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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ellipticine
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Accession:CHEBI:4776 term browser browse the term
Definition:A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.
Synonyms:exact_synonym: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
 related_synonym: Elliptisine;   Formula=C17H14N2;   InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3;   InChIKey=CTSPAMFJBXKSOY-UHFFFAOYSA-N;   NSC-71795;   SMILES=Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12
 xref: Beilstein:221300;   CAS:519-23-3;   KEGG:C09154;   KNApSAcK:C00001716;   LINCS:LSM-4842
 xref_mesh: MESH:C034192
 xref: PDBeChem:EL;   PMID:22802684;   PMID:22917556;   PMID:23697684;   PMID:23827542;   PMID:23869776;   PMID:23982874;   PMID:24106137;   PMID:24138450;   PMID:24322006;   PMID:24362092;   PMID:24501742;   Reaxys:221300


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ellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]] CTD PMID:11577022 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ellipticine results in increased expression of BAX protein CTD PMID:16027529 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ellipticine results in decreased expression of BCL2 protein CTD PMID:16027529 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO ellipticine results in decreased expression of and results in increased cleavage of BID protein CTD PMID:21843585 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]
ellipticine results in increased activity of CASP3 protein
CTD PMID:16027529, PMID:21843585 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP7 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] CTD PMID:21843585 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO ellipticine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21843585 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO ellipticine results in increased activity of CASP9 protein
ellipticine results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:16027529, PMID:21843585 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO ellipticine results in decreased expression of CCNB1 protein
ellipticine results in increased expression of CCNB1 protein
CTD PMID:16027529, PMID:21843585 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ellipticine results in decreased expression of CCND1 protein CTD PMID:21843585 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO ellipticine results in decreased expression of CDC25C protein CTD PMID:16027529 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO ellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein CTD PMID:16027529 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO ellipticine results in increased expression of CDKN1A protein
[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]
CTD PMID:29471073 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO ellipticine results in decreased expression of CDKN1B protein CTD PMID:21843585 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
increases activity
multiple interactions
ISO
EXP
CYP1A1 protein results in increased metabolism of ellipticine
ellipticine results in increased expression of CYP1A1 protein
ellipticine results in increased activity of CYP1A1 protein
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; ellipticine inhibits the reaction [troglitazone results in increased activity of CYP1A1 protein]
CTD PMID:17973980, PMID:18308446, PMID:18493746, PMID:21932800, PMID:22917556, PMID:29471073 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO
EXP
CYP1A2 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD PMID:18493746, PMID:22917556 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
CTD PMID:11577022, PMID:22917556 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form; FTL protein binds to and results in decreased uptake of ellipticine CTD PMID:30914192 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO ellipticine results in increased expression of H2AX protein modified form
[ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form
CTD PMID:30914192 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] CTD PMID:21843585 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] CTD PMID:21843585 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO ellipticine results in increased cleavage of PARP1 protein CTD PMID:21843585 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Top2b DNA topoisomerase II beta decreases response to substance
increases response to substance
ISO TOP2B protein mutant form results in decreased susceptibility to ellipticine
TOP2B protein mutant form results in increased susceptibility to ellipticine
CTD PMID:15322234, PMID:16239602 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases response to substance
ISO TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
ellipticine results in increased expression of TP53 protein
TP53 protein results in increased susceptibility to ellipticine
CTD PMID:29471073 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO ellipticine results in decreased expression of XIAP protein CTD PMID:16027529, PMID:21843585 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              ellipticine 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotetracyclic compound 4332
                                      ellipticine 30
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.