Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefazolin
go back to main search page
Accession:CHEBI:474053 term browser browse the term
Definition:A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.
Synonyms:exact_synonym: 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEZ;   Cefamezin;   Cephamezine;   Cephazolidin;   Cephazolin;   Cephazoline;   Formula=C14H14N8O4S3;   InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1;   InChIKey=MLYYVTUWGNIJIB-BXKDBHETSA-N;   SMILES=[C@]12(N(C(=C(CS1)CSC3=NN=C(S3)C)C(=O)O)C([C@H]2NC(=O)CN4C=NN=N4)=O)[H];   cefazolina;   cefazoline;   cefazolinum
 alt_id: CHEBI:3482
 xref: Beilstein:4169371;   CAS:25953-19-9;   DrugBank:DB01327;   Drug_Central:530;   HMDB:HMDB0015422;   KEGG:C06880;   KEGG:D02299;   LINCS:LSM-34744
 xref_mesh: MESH:D002437
 xref: PMID:12569987;   PMID:2083978;   PMID:22011388;   PMID:23702270;   PMID:24462449;   PMID:28543395;   PMID:29017833;   PMID:6176550;   Patent:US3516997;   Reaxys:4169371;   VSDB:1910;   Wikipedia:Cefazolin
 cyclic_relationship: is_conjugate_acid_of CHEBI:53657


show annotations for term's descendants           Sort by:
 
cefazolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Cefazolin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO Cefazolin results in increased expression of and results in decreased activity of GSR protein
Cefazolin results in increased expression of GSR mRNA
CTD PMID:32196862 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Cefazolin affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:3,889,106...3,892,360
Ensembl chr20:3,889,370...3,892,449
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of Cefazolin CTD PMID:16098483 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cefazolin binds to and results in decreased activity of SLC25A20 protein; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              cefazolin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          cefazolin 5
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.