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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bezafibrate
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Accession:CHEBI:47612 term browser browse the term
Definition:A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Synonyms:exact_synonym: 2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid
 related_synonym: 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID;   Befizal;   Bezalip;   Bezatol SR (TN);   Cedur;   Formula=C19H20ClNO4;   InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24);   InChIKey=IIBYAHWJQTYFKB-UHFFFAOYSA-N;   SMILES=CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O;   bezafibrato;   bezafibratum
 alt_id: CHEBI:31284;   CHEBI:47611
 xref: CAS:41859-67-0;   Chemspider:35728;   DrugBank:DB01393;   Drug_Central:362;   HMDB:HMDB0015465;   KEGG:D01366;   LINCS:LSM-3015
 xref_mesh: MESH:D001629
 xref: PDBeChem:PEM;   PMID:12122004;   PMID:12782154;   PMID:17379010;   PMID:18787029;   PMID:19131462;   PMID:23603800;   PMID:28931607;   PMID:32107855;   PMID:32509533;   PMID:32721217;   PMID:32798077;   PMID:32976735;   PMID:33205029;   PMID:33549744;   PMID:34447954;   Patent:DE2149070;   Patent:US3781328;   Reaxys:4267656;   Wikipedia:Bezafibrate


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bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA
Bezafibrate results in increased expression of ABCA1 mRNA; Bezafibrate results in increased expression of ABCA1 protein		 CTD PMID:12595494 PMID:19201410 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
increases expression
affects localization		 ISO Bezafibrate results in decreased expression of ABCB11 mRNA
Bezafibrate results in increased expression of ABCB11 mRNA
Bezafibrate affects the localization of ABCB11 protein		 CTD PMID:15258199 PMID:15447978 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects localization
increases expression
multiple interactions		 ISO
EXP		 Bezafibrate affects the localization of ABCB4 protein
Bezafibrate results in increased expression of ABCB4 mRNA; Bezafibrate results in increased expression of ABCB4 protein
[Bezafibrate co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB4 mRNA; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein]		 CTD PMID:15242490 PMID:15258199 PMID:15588777 PMID:17118139 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects localization
multiple interactions
increases expression		 ISO Bezafibrate affects the localization of ABCC2 protein
[Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ABCC2 mRNA
Bezafibrate results in increased expression of ABCC2 mRNA		 CTD PMID:15258199 PMID:21549692 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Bezafibrate CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression ISO Bezafibrate results in increased expression of ABCD3 protein CTD PMID:19124612 PMID:20594415 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Bezafibrate results in increased expression of ABCG5 mRNA CTD PMID:14685799 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions
increases expression		 ISO PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA] CTD PMID:19124612 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions
increases expression		 ISO Bezafibrate results in decreased expression of ACACA mRNA; Bezafibrate results in decreased expression of ACACA protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]
Bezafibrate results in increased expression of ACACA mRNA; Bezafibrate results in increased expression of ACACA protein		 CTD PMID:19124612 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression
increases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of ACACB mRNA
Bezafibrate results in increased expression of ACACB mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA]		 CTD PMID:17118139 PMID:19124612 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions
increases expression		 ISO PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein]
Bezafibrate results in increased expression of ACADL mRNA; Bezafibrate results in increased expression of ACADL protein		 CTD PMID:12782154 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
increases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]		 CTD PMID:11929713 PMID:19124612 PMID:26190035 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain affects response to substance
increases expression
multiple interactions
increases activity		 ISO ACADVL protein affects the susceptibility to Bezafibrate; ACADVL protein mutant form affects the susceptibility to Bezafibrate
Bezafibrate results in increased expression of ACADVL mRNA; Bezafibrate results in increased expression of ACADVL protein
Bezafibrate inhibits the reaction [ACADVL protein mutant form results in decreased oxidation of Fatty Acids]
Butyrates promotes the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein]
Bezafibrate results in increased activity of ACADVL protein		 CTD PMID:12782154 PMID:17118139 PMID:17999356 PMID:20060901 PMID:22338096 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:16979161 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
increases activity
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of ACOX1 mRNA
Bezafibrate results in increased activity of ACOX1 protein
[Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ACOX1 mRNA; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]
Bezafibrate results in increased expression of ACOX1 mRNA; Bezafibrate results in increased expression of ACOX1 protein		 CTD PMID:2399535 PMID:11172741 PMID:11216866 PMID:11473052 PMID:11519881 More... NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions
increases expression		 ISO Butyrates promotes the reaction [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA] CTD PMID:17118139 PMID:19124612 PMID:19682441 PMID:21640707 PMID:22338096 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression ISO Bezafibrate results in increased expression of ACSL4 mRNA CTD PMID:17118139 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression ISO Bezafibrate results in increased expression of ACSL5 mRNA CTD PMID:17118139 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 affects expression EXP Bezafibrate affects the expression of ACSS2 mRNA CTD PMID:17719200 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP
ISO		 Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]
Bezafibrate results in decreased expression of ACTA2 protein
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA]		 CTD PMID:12657956 PMID:18513333 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
increases secretion		 ISO Bezafibrate results in increased expression of ADIPOQ protein
Bezafibrate inhibits the reaction [Sodium Glutamate results in decreased expression of ADIPOQ protein]
Bezafibrate results in increased secretion of ADIPOQ protein
Bezafibrate results in increased expression of ADIPOQ mRNA; Bezafibrate results in increased expression of ADIPOQ protein		 CTD PMID:16574099 PMID:17190905 PMID:18513333 PMID:21324916 PMID:21411093 More... NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor1 adiponectin receptor 1 increases expression ISO Bezafibrate results in increased expression of ADIPOR1 mRNA CTD PMID:16574099 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO Bezafibrate results in increased expression of ADIPOR2 mRNA CTD PMID:16574099 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Bezafibrate results in increased expression of ADORA2A mRNA CTD PMID:18787029 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Bezafibrate inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency] CTD PMID:15806154 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 increases expression ISO Bezafibrate results in increased expression of ALDH1A2 mRNA CTD PMID:17118139 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases activity
affects response to substance
increases expression		 ISO Bezafibrate results in increased activity of ALDH3A2 protein
ALDH3A2 protein affects the susceptibility to Bezafibrate
Bezafibrate results in increased expression of ALDH3A2 mRNA		 CTD PMID:16837225 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases activity
increases expression
multiple interactions		 ISO Bezafibrate results in decreased activity of ALPL protein
Bezafibrate results in increased expression of ALPL mRNA
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]		 CTD PMID:8102192 PMID:21499286 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Bezafibrate results in increased expression of ANGPTL4 mRNA CTD PMID:17118139 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO Bezafibrate results in increased expression of APEX1 mRNA CTD PMID:15447978 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
decreases expression		 ISO [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Bezafibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]
Bezafibrate results in increased expression of APOA1 protein
Bezafibrate results in decreased expression of APOA1 mRNA; Bezafibrate results in decreased expression of APOA1 protein		 CTD PMID:1323073 PMID:7893284 PMID:7983038 PMID:8017468 PMID:9678787 More... NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO Bezafibrate results in increased expression of APOA2 protein CTD PMID:7893284 PMID:8017468 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apob apolipoprotein B multiple interactions
decreases expression
increases expression
decreases secretion		 ISO
EXP		 Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of APOB protein]
Bezafibrate results in decreased expression of APOB protein
Bezafibrate results in increased expression of APOB protein
[Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form
Bezafibrate results in decreased expression of APOB mRNA alternative form
Bezafibrate results in decreased secretion of APOB protein
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]		 CTD PMID:1323073 PMID:3084275 PMID:7893284 PMID:8017468 PMID:8944747 More... NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc2 apolipoprotein C2 decreases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of APOC2 mRNA
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]		 CTD PMID:12782154 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased expression of APOC3 mRNA
Bezafibrate results in decreased expression of APOC3 protein
Bezafibrate results in decreased expression of APOC3 mRNA; Bezafibrate results in decreased expression of APOC3 protein
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]		 CTD PMID:8847480 PMID:9041378 PMID:11164425 PMID:12782154 PMID:19124612 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Bezafibrate results in increased expression of APOE protein
Bezafibrate results in decreased expression of APOE protein
[Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein		 CTD PMID:8017468 PMID:8944747 PMID:9006809 PMID:19603250 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like multiple interactions ISO [CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] CTD PMID:20400680 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO Bezafibrate results in increased expression of ARPP21 mRNA CTD PMID:18787029 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression ISO Bezafibrate results in decreased expression of ASCL2 mRNA CTD PMID:15708366 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Bezafibrate results in decreased expression of BCL2 mRNA
Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein]		 CTD PMID:12704018 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of BMP2 mRNA
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]		 CTD PMID:21499286 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Bezafibrate results in increased expression of BNIP3 mRNA CTD PMID:17118139 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Btbd9 BTB domain containing 9 increases expression ISO Bezafibrate results in increased expression of BTBD9 mRNA CTD PMID:18787029 NCBI chr20:8,286,337...8,645,567
Ensembl chr20:8,288,711...8,643,960 		JBrowse link
G Car9 carbonic anhydrase 9 multiple interactions ISO Bezafibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:34520103 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Cat catalase increases activity
increases expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased activity of CAT protein
Bezafibrate results in increased expression of CAT protein
Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of CAT mRNA]		 CTD PMID:2399535 PMID:17145126 PMID:18513333 PMID:20594415 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of CCL2 mRNA
Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CCL2 mRNA]		 CTD PMID:16574099 PMID:18513333 PMID:32613381 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:12126966 PMID:12586603 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] CTD PMID:19429239 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Bezafibrate results in increased expression of CCNB1 mRNA CTD PMID:15447978 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of CD36 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA]		 CTD PMID:11473052 PMID:12759900 PMID:12782154 PMID:17118139 PMID:19124612 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases activity		 ISO [Bezafibrate co-treated with Medroxyprogesterone Acetate] results in decreased activity of CD40LG protein
Bezafibrate results in decreased activity of CD40LG protein		 CTD PMID:18923439 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Bezafibrate results in increased expression of CDK4 mRNA CTD PMID:15447978 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Chmp4b charged multivesicular body protein 4B increases expression ISO Bezafibrate results in increased expression of CHMP4B mRNA CTD PMID:18787029 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Clock clock circadian regulator multiple interactions ISO [CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] CTD PMID:20400680 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Clps colipase increases expression ISO Bezafibrate results in increased expression of CLPS mRNA CTD PMID:18787029 NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of COL1A1 mRNA]
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
Bezafibrate results in increased expression of COL1A1 mRNA		 CTD PMID:18513333 PMID:21499286 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions
increases expression		 ISO
EXP		 Bezafibrate results in decreased expression of CPT1A mRNA
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA]
Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA]
Bezafibrate results in increased expression of CPT1A mRNA
[Butyrates co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; [Sodium Glutamate co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA]		 CTD PMID:11527545 PMID:16123366 PMID:16574099 PMID:18787029 PMID:19124612 More... NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of CPT1B mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA]		 CTD PMID:11056218 PMID:11473052 PMID:21324916 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression
multiple interactions
increases activity		 EXP
ISO		 Bezafibrate results in increased expression of CPT2 mRNA
[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; [Oleic Acid co-treated with Bezafibrate] results in increased expression of CPT2 mRNA; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]		 CTD PMID:16707586 PMID:21816645 PMID:24534255 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crat carnitine O-acetyltransferase multiple interactions
increases activity		 EXP etomoxir inhibits the reaction [Bezafibrate results in increased activity of CRAT protein] CTD PMID:3421940 PMID:8075222 PMID:9920142 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein] CTD PMID:19263263 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crem cAMP responsive element modulator decreases expression ISO Bezafibrate results in decreased expression of CREM mRNA CTD PMID:18787029 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crot carnitine O-octanoyltransferase increases expression EXP Bezafibrate results in increased expression of CROT mRNA CTD PMID:17719200 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109 		JBrowse link
G Crp C-reactive protein decreases expression ISO Bezafibrate results in decreased expression of CRP protein CTD PMID:11893366 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 affects expression EXP Bezafibrate affects the expression of CYB5R3 mRNA CTD PMID:17719200 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]
Bezafibrate results in decreased expression of CYBA mRNA		 CTD PMID:11172467 PMID:12967931 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Bezafibrate results in increased expression of CYBB protein CTD PMID:20594415 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions
decreases expression		 ISO Bezafibrate results in decreased activity of CYP19A1 protein
Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]
Bezafibrate results in decreased expression of CYP19A1 mRNA		 CTD PMID:11929713 PMID:19539015 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity		 ISO
EXP		 Bezafibrate results in increased expression of CYP1A1 mRNA
Bezafibrate results in increased activity of CYP1A1 protein		 CTD PMID:9007043 PMID:15521013 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO Bezafibrate results in decreased expression of CYP2C8 protein CTD PMID:29960002
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO Bezafibrate affects the expression of CYP2J2 protein CTD PMID:29960002 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP Acetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA] CTD PMID:19647067 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Bezafibrate results in increased expression of CYP4A3 mRNA CTD PMID:17719200 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression EXP Bezafibrate affects the expression of CYP4B1 mRNA CTD PMID:17719200 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP Bezafibrate results in decreased expression of CYP51 mRNA CTD PMID:17719200 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity
decreases expression		 ISO
EXP		 Bezafibrate results in decreased activity of CYP7A1 protein
Bezafibrate results in decreased expression of CYP7A1 mRNA		 CTD PMID:2044640 PMID:14685799 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dbi diazepam binding inhibitor increases expression ISO Bezafibrate results in increased expression of DBI mRNA CTD PMID:17118139 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression EXP Bezafibrate affects the expression of DHCR7 mRNA CTD PMID:17719200 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 increases expression EXP Bezafibrate results in increased expression of DLK1 mRNA CTD PMID:11473052 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases expression ISO Bezafibrate results in decreased expression of DNAJB6 mRNA CTD PMID:18787029 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659 		JBrowse link
G Dtnb dystrobrevin, beta decreases expression ISO Bezafibrate results in decreased expression of DTNB mRNA CTD PMID:18787029 NCBI chr 6:26,566,418...26,763,467
Ensembl chr 6:26,566,925...26,766,335 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Bezafibrate results in increased expression of ECH1 mRNA CTD PMID:17118139 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 increases expression EXP Bezafibrate results in increased expression of ECI2 mRNA CTD PMID:16707586 NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased expression of EDN1 protein
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]		 CTD PMID:11330878 PMID:12967931 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
affects expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of EHHADH mRNA; Bezafibrate results in increased expression of EHHADH protein
Bezafibrate affects the expression of EHHADH mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]		 CTD PMID:12782154 PMID:17118139 PMID:17719200 PMID:19124612 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [Oleic Acid co-treated with Bezafibrate] results in increased expression of ELOVL6 mRNA CTD PMID:24534255 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression ISO Bezafibrate affects the expression of EPHX2 protein CTD PMID:29960002 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Cisplatin co-treated with Bezafibrate] results in increased expression of FABP1 mRNA; Bezafibrate affects the localization of and results in increased expression of FABP1 protein; Bezafibrate inhibits the reaction [Cisplatin results in decreased expression of FABP1 protein]
2-tetradecylglycidic acid inhibits the reaction [Bezafibrate results in increased expression of FABP1 protein]; Bezafibrate inhibits the reaction [Oleic Acid binds to FABP1 protein]
Bezafibrate results in increased expression of FABP1 mRNA; Bezafibrate results in increased expression of FABP1 protein
Butyrates promotes the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]
Bezafibrate results in decreased expression of FABP1 mRNA		 CTD PMID:2328261 PMID:10191295 PMID:12782154 PMID:15708366 PMID:16574099 More... NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression ISO Bezafibrate results in increased expression of FABP2 mRNA CTD PMID:17118139 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO Bezafibrate results in decreased expression of FABP3 mRNA CTD PMID:15708366 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of FABP4 mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA]		 CTD PMID:11473052 PMID:12759900 PMID:21324916 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fads1 fatty acid desaturase 1 increases activity EXP Bezafibrate results in increased activity of FADS1 protein CTD PMID:7606338 PMID:9032088 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fads2 fatty acid desaturase 2 increases activity EXP Bezafibrate results in increased activity of FADS2 protein CTD PMID:7606338 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of FAS mRNA
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]		 CTD PMID:16712844 PMID:26190035 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand affects expression ISO Bezafibrate affects the expression of FASLG protein modified form CTD PMID:15063428 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase affects expression
multiple interactions
decreases expression
increases expression		 EXP
ISO		 Bezafibrate affects the expression of FASN mRNA
[Oleic Acid co-treated with Bezafibrate] results in increased expression of FASN mRNA
Bezafibrate results in decreased expression of FASN mRNA; Bezafibrate results in decreased expression of FASN protein
Bezafibrate results in increased expression of FASN mRNA; Bezafibrate results in increased expression of FASN protein		 CTD PMID:17118139 PMID:17719200 PMID:19124612 PMID:24534255 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression		 ISO [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]
Bezafibrate results in increased expression of FGF21 mRNA; Bezafibrate results in increased expression of FGF21 protein		 CTD PMID:18787029 PMID:20854792 PMID:21720023 PMID:22338096 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] CTD PMID:18513333 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein] CTD PMID:17360982 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] CTD PMID:21734263 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Bezafibrate inhibits the reaction [etomoxir results in increased activity of G6PD protein] CTD PMID:3421940 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
multiple interactions
increases expression		 ISO Bezafibrate results in decreased expression of GPAM mRNA; Bezafibrate results in decreased expression of GPAM protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA]
Bezafibrate results in increased expression of GPAM mRNA; Bezafibrate results in increased expression of GPAM protein		 CTD PMID:19124612 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of GPD1 mRNA
Bucladesine promotes the reaction [Bezafibrate results in increased expression of GPD1 mRNA]		 CTD PMID:1976021 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Bezafibrate promotes the reaction [Sodium Glutamate results in increased expression of GPT protein] CTD PMID:21549692 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
Bezafibrate results in decreased activity of GSR protein		 CTD PMID:17145126 PMID:17710547 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression ISO Bezafibrate results in increased expression of HADHA mRNA CTD PMID:17118139 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Bezafibrate results in increased expression of HADHB mRNA CTD PMID:17118139 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein CTD PMID:22338096 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
increases activity		 EXP
ISO		 Bezafibrate results in decreased activity of HMGCR protein
Bezafibrate results in increased activity of HMGCR protein		 CTD PMID:2044640 PMID:2907502 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions
increases expression		 ISO Butyrates promotes the reaction [Bezafibrate results in increased expression of HMGCS2 mRNA] CTD PMID:18787029 PMID:22338096 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity
decreases expression		 ISO Bezafibrate results in decreased activity of HSD11B1 protein
Bezafibrate results in decreased expression of HSD11B1 mRNA		 CTD PMID:17190905 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Bezafibrate results in increased expression of HSD17B4 mRNA CTD PMID:17118139 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Vitamin E co-treated with Bezafibrate] results in decreased expression of ICAM1 protein modified form CTD PMID:14602771 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] CTD PMID:20631892 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Bezafibrate results in decreased expression of IGF1 protein CTD PMID:10716467 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression		 ISO
EXP		 Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate promotes the reaction [IL1B protein results in increased expression of NPHS1 mRNA]
Bezafibrate results in increased expression of IL1B protein
Bezafibrate results in decreased expression of IL1B protein
Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein]
Bezafibrate results in decreased expression of IL1B mRNA
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]		 CTD PMID:12657956 PMID:12704018 PMID:16288986 PMID:16574099 PMID:18513333 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]; Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA]
Bezafibrate results in decreased expression of IL6 protein
Bezafibrate results in decreased expression of IL6 mRNA
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]		 CTD PMID:11893366 PMID:12657956 PMID:16574099 PMID:17360982 PMID:18513333 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression		 ISO [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]
Bezafibrate results in decreased expression of INS protein		 CTD PMID:2209320 PMID:11292061 PMID:20404010 PMID:32613381 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Bezafibrate results in increased expression of INSIG1 mRNA CTD PMID:17118139 PMID:19124612 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] CTD PMID:17360982 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Bezafibrate results in increased expression of LDHA protein CTD PMID:8632003 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lep leptin decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased expression of LEP
Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein]
Bezafibrate results in decreased expression of LEP mRNA
Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein]		 CTD PMID:10726910 PMID:11216866 PMID:11473052 PMID:17379010 PMID:21549692 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lgals3 galectin 3 increases expression ISO Bezafibrate results in increased expression of LGALS3 mRNA CTD PMID:17118139 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lipc lipase C, hepatic type increases activity ISO Bezafibrate results in increased activity of LIPC protein CTD PMID:3084275 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpl lipoprotein lipase increases expression
increases activity
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of LPL mRNA
Bezafibrate results in increased activity of LPL protein
[Bezafibrate results in increased activity of LPL protein] which results in decreased abundance of Triglycerides; Bezafibrate inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA]
PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA]		 CTD PMID:2907502 PMID:8147947 PMID:8593127 PMID:9006809 PMID:11164425 More... NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO Bezafibrate results in increased expression of LY6D mRNA CTD PMID:17118139 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:11687581 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:11687581 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgll monoglyceride lipase increases expression ISO Bezafibrate results in increased expression of MGLL mRNA CTD PMID:17118139 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Bezafibrate results in increased expression of MGMT mRNA CTD PMID:15447978 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mpeg1 macrophage expressed 1 decreases expression ISO Bezafibrate results in decreased expression of MPEG1 mRNA CTD PMID:18787029 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO Bezafibrate results in increased expression of MPG mRNA CTD PMID:15447978 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression
multiple interactions
decreases expression		 ISO Bezafibrate results in increased expression of MTTP mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]
Bezafibrate results in decreased expression of MTTP mRNA		 CTD PMID:19124612 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NCF1 protein] CTD PMID:11172467 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein] CTD PMID:19263263 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein] CTD PMID:19263263 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Bezafibrate results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 ISO Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NFKB1 mRNA]
Bezafibrate results in decreased expression of NFKB1 mRNA		 CTD PMID:16574099 PMID:18513333 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation		 ISO [Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; dorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; dorsomorphin inhibits the reaction [Bezafibrate results in increased phosphorylation of NOS3 protein] CTD PMID:21499286 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of NOX4 protein
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of NOX4 mRNA]		 CTD PMID:16979161 PMID:20594415 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Npy neuropeptide Y increases expression ISO Bezafibrate results in increased expression of NPY mRNA CTD PMID:18787029 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of NR0B2 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]		 CTD PMID:19124612 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO Bezafibrate results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]
Bezafibrate results in increased expression of NR1H3 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]
NR1H3 protein affects the susceptibility to Bezafibrate		 CTD PMID:12595494 PMID:19124612 PMID:19201410 PMID:26190035 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression		 ISO PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA]
[Oleic Acid co-treated with Bezafibrate] results in increased expression of NR1H4 mRNA		 CTD PMID:15447978 PMID:19124612 PMID:24534255 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Bezafibrate binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression EXP Bezafibrate results in increased expression of NR1I3 mRNA CTD PMID:20208394 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 increases expression ISO Bezafibrate results in increased expression of NTHL1 mRNA CTD PMID:15447978 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO Bezafibrate results in increased expression of OGG1 mRNA CTD PMID:15447978 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pc pyruvate carboxylase increases expression EXP Bezafibrate results in increased expression of PC mRNA CTD PMID:11527545 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Sodium Glutamate co-treated with Bezafibrate] results in decreased expression of PCK1 mRNA CTD PMID:21549692 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP		 Bezafibrate results in increased expression of PCNA mRNA
Bezafibrate results in increased expression of PCNA protein		 CTD PMID:9007043 PMID:15447978 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Bezafibrate results in increased expression of PCSK9 protein CTD PMID:21411093 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 increases expression EXP Bezafibrate results in increased expression of PDHA1 mRNA CTD PMID:11527545 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of PDK2 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]		 CTD PMID:19124612 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of PDK4 mRNA; Bezafibrate results in increased expression of PDK4 protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA]
MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein]		 CTD PMID:17118139 PMID:19124612 PMID:19683050 PMID:21720023 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
decreases expression		 EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Plin2 perilipin 2 multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN2 mRNA] CTD PMID:24534255 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Plin4 perilipin 4 multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN4 mRNA] CTD PMID:24534255 NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056 		JBrowse link
G Pltp phospholipid transfer protein decreases activity
multiple interactions		 ISO Bezafibrate results in decreased activity of PLTP protein
[Bezafibrate results in decreased activity of PLTP protein] affects the reaction [Bezafibrate results in decreased abundance of Fatty Acids, Nonesterified]		 CTD PMID:12754275 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases expression ISO Bezafibrate results in increased expression of PNLIPRP2 mRNA CTD PMID:18787029 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434 		JBrowse link
G Polr2a RNA polymerase II subunit A multiple interactions ISO [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein CTD PMID:22338096 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Bezafibrate results in decreased expression of POMC mRNA CTD PMID:18787029 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP Bezafibrate results in increased activity of POR protein CTD PMID:7606338 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
affects binding
increases activity
affects response to substance
decreases expression
increases response to substance		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Glucose; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Ketones; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein]; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein]; Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein]; Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARA mRNA]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased susceptibility to Palmitates; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate; [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased abundance of Ceramides; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]
Bezafibrate binds to PPARA protein
PPARA protein affects the susceptibility to Bezafibrate
[Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein; Bezafibrate results in increased activity of PPARA protein
Bezafibrate results in decreased expression of PPARA mRNA
Bezafibrate results in increased expression of PPARA; Bezafibrate results in increased expression of PPARA mRNA; Bezafibrate results in increased expression of PPARA protein
[[Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Fatty Acids; [Bezafibrate co-treated with Sodium Glutamate] results in increased expression of PPARA mRNA; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased abundance of Lipid Peroxides]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of CYP4A10 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]
PPARA protein results in increased susceptibility to Bezafibrate		 CTD PMID:9836514 PMID:10585473 PMID:11056218 PMID:11172467 PMID:11341955 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
decreases expression
multiple interactions
increases expression
increases activity		 ISO
EXP		 Bezafibrate binds to PPARB protein; Bezafibrate binds to PPARD protein
Bezafibrate results in decreased expression of PPARD mRNA
PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA]
Bezafibrate results in increased expression of PPARD; Bezafibrate results in increased expression of PPARD mRNA
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARB mRNA]
Bezafibrate results in increased expression of PPARD mRNA; Bezafibrate results in increased expression of PPARD protein
Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARD mRNA]
Bezafibrate results in increased activity of PPARD protein		 CTD PMID:10585473 PMID:11172467 PMID:11779144 PMID:12782154 PMID:19124612 More... NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
affects binding
decreases expression
increases activity		 ISO
EXP		 [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein]
Bezafibrate results in increased expression of PPARG mRNA
Bezafibrate binds to PPARG protein
Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]
Bezafibrate results in decreased expression of PPARG mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA]
Bezafibrate results in increased activity of PPARG protein		 CTD PMID:11473052 PMID:11779144 PMID:12401884 PMID:12967931 PMID:15708366 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Bezafibrate results in increased expression of PPARGC1A mRNA CTD PMID:17275789 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Psmc3ip PSMC3 interacting protein decreases expression ISO Bezafibrate results in decreased expression of PSMC3IP mRNA CTD PMID:18787029 NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423 		JBrowse link
G Rarb retinoic acid receptor, beta decreases expression EXP Bezafibrate results in decreased expression of RARB mRNA CTD PMID:11519881 PMID:11579993 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein] CTD PMID:18660453 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Reln reelin increases expression ISO Bezafibrate results in increased expression of RELN mRNA CTD PMID:18787029 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rida reactive intermediate imine deaminase A homolog multiple interactions EXP [Bezafibrate co-treated with Sunflower Oil] results in increased expression of RIDA protein CTD PMID:16843601 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716 		JBrowse link
G Rmnd1 required for meiotic nuclear division 1 homolog decreases expression ISO Bezafibrate results in decreased expression of RMND1 mRNA CTD PMID:18787029 NCBI chr 1:40,859,829...40,894,390
Ensembl chr 1:40,859,829...40,894,314 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of RUNX2 mRNA
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA]		 CTD PMID:21499286 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
affects binding		 ISO Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
Bezafibrate binds to RXRA protein		 CTD PMID:11779144 PMID:23843199 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO Bezafibrate binds to RXRB protein CTD PMID:23843199 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO Bezafibrate binds to RXRG protein CTD PMID:23843199 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G Scap SREBF chaperone decreases expression
multiple interactions
increases expression		 ISO Bezafibrate results in decreased expression of SCAP mRNA; Bezafibrate results in decreased expression of SCAP protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein]
Bezafibrate results in increased expression of SCAP mRNA; Bezafibrate results in increased expression of SCAP protein		 CTD PMID:19124612 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
increases expression
increases activity
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased expression of SCD1 mRNA
Bezafibrate results in increased expression of SCD1 mRNA
Bezafibrate results in increased activity of SCD protein; Bezafibrate results in increased activity of SCD1 protein
[Oleic Acid co-treated with Bezafibrate] results in increased expression of SCD1 mRNA; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]
PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA]		 CTD PMID:7606338 PMID:11172741 PMID:12782154 PMID:19124612 PMID:24534255 More... NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Bezafibrate results in increased expression of SCD mRNA CTD PMID:17118139 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Sele selectin E multiple interactions ISO [Vitamin E co-treated with Bezafibrate] results in decreased expression of SELE protein modified form CTD PMID:14602771 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
increases secretion
increases activity		 ISO [CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]
Bezafibrate results in increased secretion of SERPINE1 protein
Bezafibrate results in increased activity of SERPINE1 protein
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]		 CTD PMID:9678787 PMID:10364093 PMID:11292061 PMID:17118139 PMID:20400680 More... NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions
increases expression		 ISO PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA] CTD PMID:19124612 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 multiple interactions
increases expression		 ISO Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA] CTD PMID:11929713 PMID:17118139 PMID:19124612 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of SLC2A2 mRNA]
Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA]		 CTD PMID:11527545 PMID:12048068 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Bezafibrate inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity EXP [Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein CTD PMID:18024222 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein CTD PMID:18024222 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Soat1 sterol O-acyltransferase 1 decreases activity EXP Bezafibrate results in decreased activity of SOAT1 protein CTD PMID:2044640 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of SOD1 mRNA; Bezafibrate results in increased expression of SOD1 protein
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of SOD1 mRNA]		 CTD PMID:11172467 PMID:18513333 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
decreases expression		 ISO Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]
Bezafibrate results in decreased expression of SPP1 protein		 CTD PMID:17360982 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
Bezafibrate results in increased expression of SREBF1 mRNA; Bezafibrate results in increased expression of SREBF1 protein
[Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]
Bezafibrate results in decreased expression of SREBF1 mRNA; Bezafibrate results in decreased expression of SREBF1 protein		 CTD PMID:11779144 PMID:19124612 PMID:26190035 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO Bezafibrate results in increased expression of SREBF2 mRNA CTD PMID:14685799 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Bezafibrate results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression EXP Bezafibrate results in increased expression of SUCLG1 mRNA CTD PMID:16707586 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600 		JBrowse link
G Tdg thymine-DNA glycosylase increases expression ISO Bezafibrate results in increased expression of TDG mRNA CTD PMID:15447978 NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
Bezafibrate results in decreased expression of TGFB1 mRNA
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of TGFB1 mRNA]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]		 CTD PMID:16574099 PMID:18513333 PMID:19429239 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression EXP Bezafibrate results in decreased expression of THRA mRNA CTD PMID:11519881 PMID:11579993 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP Bezafibrate results in decreased expression of THRB mRNA CTD PMID:11519881 PMID:11579993 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in decreased expression of THRSP mRNA] CTD PMID:24534255 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP1 mRNA] CTD PMID:18513333 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA] CTD PMID:18513333 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
decreases expression
increases response to substance		 ISO
EXP		 Bezafibrate results in decreased susceptibility to TNF protein
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]
[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein]
Bezafibrate results in decreased expression of TNF mRNA
Bezafibrate results in decreased expression of TNF mRNA; Bezafibrate results in decreased expression of TNF protein		 CTD PMID:11473052 PMID:11893366 PMID:12586603 PMID:12657956 PMID:16574099 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO [Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA CTD PMID:19593819 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression
multiple interactions
affects expression		 ISO
EXP		 Bezafibrate results in increased expression of UCP2 mRNA
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]
Bezafibrate affects the expression of UCP2 mRNA		 CTD PMID:10933891 PMID:11056218 PMID:11341955 PMID:11473052 PMID:12588052 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression
decreases expression		 EXP
ISO		 Bezafibrate results in increased expression of UCP3 mRNA
Bezafibrate results in decreased expression of UCP3 mRNA		 CTD PMID:10342807 PMID:10403804 PMID:10909982 PMID:10933891 PMID:11473052 More... NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases response to substance ISO UGT1A9 results in increased susceptibility to Bezafibrate CTD PMID:17880178 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Bezafibrate CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases response to substance ISO UGT2B7 results in increased susceptibility to Bezafibrate CTD PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vbp1 VHL binding protein 1 increases expression ISO Bezafibrate results in increased expression of VBP1 mRNA CTD PMID:18787029
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO		 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
[Vitamin E co-treated with Bezafibrate] results in decreased expression of VCAM1 protein modified form		 CTD PMID:14602771 PMID:16979161 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcan versican decreases expression ISO Bezafibrate results in decreased expression of VCAN mRNA CTD PMID:11522680 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Calcitriol co-treated with Bezafibrate] results in increased expression of VDR mRNA CTD PMID:19667161 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity
multiple interactions
decreases expression		 EXP Bezafibrate results in decreased activity of XDH protein
Bezafibrate results in increased degradation of and results in decreased expression of XDH mRNA
Bezafibrate results in decreased expression of XDH protein		 CTD PMID:8373410 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Zfp704 zinc finger protein 704 increases expression ISO Bezafibrate results in increased expression of ZFP704 mRNA CTD PMID:18787029 NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        xenobiotic 18699
          bezafibrate 219
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  bezafibrate 219
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