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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mometasone furoate
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Accession:CHEBI:47564 term browser browse the term
Definition:A 2-furoate ester that has formula C27H30Cl2O6.
Synonyms:exact_synonym: 9,21-dichloro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
 related_synonym: Formula=C27H30Cl2O6;   InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1;   InChIKey=WOFMFGQZHJDGCX-ZULDAHANSA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   mometasone 17-furoate
 alt_id: CHEBI:6971
 xref: Beilstein:4340538;   CAS:83919-23-7;   DrugBank:DB00764;   Drug_Central:1832;   KEGG:D00690
 xref_mesh: MESH:C053915
 xref: PDBeChem:MOF;   Patent:EP57401;   Patent:US4472393;   Wikipedia:Mometasone


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mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850 PMID:19422381 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034 PMID:19422381 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297 PMID:10100995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      application 19467
        anti-inflammatory agent 15834
          anti-inflammatory drug 13623
            mometasone furoate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        oxo steroid 9719
                                          3-oxo steroid 9282
                                            3-oxo-Delta(4) steroid 8424
                                              progesterone 2715
                                                Delta(1)-progesterone 236
                                                  mometasone 16
                                                    mometasone furoate 16
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