,188 		JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions EXP Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 multiple interactions ISO Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions ISO Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15100168 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 affects abundance EXP SLCO1B1 gene polymorphism affects the abundance of Enalapril CTD PMID:21665049 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD7 SMAD family member 7 increases expression ISO Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein CTD PMID:19197123 PMID:19349682 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases expression		 ISO [paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
Enalapril results in increased expression of SOD1 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 decreases activity
decreases expression
multiple interactions		 ISO Enalapril results in decreased activity of SOD2 protein
Enalapril results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein		 CTD PMID:18765277 PMID:20720404 PMID:25037058 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]		 CTD PMID:25037058 PMID:30423288 PMID:31887396 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 increases expression ISO Enalapril results in increased expression of SSBP1 mRNA CTD PMID:18765277 NCBI chr 7:141,738,321...141,750,488
Ensembl chr 7:141,738,334...141,787,922 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:19958114 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TEK TEK receptor tyrosine kinase multiple interactions ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] CTD PMID:19958114 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 ISO [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein		 CTD PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 More... NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression ISO Enalapril results in decreased expression of TGFB2 mRNA CTD PMID:17164399 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFBI transforming growth factor beta induced decreases secretion
multiple interactions		 ISO Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein		 CTD PMID:18682491 NCBI chr 5:136,028,988...136,063,818
Ensembl chr 5:136,028,988...136,063,818 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 decreases expression ISO Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein CTD PMID:12883979 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G THBS4 thrombospondin 4 increases expression ISO Enalapril results in increased expression of THBS4 mRNA CTD PMID:25037058 NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]		 CTD PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 decreases expression ISO Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837 		JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 affects expression
decreases expression		 ISO Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form		 CTD PMID:17347482 PMID:19939336 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression		 ISO
EXP		 Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein		 CTD PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VWF von Willebrand factor decreases expression ISO Enalapril results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pro-agent 12044
          prodrug 11725
            enalapril 128
              enalapril maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      carboacyl group 20055
                                        univalent carboacyl group 20055
                                          carbamoyl group 19568
                                            carboxamide 19580
                                              peptide 11627
                                                oligopeptide 1341
                                                  dipeptide 408
                                                    enalaprilat (anhydrous) 135
                                                      enalapril 128
                                                        enalapril maleate 0
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