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ONTOLOGY REPORT - ANNOTATIONS


Term:cefazolin
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Accession:CHEBI:474053 term browser browse the term
Definition:A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.
Synonyms:exact_synonym: 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEZ;   Cefamezin;   Cephamezine;   Cephazolidin;   Cephazolin;   Cephazoline;   Formula=C14H14N8O4S3;   InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1;   InChIKey=MLYYVTUWGNIJIB-BXKDBHETSA-N;   SMILES=[C@]12(N(C(=C(CS1)CSC3=NN=C(S3)C)C(=O)O)C([C@H]2NC(=O)CN4C=NN=N4)=O)[H];   cefazolina;   cefazoline;   cefazolinum
 alt_id: CHEBI:3482
 xref: Beilstein:4169371 "Beilstein";   CAS:25953-19-9 "ChemIDplus";   CAS:25953-19-9 "DrugBank";   CAS:25953-19-9 "KEGG COMPOUND";   CAS:25953-19-9 "KEGG DRUG";   DrugBank:DB01327;   Drug_Central:530 "DrugCentral";   HMDB:HMDB0015422;   KEGG:C06880;   KEGG:D02299;   LINCS:LSM-34744
 xref_mesh: MESH:D002437
 xref: PMID:12569987 "Europe PMC";   PMID:2083978 "Europe PMC";   PMID:22011388 "Europe PMC";   PMID:23702270 "Europe PMC";   PMID:24462449 "Europe PMC";   PMID:28543395 "Europe PMC";   PMID:29017833 "Europe PMC";   PMID:6176550 "Europe PMC";   Patent:US3516997;   Reaxys:4169371 "Reaxys";   VSDB:1910;   Wikipedia:Cefazolin
 cyclic_relationship: is_conjugate_acid_of CHEBI:53657


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cefazolin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G RT1-DOa RT1 class II, locus DOa JBrowse link 20 3,889,106 3,892,360 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        antimicrobial agent 17143
          antibacterial agent 12897
            antibacterial drug 3035
              cefazolin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            carbamoyl group 16610
                                              carboxamide 16610
                                                lactam 2919
                                                  beta-lactam 707
                                                    beta-lactam antibiotic 695
                                                      cephem 535
                                                        cephalosporin 534
                                                          cefazolin 4
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