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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:roflumilast
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Accession:CHEBI:47657 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Synonyms:related_synonym: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE;   Daliresp;   Formula=C17H14Cl2F2N2O3;   InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24);   InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N;   SMILES=FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl;   roflumilastum
 alt_id: MESH:C424423
 xref: CAS:162401-32-3;   Drug_Central:3531;   KEGG:D05744
 xref_mesh: MESH:C424423
 xref: PDBeChem:ROF;   PMID:21778965;   PMID:21913898;   PMID:21965226;   PMID:22041526;   PMID:22258322;   PMID:22284994;   PMID:22306235;   PMID:22364166;   PMID:22385203;   PMID:22421519;   PMID:22425388;   PMID:22433610;   PMID:22452977;   PMID:22500119;   PMID:22605906;   PMID:22723325;   PMID:22790061;   PMID:22791991;   PMID:22833385;   PMID:22952743;   PMID:22955248;   PMID:22997924;   Patent:US2008181876;   Patent:US2008221111;   Patent:WO2008017827;   Patent:WO2008090355;   Reaxys:9802592;   Wikipedia:Roflumilast



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roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]
[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein]
Roflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX protein
CTD PMID:33757793 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 mRNA]; Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 protein]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast results in decreased expression of BCL2 mRNA; Roflumilast results in decreased expression of BCL2 protein
Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:33757793 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
ISO
EXP
Roflumilast results in increased expression of CASP3 mRNA
Roflumilast results in increased activity of CASP3 protein
Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]
[Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]
CTD PMID:33757793 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:33757793 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein
CTD PMID:18276108 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in increased expression of HMOX1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
Roflumilast promotes the reaction [Cisplatin results in increased activity of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
CTD PMID:33757793 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33757793 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
EXP
ISO
Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
Roflumilast results in increased expression of NFE2L2 mRNA
Cisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
CTD PMID:33757793 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:33757793 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pde3a phosphodiesterase 3A decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274
JBrowse link
G Pde3b phosphodiesterase 3B decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO Roflumilast results in decreased activity of PDE4A protein CTD PMID:15901792 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B decreases activity ISO Roflumilast results in decreased activity of PDE4B protein CTD PMID:15901792 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde4c phosphodiesterase 4C decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640
JBrowse link
G Pde4d phosphodiesterase 4D decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression
EXP RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein
CTD PMID:18276108 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP
ISO
Roflumilast inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]
Roflumilast results in decreased expression of RELA mRNA
Cisplatin promotes the reaction [Roflumilast results in decreased expression of RELA mRNA]
CTD PMID:33757793 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:21913898 PMID:33757793 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        anti-asthmatic agent 9239
          anti-asthmatic drug 8611
            roflumilast 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                monocarboxylic acid amide 15010
                                                  arenecarboxamide 7270
                                                    benzamides 7270
                                                      roflumilast 28
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