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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:echinacoside
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Accession:CHEBI:4745 term browser browse the term
Definition:An oligosaccharide that has formula C35H46O20.
Synonyms:related_synonym: Formula=C35H46O20;   InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1;   InChIKey=FSBUXLDOLNLABB-ISAKITKMSA-N;   SMILES=C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2OC(=O)\\C=C\\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
 xref: CAS:82854-37-3;   KEGG:C10450;   KNApSAcK:C00002738
 xref_mesh: MESH:C060297



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echinacoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 multiple interactions ISO echinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ATF3] CTD PMID:27432061 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases expression ISO echinacoside results in decreased expression of BACH1 protein CTD PMID:22735309 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP echinacoside inhibits the reaction [Rotenone results in decreased expression of BDNF protein]; staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased expression of BDNF protein]] CTD PMID:23189969 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions ISO echinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:27432061 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO echinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3] CTD PMID:27432061 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO echinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF] CTD PMID:27432061 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO echinacoside results in increased expression of HMOX1 mRNA; echinacoside results in increased expression of HMOX1 protein CTD PMID:22735309 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
echinacoside results in increased activity of and affects the localization of NFE2L2 protein
[echinacoside co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein
CTD PMID:22735309 PMID:31412289 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions EXP echinacoside inhibits the reaction [Rotenone results in decreased expression of NGF protein]; staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased expression of NGF protein]] CTD PMID:23189969 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]; staurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK1 protein]
echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]; staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]]
CTD PMID:23189969 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases phosphorylation
EXP
ISO
echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]; staurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK2 protein]
echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]; staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]]
CTD PMID:23189969 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Snca synuclein alpha multiple interactions ISO echinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA] CTD PMID:27432061 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      atom 20071
        nonmetal atom 19959
          oxygen atom 19681
            oxygen molecular entity 19681
              organooxygen compound 19239
                carbohydrates and carbohydrate derivatives 13962
                  glycan 3409
                    oligosaccharide 582
                      echinacoside 12
                        Echinacea extract 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            heteroorganic entity 19577
                              organochalcogen compound 19339
                                organooxygen compound 19239
                                  carbohydrates and carbohydrate derivatives 13962
                                    carbohydrate 13962
                                      oligosaccharide 582
                                        echinacoside 12
                                          Echinacea extract 0
paths to the root