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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:11-oxo steroid
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Accession:CHEBI:47787 term browser browse the term
Definition:Any oxo steroid that has an oxo substituent at position 11.
Synonyms:related_synonym: 11-Oxosteroid;   11-oxo steroids;   11-oxosteroids;   Formula=C19H29OR;   SMILES=C12(CCCCC1CCC3C2C(CC4(C3CCC4*)C)=O)C;   an 11-oxosteroid
 alt_id: CHEBI:13773;   CHEBI:19127;   CHEBI:725
 xref: KEGG:C01985



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11-dehydrocorticosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases metabolic processing
increases reduction
affects abundance
multiple interactions
affects response to substance
ISO
EXP
HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone
HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone
HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosterone
[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; Resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
HSD11B1 gene affects the susceptibility to 11-dehydrocorticosterone
CTD PMID:16751407 PMID:23814014 PMID:25061560 PMID:26859423 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone] CTD PMID:26859423 PMID:32243540 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 11-dehydrocorticosterone results in increased expression of IL6 mRNA
11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]
CTD PMID:30993381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA] CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
17,21-dihydroxy-5beta-pregnane-3,11,20-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C4 protein results in increased reduction of 5-dihydrocortisone CTD PMID:8543560 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
adrenosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO adrenosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
cortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Calcitriol co-treated with Cortisone] results in decreased expression of ADIPOQ mRNA CTD PMID:19918113 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Cortisone CTD PMID:25500266 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Cortisone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:15755911 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Cortisone results in increased expression of CCL2 mRNA CTD PMID:24135201 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Cortisone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions
ISO Cortisone results in increased expression of FABP4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of FABP4 mRNA]
CTD PMID:21315688 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Glul glutamate-ammonia ligase increases activity EXP Cortisone results in increased activity of GLUL protein CTD PMID:30993381 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases expression
increases reduction
affects response to substance
increases metabolic processing
affects metabolic processing
ISO
EXP
[Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA; [HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; [HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; [HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
Cortisone results in increased expression of HSD11B1 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]; Cortisone results in increased expression of and results in increased activity of HSD11B1 protein
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein; [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]
HSD11B1 protein results in increased metabolism of Cortisone
HSD11B1 protein affects the metabolism of Cortisone
CTD PMID:16054388 PMID:16751407 PMID:19918113 PMID:21315688 PMID:22606287 More... NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases chemical synthesis
multiple interactions
ISO HSD11B2 protein results in increased chemical synthesis of Cortisone
[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]
CTD PMID:22796344 PMID:26859423 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL1B] CTD PMID:27288094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Cortisone results in decreased expression of IL6
perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL6]
CTD PMID:27288094 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK1 protein CTD PMID:24135201 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK3 protein CTD PMID:24135201 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein
CTD PMID:22606287 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Cortisone results in increased expression of NOS2 protein CTD PMID:24135201 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA CTD PMID:22606287 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
multiple interactions
increases activity
ISO Cortisone binds to NR3C1 protein
[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
Cortisone results in increased activity of NR3C1 protein
CTD PMID:15705660 PMID:15780662 PMID:22606287 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortisone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of PPARG mRNA] CTD PMID:21315688 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Cortisone results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Cortisone results in increased phosphorylation of RELA protein CTD PMID:24135201 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
EXP Cortisone results in increased expression of SGK1 mRNA
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]
CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cortisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
ISO Cortisone results in increased expression of SLC2A4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of SLC2A4 mRNA]
CTD PMID:21315688 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cortisone results in increased expression of TNF mRNA CTD PMID:24135201 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
prednisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Prednisone results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases secretion
ISO Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]
ABCB1A protein affects the susceptibility to Prednisone
CTD PMID:15502009 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prednisone CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases activity
ISO Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]
Prednisone results in increased activity of ABCC3 protein
CTD PMID:15979871 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ar androgen receptor multiple interactions ISO Prednisone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Prednisone results in decreased expression of CCL11 protein CTD PMID:15523430 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 decreases expression ISO Prednisone results in decreased expression of CCL13 protein CTD PMID:15523430 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Prednisone results in increased expression of CDKN1A protein CTD PMID:15034294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Prednisone results in increased expression of CDKN1B protein CTD PMID:15034294 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Prednisone results in increased expression of CDKN2B protein CTD PMID:15034294 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gcg glucagon multiple interactions
decreases expression
EXP [Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA
Prednisone results in decreased expression of GCG mRNA
CTD PMID:12524409 PMID:14705828 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Prednisone results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 decreases expression ISO Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 decreases expression ISO Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression ISO Prednisone results in decreased expression of IL5 protein CTD PMID:12722970 PMID:15523430 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Prednisone results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS2 mRNA] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Prednisone binds to and results in increased activity of NR3C1 protein CTD PMID:28973534 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Prednisone results in increased expression of PLAT protein CTD PMID:10452346 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Prednisone results in decreased expression of PYGM protein CTD PMID:8815173 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Prednisone results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prednisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Prednisone results in decreased expression of TGFB1 protein CTD PMID:12722970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Prednisone results in increased expression of TNF protein CTD PMID:19584951 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vdr vitamin D receptor increases expression
affects response to substance
ISO Prednisone results in increased expression of VDR protein
VDR gene polymorphism affects the susceptibility to Prednisone
CTD PMID:7662588 PMID:15713801 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
RU 5135 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 multiple interactions ISO RU 5135 binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      group 19731
        inorganic group 19262
          oxo group 18668
            organic oxo compound 18668
              carbonyl compound 18668
                ketone 16926
                  oxo steroid 9721
                    11-oxo steroid 60
                      (17Z)-3,11-dioxopregna-4,17(20)-dien-21-oic acid methyl ester 0
                      11,21-dioxoprogesterone 0
                      11-dehydrocorticosterone 4
                      11-oxotestosterone 0
                      16beta-Hydroxy-3,11-dioxopregna-4,17(20)-dien-21-oic acid, gamma-lactone 0
                      21-dehydrocortisone 0
                      3alpha,21-dihydroxy-D-homo-5beta-pregn-17a(20)-en-11-one 0
                      4,5-dihydrocortisone + 1
                      6beta-hydroxycortisone 0
                      9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                      Cucurbitacin S 0
                      RU 5135 1
                      adrenosterone 1
                      cortancyl 0
                      cortisone + 26
                      ganolucidic acid D 0
                      prednisone + 38
                      zhankuic acid A + 0
                      zhankuic acid A methyl ester 0
                      zhankuic acid B 0
                      zhankuic acid C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    p-block element atom 19706
                      carbon group element atom 19628
                        carbon atom 19618
                          organic molecular entity 19618
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18668
                                    carbonyl compound 18668
                                      ketone 16926
                                        oxo steroid 9721
                                          11-oxo steroid 60
                                            (17Z)-3,11-dioxopregna-4,17(20)-dien-21-oic acid methyl ester 0
                                            11,21-dioxoprogesterone 0
                                            11-dehydrocorticosterone 4
                                            11-oxotestosterone 0
                                            16beta-Hydroxy-3,11-dioxopregna-4,17(20)-dien-21-oic acid, gamma-lactone 0
                                            21-dehydrocortisone 0
                                            3alpha,21-dihydroxy-D-homo-5beta-pregn-17a(20)-en-11-one 0
                                            4,5-dihydrocortisone + 1
                                            6beta-hydroxycortisone 0
                                            9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                                            Cucurbitacin S 0
                                            RU 5135 1
                                            adrenosterone 1
                                            cortancyl 0
                                            cortisone + 26
                                            ganolucidic acid D 0
                                            prednisone + 38
                                            zhankuic acid A + 0
                                            zhankuic acid A methyl ester 0
                                            zhankuic acid B 0
                                            zhankuic acid C 0
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