Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:47657 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Synonyms:related_synonym: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE;   Daliresp;   Formula=C17H14Cl2F2N2O3;   InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24);   InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N;   SMILES=FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl;   roflumilastum
 alt_id: MESH:C424423
 xref: CAS:162401-32-3 "ChemIDplus";   CAS:162401-32-3 "KEGG DRUG";   Drug_Central:3531 "DrugCentral";   KEGG:D05744
 xref_mesh: MESH:C424423
 xref: PDBeChem:ROF;   PMID:21778965 "Europe PMC";   PMID:21913898 "Europe PMC";   PMID:21965226 "Europe PMC";   PMID:22041526 "Europe PMC";   PMID:22258322 "Europe PMC";   PMID:22284994 "Europe PMC";   PMID:22306235 "Europe PMC";   PMID:22364166 "Europe PMC";   PMID:22385203 "Europe PMC";   PMID:22421519 "Europe PMC";   PMID:22425388 "Europe PMC";   PMID:22433610 "Europe PMC";   PMID:22452977 "Europe PMC";   PMID:22500119 "Europe PMC";   PMID:22605906 "Europe PMC";   PMID:22723325 "Europe PMC";   PMID:22790061 "Europe PMC";   PMID:22791991 "Europe PMC";   PMID:22833385 "Europe PMC";   PMID:22952743 "Europe PMC";   PMID:22955248 "Europe PMC";   PMID:22997924 "Europe PMC";   Patent:US2008181876;   Patent:US2008221111;   Patent:WO2008017827;   Patent:WO2008090355;   Reaxys:9802592 "Reaxys";   Wikipedia:Roflumilast

show annotations for term's descendants       view all columns           Sort by:
roflumilast term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Pde3a phosphodiesterase 3A JBrowse link 4 175,431,904 175,703,844 RGD:6480464
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:6480464
G Pde4a phosphodiesterase 4A JBrowse link 8 22,189,533 22,234,036 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Pde4c phosphodiesterase 4C JBrowse link 16 20,442,305 20,466,386 RGD:6480464
G Pde4d phosphodiesterase 4D JBrowse link 2 40,219,999 41,468,551 RGD:6480464
G Pde7a phosphodiesterase 7A JBrowse link 2 104,042,124 104,134,101 RGD:6480464
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:6480464
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        anti-asthmatic agent 9166
          anti-asthmatic drug 8543
            roflumilast 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            carbamoyl group 16610
                                              carboxamide 16610
                                                monocarboxylic acid amide 13174
                                                  arenecarboxamide 6402
                                                    benzamides 6402
                                                      roflumilast 16
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.