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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefepime
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Accession:CHEBI:478164 term browser browse the term
Definition:A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate
 related_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;   CFPM;   Formula=C19H24N6O5S2;   InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1;   InChIKey=HVFLCNVBZFFHBT-ZKDACBOMSA-N;   SMILES=[H][C@]12SCC(C[N+]3(C)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C([O-])=O;   cefepima;   cefepimum
 alt_id: CHEBI:3486;   CHEBI:473919
 xref: Beilstein:7453587;   CAS:88040-23-7;   DrugBank:DB01413;   Drug_Central:535;   KEGG:C08111;   KEGG:D02376
 xref_mesh: MESH:C043266
 xref: PMID:11084674;   PMID:11179650;   PMID:11191931;   PMID:11260566;   PMID:11280610;   PMID:11303846;   PMID:11306793;   PMID:11328792;   PMID:11431192;   PMID:11442796;   PMID:11864944;   PMID:11910959;   PMID:11964152;   PMID:12848746;   PMID:14628573;   PMID:14642333;   PMID:15303411;   PMID:15494381;   PMID:15830071;   PMID:15978309;   PMID:15980347;   PMID:16207962;   PMID:16650951;   PMID:16705389;   PMID:16930923;   PMID:17042189;   PMID:17214092;   PMID:17323865;   PMID:17448937;   PMID:17625777;   PMID:18025111;   PMID:18154532;   PMID:18651542;   PMID:18673128;   PMID:18717040;   PMID:19053894;   PMID:19304881;   PMID:21425867;   PMID:28543395;   PMID:29017833;   Patent:DE3307550;   Patent:US4406899;   Reaxys:7453587;   Wikipedia:Cefepime
 cyclic_relationship: is_conjugate_base_of CHEBI:59349


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cefepime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO cefepime affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Cat catalase multiple interactions ISO cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein] CTD PMID:18781908 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO cefepime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP cefepime results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO cefepime affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              cefepime 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          cefepime 5
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