Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ecothiopate
go back to main search page
Accession:CHEBI:4753 term browser browse the term
Definition:The phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Synonyms:exact_synonym: 2-[(diethoxyphosphoryl)sulfanyl]-N,N,N-trimethylethanaminium
 related_synonym: (2-diethoxyphosphinylthioethyl)trimethylammonium;   Echothiophate;   Formula=C9H23NO3PS;   InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1;   InChIKey=BJOLKYGKSZKIGU-UHFFFAOYSA-N;   SMILES=CCOP(=O)(OCC)SCC[N+](C)(C)C;   ecothiopatum
 xref: Beilstein:1794025;   CAS:6736-03-4;   DrugBank:DB01057;   Drug_Central:982;   KEGG:C06975;   Wikipedia:Echothiophate


show annotations for term's descendants           Sort by:
 
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]
CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          neurotransmitter agent 16447
            miotic 70
              ecothiopate 4
                ecothiopate iodide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  ammonium 8210
                                    ammonium ion derivative 8206
                                      quaternary ammonium ion 5090
                                        cholines 4786
                                          choline 3537
                                            choline ester 126
                                              phosphocholines 126
                                                ecothiopate 4
                                                  ecothiopate iodide 4
paths to the root