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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imipramine
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Accession:CHEBI:47499 term browser browse the term
Definition:A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Synonyms:exact_synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
 related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine;   3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE;   5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;   Antideprin;   Formula=C19H24N2;   Imipramin;   InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3;   InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N;   Irmin;   Melipramine;   N-(gamma-dimethylaminopropyl)iminodibenzyl;   SMILES=CN(C)CCCN1c2ccccc2CCc2ccccc12;   imipraminum;   imizine
 alt_id: CHEBI:47498;   CHEBI:5881
 xref: Beilstein:256892;   CAS:50-49-7;   DrugBank:DB00458;   Drug_Central:1427;   Gmelin:1572523;   HMDB:HMDB0001848;   KEGG:C07049;   KEGG:D08070;   LINCS:LSM-2852
 xref_mesh: MESH:D007099
 xref: PDBeChem:IXX;   PMID:20825390;   Patent:US2554736;   Reaxys:256892;   Wikipedia:Imipramine


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imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression ISO Imipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects expression ISO Imipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Imipramine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases activity		 ISO
EXP		 Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Imipramine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Imipramine results in increased activity of ACHE protein
Imipramine results in decreased activity of ACHE protein		 CTD PMID:25522658 PMID:29614332 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Adrb1 adrenergic receptor, beta 1 multiple interactions
decreases activity		 ISO [Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein; [Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein
Imipramine results in decreased activity of ADRB1 protein		 CTD PMID:2868116 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 decreases expression ISO Imipramine results in decreased expression of ADRB2 protein CTD PMID:10618463 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Alb albumin affects binding ISO Imipramine binds to ALB protein CTD PMID:20956006 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects expression ISO Imipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Ap2m1 adaptor-related protein complex 2, mu 1 subunit multiple interactions EXP Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659 		JBrowse link
G Apoa4 apolipoprotein A-IV affects expression ISO Imipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Arg1 arginase, liver multiple interactions EXP Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ARG1 protein]] CTD PMID:30620895 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Imipramine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Asns asparagine synthetase increases expression ISO Imipramine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Bdnf brain derived neurotrophic factor increases expression
affects expression
multiple interactions		 EXP
ISO		 Imipramine results in increased expression of BDNF mRNA
Imipramine affects the expression of BDNF protein
Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]		 CTD PMID:8601816 PMID:15157811 PMID:17617388 PMID:17950272 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bhmt betaine-homocysteine methyltransferase affects expression ISO Imipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Imipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Imipramine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase affects activity
multiple interactions		 EXP
ISO		 Imipramine affects the activity of CAT protein
Imipramine inhibits the reaction [Streptozocin results in increased activity of CAT protein]		 CTD PMID:19798453 PMID:34352274 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects expression ISO Imipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Ces2h carboxylesterase 2H affects expression ISO Imipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression ISO Imipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 9:114,560,184...114,578,412
Ensembl chr 9:114,560,184...114,578,412 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression ISO Imipramine results in decreased expression of CNR1 protein CTD PMID:28866072 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Imipramine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 4:135,622,500...135,647,530
Ensembl chr 4:135,622,705...135,647,518 		JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression ISO Imipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:11,621,546...11,727,377
Ensembl chr16:11,621,585...11,727,309 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Imipramine results in increased expression of CREB1 mRNA
Imipramine results in increased phosphorylation of CREB1 protein
Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]		 CTD PMID:8601816 PMID:22396798 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crem cAMP responsive element modulator affects expression ISO Imipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Crh corticotropin releasing hormone affects activity ISO Imipramine affects the activity of CRH protein CTD PMID:2553044 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions		 ISO CYP1A2 protein affects the metabolism of Imipramine
CYP1A2 protein results in increased metabolism of Imipramine
CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine; Imipramine inhibits the reaction [resveratrol results in decreased activity of CYP1A2 protein]; Organophosphorus Compounds inhibits the reaction [CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine]		 CTD PMID:11714871 PMID:15286053 PMID:15922009 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 affects expression ISO Imipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects metabolic processing
multiple interactions		 ISO CYP2C19 protein affects the metabolism of Imipramine
CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine]		 CTD PMID:15286053 PMID:15922009 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 affects expression ISO Imipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr17:33,122,331...33,136,353
Ensembl chr17:33,124,044...33,136,316 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression ISO Imipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:171,975,574...172,023,959
Ensembl chr 1:171,975,651...172,024,572 		JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Imipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755 		JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Imipramine results in increased expression of DNAJC5 mRNA; Imipramine results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression ISO Imipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr15:101,982,208...102,005,608
Ensembl chr15:101,982,208...102,005,608 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects expression ISO Imipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression ISO Imipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO Imipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Imipramine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO Imipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Imipramine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014 		JBrowse link
G Gckr glucokinase regulatory protein affects expression ISO Imipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Imipramine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821 		JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) affects expression ISO Imipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873 		JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial affects expression ISO Imipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175 		JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression ISO Imipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:64,742,820...64,853,143
Ensembl chr 2:64,742,820...64,855,331 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) decreases expression ISO Imipramine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO Imipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Hal histidine ammonia lyase affects expression ISO Imipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166 		JBrowse link
G Hdac5 histone deacetylase 5 increases expression EXP Imipramine results in increased expression of HDAC5 mRNA CTD PMID:17988634 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity ISO Imipramine results in decreased activity of HMBS protein CTD PMID:10416826 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G Hmgb2 high mobility group box 2 affects expression ISO Imipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Imipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Hpn hepsin increases expression ISO Imipramine results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:30,798,150...30,814,751
Ensembl chr 7:30,798,150...30,814,715 		JBrowse link
G Hsf1 heat shock factor 1 decreases activity ISO Imipramine results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa8 heat shock protein 8 increases expression ISO Imipramine results in increased expression of HSPA8 mRNA alternative form; Imipramine results in increased expression of HSPA8 protein alternative form CTD PMID:10425221 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A affects expression ISO Imipramine affects the expression of HTR1A mRNA CTD PMID:17617388 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A decreases expression ISO Imipramine results in decreased expression of HTR2A CTD PMID:2553044 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Imipramine affects the reaction [caryophyllene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL10 protein]] CTD PMID:30620895 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:30620895 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il33 interleukin 33 affects expression ISO Imipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Imipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280 		JBrowse link
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 multiple interactions ISO Imipramine binds to and results in decreased activity of KCNH1 protein CTD PMID:18497958 NCBI chr 1:191,871,759...192,192,467
Ensembl chr 1:191,873,082...192,192,467 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions
decreases activity
decreases localization		 ISO Imipramine binds to and results in decreased activity of KCNH2 protein; Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Imipramine results in decreased activity of KCNH2 protein
Imipramine results in decreased localization of KCNH2 protein		 CTD PMID:15272206 PMID:19583963 PMID:21158687 PMID:21525004 PMID:24052561 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 decreases activity ISO Imipramine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950 		JBrowse link
G Lox lysyl oxidase affects expression ISO Imipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939 		JBrowse link
G Lss lanosterol synthase increases expression ISO Imipramine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972 		JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression ISO Imipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr13:56,221,435...56,283,439
Ensembl chr13:56,221,432...56,284,174 		JBrowse link
G Manba mannosidase, beta A, lysosomal affects expression ISO Imipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 3:135,191,367...135,277,165
Ensembl chr 3:135,191,372...135,277,165 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK1 protein]; Imipramine binds to and results in increased activity of MAPK1 protein CTD PMID:20484120 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK3 protein]; Imipramine binds to and results in increased activity of MAPK3 protein CTD PMID:20484120 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mlx MAX-like protein X affects expression ISO Imipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr11:100,978,116...100,983,033
Ensembl chr11:100,978,103...100,983,033 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression ISO Imipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr17:36,221,272...36,227,332
Ensembl chr17:36,221,271...36,227,281 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 affects expression ISO Imipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Imipramine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nrep neuronal regeneration related protein affects expression ISO Imipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions
increases phosphorylation		 EXP Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]; Imipramine results in increased phosphorylation of and results in increased activity of NTRK2 protein
Imipramine results in increased phosphorylation of NTRK2 protein		 CTD PMID:21666748 PMID:22396798 PMID:31631060 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Imipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Oaf out at first homolog affects expression ISO Imipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208 		JBrowse link
G Orm2 orosomucoid 2 multiple interactions
affects binding		 ISO Chlorpromazine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Dipyridamole inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Disopyramide inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Lidocaine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Methadone inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Progesterone inhibits the reaction [Imipramine binds to ORM2 protein alternative form] CTD PMID:8946472 NCBI chr 4:63,280,543...63,284,114
Ensembl chr 4:63,280,686...63,284,115 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Imipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcx pyruvate carboxylase affects expression ISO Imipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Imipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 1:72,298,331...72,323,480
Ensembl chr 1:72,298,326...72,323,473 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form] CTD PMID:22396798 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Imipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform multiple interactions ISO Imipramine inhibits the reaction [Ethanol results in increased activity of PPP2CA protein] CTD PMID:20224005 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression ISO Imipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Imipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Imipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
G Serpini1 serine (or cysteine) peptidase inhibitor, clade I, member 1 increases expression ISO Imipramine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 3:75,464,800...75,549,830
Ensembl chr 3:75,464,854...75,550,802 		JBrowse link
G Sh3gl3 SH3-domain GRB2-like 3 affects expression ISO Imipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 7:81,824,581...81,956,618
Ensembl chr 7:81,823,588...81,956,627 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Imipramine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:24947867 PMID:25106415 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Imipramine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Imipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions ISO Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:10966924 PMID:21697722 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression ISO Imipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc47a1 solute carrier family 47, member 1 decreases activity
multiple interactions		 ISO Imipramine results in decreased activity of SLC47A1 protein
Imipramine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]		 CTD PMID:16928787 PMID:21599003 NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 decreases activity ISO Imipramine results in decreased activity of SLC6A4 protein CTD PMID:18561912 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 affects expression ISO Imipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression ISO Imipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G St13 suppression of tumorigenicity 13 affects expression ISO Imipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr15:81,247,869...81,284,278
Ensembl chr15:81,247,870...81,284,278 		JBrowse link
G Stbd1 starch binding domain 1 affects expression ISO Imipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 5:92,750,910...92,754,438
Ensembl chr 5:92,750,900...92,754,438 		JBrowse link
G Stmn1 stathmin 1 affects expression ISO Imipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Tac1 tachykinin 1 decreases expression ISO Imipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tagln transgelin decreases expression ISO Imipramine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tex261 testis expressed gene 261 affects expression ISO Imipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 6:83,745,863...83,752,804
Ensembl chr 6:83,745,867...83,752,795 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression ISO Imipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 7:105,289,652...105,304,955
Ensembl chr 7:105,289,263...105,292,844
Ensembl chr 7:105,289,263...105,292,844 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Imipramine promotes the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]		 CTD PMID:15946935 PMID:30529211 PMID:30620895 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Imipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects expression ISO Imipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 affects metabolic processing
multiple interactions
increases glucuronidation		 ISO UGT1A4 protein affects the metabolism of Imipramine
Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]
UGT1A4 protein results in increased glucuronidation of Imipramine; UGT1A4 protein SNP results in increased glucuronidation of Imipramine		 CTD PMID:9264550 PMID:14570768 PMID:15286053 PMID:15708967 PMID:25448279 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 affects expression ISO Imipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression ISO Imipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Imipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793 		JBrowse link
clomipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression ISO Clomipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects expression ISO Clomipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects expression ISO Clomipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Ap1s1 adaptor protein complex AP-1, sigma 1 decreases expression ISO Clomipramine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:137,063,852...137,074,917
Ensembl chr 5:137,063,847...137,074,989 		JBrowse link
G Apoa4 apolipoprotein A-IV affects expression ISO Clomipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Asns asparagine synthetase increases expression ISO Clomipramine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Bhmt betaine-homocysteine methyltransferase affects expression ISO Clomipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Clomipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 PMID:28482088 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 increases activity EXP Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity EXP Clomipramine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase decreases expression ISO Clomipramine results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects expression ISO Clomipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Ces2h carboxylesterase 2H affects expression ISO Clomipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression ISO Clomipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 9:114,560,184...114,578,412
Ensembl chr 9:114,560,184...114,578,412 		JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression ISO Clomipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:11,621,546...11,727,377
Ensembl chr16:11,621,585...11,727,309 		JBrowse link
G Crem cAMP responsive element modulator affects expression ISO Clomipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Clomipramine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 affects expression ISO Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809 		JBrowse link
G Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 affects expression ISO Clomipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr17:33,122,331...33,136,353
Ensembl chr17:33,124,044...33,136,316 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression ISO Clomipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:171,975,574...172,023,959
Ensembl chr 1:171,975,651...172,024,572 		JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Clomipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755 		JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO Clomipramine results in increased expression of DRD2 protein CTD PMID:20619828 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression ISO Clomipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr15:101,982,208...102,005,608
Ensembl chr15:101,982,208...102,005,608 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects expression ISO Clomipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression ISO Clomipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO Clomipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fh1 fumarate hydratase 1 multiple interactions ISO Clomipramine results in increased activity of and results in increased secretion of FH protein CTD PMID:37217012 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression
decreases expression		 ISO Clomipramine results in increased expression of FNDC4 mRNA
Clomipramine results in decreased expression of FNDC4 mRNA		 CTD PMID:17175557 NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424 		JBrowse link
G Gckr glucokinase regulatory protein affects expression ISO Clomipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clomipramine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821 		JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) affects expression ISO Clomipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873 		JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial affects expression ISO Clomipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases export		 ISO Clomipramine results in increased activity of and results in increased secretion of GPT protein
Clomipramine results in increased export of GPT protein		 CTD PMID:37217012 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression ISO Clomipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:64,742,820...64,853,143
Ensembl chr 2:64,742,820...64,855,331 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO Clomipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Hal histidine ammonia lyase affects expression ISO Clomipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166 		JBrowse link
G Hmgb2 high mobility group box 2 affects expression ISO Clomipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Clomipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Hpn hepsin increases expression ISO Clomipramine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 7:30,798,150...30,814,751
Ensembl chr 7:30,798,150...30,814,715 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects binding
increases expression		 ISO Clomipramine binds to HTR2C protein
Clomipramine results in increased expression of HTR2C protein		 CTD PMID:18083778 PMID:20619828 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il33 interleukin 33 affects expression ISO Clomipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Clomipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Lox lysyl oxidase affects expression ISO Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939 		JBrowse link
G Lss lanosterol synthase increases expression ISO Clomipramine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972 		JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression ISO Clomipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr13:56,221,435...56,283,439
Ensembl chr13:56,221,432...56,284,174 		JBrowse link
G Manba mannosidase, beta A, lysosomal affects expression ISO Clomipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 3:135,191,367...135,277,165
Ensembl chr 3:135,191,372...135,277,165 		JBrowse link
G Mlx MAX-like protein X affects expression ISO Clomipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr11:100,978,116...100,983,033
Ensembl chr11:100,978,103...100,983,033 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression ISO Clomipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr17:36,221,272...36,227,332
Ensembl chr17:36,221,271...36,227,281 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 affects expression ISO Clomipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clomipramine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nrep neuronal regeneration related protein affects expression ISO Clomipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 increases phosphorylation EXP Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Clomipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Oaf out at first homolog affects expression ISO Clomipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcx pyruvate carboxylase affects expression ISO Clomipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Clomipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 1:72,298,331...72,323,480
Ensembl chr 1:72,298,326...72,323,473 		JBrowse link
G Phyh phytanoyl-CoA hydroxylase increases expression ISO Clomipramine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Clomipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Prl prolactin affects secretion
increases secretion
multiple interactions
increases expression		 ISO Clomipramine affects the secretion of PRL protein
Clomipramine results in increased secretion of PRL protein
SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein]
Clomipramine results in increased expression of PRL protein		 CTD PMID:3602989 PMID:7930386 PMID:17000009 PMID:19698552 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Proc protein C increases expression ISO Clomipramine results in increased expression of PROC protein CTD PMID:17891354 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression ISO Clomipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Clomipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Clomipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
G Sh3gl3 SH3-domain GRB2-like 3 affects expression ISO Clomipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 7:81,824,581...81,956,618
Ensembl chr 7:81,823,588...81,956,627 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Clomipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression ISO Clomipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 multiple interactions ISO Clomipramine binds to and results in decreased activity of SLC6A4 protein; SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein] CTD PMID:16272152 PMID:17000009 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 affects expression ISO Clomipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression ISO Clomipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G St13 suppression of tumorigenicity 13 affects expression ISO Clomipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr15:81,247,869...81,284,278
Ensembl chr15:81,247,870...81,284,278 		JBrowse link
G Stbd1 starch binding domain 1 affects expression ISO Clomipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 5:92,750,910...92,754,438
Ensembl chr 5:92,750,900...92,754,438 		JBrowse link
G Stmn1 stathmin 1 affects expression ISO Clomipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Tac1 tachykinin 1 decreases expression ISO Clomipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tagln transgelin decreases expression ISO Clomipramine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tex261 testis expressed gene 261 affects expression ISO Clomipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 6:83,745,863...83,752,804
Ensembl chr 6:83,745,867...83,752,795 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Clomipramine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression ISO Clomipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 7:105,289,652...105,304,955
Ensembl chr 7:105,289,263...105,292,844
Ensembl chr 7:105,289,263...105,292,844 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Clomipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects expression ISO Clomipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 affects expression ISO Clomipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression ISO Clomipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clomipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793 		JBrowse link
trimipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Trimipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        pharmacological role 19771
          neurotransmitter agent 17109
            adrenergic agent 9205
              adrenergic uptake inhibitor 4776
                imipramine 132
                  clomipramine 90
                  imipramine hydrochloride 0
                  trimipramine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterotricyclic compound 16298
                                      mancude organic heterotricyclic parent 370
                                        5H-dibenzo[b,f]azepine 131
                                          imipramine 132
                                            clomipramine 90
                                            imipramine hydrochloride 0
                                            trimipramine + 1
paths to the root