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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:furofuran
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Accession:CHEBI:47790 term browser browse the term
Definition:Organic heterobicyclic compounds containing a two furan rings ortho-fused to each other.
Synonyms:related_synonym: furofurans



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(+)-pinoresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression
ISO [loliolide co-treated with pinoresinol] results in decreased expression of ACACA protein
pinoresinol results in decreased expression of ACACA protein
CTD PMID:31610126 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression
ISO [loliolide co-treated with pinoresinol] results in decreased expression of FASN protein
pinoresinol results in decreased expression of FASN protein
CTD PMID:31610126 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H2 protein CTD PMID:31610126 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H3 protein CTD PMID:31610126 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pinoresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions
ISO pinoresinol results in decreased expression of SREBF1 protein
[loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 protein
CTD PMID:31610126 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO pinoresinol results in decreased secretion of TNF protein CTD PMID:29740324 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
(+)-sesamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [sesamin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP sesamin affects the reaction [Glucose affects the localization of AIFM1 protein] CTD PMID:22524206 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
sesamin affects the reaction [Glucose affects the expression of BAX protein]
CTD PMID:22524206 PMID:23317420 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
sesamin inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
sesamin affects the reaction [Glucose affects the expression of BCL2 protein]
CTD PMID:22524206 PMID:23317420 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
sesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]
sesamin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]
CTD PMID:22524206 PMID:23317420 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
sesamin results in decreased activity of CAT protein
sesamin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]
sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CAT protein]; sesamin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
CTD PMID:19794909 PMID:23317420 PMID:26825964 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdh1 cadherin 1 increases expression ISO sesamin results in increased expression of CDH1 mRNA; sesamin results in increased expression of CDH1 protein CTD PMID:33561518 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO sesamin results in increased expression of CTNNB1 mRNA; sesamin results in increased expression of CTNNB1 protein CTD PMID:33561518 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Fads1 fatty acid desaturase 1 decreases activity EXP sesamin results in decreased activity of FADS1 protein CTD PMID:14974737 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP sesamin results in increased activity of GSR protein CTD PMID:19835851 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein] CTD PMID:22919443 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein] CTD PMID:19794909 PMID:22919443 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP sesamin results in decreased expression of NOS2 protein
sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]
CTD PMID:19794909 PMID:22919443 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP sesamin inhibits the reaction [Glucose results in increased cleavage of PARP1 protein] CTD PMID:22524206 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin results in increased expression of and results in increased activity of SOD2 protein]; sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]; sesamin results in increased expression of and results in increased activity of SOD2 protein CTD PMID:24211423 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:19794909 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein] CTD PMID:22919443 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
(+)-syringaresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO syringaresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
(+)-syringaresinol beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein] CTD PMID:31077737 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein CTD PMID:31077737 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cat catalase multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:31077737 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:31077737 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Il10 interleukin 10 multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein] CTD PMID:31077737 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein] CTD PMID:31077737 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:31077737 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] CTD PMID:31077737 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein] CTD PMID:31077737 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
NORCANTHARIDIN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 decreases expression ISO norcantharidin results in decreased expression of ANGPT2 mRNA; norcantharidin results in decreased expression of ANGPT2 protein CTD PMID:16681930 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO [norcantharidin co-treated with Paclitaxel] results in increased expression of ATF4 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of ATF4 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of ATF4 protein] CTD PMID:34272796 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [Paclitaxel results in decreased susceptibility to norcantharidin] which results in increased expression of AURKA protein CTD PMID:34272796 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO norcantharidin results in increased expression of BAD protein CTD PMID:21266192 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO norcantharidin results in increased expression of BAK1 protein alternative form CTD PMID:29193574 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO norcantharidin results in increased expression of BAX protein CTD PMID:21266192 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation
decreases expression
ISO norcantharidin results in increased phosphorylation of BCL2 protein
norcantharidin results in decreased expression of BCL2 protein
CTD PMID:21266192 PMID:29193574 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO norcantharidin results in decreased expression of BCL2L1 protein CTD PMID:21266192 PMID:29193574 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO norcantharidin results in increased expression of BCL2L11 protein alternative form CTD PMID:29193574 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO norcantharidin results in increased expression of BID protein modified form CTD PMID:29193574 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO norcantharidin results in increased activity of CASP3 protein
Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP3 protein modified form]; U 0126 inhibits the reaction [norcantharidin results in increased expression of CASP3 protein modified form]
CTD PMID:20040369 PMID:21266192 PMID:29193574 PMID:34272796 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression
increases activity
multiple interactions
ISO norcantharidin results in increased expression of CASP8 protein modified form
norcantharidin results in increased activity of CASP8 protein
Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP8 protein modified form]; U 0126 inhibits the reaction [norcantharidin results in increased expression of CASP8 protein modified form]
CTD PMID:20040369 PMID:21266192 PMID:29193574 PMID:34272796 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP9 protein modified form]
norcantharidin results in increased activity of CASP9 protein
CTD PMID:20040369 PMID:21266192 PMID:29193574 PMID:34272796 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP norcantharidin results in decreased expression of CCN2 mRNA; norcantharidin results in decreased expression of CCN2 protein CTD PMID:18176075 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions
ISO norcantharidin results in decreased expression of CCNB1 protein
Paclitaxel promotes the reaction [norcantharidin results in decreased expression of CCNB1 protein]
CTD PMID:34272796 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO Paclitaxel promotes the reaction [norcantharidin results in decreased expression of CDC25C protein] CTD PMID:21266192 PMID:34272796 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO norcantharidin results in decreased expression of CDH2 protein CTD PMID:15711181 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases phosphorylation ISO norcantharidin results in increased phosphorylation of CDKN1A protein CTD PMID:21266192 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO norcantharidin results in increased phosphorylation of CHEK1 protein CTD PMID:21266192 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO norcantharidin results in increased phosphorylation of CHEK2 protein CTD PMID:21266192 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO norcantharidin results in increased expression of DDIT3 protein
[norcantharidin co-treated with Paclitaxel] results in increased expression of DDIT3 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of DDIT3 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of DDIT3 protein]
CTD PMID:34272796 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dsg1 desmoglein 1 decreases expression ISO norcantharidin results in decreased expression of DSG1 protein CTD PMID:15711181 NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO norcantharidin results in increased phosphorylation of EIF2S1 protein
[norcantharidin co-treated with Paclitaxel] results in increased phosphorylation of EIF2S1 protein; Paclitaxel promotes the reaction [norcantharidin results in increased phosphorylation of EIF2S1 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased phosphorylation of EIF2S1 protein]
CTD PMID:34272796 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
ISO Paclitaxel promotes the reaction [norcantharidin results in increased expression of ERN1 protein] CTD PMID:34272796 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO norcantharidin results in increased expression of FAS protein CTD PMID:21266192 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO norcantharidin results in increased expression of H2AX protein modified form
Paclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form]
CTD PMID:34272796 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [norcantharidin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]]; norcantharidin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]; SB 203580 inhibits the reaction [norcantharidin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]] CTD PMID:21075198 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO norcantharidin results in increased phosphorylation of MAPK1 protein CTD PMID:21075198 PMID:21266192 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO norcantharidin results in increased phosphorylation of MAPK3 protein CTD PMID:21075198 PMID:21266192 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO norcantharidin results in increased phosphorylation of MAPK8 protein CTD PMID:21266192 PMID:29193574 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO norcantharidin results in increased phosphorylation of MAPK9 protein CTD PMID:29193574 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO norcantharidin results in decreased expression of MCL1 protein CTD PMID:21266192 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO norcantharidin results in decreased activity of MMP2 protein CTD PMID:15711181 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO norcantharidin results in decreased expression of and results in decreased activity of MMP9 protein; SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA]
norcantharidin results in decreased activity of MMP9 protein
CTD PMID:15711181 PMID:19616522 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO norcantharidin results in increased expression of PARP1 protein modified form
[norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of PARP1 protein modified form]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein]
CTD PMID:34272796 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO norcantharidin results in decreased expression of PCNA protein CTD PMID:16681930 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP norcantharidin results in decreased expression of RELA mRNA; norcantharidin results in decreased expression of RELA protein CTD PMID:18176075 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt2 sirtuin 2 decreases expression ISO norcantharidin results in decreased expression of SIRT2 mRNA CTD PMID:34272796 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Sirt6 sirtuin 6 decreases expression ISO norcantharidin results in decreased expression of SIRT6 mRNA CTD PMID:34272796 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Sirt7 sirtuin 7 multiple interactions
decreases expression
ISO [norcantharidin co-treated with Paclitaxel] results in decreased expression of and affects the localization of SIRT7 protein; [norcantharidin co-treated with Paclitaxel] results in decreased expression of SIRT7 mRNA; Paclitaxel promotes the reaction [norcantharidin results in decreased expression of SIRT7 mRNA]; Paclitaxel promotes the reaction [norcantharidin results in decreased expression of SIRT7 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of ATF4 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of DDIT3 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased phosphorylation of EIF2S1 protein]
norcantharidin results in decreased expression of SIRT7 mRNA; norcantharidin results in decreased expression of SIRT7 protein
CTD PMID:34272796 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
decreases activity
ISO SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA]
norcantharidin results in decreased activity of SP1 protein
CTD PMID:19616522 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO norcantharidin results in increased expression of STAT1 protein CTD PMID:19616522 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO norcantharidin results in decreased phosphorylation of STAT3 protein CTD PMID:21266192 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases phosphorylation ISO norcantharidin results in decreased phosphorylation of STAT5A protein CTD PMID:21266192 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases phosphorylation ISO norcantharidin results in decreased phosphorylation of STAT5B protein CTD PMID:21266192 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO norcantharidin results in increased expression of THBS1 protein CTD PMID:16681930 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO norcantharidin results in increased expression of TIMP2 mRNA; norcantharidin results in increased expression of TIMP2 protein CTD PMID:16681930 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO norcantharidin results in decreased expression of VEGFA mRNA; norcantharidin results in decreased expression of VEGFA protein CTD PMID:16681930 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          oxygen atom 19560
            oxygen molecular entity 19560
              organooxygen compound 19215
                oxacycle 17926
                  furofuran 72
                    (+)-(7R,7'R,7''R,7'''R,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                    (+)-(7R,7'R,7''R,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                    (+)-(7R,7'R,7''S,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                    (+)-sesamin + 17
                    (+)-sesamin dicatechol 0
                    (+)-sesamin monocatechol + 0
                    (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                    (-)-(7R,7'R,8S,8'S)-4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,9':7',9-diepoxylignane 0
                    (-)-demethoxylpinoresinol 0
                    (-)-medioresinol 0
                    (1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 0
                    (1S,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-propan-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 0
                    (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-\{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]benzyl\}propyl]carbamate 0
                    (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl glycolate 0
                    11,12-epoxy-5,6-seco-1,6(13)-tremuladien-5,12-olide 0
                    13-Hydroxymarasmene 0
                    14,15-dihydroajugapitin 0
                    14,15-dihydroclerodin 0
                    14-hydro-15-hydroxyajugachin A 0
                    14-hydro-15-hydroxyajugapitin 0
                    15-Hydroxymarasmen-3-one 0
                    15-epi-lupulin B 0
                    15-hydroxyajubractin C 0
                    1alpha,15-Dihydroxymarasmene 0
                    22-epi-methylatranone B 0
                    3-epi-14,15-dihydrocaryoptin 0
                    3-epi-caryoptin 0
                    3alpha,15-Dihydroxymarasmene 0
                    3beta-Dihydroxymarasmene 0
                    4-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)tetrahydrofuro[3,4-c]furan-1-yl]-2-methoxyphenol 0
                    4-epi-Ethiosolide 0
                    4alpha-hydroxypinoresinol 0
                    4beta-[(beta-D-glucopyranosyl)hydroxy]-pinoresinol 0
                    6-(7-methyloctyl)-1H,3H,4H,6H-furo[3,4-c]furan-1-one 0
                    6-hexyl-3-methyl-(3S,3aS,6R,6aR)-perhydrofuro[3,4-b]furan-2,4-dione 0
                    Agrocybolactone 0
                    Anhydromarasmone 0
                    Ascospiroketal A 0
                    Ascospiroketal B 0
                    Asperochrin E 0
                    Aspersclerotiorone C 0
                    Asteltoxin 0
                    Asteltoxin B 0
                    Asteltoxin C 0
                    Asteltoxin D 0
                    Asteltoxin E 0
                    Asteltoxin F 0
                    Atranone A 0
                    Atranone B 0
                    Atranone C 0
                    Atranone H 0
                    Atranone I 0
                    Atranone T 0
                    Atranone U 0
                    Avenaciolid 1 0
                    Avenaciolid 4 0
                    Avertoxin A 0
                    Avertoxin B 0
                    Avertoxin C 0
                    Avertoxin D 0
                    Cephalosporolide E 0
                    Cephalosporolide F 0
                    Cephalosporolide H 0
                    Cephalosporolide I 0
                    Clerodendrin A 0
                    Communiol D 0
                    Conosilane A 0
                    Dermatolactone 0
                    Diasteltoxin A 0
                    Diasteltoxin B 0
                    Diasteltoxin C 0
                    Dibetaeminin A 0
                    Dihydromarasmone 0
                    Discosiolide 0
                    Eremantholide A 0
                    Erythroskyrin 0
                    GS-8373 0
                    Gilluone A 0
                    Gymnodrimane D 0
                    Isoasteltoxin 0
                    Isomarasmone 0
                    Jodrellin A 0
                    LSM-4433 0
                    Mabetaarilactone A 0
                    Mabetaarilactone F 0
                    Mabetaarilactone acetonide 0
                    Manginoid E 0
                    Manginoid F 0
                    Marasmene 0
                    Marasmene B 0
                    Marasmone 0
                    NORCANTHARIDIN 48
                    Neglectine A 0
                    Nesteretal A 0
                    No. 2106 A 0
                    Penisporolide B 0
                    Protulactone A 0
                    Pseudonocardide D 0
                    Purpurogenolide A 0
                    Pyrenolide D 0
                    Rubetaulanorol-beta 0
                    Sculponeatin C 0
                    Spiroleptosphol T1 0
                    Spiroleptosphol T2 0
                    Spiroleptosphol W 0
                    Spiromabetaaritone 0
                    Syringolide 1 0
                    Syringolide 2 0
                    Taichunin A 0
                    Trichodermaketone A 0
                    Trichodermaketone B 0
                    Trichodermaketone E 0
                    V214w 0
                    Varioxiranol L 0
                    Velleratretraol 0
                    Virgineol 0
                    Xylobovide 0
                    [(1S,3R,7Z,9R,12S,13R,15R)-13-Butan-2-yl-13-hydroxy-3,12-dimethyl-4,11-dioxo-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-dien-7-yl]methyl acetate 0
                    ajubractin A 0
                    ajubractin B 0
                    ajubractin C 0
                    ajubractin D 0
                    ajubractin E 0
                    ajugapitin 0
                    alpha-mannofuranuronic acid gamma-lactone 0
                    aplysiallene 0
                    areptin A 0
                    areptin B 0
                    buddlenol C 0
                    caryoptin 0
                    clerodin 0
                    darunavir + 0
                    demethoxyaschantin 0
                    dihydrocanadensolide 0
                    ficusequilignan A 0
                    ivain II 0
                    lupulin A 0
                    pinoresinol + 7
                    salicifoliol 0
                    sesaminol + 0
                    sesaminol 2-O-beta-D-gentiobioside 0
                    sesaminol 2-O-beta-D-glucoside 0
                    sporothriolide 0
                    stemocurtisine 0
                    stemocurtisine N-oxide 0
                    syringaresinol + 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteropolycyclic compound 18322
                                    organic heterobicyclic compound 17272
                                      furofuran 72
                                        (+)-(7R,7'R,7''R,7'''R,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                        (+)-(7R,7'R,7''R,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                        (+)-(7R,7'R,7''S,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                        (+)-sesamin + 17
                                        (+)-sesamin dicatechol 0
                                        (+)-sesamin monocatechol + 0
                                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                        (-)-(7R,7'R,8S,8'S)-4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,9':7',9-diepoxylignane 0
                                        (-)-demethoxylpinoresinol 0
                                        (-)-medioresinol 0
                                        (1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 0
                                        (1S,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-propan-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 0
                                        (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-\{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]benzyl\}propyl]carbamate 0
                                        (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl glycolate 0
                                        11,12-epoxy-5,6-seco-1,6(13)-tremuladien-5,12-olide 0
                                        13-Hydroxymarasmene 0
                                        14,15-dihydroajugapitin 0
                                        14,15-dihydroclerodin 0
                                        14-hydro-15-hydroxyajugachin A 0
                                        14-hydro-15-hydroxyajugapitin 0
                                        15-Hydroxymarasmen-3-one 0
                                        15-epi-lupulin B 0
                                        15-hydroxyajubractin C 0
                                        1alpha,15-Dihydroxymarasmene 0
                                        22-epi-methylatranone B 0
                                        3-epi-14,15-dihydrocaryoptin 0
                                        3-epi-caryoptin 0
                                        3alpha,15-Dihydroxymarasmene 0
                                        3beta-Dihydroxymarasmene 0
                                        4-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)tetrahydrofuro[3,4-c]furan-1-yl]-2-methoxyphenol 0
                                        4-epi-Ethiosolide 0
                                        4alpha-hydroxypinoresinol 0
                                        4beta-[(beta-D-glucopyranosyl)hydroxy]-pinoresinol 0
                                        6-(7-methyloctyl)-1H,3H,4H,6H-furo[3,4-c]furan-1-one 0
                                        6-hexyl-3-methyl-(3S,3aS,6R,6aR)-perhydrofuro[3,4-b]furan-2,4-dione 0
                                        Agrocybolactone 0
                                        Anhydromarasmone 0
                                        Ascospiroketal A 0
                                        Ascospiroketal B 0
                                        Asperochrin E 0
                                        Aspersclerotiorone C 0
                                        Asteltoxin 0
                                        Asteltoxin B 0
                                        Asteltoxin C 0
                                        Asteltoxin D 0
                                        Asteltoxin E 0
                                        Asteltoxin F 0
                                        Atranone A 0
                                        Atranone B 0
                                        Atranone C 0
                                        Atranone H 0
                                        Atranone I 0
                                        Atranone T 0
                                        Atranone U 0
                                        Avenaciolid 1 0
                                        Avenaciolid 4 0
                                        Avertoxin A 0
                                        Avertoxin B 0
                                        Avertoxin C 0
                                        Avertoxin D 0
                                        Cephalosporolide E 0
                                        Cephalosporolide F 0
                                        Cephalosporolide H 0
                                        Cephalosporolide I 0
                                        Clerodendrin A 0
                                        Communiol D 0
                                        Conosilane A 0
                                        Dermatolactone 0
                                        Diasteltoxin A 0
                                        Diasteltoxin B 0
                                        Diasteltoxin C 0
                                        Dibetaeminin A 0
                                        Dihydromarasmone 0
                                        Discosiolide 0
                                        Eremantholide A 0
                                        Erythroskyrin 0
                                        GS-8373 0
                                        Gilluone A 0
                                        Gymnodrimane D 0
                                        Isoasteltoxin 0
                                        Isomarasmone 0
                                        Jodrellin A 0
                                        LSM-4433 0
                                        Mabetaarilactone A 0
                                        Mabetaarilactone F 0
                                        Mabetaarilactone acetonide 0
                                        Manginoid E 0
                                        Manginoid F 0
                                        Marasmene 0
                                        Marasmene B 0
                                        Marasmone 0
                                        NORCANTHARIDIN 48
                                        Neglectine A 0
                                        Nesteretal A 0
                                        No. 2106 A 0
                                        Penisporolide B 0
                                        Protulactone A 0
                                        Pseudonocardide D 0
                                        Purpurogenolide A 0
                                        Pyrenolide D 0
                                        Rubetaulanorol-beta 0
                                        Sculponeatin C 0
                                        Spiroleptosphol T1 0
                                        Spiroleptosphol T2 0
                                        Spiroleptosphol W 0
                                        Spiromabetaaritone 0
                                        Syringolide 1 0
                                        Syringolide 2 0
                                        Taichunin A 0
                                        Trichodermaketone A 0
                                        Trichodermaketone B 0
                                        Trichodermaketone E 0
                                        V214w 0
                                        Varioxiranol L 0
                                        Velleratretraol 0
                                        Virgineol 0
                                        Xylobovide 0
                                        [(1S,3R,7Z,9R,12S,13R,15R)-13-Butan-2-yl-13-hydroxy-3,12-dimethyl-4,11-dioxo-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-dien-7-yl]methyl acetate 0
                                        ajubractin A 0
                                        ajubractin B 0
                                        ajubractin C 0
                                        ajubractin D 0
                                        ajubractin E 0
                                        ajugapitin 0
                                        alpha-mannofuranuronic acid gamma-lactone 0
                                        aplysiallene 0
                                        areptin A 0
                                        areptin B 0
                                        buddlenol C 0
                                        caryoptin 0
                                        clerodin 0
                                        darunavir + 0
                                        demethoxyaschantin 0
                                        dihydrocanadensolide 0
                                        ficusequilignan A 0
                                        ivain II 0
                                        lupulin A 0
                                        pinoresinol + 7
                                        salicifoliol 0
                                        sesaminol + 0
                                        sesaminol 2-O-beta-D-gentiobioside 0
                                        sesaminol 2-O-beta-D-glucoside 0
                                        sporothriolide 0
                                        stemocurtisine 0
                                        stemocurtisine N-oxide 0
                                        syringaresinol + 11
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