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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ellipticine
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Accession:CHEBI:4776 term browser browse the term
Definition:A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.
Synonyms:exact_synonym: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
 related_synonym: Elliptisine;   Formula=C17H14N2;   InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3;   InChIKey=CTSPAMFJBXKSOY-UHFFFAOYSA-N;   NSC-71795;   SMILES=Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12
 xref: Beilstein:221300;   CAS:519-23-3;   KEGG:C09154;   KNApSAcK:C00001716;   LINCS:LSM-4842
 xref_mesh: MESH:C034192
 xref: PDBeChem:EL;   PMID:22802684;   PMID:22917556;   PMID:23697684;   PMID:23827542;   PMID:23869776;   PMID:23982874;   PMID:24106137;   PMID:24138450;   PMID:24322006;   PMID:24362092;   PMID:24501742;   Reaxys:221300


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ellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]] CTD PMID:11577022 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ellipticine results in increased expression of BAX protein CTD PMID:16027529 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ellipticine results in decreased expression of BCL2 protein CTD PMID:16027529 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO ellipticine results in decreased expression of and results in increased cleavage of BID protein CTD PMID:21843585 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]
ellipticine results in increased activity of CASP3 protein
CTD PMID:16027529 PMID:21843585 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP7 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] CTD PMID:21843585 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO ellipticine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21843585 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO ellipticine results in increased activity of CASP9 protein
ellipticine results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:16027529 PMID:21843585 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO ellipticine results in decreased expression of CCNB1 protein
ellipticine results in increased expression of CCNB1 protein
CTD PMID:16027529 PMID:21843585 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ellipticine results in decreased expression of CCND1 protein CTD PMID:21843585 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO ellipticine results in decreased expression of CDC25C protein CTD PMID:16027529 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO ellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein CTD PMID:16027529 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO ellipticine results in increased expression of CDKN1A protein
[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]
CTD PMID:29471073 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO ellipticine results in decreased expression of CDKN1B protein CTD PMID:21843585 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
increases activity
multiple interactions
ISO
EXP
CYP1A1 protein results in increased metabolism of ellipticine
ellipticine results in increased expression of CYP1A1 protein
ellipticine results in increased activity of CYP1A1 protein
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; ellipticine inhibits the reaction [troglitazone results in increased activity of CYP1A1 protein]
CTD PMID:17973980 PMID:18308446 PMID:18493746 PMID:21932800 PMID:22917556 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO
EXP
CYP1A2 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD PMID:18493746 PMID:22917556 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
CTD PMID:11577022 PMID:22917556 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing ISO CYP2C9 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
ISO [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 12-hydroxyellipticine; [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 13-hydroxyellipticine; [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine; [CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine; [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 12-hydroxyellipticine]; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 13-hydroxyellipticine]; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine]; Protons inhibits the reaction [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine]
CYP3A4 protein results in increased metabolism of ellipticine
CTD PMID:22390216 PMID:22917556 PMID:30914192 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form; FTL protein binds to and results in decreased uptake of ellipticine CTD PMID:30914192 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO ellipticine results in increased expression of H2AX protein modified form
[ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form
CTD PMID:30914192 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] CTD PMID:21843585 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] CTD PMID:21843585 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO ellipticine results in increased cleavage of PARP1 protein CTD PMID:21843585 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine CTD PMID:22390216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Top2b DNA topoisomerase II beta decreases response to substance
increases response to substance
ISO TOP2B protein mutant form results in decreased susceptibility to ellipticine
TOP2B protein mutant form results in increased susceptibility to ellipticine
CTD PMID:15322234 PMID:16239602 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases response to substance
ISO TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
ellipticine results in increased expression of TP53 protein
TP53 protein results in increased susceptibility to ellipticine
CTD PMID:29471073 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO ellipticine results in decreased expression of XIAP protein CTD PMID:16027529 PMID:21843585 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

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            antineoplastic agent 17316
              ellipticine 32
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
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            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotetracyclic compound 9067
                                      ellipticine 32
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