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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4,6-tribromophenol
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Accession:CHEBI:47696 term browser browse the term
Definition:A bromophenol that is phenol in which the hydrogens at positions 2, 4 and 6 have been replaced by bromines. It is commonly used as a fungicide and in the preparation of flame retardants.
Synonyms:related_synonym: 2,4,6-TBP;   Bromol;   Formula=C6H3Br3O;   InChI=1S/C6H3Br3O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H;   InChIKey=BSWWXRFVMJHFBN-UHFFFAOYSA-N;   SMILES=C=1(C(=C(C=C(C1)Br)Br)O)Br;   Tribromophenol;   Xeroform
 alt_id: CHEBI:34234
 xref: CAS:118-79-6;   DrugBank:DB02417;   HMDB:HMDB0029642;   KEGG:C14454
 xref_mesh: MESH:C004554
 xref: PDBeChem:TBP;   PMID:16134480;   PMID:18460800;   PMID:19701836;   PMID:19931292;   PMID:24263137;   Reaxys:776920;   Wikipedia:2\,4\,6-tribromophenol

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2,4,6-tribromophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
decreases expression		 ISO
EXP		 2,4,6-tribromophenol results in decreased activity of ABCB1A protein
Go 6976 inhibits the reaction [2,4,6-tribromophenol results in decreased activity of ABCB1A protein]; ruboxistaurin inhibits the reaction [2,4,6-tribromophenol results in decreased activity of ABCB1A protein]
2,4,6-tribromophenol results in decreased expression of ABCB1A protein		 CTD PMID:31368499 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb5 ATP binding cassette subfamily B member 5 increases expression ISO 2,4,6-tribromophenol results in increased expression of ABCB5 mRNA CTD PMID:29427708 NCBI chr 6:146,805,481...146,902,339
Ensembl chr 6:146,805,599...146,902,339 		JBrowse link
G Ache acetylcholinesterase increases activity ISO 2,4,6-tribromophenol results in increased activity of ACHE protein CTD PMID:14599456 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO 2,4,6-tribromophenol results in increased expression of CYP11A1 mRNA CTD PMID:17447562 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression ISO 2,4,6-tribromophenol results in decreased expression of CYP11B2 mRNA CTD PMID:17447562 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 2,4,6-tribromophenol results in decreased expression of CYP17A1 mRNA CTD PMID:17447562 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity		 ISO 2,4,6-tribromophenol results in increased expression of CYP19A1 mRNA
2,4,6-tribromophenol results in increased activity of CYP19A1 protein		 CTD PMID:16177243 PMID:17447562 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO 2,4,6-tribromophenol results in increased expression of HSD3B2 mRNA CTD PMID:17447562 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO 2,4,6-tribromophenol binds to PPARG protein CTD PMID:25314719 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO 2,4,6-tribromophenol results in increased expression of STAR mRNA CTD PMID:17447562 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO 2,4,6-tribromophenol promotes the reaction [Estradiol results in increased expression of TFF1 protein] CTD PMID:11879974 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 2,4,6-tribromophenol inhibits the reaction [Triiodothyronine binds to THRB protein] CTD PMID:29409039 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Ttr transthyretin affects binding ISO 2,4,6-tribromophenol binds to TTR protein CTD PMID:10869457 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      chemical role 19256
        environmental contaminant 18595
          2,4,6-tribromophenol 13
            2-propyn-1-yl 2,4,6-tribromophenyl phthalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                carbocyclic compound 18297
                                  benzenoid aromatic compound 17402
                                    benzenes 17174
                                      bromobenzenes 2724
                                        bromophenol 358
                                          2,4,6-tribromophenol 13
                                            2-propyn-1-yl 2,4,6-tribromophenyl phthalate 0
paths to the root