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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mometasone furoate
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Accession:CHEBI:47564 term browser browse the term
Definition:A 2-furoate ester that has formula C27H30Cl2O6.
Synonyms:exact_synonym: 9,21-dichloro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
 related_synonym: Formula=C27H30Cl2O6;   InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1;   InChIKey=WOFMFGQZHJDGCX-ZULDAHANSA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   mometasone 17-furoate
 alt_id: CHEBI:6971
 xref: Beilstein:4340538;   CAS:83919-23-7;   DrugBank:DB00764;   Drug_Central:1832;   KEGG:D00690
 xref_mesh: MESH:C053915
 xref: PDBeChem:MOF;   Patent:EP57401;   Patent:US4472393;   Wikipedia:Mometasone


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mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850, PMID:19422381 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034, PMID:19422381 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297, PMID:10100995 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          anti-inflammatory drug 13613
            mometasone furoate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxo steroid 9276
                                          3-oxo steroid 8806
                                            3-oxo-Delta(4) steroid 7935
                                              progesterone 2708
                                                Delta(1)-progesterone 236
                                                  mometasone 16
                                                    mometasone furoate 16
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