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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
ISO |
[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA Bezafibrate results in increased expression of ABCA1 mRNA; Bezafibrate results in increased expression of ABCA1 protein |
CTD |
PMID:12595494 PMID:19201410 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression increases expression affects localization |
ISO |
Bezafibrate results in decreased expression of ABCB11 mRNA Bezafibrate results in increased expression of ABCB11 mRNA Bezafibrate affects the localization of ABCB11 protein |
CTD |
PMID:15258199 PMID:15447978 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
affects localization increases expression multiple interactions |
ISO EXP |
Bezafibrate affects the localization of ABCB4 protein Bezafibrate results in increased expression of ABCB4 mRNA; Bezafibrate results in increased expression of ABCB4 protein [Bezafibrate co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB4 mRNA; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein] |
CTD |
PMID:15242490 PMID:15258199 PMID:15588777 PMID:17118139 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects localization multiple interactions increases expression |
ISO |
Bezafibrate affects the localization of ABCC2 protein [Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ABCC2 mRNA Bezafibrate results in increased expression of ABCC2 mRNA |
CTD |
PMID:15258199 PMID:21549692 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases transport |
ISO |
ABCC4 protein results in increased transport of Bezafibrate |
CTD |
PMID:17939016 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcd3 |
ATP binding cassette subfamily D member 3 |
increases expression |
ISO |
Bezafibrate results in increased expression of ABCD3 protein |
CTD |
PMID:19124612 PMID:20594415 |
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NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
increases expression |
ISO |
Bezafibrate results in increased expression of ABCG5 mRNA |
CTD |
PMID:14685799 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
multiple interactions increases expression |
ISO |
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA] |
CTD |
PMID:19124612 |
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NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
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G |
Acaca |
acetyl-CoA carboxylase alpha |
decreases expression multiple interactions increases expression |
ISO |
Bezafibrate results in decreased expression of ACACA mRNA; Bezafibrate results in decreased expression of ACACA protein PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein] Bezafibrate results in increased expression of ACACA mRNA; Bezafibrate results in increased expression of ACACA protein |
CTD |
PMID:19124612 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
decreases expression increases expression multiple interactions |
ISO |
Bezafibrate results in decreased expression of ACACB mRNA Bezafibrate results in increased expression of ACACB mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA] |
CTD |
PMID:17118139 PMID:19124612 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acadl |
acyl-CoA dehydrogenase, long chain |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein] Bezafibrate results in increased expression of ACADL mRNA; Bezafibrate results in increased expression of ACADL protein |
CTD |
PMID:12782154 |
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NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
multiple interactions increases expression |
ISO EXP |
Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA] Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA] |
CTD |
PMID:11929713 PMID:19124612 PMID:26190035 |
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NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
affects response to substance increases expression multiple interactions increases activity |
ISO |
ACADVL protein affects the susceptibility to Bezafibrate; ACADVL protein mutant form affects the susceptibility to Bezafibrate Bezafibrate results in increased expression of ACADVL mRNA; Bezafibrate results in increased expression of ACADVL protein Bezafibrate inhibits the reaction [ACADVL protein mutant form results in decreased oxidation of Fatty Acids] Butyrates promotes the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein] Bezafibrate results in increased activity of ACADVL protein |
CTD |
PMID:12782154 PMID:17118139 PMID:17999356 PMID:20060901 PMID:22338096 |
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NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein] |
CTD |
PMID:16979161 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression increases activity multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of ACOX1 mRNA Bezafibrate results in increased activity of ACOX1 protein [Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ACOX1 mRNA; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA] Bezafibrate results in increased expression of ACOX1 mRNA; Bezafibrate results in increased expression of ACOX1 protein |
CTD |
PMID:2399535 PMID:11172741 PMID:11216866 PMID:11473052 PMID:11519881 PMID:11527545 PMID:11579993 PMID:11929713 PMID:12782154 PMID:15447978 PMID:16574099 PMID:16707586 PMID:17118139 PMID:21324916 PMID:21549692 PMID:21640707 More...
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NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions increases expression |
ISO |
Butyrates promotes the reaction [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA] |
CTD |
PMID:17118139 PMID:19124612 PMID:19682441 PMID:21640707 PMID:22338096 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
ISO |
Bezafibrate results in increased expression of ACSL4 mRNA |
CTD |
PMID:17118139 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
increases expression |
ISO |
Bezafibrate results in increased expression of ACSL5 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
affects expression |
EXP |
Bezafibrate affects the expression of ACSS2 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
EXP ISO |
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] Bezafibrate results in decreased expression of ACTA2 protein Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA] |
CTD |
PMID:12657956 PMID:18513333 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression multiple interactions increases secretion |
ISO |
Bezafibrate results in increased expression of ADIPOQ protein Bezafibrate inhibits the reaction [Sodium Glutamate results in decreased expression of ADIPOQ protein] Bezafibrate results in increased secretion of ADIPOQ protein Bezafibrate results in increased expression of ADIPOQ mRNA; Bezafibrate results in increased expression of ADIPOQ protein |
CTD |
PMID:16574099 PMID:17190905 PMID:18513333 PMID:21324916 PMID:21411093 PMID:21549692 More...
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adipor1 |
adiponectin receptor 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of ADIPOR1 mRNA |
CTD |
PMID:16574099 |
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NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
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G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:16574099 |
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NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Adora2a |
adenosine A2a receptor |
increases expression |
ISO |
Bezafibrate results in increased expression of ADORA2A mRNA |
CTD |
PMID:18787029 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency] |
CTD |
PMID:15806154 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
increases expression |
ISO |
Bezafibrate results in increased expression of ALDH1A2 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
increases activity affects response to substance increases expression |
ISO |
Bezafibrate results in increased activity of ALDH3A2 protein ALDH3A2 protein affects the susceptibility to Bezafibrate Bezafibrate results in increased expression of ALDH3A2 mRNA |
CTD |
PMID:16837225 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
decreases activity increases expression multiple interactions |
ISO |
Bezafibrate results in decreased activity of ALPL protein Bezafibrate results in increased expression of ALPL mRNA dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA] |
CTD |
PMID:8102192 PMID:21499286 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Angptl4 |
angiopoietin-like 4 |
increases expression |
ISO |
Bezafibrate results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of APEX1 mRNA |
CTD |
PMID:15447978 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions increases expression decreases expression |
ISO |
[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Bezafibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids] Bezafibrate results in increased expression of APOA1 protein Bezafibrate results in decreased expression of APOA1 mRNA; Bezafibrate results in decreased expression of APOA1 protein |
CTD |
PMID:1323073 PMID:7893284 PMID:7983038 PMID:8017468 PMID:9678787 PMID:10751747 PMID:12595494 PMID:19201410 More...
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoa2 |
apolipoprotein A2 |
increases expression |
ISO |
Bezafibrate results in increased expression of APOA2 protein |
CTD |
PMID:7893284 PMID:8017468 |
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NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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G |
Apob |
apolipoprotein B |
multiple interactions decreases expression increases expression decreases secretion |
ISO EXP |
Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of APOB protein] Bezafibrate results in decreased expression of APOB protein Bezafibrate results in increased expression of APOB protein [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form Bezafibrate results in decreased expression of APOB mRNA alternative form Bezafibrate results in decreased secretion of APOB protein PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form] |
CTD |
PMID:1323073 PMID:3084275 PMID:7893284 PMID:8017468 PMID:8944747 PMID:9006809 PMID:9223394 PMID:9822092 PMID:12048068 PMID:12782154 PMID:21640707 More...
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc2 |
apolipoprotein C2 |
decreases expression multiple interactions |
ISO |
Bezafibrate results in decreased expression of APOC2 mRNA PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA] |
CTD |
PMID:12782154 |
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NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression multiple interactions |
ISO EXP |
Bezafibrate results in decreased expression of APOC3 mRNA Bezafibrate results in decreased expression of APOC3 protein Bezafibrate results in decreased expression of APOC3 mRNA; Bezafibrate results in decreased expression of APOC3 protein PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA] |
CTD |
PMID:8847480 PMID:9041378 PMID:11164425 PMID:12782154 PMID:19124612 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Apoe |
apolipoprotein E |
multiple interactions increases expression decreases expression |
ISO EXP |
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein Bezafibrate results in increased expression of APOE protein Bezafibrate results in decreased expression of APOE protein [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein |
CTD |
PMID:8017468 PMID:8944747 PMID:9006809 PMID:19603250 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
multiple interactions |
ISO |
[CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:20400680 |
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NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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G |
Arpp21 |
cAMP regulated phosphoprotein 21 |
increases expression |
ISO |
Bezafibrate results in increased expression of ARPP21 mRNA |
CTD |
PMID:18787029 |
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NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
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G |
Ascl2 |
achaete-scute family bHLH transcription factor 2 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of ASCL2 mRNA |
CTD |
PMID:15708366 |
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NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP |
Bezafibrate results in decreased expression of BCL2 mRNA Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein] |
CTD |
PMID:12704018 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of BMP2 mRNA dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA] |
CTD |
PMID:21499286 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Bezafibrate results in increased expression of BNIP3 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Btbd9 |
BTB domain containing 9 |
increases expression |
ISO |
Bezafibrate results in increased expression of BTBD9 mRNA |
CTD |
PMID:18787029 |
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NCBI chr20:8,286,337...8,645,567
Ensembl chr20:8,288,711...8,643,960
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G |
Car9 |
carbonic anhydrase 9 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] |
CTD |
PMID:34520103 |
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NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Cat |
catalase |
increases activity increases expression multiple interactions |
EXP ISO |
Bezafibrate results in increased activity of CAT protein Bezafibrate results in increased expression of CAT protein Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of CAT protein] Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of CAT mRNA] |
CTD |
PMID:2399535 PMID:17145126 PMID:18513333 PMID:20594415 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO |
Bezafibrate results in decreased expression of CCL2 mRNA Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein] Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CCL2 mRNA] |
CTD |
PMID:16574099 PMID:18513333 PMID:32613381 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] |
CTD |
PMID:21745629 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein] |
CTD |
PMID:12126966 PMID:12586603 |
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NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] |
CTD |
PMID:19429239 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
Bezafibrate results in increased expression of CCNB1 mRNA |
CTD |
PMID:15447978 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Cd36 |
CD36 molecule |
increases expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of CD36 mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA] |
CTD |
PMID:11473052 PMID:12759900 PMID:12782154 PMID:17118139 PMID:19124612 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40lg |
CD40 ligand |
multiple interactions decreases activity |
ISO |
[Bezafibrate co-treated with Medroxyprogesterone Acetate] results in decreased activity of CD40LG protein Bezafibrate results in decreased activity of CD40LG protein |
CTD |
PMID:18923439 |
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NCBI chr X:135,127,119...135,138,302
Ensembl chr X:135,126,969...135,138,306
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
Bezafibrate results in increased expression of CDK4 mRNA |
CTD |
PMID:15447978 |
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NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Chmp4b |
charged multivesicular body protein 4B |
increases expression |
ISO |
Bezafibrate results in increased expression of CHMP4B mRNA |
CTD |
PMID:18787029 |
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NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844
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Clock |
clock circadian regulator |
multiple interactions |
ISO |
[CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:20400680 |
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NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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Clps |
colipase |
increases expression |
ISO |
Bezafibrate results in increased expression of CLPS mRNA |
CTD |
PMID:18787029 |
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NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO EXP |
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of COL1A1 mRNA] Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] Bezafibrate results in increased expression of COL1A1 mRNA |
CTD |
PMID:18513333 PMID:21499286 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression multiple interactions increases expression |
ISO EXP |
Bezafibrate results in decreased expression of CPT1A mRNA Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA] Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA] Bezafibrate results in increased expression of CPT1A mRNA [Butyrates co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; [Sodium Glutamate co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA] |
CTD |
PMID:11527545 PMID:16123366 PMID:16574099 PMID:18787029 PMID:19124612 PMID:19682441 PMID:21549692 PMID:21640707 PMID:21816645 PMID:22338096 PMID:24534255 PMID:26190035 PMID:32613381 More...
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
increases expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of CPT1B mRNA PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA] |
CTD |
PMID:11056218 PMID:11473052 PMID:21324916 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
increases expression multiple interactions increases activity |
EXP ISO |
Bezafibrate results in increased expression of CPT2 mRNA [Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; [Oleic Acid co-treated with Bezafibrate] results in increased expression of CPT2 mRNA; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] |
CTD |
PMID:16707586 PMID:21816645 PMID:24534255 |
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NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Crat |
carnitine O-acetyltransferase |
multiple interactions increases activity |
EXP |
etomoxir inhibits the reaction [Bezafibrate results in increased activity of CRAT protein] |
CTD |
PMID:3421940 PMID:8075222 PMID:9920142 |
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NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein] |
CTD |
PMID:19263263 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Crem |
cAMP responsive element modulator |
decreases expression |
ISO |
Bezafibrate results in decreased expression of CREM mRNA |
CTD |
PMID:18787029 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Crot |
carnitine O-octanoyltransferase |
increases expression |
EXP |
Bezafibrate results in increased expression of CROT mRNA |
CTD |
PMID:17719200 |
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NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
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G |
Crp |
C-reactive protein |
decreases expression |
ISO |
Bezafibrate results in decreased expression of CRP protein |
CTD |
PMID:11893366 |
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NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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G |
Cyb5r3 |
cytochrome b5 reductase 3 |
affects expression |
EXP |
Bezafibrate affects the expression of CYB5R3 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions decreases expression |
ISO EXP |
Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA] Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA] Bezafibrate results in decreased expression of CYBA mRNA |
CTD |
PMID:11172467 PMID:12967931 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
increases expression |
ISO |
Bezafibrate results in increased expression of CYBB protein |
CTD |
PMID:20594415 |
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NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity multiple interactions decreases expression |
ISO |
Bezafibrate results in decreased activity of CYP19A1 protein Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA] Bezafibrate results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:11929713 PMID:19539015 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression increases activity |
ISO EXP |
Bezafibrate results in increased expression of CYP1A1 mRNA Bezafibrate results in increased activity of CYP1A1 protein |
CTD |
PMID:9007043 PMID:15521013 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] |
CTD |
PMID:19667161 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of CYP2C8 protein |
CTD |
PMID:29960002 |
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
affects expression |
ISO |
Bezafibrate affects the expression of CYP2J2 protein |
CTD |
PMID:29960002 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions increases expression |
EXP |
Acetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA] |
CTD |
PMID:19647067 |
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Bezafibrate results in increased expression of CYP4A3 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyp4b1 |
cytochrome P450, family 4, subfamily b, polypeptide 1 |
affects expression |
EXP |
Bezafibrate affects the expression of CYP4B1 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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G |
Cyp51 |
cytochrome P450, family 51 |
decreases expression |
EXP |
Bezafibrate results in decreased expression of CYP51 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases activity decreases expression |
ISO EXP |
Bezafibrate results in decreased activity of CYP7A1 protein Bezafibrate results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:2044640 PMID:14685799 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Dbi |
diazepam binding inhibitor |
increases expression |
ISO |
Bezafibrate results in increased expression of DBI mRNA |
CTD |
PMID:17118139 |
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NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
affects expression |
EXP |
Bezafibrate affects the expression of DHCR7 mRNA |
CTD |
PMID:17719200 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
increases expression |
EXP |
Bezafibrate results in increased expression of DLK1 mRNA |
CTD |
PMID:11473052 |
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NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Dnajb6 |
DnaJ heat shock protein family (Hsp40) member B6 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of DNAJB6 mRNA |
CTD |
PMID:18787029 |
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NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
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G |
Dtnb |
dystrobrevin, beta |
decreases expression |
ISO |
Bezafibrate results in decreased expression of DTNB mRNA |
CTD |
PMID:18787029 |
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NCBI chr 6:26,566,418...26,763,467
Ensembl chr 6:26,566,925...26,766,335
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of ECH1 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Eci2 |
enoyl-CoA delta isomerase 2 |
increases expression |
EXP |
Bezafibrate results in increased expression of ECI2 mRNA |
CTD |
PMID:16707586 |
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NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781
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G |
Edn1 |
endothelin 1 |
decreases expression multiple interactions |
ISO EXP |
Bezafibrate results in decreased expression of EDN1 protein Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA] |
CTD |
PMID:11330878 PMID:12967931 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression affects expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of EHHADH mRNA; Bezafibrate results in increased expression of EHHADH protein Bezafibrate affects the expression of EHHADH mRNA PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA] |
CTD |
PMID:12782154 PMID:17118139 PMID:17719200 PMID:19124612 |
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NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
multiple interactions |
ISO |
[Oleic Acid co-treated with Bezafibrate] results in increased expression of ELOVL6 mRNA |
CTD |
PMID:24534255 |
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NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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G |
Ephx2 |
epoxide hydrolase 2 |
affects expression |
ISO |
Bezafibrate affects the expression of EPHX2 protein |
CTD |
PMID:29960002 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Fabp1 |
fatty acid binding protein 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
[Cisplatin co-treated with Bezafibrate] results in increased expression of FABP1 mRNA; Bezafibrate affects the localization of and results in increased expression of FABP1 protein; Bezafibrate inhibits the reaction [Cisplatin results in decreased expression of FABP1 protein] 2-tetradecylglycidic acid inhibits the reaction [Bezafibrate results in increased expression of FABP1 protein]; Bezafibrate inhibits the reaction [Oleic Acid binds to FABP1 protein] Bezafibrate results in increased expression of FABP1 mRNA; Bezafibrate results in increased expression of FABP1 protein Butyrates promotes the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein] Bezafibrate results in decreased expression of FABP1 mRNA |
CTD |
PMID:2328261 PMID:10191295 PMID:12782154 PMID:15708366 PMID:16574099 PMID:17118139 PMID:18368030 PMID:22338096 More...
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp2 |
fatty acid binding protein 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of FABP2 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fabp3 |
fatty acid binding protein 3 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of FABP3 mRNA |
CTD |
PMID:15708366 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp4 |
fatty acid binding protein 4 |
increases expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of FABP4 mRNA PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA] |
CTD |
PMID:11473052 PMID:12759900 PMID:21324916 |
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NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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G |
Fads1 |
fatty acid desaturase 1 |
increases activity |
EXP |
Bezafibrate results in increased activity of FADS1 protein |
CTD |
PMID:7606338 PMID:9032088 |
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NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fads2 |
fatty acid desaturase 2 |
increases activity |
EXP |
Bezafibrate results in increased activity of FADS2 protein |
CTD |
PMID:7606338 |
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NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of FAS mRNA Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA] |
CTD |
PMID:16712844 PMID:26190035 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
affects expression |
ISO |
Bezafibrate affects the expression of FASLG protein modified form |
CTD |
PMID:15063428 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
affects expression multiple interactions decreases expression increases expression |
EXP ISO |
Bezafibrate affects the expression of FASN mRNA [Oleic Acid co-treated with Bezafibrate] results in increased expression of FASN mRNA Bezafibrate results in decreased expression of FASN mRNA; Bezafibrate results in decreased expression of FASN protein Bezafibrate results in increased expression of FASN mRNA; Bezafibrate results in increased expression of FASN protein |
CTD |
PMID:17118139 PMID:17719200 PMID:19124612 PMID:24534255 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions increases expression |
ISO |
[Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA] Bezafibrate results in increased expression of FGF21 mRNA; Bezafibrate results in increased expression of FGF21 protein |
CTD |
PMID:18787029 PMID:20854792 PMID:21720023 PMID:22338096 |
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NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] |
CTD |
PMID:18513333 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein] |
CTD |
PMID:17360982 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] |
CTD |
PMID:21734263 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
Bezafibrate inhibits the reaction [etomoxir results in increased activity of G6PD protein] |
CTD |
PMID:3421940 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression multiple interactions increases expression |
ISO |
Bezafibrate results in decreased expression of GPAM mRNA; Bezafibrate results in decreased expression of GPAM protein PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA] Bezafibrate results in increased expression of GPAM mRNA; Bezafibrate results in increased expression of GPAM protein |
CTD |
PMID:19124612 |
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NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of GPD1 mRNA Bucladesine promotes the reaction [Bezafibrate results in increased expression of GPD1 mRNA] |
CTD |
PMID:1976021 |
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NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [Sodium Glutamate results in increased expression of GPT protein] |
CTD |
PMID:21549692 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity |
EXP |
Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of GSR protein] Bezafibrate results in decreased activity of GSR protein |
CTD |
PMID:17145126 PMID:17710547 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression |
ISO |
Bezafibrate results in increased expression of HADHA mRNA |
CTD |
PMID:17118139 |
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NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
ISO |
Bezafibrate results in increased expression of HADHB mRNA |
CTD |
PMID:17118139 |
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NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hdac3 |
histone deacetylase 3 |
multiple interactions |
ISO |
[Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein |
CTD |
PMID:22338096 |
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NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases activity increases activity |
EXP ISO |
Bezafibrate results in decreased activity of HMGCR protein Bezafibrate results in increased activity of HMGCR protein |
CTD |
PMID:2044640 PMID:2907502 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
multiple interactions increases expression |
ISO |
Butyrates promotes the reaction [Bezafibrate results in increased expression of HMGCS2 mRNA] |
CTD |
PMID:18787029 PMID:22338096 |
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NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases activity decreases expression |
ISO |
Bezafibrate results in decreased activity of HSD11B1 protein Bezafibrate results in decreased expression of HSD11B1 mRNA |
CTD |
PMID:17190905 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
increases expression |
ISO |
Bezafibrate results in increased expression of HSD17B4 mRNA |
CTD |
PMID:17118139 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Vitamin E co-treated with Bezafibrate] results in decreased expression of ICAM1 protein modified form |
CTD |
PMID:14602771 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] |
CTD |
PMID:20631892 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of IGF1 protein |
CTD |
PMID:10716467 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression decreases expression |
ISO EXP |
Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate promotes the reaction [IL1B protein results in increased expression of NPHS1 mRNA] Bezafibrate results in increased expression of IL1B protein Bezafibrate results in decreased expression of IL1B protein Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] Bezafibrate results in decreased expression of IL1B mRNA Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA] |
CTD |
PMID:12657956 PMID:12704018 PMID:16288986 PMID:16574099 PMID:18513333 PMID:20631892 PMID:32613381 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO EXP |
Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]; Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA] Bezafibrate results in decreased expression of IL6 protein Bezafibrate results in decreased expression of IL6 mRNA Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA] |
CTD |
PMID:11893366 PMID:12657956 PMID:16574099 PMID:17360982 PMID:18513333 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins2 |
insulin 2 |
multiple interactions decreases expression |
ISO |
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein] Bezafibrate results in decreased expression of INS protein |
CTD |
PMID:2209320 PMID:11292061 PMID:20404010 PMID:32613381 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig1 |
insulin induced gene 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of INSIG1 mRNA |
CTD |
PMID:17118139 PMID:19124612 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] |
CTD |
PMID:17360982 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Ldha |
lactate dehydrogenase A |
increases expression |
EXP |
Bezafibrate results in increased expression of LDHA protein |
CTD |
PMID:8632003 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lep |
leptin |
decreases expression multiple interactions |
ISO EXP |
Bezafibrate results in decreased expression of LEP Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] Bezafibrate results in decreased expression of LEP mRNA Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] |
CTD |
PMID:10726910 PMID:11216866 PMID:11473052 PMID:17379010 PMID:21549692 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Bezafibrate results in increased expression of LGALS3 mRNA |
CTD |
PMID:17118139 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lipc |
lipase C, hepatic type |
increases activity |
ISO |
Bezafibrate results in increased activity of LIPC protein |
CTD |
PMID:3084275 |
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NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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G |
Lpl |
lipoprotein lipase |
increases expression increases activity multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of LPL mRNA Bezafibrate results in increased activity of LPL protein [Bezafibrate results in increased activity of LPL protein] which results in decreased abundance of Triglycerides; Bezafibrate inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA] PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA] |
CTD |
PMID:2907502 PMID:8147947 PMID:8593127 PMID:9006809 PMID:11164425 PMID:12782154 PMID:17379010 PMID:19124612 More...
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Ly6d |
lymphocyte antigen 6 family member D |
increases expression |
ISO |
Bezafibrate results in increased expression of LY6D mRNA |
CTD |
PMID:17118139 |
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NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein |
CTD |
PMID:11687581 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein |
CTD |
PMID:11687581 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mgll |
monoglyceride lipase |
increases expression |
ISO |
Bezafibrate results in increased expression of MGLL mRNA |
CTD |
PMID:17118139 |
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NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression |
ISO |
Bezafibrate results in increased expression of MGMT mRNA |
CTD |
PMID:15447978 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mpeg1 |
macrophage expressed 1 |
decreases expression |
ISO |
Bezafibrate results in decreased expression of MPEG1 mRNA |
CTD |
PMID:18787029 |
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NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855
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G |
Mpg |
N-methylpurine-DNA glycosylase |
increases expression |
ISO |
Bezafibrate results in increased expression of MPG mRNA |
CTD |
PMID:15447978 |
|
NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
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G |
Mttp |
microsomal triglyceride transfer protein |
increases expression multiple interactions decreases expression |
ISO |
Bezafibrate results in increased expression of MTTP mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA] Bezafibrate results in decreased expression of MTTP mRNA |
CTD |
PMID:19124612 |
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NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NCF1 protein] |
CTD |
PMID:11172467 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein] |
CTD |
PMID:19263263 |
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NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein] |
CTD |
PMID:19263263 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity |
ISO |
Bezafibrate results in increased activity of NFE2L2 protein |
CTD |
PMID:30114225 PMID:30203046 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases expression |
ISO |
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NFKB1 mRNA] Bezafibrate results in decreased expression of NFKB1 mRNA |
CTD |
PMID:16574099 PMID:18513333 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases phosphorylation |
ISO |
[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; dorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; dorsomorphin inhibits the reaction [Bezafibrate results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:21499286 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nox4 |
NADPH oxidase 4 |
increases expression multiple interactions |
ISO EXP |
Bezafibrate results in increased expression of NOX4 protein Bezafibrate inhibits the reaction [Streptozocin results in increased expression of NOX4 mRNA] |
CTD |
PMID:16979161 PMID:20594415 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Npy |
neuropeptide Y |
increases expression |
ISO |
Bezafibrate results in increased expression of NPY mRNA |
CTD |
PMID:18787029 |
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NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of NR0B2 mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA] |
CTD |
PMID:19124612 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of NR1H2 mRNA |
CTD |
PMID:19201410 |
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NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
multiple interactions increases expression affects response to substance |
ISO EXP |
[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA] Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of NR1H3 mRNA] Bezafibrate results in increased expression of NR1H3 mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA] NR1H3 protein affects the susceptibility to Bezafibrate |
CTD |
PMID:12595494 PMID:19124612 PMID:19201410 PMID:26190035 |
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NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions increases expression |
ISO |
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA] [Oleic Acid co-treated with Bezafibrate] results in increased expression of NR1H4 mRNA |
CTD |
PMID:15447978 PMID:19124612 PMID:24534255 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Bezafibrate binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:20024649 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases expression |
EXP |
Bezafibrate results in increased expression of NR1I3 mRNA |
CTD |
PMID:20208394 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nthl1 |
nth-like DNA glycosylase 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of NTHL1 mRNA |
CTD |
PMID:15447978 |
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NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
increases expression |
ISO |
Bezafibrate results in increased expression of OGG1 mRNA |
CTD |
PMID:15447978 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Pc |
pyruvate carboxylase |
increases expression |
EXP |
Bezafibrate results in increased expression of PC mRNA |
CTD |
PMID:11527545 |
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NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
ISO |
[Sodium Glutamate co-treated with Bezafibrate] results in decreased expression of PCK1 mRNA |
CTD |
PMID:21549692 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO EXP |
Bezafibrate results in increased expression of PCNA mRNA Bezafibrate results in increased expression of PCNA protein |
CTD |
PMID:9007043 PMID:15447978 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
increases expression |
ISO |
Bezafibrate results in increased expression of PCSK9 protein |
CTD |
PMID:21411093 |
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NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Pdha1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
increases expression |
EXP |
Bezafibrate results in increased expression of PDHA1 mRNA |
CTD |
PMID:11527545 |
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NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
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G |
Pdk2 |
pyruvate dehydrogenase kinase 2 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of PDK2 mRNA PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA] |
CTD |
PMID:19124612 |
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NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of PDK4 mRNA; Bezafibrate results in increased expression of PDK4 protein PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA] MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein] |
CTD |
PMID:17118139 PMID:19124612 PMID:19683050 PMID:21720023 |
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NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions decreases expression |
EXP |
Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] |
CTD |
PMID:11527545 |
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NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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G |
Plin2 |
perilipin 2 |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN2 mRNA] |
CTD |
PMID:24534255 |
|
NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Plin4 |
perilipin 4 |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN4 mRNA] |
CTD |
PMID:24534255 |
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NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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G |
Pltp |
phospholipid transfer protein |
decreases activity multiple interactions |
ISO |
Bezafibrate results in decreased activity of PLTP protein [Bezafibrate results in decreased activity of PLTP protein] affects the reaction [Bezafibrate results in decreased abundance of Fatty Acids, Nonesterified] |
CTD |
PMID:12754275 |
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NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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G |
Pnliprp2 |
pancreatic lipase related protein 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of PNLIPRP2 mRNA |
CTD |
PMID:18787029 |
|
NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
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G |
Polr2a |
RNA polymerase II subunit A |
multiple interactions |
ISO |
[Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein |
CTD |
PMID:22338096 |
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NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
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G |
Pomc |
proopiomelanocortin |
decreases expression |
ISO |
Bezafibrate results in decreased expression of POMC mRNA |
CTD |
PMID:18787029 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Por |
cytochrome p450 oxidoreductase |
increases activity |
EXP |
Bezafibrate results in increased activity of POR protein |
CTD |
PMID:7606338 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases expression affects binding increases activity affects response to substance decreases expression increases response to substance |
ISO EXP |
[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Glucose; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Ketones; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein]; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein]; Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein]; Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARA mRNA]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased susceptibility to Palmitates; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate; [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased abundance of Ceramides; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] Bezafibrate binds to PPARA protein PPARA protein affects the susceptibility to Bezafibrate [Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein; Bezafibrate results in increased activity of PPARA protein Bezafibrate results in decreased expression of PPARA mRNA Bezafibrate results in increased expression of PPARA; Bezafibrate results in increased expression of PPARA mRNA; Bezafibrate results in increased expression of PPARA protein [[Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Fatty Acids; [Bezafibrate co-treated with Sodium Glutamate] results in increased expression of PPARA mRNA; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased abundance of Lipid Peroxides]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of CYP4A10 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA] PPARA protein results in increased susceptibility to Bezafibrate |
CTD |
PMID:9836514 PMID:10585473 PMID:11056218 PMID:11172467 PMID:11341955 PMID:11519881 PMID:11527545 PMID:11579993 PMID:11779144 PMID:12401884 PMID:12595494 PMID:12782154 PMID:12967931 PMID:15258199 PMID:15447978 PMID:15491415 PMID:16054168 PMID:17360982 PMID:18024222 PMID:19124612 PMID:19201410 PMID:19263263 PMID:19593819 PMID:19667161 PMID:19682441 PMID:19683050 PMID:20040336 PMID:20400680 PMID:20404010 PMID:20594415 PMID:20854792 PMID:21209018 PMID:21324916 PMID:21549692 PMID:21640707 PMID:21687928 PMID:22338096 PMID:23843199 PMID:24759758 PMID:25689681 PMID:26190035 PMID:27665777 PMID:30203046 PMID:31472229 PMID:31538121 More...
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
affects binding decreases expression multiple interactions increases expression increases activity |
ISO EXP |
Bezafibrate binds to PPARB protein; Bezafibrate binds to PPARD protein Bezafibrate results in decreased expression of PPARD mRNA PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA] Bezafibrate results in increased expression of PPARD; Bezafibrate results in increased expression of PPARD mRNA Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARB mRNA] Bezafibrate results in increased expression of PPARD mRNA; Bezafibrate results in increased expression of PPARD protein Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARD mRNA] Bezafibrate results in increased activity of PPARD protein |
CTD |
PMID:10585473 PMID:11172467 PMID:11779144 PMID:12782154 PMID:19124612 PMID:19201410 PMID:19214135 PMID:19667161 PMID:21687928 PMID:21816645 PMID:23843199 PMID:24759758 PMID:26190035 More...
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression affects binding decreases expression increases activity |
ISO EXP |
[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein] Bezafibrate results in increased expression of PPARG mRNA Bezafibrate binds to PPARG protein Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA] Bezafibrate results in decreased expression of PPARG mRNA PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA] Bezafibrate results in increased activity of PPARG protein |
CTD |
PMID:11473052 PMID:11779144 PMID:12401884 PMID:12967931 PMID:15708366 PMID:19201410 PMID:21324916 PMID:21734263 PMID:23843199 PMID:24759758 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Bezafibrate results in increased expression of PPARGC1A mRNA |
CTD |
PMID:17275789 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Psmc3ip |
PSMC3 interacting protein |
decreases expression |
ISO |
Bezafibrate results in decreased expression of PSMC3IP mRNA |
CTD |
PMID:18787029 |
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NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
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G |
Rarb |
retinoic acid receptor, beta |
decreases expression |
EXP |
Bezafibrate results in decreased expression of RARB mRNA |
CTD |
PMID:11519881 PMID:11579993 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein] |
CTD |
PMID:18660453 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Reln |
reelin |
increases expression |
ISO |
Bezafibrate results in increased expression of RELN mRNA |
CTD |
PMID:18787029 |
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NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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G |
Rida |
reactive intermediate imine deaminase A homolog |
multiple interactions |
EXP |
[Bezafibrate co-treated with Sunflower Oil] results in increased expression of RIDA protein |
CTD |
PMID:16843601 |
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NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716
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G |
Rmnd1 |
required for meiotic nuclear division 1 homolog |
decreases expression |
ISO |
Bezafibrate results in decreased expression of RMND1 mRNA |
CTD |
PMID:18787029 |
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NCBI chr 1:40,859,829...40,894,390
Ensembl chr 1:40,859,829...40,894,314
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G |
Runx2 |
RUNX family transcription factor 2 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of RUNX2 mRNA dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA] |
CTD |
PMID:21499286 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions affects binding |
ISO |
Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] Bezafibrate binds to RXRA protein |
CTD |
PMID:11779144 PMID:23843199 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Rxrb |
retinoid X receptor beta |
affects binding |
ISO |
Bezafibrate binds to RXRB protein |
CTD |
PMID:23843199 |
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NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
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G |
Rxrg |
retinoid X receptor gamma |
affects binding |
ISO |
Bezafibrate binds to RXRG protein |
CTD |
PMID:23843199 |
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NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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G |
Scap |
SREBF chaperone |
decreases expression multiple interactions increases expression |
ISO |
Bezafibrate results in decreased expression of SCAP mRNA; Bezafibrate results in decreased expression of SCAP protein PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein] Bezafibrate results in increased expression of SCAP mRNA; Bezafibrate results in increased expression of SCAP protein |
CTD |
PMID:19124612 |
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NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression increases expression increases activity multiple interactions |
ISO EXP |
Bezafibrate results in decreased expression of SCD1 mRNA Bezafibrate results in increased expression of SCD1 mRNA Bezafibrate results in increased activity of SCD protein; Bezafibrate results in increased activity of SCD1 protein [Oleic Acid co-treated with Bezafibrate] results in increased expression of SCD1 mRNA; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA] PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA] |
CTD |
PMID:7606338 PMID:11172741 PMID:12782154 PMID:19124612 PMID:24534255 PMID:32613381 More...
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scd2 |
stearoyl-Coenzyme A desaturase 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of SCD mRNA |
CTD |
PMID:17118139 |
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NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
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G |
Sele |
selectin E |
multiple interactions |
ISO |
[Vitamin E co-treated with Bezafibrate] results in decreased expression of SELE protein modified form |
CTD |
PMID:14602771 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions increases expression increases secretion increases activity |
ISO |
[CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] Bezafibrate results in increased secretion of SERPINE1 protein Bezafibrate results in increased activity of SERPINE1 protein Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein] |
CTD |
PMID:9678787 PMID:10364093 PMID:11292061 PMID:17118139 PMID:20400680 PMID:20854792 PMID:21757225 More...
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Slc27a1 |
solute carrier family 27 member 1 |
multiple interactions increases expression |
ISO |
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA] |
CTD |
PMID:19124612 |
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NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
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G |
Slc27a2 |
solute carrier family 27 member 2 |
multiple interactions increases expression |
ISO |
Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA] |
CTD |
PMID:11929713 PMID:17118139 PMID:19124612 |
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NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions decreases expression |
ISO EXP |
Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of SLC2A2 mRNA] Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] |
CTD |
PMID:11527545 PMID:12048068 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] |
CTD |
PMID:21802492 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Smpd1 |
sphingomyelin phosphodiesterase 1 |
increases activity |
EXP |
[Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein |
CTD |
PMID:18024222 |
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NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
multiple interactions |
EXP |
[Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein |
CTD |
PMID:18024222 |
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NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
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G |
Soat1 |
sterol O-acyltransferase 1 |
decreases activity |
EXP |
Bezafibrate results in decreased activity of SOAT1 protein |
CTD |
PMID:2044640 |
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NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
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G |
Sod1 |
superoxide dismutase 1 |
increases expression multiple interactions |
ISO |
Bezafibrate results in increased expression of SOD1 mRNA; Bezafibrate results in increased expression of SOD1 protein Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of SOD1 mRNA] |
CTD |
PMID:11172467 PMID:18513333 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions decreases expression |
ISO |
Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]] Bezafibrate results in decreased expression of SPP1 protein |
CTD |
PMID:17360982 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] Bezafibrate results in increased expression of SREBF1 mRNA; Bezafibrate results in increased expression of SREBF1 protein [Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein] Bezafibrate results in decreased expression of SREBF1 mRNA; Bezafibrate results in decreased expression of SREBF1 protein |
CTD |
PMID:11779144 PMID:19124612 PMID:26190035 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
increases expression |
ISO |
Bezafibrate results in increased expression of SREBF2 mRNA |
CTD |
PMID:14685799 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Stat5b |
signal transducer and activator of transcription 5B |
decreases activity |
ISO |
Bezafibrate results in decreased activity of STAT5B protein |
CTD |
PMID:30114225 |
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NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Suclg1 |
succinate-CoA ligase GDP/ADP-forming subunit alpha |
increases expression |
EXP |
Bezafibrate results in increased expression of SUCLG1 mRNA |
CTD |
PMID:16707586 |
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NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
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G |
Tdg |
thymine-DNA glycosylase |
increases expression |
ISO |
Bezafibrate results in increased expression of TDG mRNA |
CTD |
PMID:15447978 |
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NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
ISO EXP |
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] Bezafibrate results in decreased expression of TGFB1 mRNA Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of TGFB1 mRNA] Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA] |
CTD |
PMID:16574099 PMID:18513333 PMID:19429239 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thra |
thyroid hormone receptor alpha |
decreases expression |
EXP |
Bezafibrate results in decreased expression of THRA mRNA |
CTD |
PMID:11519881 PMID:11579993 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
decreases expression |
EXP |
Bezafibrate results in decreased expression of THRB mRNA |
CTD |
PMID:11519881 PMID:11579993 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Thrsp |
thyroid hormone responsive |
multiple interactions |
ISO |
Bezafibrate promotes the reaction [Oleic Acid results in decreased expression of THRSP mRNA] |
CTD |
PMID:24534255 |
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NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP1 mRNA] |
CTD |
PMID:18513333 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
ISO |
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA] |
CTD |
PMID:18513333 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
decreases response to substance multiple interactions decreases expression increases response to substance |
ISO EXP |
Bezafibrate results in decreased susceptibility to TNF protein Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA] [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein] Bezafibrate results in decreased expression of TNF mRNA Bezafibrate results in decreased expression of TNF mRNA; Bezafibrate results in decreased expression of TNF protein |
CTD |
PMID:11473052 PMID:11893366 PMID:12586603 PMID:12657956 PMID:16574099 PMID:17360982 PMID:18513333 PMID:21734263 PMID:32613381 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trib3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
[Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA |
CTD |
PMID:19593819 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Ucp2 |
uncoupling protein 2 |
increases expression multiple interactions affects expression |
ISO EXP |
Bezafibrate results in increased expression of UCP2 mRNA [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA] Bezafibrate affects the expression of UCP2 mRNA |
CTD |
PMID:10933891 PMID:11056218 PMID:11341955 PMID:11473052 PMID:12588052 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ucp3 |
uncoupling protein 3 |
increases expression decreases expression |
EXP ISO |
Bezafibrate results in increased expression of UCP3 mRNA Bezafibrate results in decreased expression of UCP3 mRNA |
CTD |
PMID:10342807 PMID:10403804 PMID:10909982 PMID:10933891 PMID:11473052 PMID:21324916 More...
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NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases response to substance |
ISO |
UGT1A9 results in increased susceptibility to Bezafibrate |
CTD |
PMID:17880178 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of Bezafibrate |
CTD |
PMID:8302279 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases response to substance |
ISO |
UGT2B7 results in increased susceptibility to Bezafibrate |
CTD |
PMID:17880178 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Vbp1 |
VHL binding protein 1 |
increases expression |
ISO |
Bezafibrate results in increased expression of VBP1 mRNA |
CTD |
PMID:18787029 |
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP ISO |
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA] [Vitamin E co-treated with Bezafibrate] results in decreased expression of VCAM1 protein modified form |
CTD |
PMID:14602771 PMID:16979161 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vcan |
versican |
decreases expression |
ISO |
Bezafibrate results in decreased expression of VCAN mRNA |
CTD |
PMID:11522680 |
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NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
[Calcitriol co-treated with Bezafibrate] results in increased expression of VDR mRNA |
CTD |
PMID:19667161 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Xdh |
xanthine dehydrogenase |
decreases activity multiple interactions decreases expression |
EXP |
Bezafibrate results in decreased activity of XDH protein Bezafibrate results in increased degradation of and results in decreased expression of XDH mRNA Bezafibrate results in decreased expression of XDH protein |
CTD |
PMID:8373410 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Zfp704 |
zinc finger protein 704 |
increases expression |
ISO |
Bezafibrate results in increased expression of ZFP704 mRNA |
CTD |
PMID:18787029 |
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NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282
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