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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diclofenac
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Accession:CHEBI:47381 term browser browse the term
Definition:A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Synonyms:exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
 related_synonym: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID;   Formula=C14H11Cl2NO2;   InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19);   InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N;   SMILES=C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl;   [2-(2,6-dichloroanilino)phenyl]acetic acid;   diclofenac acid;   diclofenaco;   diclofenacum;   diclofenamic acid
 alt_id: CHEBI:4507;   CHEBI:47380
 xref: CAS:15307-86-5;   DrugBank:DB00586;   Drug_Central:865;   HMDB:HMDB0014724;   KEGG:C01690;   KEGG:D07816;   LINCS:LSM-2160
 xref_mesh: MESH:D004008
 xref: PDBeChem:DIF;   PMID:11322639;   PMID:1502708;   PMID:23777257;   PMID:27967303;   PMID:7838674;   Patent:NL6604752;   Patent:US3558690;   Reaxys:2146636;   VSDB:1933;   Wikipedia:Diclofenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:48311


show annotations for term's descendants           Sort by:
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Aacs acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543 		JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of AARS1 mRNA CTD PMID:35537566 NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity 		ISO Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of ABCB11 mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of ABCB11 mRNA]
Diclofenac results in decreased activity of ABCB11 protein 		CTD PMID:24014644 PMID:28437613 PMID:38945390 PMID:39023798 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases response to substance
decreases activity 		ISO Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein 		CTD PMID:15458769 PMID:19022234 PMID:28193520 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases expression EXP Diclofenac results in decreased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity 		ISO Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein 		CTD PMID:19022234 PMID:28437613 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions 		ISO
EXP 		Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac 		CTD PMID:19022234 PMID:22646477 PMID:25450747 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO Diclofenac results in decreased activity of ABCC3 protein CTD PMID:39023798 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Diclofenac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr15:32,072,121...32,117,004
Ensembl chr15:32,072,123...32,117,166 		JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACP3 mRNA CTD PMID:26934552 NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:113,785,032...113,833,033 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects expression ISO Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178 		JBrowse link
G Actl9 actin-like 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ACTL9 mRNA CTD PMID:37844793 NCBI chr 7:14,936,690...14,938,067
Ensembl chr 7:14,935,601...15,006,102 		JBrowse link
G Actn1 actinin, alpha 1 affects expression EXP Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172 		JBrowse link
G Acvr1 activin A receptor type 1 affects expression ISO Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:63,387,381...63,477,884 		JBrowse link
G Acvr1b activin A receptor type 1B affects expression
multiple interactions 		ISO Diclofenac affects the expression of ACVR1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ACVR1B mRNA 		CTD PMID:24752500 PMID:37844793 NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:134,164,991...134,208,388 		JBrowse link
G Acvr2b activin A receptor type 2B affects expression ISO Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:128,016,526...128,048,171 		JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr15:47,076,011...47,097,065
Ensembl chr15:47,076,019...47,097,065 		JBrowse link
G Adcy6 adenylate cyclase 6 affects expression ISO Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:131,621,860...131,642,770 		JBrowse link
G Adcy9 adenylate cyclase 9 affects expression
decreases expression 		ISO Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,645,282...11,765,792 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression EXP Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Diclofenac results in decreased expression of ADH7 mRNA CTD PMID:35537566 NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:229,421,252...229,436,691 		JBrowse link
G Adk adenosine kinase increases expression
decreases expression 		ISO
EXP 		Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA 		CTD PMID:19022234 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745 		JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO Diclofenac results in increased expression of AEN mRNA CTD PMID:35537566 NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:142,224,493...142,233,898 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151 PMID:28138970 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Aggf1 angiogenic factor with G patch and FHA domains 1 affects expression ISO Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 2:28,354,073...28,380,794
Ensembl chr 2:28,354,073...28,380,759 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 affects expression ISO Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 affects expression ISO Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 5:143,913,957...143,998,746
Ensembl chr 5:143,926,501...143,998,737 		JBrowse link
G Ago4 argonaute RISC component 4 affects expression ISO Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 5:144,064,949...144,110,422
Ensembl chr 5:144,064,949...144,110,402 		JBrowse link
G Agrp agouti related neuropeptide increases expression EXP Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:50,357,905...50,358,698 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression ISO Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr13:88,397,516...88,439,325
Ensembl chr13:88,404,048...88,439,318 		JBrowse link
G Akna AT-hook transcription factor decreases expression ISO Diclofenac results in decreased expression of AKNA mRNA CTD PMID:35537566 NCBI chr 5:81,792,928...81,839,936
Ensembl chr 5:81,792,929...81,831,528 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA CTD PMID:37844793 NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 affects expression ISO Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:22,890,689...22,914,043 		JBrowse link
G Alb albumin affects binding
increases expression
decreases expression
multiple interactions
decreases secretion 		ISO
EXP 		Diclofenac binds to ALB protein
Diclofenac results in increased expression of ALB mRNA
Diclofenac results in decreased expression of ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased secretion of ALB protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of ALB protein 		CTD PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613 PMID:38945390 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression
decreases expression 		ISO Diclofenac results in increased expression of ALDH18A1 mRNA
Diclofenac results in decreased expression of ALDH18A1 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression
multiple interactions 		EXP
ISO 		Diclofenac results in increased expression of ALOX15 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ALOX15 mRNA 		CTD PMID:23939143 PMID:37844793 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Amh anti-Mullerian hormone increases expression
multiple interactions 		ISO Diclofenac results in increased expression of AMH mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AMH mRNA 		CTD PMID:35537566 PMID:37844793 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867 		JBrowse link
G Amotl2 angiomotin like 2 decreases expression ISO Diclofenac results in decreased expression of AMOTL2 mRNA CTD PMID:35537566 NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030 		JBrowse link
G Ang angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106 		JBrowse link
G Anxa8 annexin A8 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ANXA8 mRNA CTD PMID:37844793 NCBI chr16:9,403,267...9,418,317
Ensembl chr16:9,403,353...9,418,310 		JBrowse link
G Aoc3 amine oxidase, copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr10:86,773,018...86,780,961 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Apcs amyloid P component, serum multiple interactions
increases expression 		EXP
ISO 		[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein 		CTD PMID:25772430 PMID:26934552 NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824 		JBrowse link
G Apoa4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319 		JBrowse link
G Aqp9 aquaporin 9 decreases expression ISO Diclofenac results in decreased expression of AQP9 mRNA CTD PMID:35537566 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Aqr aquarius intron-binding spliceosomal factor affects expression ISO Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr 3:121,329,287...121,399,375
Ensembl chr 3:121,329,289...121,399,321 		JBrowse link
G Ar androgen receptor affects activity ISO Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:3,780,932...3,845,919
Ensembl chr  X:3,780,932...3,792,611 		JBrowse link
G Arhgap20 Rho GTPase activating protein 20 increases expression EXP Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr 8:60,970,480...61,055,199
Ensembl chr 8:60,970,475...61,055,198 		JBrowse link
G Arhgap26 Rho GTPase activating protein 26 affects expression ISO Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr18:30,702,602...31,489,047
Ensembl chr18:31,089,787...31,489,047 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:176,358,904...176,417,646 		JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects expression
decreases expression 		ISO Diclofenac affects the expression of ARHGEF3 mRNA
Diclofenac results in decreased expression of ARHGEF3 mRNA 		CTD PMID:24752500 PMID:35537566 NCBI chr16:2,308,311...2,588,634
Ensembl chr16:2,308,400...2,588,819 		JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression ISO Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597 		JBrowse link
G Arid4a AT-rich interaction domain 4A multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARID4A mRNA CTD PMID:37844793 NCBI chr 6:95,258,429...95,335,987
Ensembl chr 6:95,258,429...95,329,840 		JBrowse link
G Arid5a AT-rich interaction domain 5A decreases expression ISO Diclofenac results in decreased expression of ARID5A mRNA CTD PMID:35537566 NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:46,030,548...46,045,363 		JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686 		JBrowse link
G Arl11 ARF like GTPase 11 decreases expression ISO Diclofenac results in decreased expression of ARL11 mRNA CTD PMID:35537566 NCBI chr15:39,659,404...39,661,651
Ensembl chr15:39,656,050...39,664,105 		JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression EXP Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:102,192,225...102,196,130
Ensembl chr  X:102,192,015...102,199,115 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects expression ISO Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARRB1 mRNA CTD PMID:37844793 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Diclofenac results in increased expression of ARRDC3 mRNA CTD PMID:35537566 NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression ISO Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:97,675,354...97,982,024 		JBrowse link
G Ash2l ASH2 like histone lysine methyltransferase complex subunit affects expression ISO Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr16:72,943,527...72,966,791
Ensembl chr16:72,944,949...72,967,839 		JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr 7:132,677,158...132,707,379
Ensembl chr 7:132,698,723...132,707,832 		JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:66,368,308...67,438,237
Ensembl chr10:66,368,310...66,636,245 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression
decreases activity 		EXP Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein 		CTD PMID:11588175 NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:11,652,946...11,657,367 		JBrowse link
G Asl argininosuccinate lyase affects expression ISO Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression 		ISO Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA 		CTD PMID:19192274 PMID:26934552 PMID:35537566 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627 		JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745 		JBrowse link
G Atf4 activating transcription factor 4 affects expression
decreases expression
increases expression 		ISO Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in decreased expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA 		CTD PMID:24752500 PMID:27313093 PMID:35537566 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Diclofenac results in decreased expression of ATF5 mRNA CTD PMID:35537566 NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183 		JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr16:83,359,884...83,469,807
Ensembl chr16:83,359,884...83,469,767 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
increases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein 		CTD PMID:25772430 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions
increases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein 		CTD PMID:25772430 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein 		CTD PMID:25772430 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466 		JBrowse link
G Azin1 antizyme inhibitor 1 affects expression ISO Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515 		JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 3:72,661,410...73,234,447
Ensembl chr 3:72,660,801...73,235,276 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects expression ISO Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:80,069,960...80,176,873 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization 		ISO
EXP 		Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein 		CTD PMID:18191430 PMID:29027214 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member decreases expression ISO Diclofenac results in decreased expression of BCAR3 mRNA CTD PMID:35537566 NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO
EXP 		Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects expression 		ISO Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA 		CTD PMID:14609740 PMID:24752500 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression ISO Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases activity 		ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA 		CTD PMID:18191430 PMID:24752500 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of BMP6 mRNA
Diclofenac results in increased expression of BMP6 mRNA 		CTD PMID:26934552 PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNA CTD PMID:37844793 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194 		JBrowse link
G Brd3os BRD3 opposite strand decreases expression ISO Diclofenac results in decreased expression of BRD3OS mRNA CTD PMID:35537566 NCBI chr 3:31,168,289...31,169,920
Ensembl chr 3:31,168,289...31,169,920 		JBrowse link
G Brdt bromodomain testis associated decreases expression ISO Diclofenac results in decreased expression of BRDT mRNA CTD PMID:35537566 NCBI chr14:2,532,275...2,590,780
Ensembl chr14:2,532,275...2,590,760 		JBrowse link
G Brip1 BRCA1 interacting DNA helicase 1 affects expression ISO Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr10:71,402,035...71,528,083
Ensembl chr10:71,401,151...71,575,206 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406 		JBrowse link
G C1qa complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732 		JBrowse link
G C1qb complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840 		JBrowse link
G C1qc complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:154,410,848...154,414,468 		JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G C4b complement C4B increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289 		JBrowse link
G Ca1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454 		JBrowse link
G Ca13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression
increases secretion 		ISO
EXP 		Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein 		CTD PMID:24038040 PMID:26934552 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:27,779,166...27,944,285 		JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Calm1 calmodulin 1 affects expression ISO Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Calml3 calmodulin-like 3 increases expression EXP Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr17:71,329,438...71,333,068
Ensembl chr17:71,319,943...71,335,682 		JBrowse link
G Calr calreticulin affects expression
decreases expression 		EXP Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA 		CTD PMID:18246545 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236 		JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr17:77,491,191...77,892,018
Ensembl chr17:77,491,220...77,892,012 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485 		JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998 		JBrowse link
G Capn10 calpain 10 affects expression ISO Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:100,945,551...100,957,912 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of CARS1 mRNA CTD PMID:35537566 NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage 		EXP diacerein inhibits the reaction [Diclofenac results in increased cleavage of CASP1 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 PMID:38582345 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp2 caspase 2 multiple interactions
affects expression 		ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA 		CTD PMID:16388830 PMID:24752500 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		ISO
EXP 		Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein] 		CTD PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 affects expression ISO Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp8 caspase 8 increases activity
affects expression
multiple interactions 		EXP
ISO 		Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein] 		CTD PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity 		ISO
EXP 		[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA 		CTD PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases activity
decreases activity
multiple interactions 		EXP
ISO 		Diclofenac results in increased activity of CAT protein
Diclofenac results in decreased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein] 		CTD PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbl Cbl proto-oncogene affects expression ISO Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104 		JBrowse link
G Cbs cystathionine beta synthase affects expression ISO Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccdc137 coiled-coil domain containing 137 increases expression ISO Diclofenac results in increased expression of CCDC137 mRNA CTD PMID:35537566 NCBI chr10:106,229,099...106,235,502
Ensembl chr10:106,229,099...106,235,502 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression 		EXP
ISO 		[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA 		CTD PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 More... NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression 		EXP
ISO 		Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]
Diclofenac results in decreased expression of CCL3 mRNA 		CTD PMID:23939143 PMID:35537566 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877 		JBrowse link
G Ccn1 cellular communication network factor 1 affects expression
increases expression 		ISO Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA 		CTD PMID:19192274 PMID:24752500 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression 		ISO
EXP 		Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein 		CTD PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccnd3 cyclin D3 affects expression ISO Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccne2 cyclin E2 affects expression ISO Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Ccnf cyclin F affects expression ISO Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,758,421...13,783,837 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Ccnh cyclin H affects expression ISO Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146 		JBrowse link
G Cd200r1l CD200 receptor 1-like decreases expression ISO Diclofenac results in decreased expression of CD200R4 mRNA CTD PMID:35537566 NCBI chr11:69,348,638...69,366,916
Ensembl chr11:69,312,691...69,365,041 		JBrowse link
G Cd244 CD244 molecule decreases expression ISO Diclofenac results in decreased expression of CD244 mRNA CTD PMID:35537566 NCBI chr13:86,583,727...86,606,902
Ensembl chr13:86,584,826...86,616,009 		JBrowse link
G Cd28 Cd28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cd44 CD44 molecule increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107 		JBrowse link
G Cd5l Cd5 molecule-like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:175,088,884...175,099,926 		JBrowse link
G Cd9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444 		JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr 1:79,108,036...79,110,550 JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241 		JBrowse link
G Cdc7 cell division cycle 7 affects expression ISO Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr14:2,949,538...2,969,656
Ensembl chr14:2,949,539...2,969,656 		JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr 1:212,807,863...212,821,313
Ensembl chr 1:212,804,014...212,821,309 		JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
decreases expression 		ISO
EXP 		Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA 		CTD PMID:19022234 PMID:19628293 PMID:24752500 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression ISO Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression EXP Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects expression ISO Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP 		Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234 PMID:26934552 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression ISO Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr19:67,529,249...67,534,195
Ensembl chr19:67,529,201...67,534,194 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression 		ISO
EXP 		Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA 		CTD PMID:19022234 PMID:24752500 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression ISO Diclofenac results in decreased expression of CEBPG mRNA CTD PMID:35537566 NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283 		JBrowse link
G Cep162 centrosomal protein 162 decreases expression ISO Diclofenac results in decreased expression of CEP162 mRNA CTD PMID:35537566 NCBI chr 8:97,029,677...97,088,243
Ensembl chr 8:97,029,677...97,088,207 		JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cfap97d1 CFAP97 domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CFAP97D1 mRNA CTD PMID:37844793 NCBI chr10:87,432,559...87,444,711
Ensembl chr10:87,434,008...87,441,577 		JBrowse link
G Cfh complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects expression 		ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA 		CTD PMID:20237495 PMID:24752500 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:31,151,795...31,163,800 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression
decreases expression 		ISO Diclofenac results in increased expression of CHAC1 mRNA
Diclofenac results in decreased expression of CHAC1 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361 		JBrowse link
G Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CHCHD1 mRNA CTD PMID:37844793 NCBI chr15:3,641,973...3,643,155
Ensembl chr15:3,641,981...3,643,155 		JBrowse link
G Chdh choline dehydrogenase affects expression ISO Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr16:5,199,738...5,232,067
Ensembl chr16:5,200,763...5,232,997 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chka choline kinase alpha affects expression ISO Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752 		JBrowse link
G Chkb choline kinase beta affects expression ISO Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr 7:122,380,592...122,385,102
Ensembl chr 7:122,380,594...122,383,949 		JBrowse link
G Chl1 cell adhesion molecule L1-like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:137,847,895...138,062,077 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr19:54,900,914...54,911,735
Ensembl chr19:54,882,719...54,916,648 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP 		Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] 		CTD PMID:15489888 PMID:25935278 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CIB1 mRNA CTD PMID:37844793 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:143,587,021...143,593,326 		JBrowse link
G Clec4a C-type lectin domain family 4, member A increases expression ISO Diclofenac results in increased expression of CLEC4N mRNA CTD PMID:26934552 NCBI chr 4:158,026,138...158,119,904
Ensembl chr 4:158,100,615...158,118,094 		JBrowse link
G Clu clusterin increases expression
multiple interactions 		ISO
EXP 		Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein 		CTD PMID:23506792 PMID:25772430 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 affects expression ISO Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:48,802,321...48,813,652 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions 		ISO
EXP 		Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein] 		CTD PMID:26934552 PMID:31042592 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Coq8a coenzyme Q8A decreases expression ISO Diclofenac results in decreased expression of ADCK3 mRNA CTD PMID:26934552 NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378 		JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr19:64,780,309...64,814,629
Ensembl chr19:64,780,322...64,814,840 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 increases expression ISO Diclofenac results in increased expression of COX4I2 mRNA CTD PMID:35537566 NCBI chr 3:161,686,193...161,699,605
Ensembl chr 3:161,689,017...161,699,602 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO Diclofenac results in decreased expression of COX6A2 mRNA CTD PMID:35537566 NCBI chr 1:192,218,970...192,221,188
Ensembl chr 1:192,218,970...192,219,716 		JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962 		JBrowse link
G Cplx1 complexin 1 increases expression EXP Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr14:1,329,073...1,360,781
Ensembl chr14:1,329,032...1,360,769 		JBrowse link
G Cplx4 complexin 4 increases expression EXP Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:61,751,336...61,774,669
Ensembl chr18:61,750,990...61,767,754 		JBrowse link
G Cpne8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr 7:123,494,864...123,669,060
Ensembl chr 7:123,494,865...123,669,060 		JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 affects expression ISO Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr 7:54,798,452...54,887,711
Ensembl chr 7:54,842,490...54,873,998 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO
EXP 		Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:109,103,235...109,188,869 		JBrowse link
G Cr2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:109,213,867...109,244,552 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:66,387,126...66,990,832 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 affects expression ISO Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:177,987,981...177,993,485 		JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression 		EXP
ISO 		[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein] 		CTD PMID:25772430 PMID:27313093 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression
increases secretion 		ISO Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein 		CTD PMID:26934552 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:111,757,405...111,784,654 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 affects expression ISO Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr19:9,562,340...9,602,136
Ensembl chr19:9,562,321...9,602,136 		JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 increases expression EXP Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 3:70,906,587...71,102,596
Ensembl chr 3:70,906,380...71,094,009 		JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 affects expression ISO Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:101,546,809...101,572,760
Ensembl chr  X:101,546,819...101,572,764 		JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects expression ISO Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr 3:111,421,291...111,492,539
Ensembl chr 3:111,421,234...111,497,046 		JBrowse link
G Ctbp2 C-terminal binding protein 2 affects expression ISO Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr 1:197,208,536...197,348,802
Ensembl chr 1:197,212,133...197,254,261 		JBrowse link
G Cth cystathionine gamma-lyase affects expression
decreases expression 		ISO Diclofenac affects the expression of CTH mRNA
Diclofenac results in decreased expression of CTH mRNA 		CTD PMID:24752500 PMID:35537566 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctps1 CTP synthase 1 affects expression ISO Diclofenac affects the expression of CTPS1 mRNA CTD PMID:24752500 NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:139,410,249...139,440,465 		JBrowse link
G Ctps2 CTP synthase 2 affects expression ISO Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:35,277,658...35,418,505
Ensembl chr  X:35,277,658...35,418,505 		JBrowse link
G Ctsc cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082 		JBrowse link
G Ctse cathepsin E decreases expression ISO Diclofenac results in decreased expression of CTSE mRNA CTD PMID:35537566 NCBI chr13:45,644,168...45,666,722
Ensembl chr13:45,644,147...45,666,722 		JBrowse link
G Ctss cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440 		JBrowse link
G Cul3 cullin 3 affects expression ISO Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427 		JBrowse link
G Cul7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 9:21,816,703...21,830,344
Ensembl chr 9:21,816,703...21,830,344 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23939143 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression 		EXP
ISO 		Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein 		CTD PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
decreases expression 		ISO Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA 		CTD PMID:26934552 PMID:27671914 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr10:91,377,866...91,388,548
Ensembl chr10:91,377,866...91,385,097 		JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP19A1 mRNA CTD PMID:37844793 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity 		ISO Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein 		CTD PMID:18420780 PMID:21784029 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions 		ISO Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac 		CTD PMID:21784029 PMID:23397584 PMID:28960974 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP26B1 mRNA CTD PMID:37844793 NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO [Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of CYP27A1 mRNA; [Sodium Selenite co-treated with Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of CYP27A1 mRNA CTD PMID:38945390 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity
affects expression 		ISO Diclofenac results in decreased activity of CYP2A4 protein
Diclofenac affects the expression of CYP2A4 mRNA 		CTD PMID:18420780 PMID:26934552 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Diclofenac results in decreased expression of CYP2C55 mRNA CTD PMID:26934552 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation
decreases activity
increases response to substance
multiple interactions 		EXP
ISO 		CYP2C6 protein results in increased hydroxylation of Diclofenac
Diclofenac results in decreased activity of CYP2C29 protein
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac 		CTD PMID:11911841 PMID:15486075 PMID:18420780 PMID:18511451 PMID:23397584 More... NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540 NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584 PMID:24246759 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 9:24,727,817...24,804,060
Ensembl chr 9:24,727,817...24,804,060 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
increases expression
multiple interactions
increases response to substance 		ISO Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Diclofenac
Diclofenac results in increased expression of CYP3A4 mRNA
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
CYP3A4 protein results in increased susceptibility to Diclofenac 		CTD PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diclofenac results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19022234 PMID:29027214 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases expression 		ISO Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA 		CTD PMID:26934552 PMID:28960974 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:133,011,989...133,041,971 		JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 decreases expression ISO Diclofenac results in decreased expression of CYP4F39 mRNA CTD PMID:35537566 NCBI chr 7:12,082,821...12,156,076
Ensembl chr 7:12,083,888...12,156,076 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr16:53,650,978...53,675,916
Ensembl chr16:53,650,569...53,676,746 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression 		ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA 		CTD PMID:26934552 PMID:28960974 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression
multiple interactions 		ISO Diclofenac results in increased expression of CYP7A1 mRNA; Diclofenac results in increased expression of CYP7A1 protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of CYP7A1 mRNA; Sodium Selenite inhibits the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of CYP7A1 mRNA] 		CTD PMID:26934552 PMID:38815664 PMID:38945390 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Dap death-associated protein increases expression ISO Diclofenac results in increased expression of DAP mRNA CTD PMID:26934552 NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 affects expression ISO Diclofenac affects the expression of DBT mRNA CTD PMID:24752500 NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:207,166,652...207,195,525 		JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 affects expression ISO Diclofenac affects the expression of DCTPP1 mRNA CTD PMID:24752500 NCBI chr 1:191,307,933...191,311,326
Ensembl chr 1:191,307,935...191,313,405 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases response to substance
decreases expression
increases expression 		ISO
EXP 		DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in decreased expression of DDIT3 mRNA
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein 		CTD PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 More... NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Diclofenac results in increased expression of DDIT4 mRNA CTD PMID:26934552 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 affects expression ISO Diclofenac affects the expression of DDR1 mRNA CTD PMID:24752500 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Diclofenac results in decreased expression of DDT mRNA CTD PMID:26934552 NCBI chr20:12,883,025...12,886,121 JBrowse link
G Ddx5 DEAD-box helicase 5 affects expression ISO Diclofenac affects the expression of DDX5 mRNA CTD PMID:24752500 NCBI chr10:92,224,393...92,231,928
Ensembl chr10:92,224,395...92,231,300 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Diclofenac results in increased expression of DECR1 protein CTD PMID:25772430 NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033 		JBrowse link
G Dennd2d DENN domain containing 2D decreases expression ISO Diclofenac results in decreased expression of DENND2D mRNA CTD PMID:35537566 NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397 		JBrowse link
G Derl1 derlin 1 increases expression ISO Diclofenac results in increased expression of DERL1 mRNA CTD PMID:26934552 NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678 		JBrowse link
G Derl3 derlin 3 increases expression ISO Diclofenac results in increased expression of DERL3 mRNA CTD PMID:26934552 NCBI chr20:12,753,926...12,766,478
Ensembl chr20:12,762,981...12,766,477 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression ISO Diclofenac affects the expression of DFFA mRNA CTD PMID:24752500 NCBI chr 5:164,823,807...164,836,729
Ensembl chr 5:164,823,807...164,836,728 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Diclofenac results in increased expression of DHCR24 mRNA CTD PMID:26934552 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhfr dihydrofolate reductase affects expression ISO Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Dhrs3 dehydrogenase/reductase 3 decreases expression ISO Diclofenac results in decreased expression of DHRS3 mRNA CTD PMID:35537566 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects expression ISO Diclofenac affects the expression of DKK1 mRNA CTD PMID:24752500 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650 		JBrowse link
G Dnaaf2 dynein, axonemal, assembly factor 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of DNAAF2 mRNA CTD PMID:37844793 NCBI chr 6:93,397,157...93,406,323
Ensembl chr 6:93,397,164...93,406,323 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects expression ISO Diclofenac affects the expression of DNAJA1 mRNA CTD PMID:24752500 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 affects expression ISO Diclofenac affects the expression of DNAJA2 mRNA CTD PMID:24752500 NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 affects expression
decreases expression 		ISO Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Diclofenac affects the expression of DNAJB1 mRNA CTD PMID:24752500 NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416 		JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 affects expression ISO Diclofenac affects the expression of DNAJB14 mRNA CTD PMID:24752500 NCBI chr 2:229,032,415...229,075,905
Ensembl chr 2:229,032,286...229,075,922 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 affects expression ISO Diclofenac affects the expression of DNAJB4 mRNA CTD PMID:24752500 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 affects expression ISO Diclofenac affects the expression of DNAJB6 mRNA CTD PMID:24752500 NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005 		JBrowse link
G Dnajb7 DnaJ heat shock protein family (Hsp40) member B7 increases expression EXP Diclofenac results in increased expression of DNAJB7 mRNA CTD PMID:30723492 NCBI chr 7:114,812,886...114,814,200
Ensembl chr 7:114,810,853...114,814,405 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression
increases expression 		ISO Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 affects expression
increases expression 		ISO Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368 		JBrowse link
G Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 affects expression ISO Diclofenac affects the expression of DNAJC11 mRNA CTD PMID:24752500 NCBI chr 5:167,724,776...167,770,032
Ensembl chr 5:167,724,717...167,770,694 		JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression
decreases expression 		ISO Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA 		CTD PMID:26934552 NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251 		JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 affects expression ISO Diclofenac affects the expression of DNAJC15 mRNA CTD PMID:24752500 NCBI chr15:59,594,314...59,658,862
Ensembl chr15:59,594,314...59,658,987 		JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 affects expression ISO Diclofenac affects the expression of DNAJC18 mRNA CTD PMID:24752500 NCBI chr18:27,543,438...27,577,535
Ensembl chr18:27,543,438...27,577,535 		JBrowse link
G Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 affects expression ISO Diclofenac affects the expression of DNAJC21 mRNA CTD PMID:24752500 NCBI chr 2:61,146,669...61,173,908
Ensembl chr 2:61,145,142...61,174,126 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Diclofenac results in increased expression of DNAJC3 mRNA CTD PMID:26934552 NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643 		JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 affects expression ISO Diclofenac affects the expression of DNAJC5 mRNA CTD PMID:24752500 NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:188,999,470...189,034,089 		JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 affects expression ISO Diclofenac affects the expression of DNAJC6 mRNA CTD PMID:24752500 NCBI chr 5:121,232,532...121,398,775
Ensembl chr 5:121,235,425...121,398,775 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 affects expression ISO Diclofenac affects the expression of DNAJC7 mRNA CTD PMID:24752500 NCBI chr10:86,018,977...86,055,419
Ensembl chr10:86,018,961...86,055,489 		JBrowse link
G Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 affects expression ISO Diclofenac affects the expression of DNAJC8 mRNA CTD PMID:24752500 NCBI chr 5:150,029,064...150,047,115
Ensembl chr 5:150,026,286...150,047,117 		JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 affects expression ISO Diclofenac affects the expression of DNAJC9 mRNA CTD PMID:24752500 NCBI chr15:3,970,843...4,003,009
Ensembl chr15:3,970,114...3,977,304 		JBrowse link
G Dnd1 DND microRNA-mediated repression inhibitor 1 increases expression ISO Diclofenac results in increased expression of DND1 mRNA CTD PMID:35537566 NCBI chr18:28,652,712...28,655,336
Ensembl chr18:28,652,712...28,655,336 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Diclofenac results in decreased expression of DNER mRNA CTD PMID:35537566 NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects expression ISO Diclofenac affects the expression of DPYSL2 mRNA CTD PMID:24752500 NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065 		JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Diclofenac results in increased expression of DRD1 mRNA CTD PMID:26934552 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Dtymk deoxythymidylate kinase affects expression ISO Diclofenac affects the expression of DTYMK mRNA CTD PMID:24752500 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression
decreases expression 		ISO Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Diclofenac affects the expression of DUT mRNA CTD PMID:24752500 NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 increases expression EXP Diclofenac results in increased expression of DYNC1I1 mRNA CTD PMID:30723492 NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:34,819,430...35,142,319 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Diclofenac affects the expression of E2F1 mRNA CTD PMID:24752500 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Diclofenac affects the expression of E2F2 mRNA CTD PMID:24752500 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087 		JBrowse link
G E2f5 E2F transcription factor 5 affects expression ISO Diclofenac affects the expression of E2F5 mRNA CTD PMID:24752500 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143 		JBrowse link
G Ebln1l1 endogenous Bornavirus like nucleoprotein 1 like 1 increases expression EXP Diclofenac results in increased expression of IGKV8-24 mRNA CTD PMID:30723492 NCBI chr10:79,435,547...79,437,553 JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Diclofenac results in decreased expression of ECM1 mRNA CTD PMID:26934552 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606 		JBrowse link
G Ect2 epithelial cell transforming 2 increases expression ISO Diclofenac results in increased expression of ECT2 mRNA CTD PMID:26934552 NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:111,904,522...111,966,626 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Diclofenac results in increased expression of EDEM1 mRNA CTD PMID:26934552 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Diclofenac results in decreased expression of EDIL3 mRNA CTD PMID:26934552 NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Edn2 endothelin 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EDN2 mRNA CTD PMID:37844793 NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Diclofenac results in decreased expression of EEF2K mRNA CTD PMID:35537566 NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048 		JBrowse link
G Egf epidermal growth factor increases expression ISO Diclofenac results in increased expression of EGF protein CTD PMID:23506792 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Diclofenac results in increased expression of EGFR mRNA CTD PMID:26934552 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
affects expression 		ISO Diclofenac results in increased expression of EGR1 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA 		CTD PMID:15509713 PMID:26934552 PMID:37844793 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Diclofenac affects the expression of EIF1 mRNA CTD PMID:24752500 NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654 		JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression ISO Diclofenac results in increased expression of EIF1A mRNA CTD PMID:26934552 NCBI chr18:41,512,298...41,524,645
Ensembl chr18:41,503,180...41,549,696 		JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked affects expression ISO Diclofenac affects the expression of EIF1AX mRNA CTD PMID:24752500 NCBI chr  X:39,307,320...39,322,023
Ensembl chr  X:39,307,137...39,322,021 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A affects expression ISO Diclofenac affects the expression of EIF2A mRNA CTD PMID:24752500 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects expression
decreases expression 		ISO Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr12:15,824,431...15,858,266
Ensembl chr12:15,825,124...15,858,281 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity 		ISO Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein 		CTD PMID:24752500 PMID:26609140 PMID:26934552 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Diclofenac affects the expression of EIF2AK4 mRNA CTD PMID:24752500 NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha affects expression ISO Diclofenac affects the expression of EIF2B1 mRNA CTD PMID:24752500 NCBI chr12:37,686,149...37,694,830
Ensembl chr12:37,686,559...37,708,078 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects expression
multiple interactions 		ISO Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein 		CTD PMID:24752500 PMID:27313093 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta affects expression ISO Diclofenac affects the expression of EIF2S2 mRNA CTD PMID:24752500 NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:163,834,851...163,855,570 		JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A affects expression ISO Diclofenac affects the expression of EIF3A mRNA CTD PMID:24752500 NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:269,888,615...269,919,025 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B affects expression ISO Diclofenac affects the expression of EIF3B mRNA CTD PMID:24752500 NCBI chr12:19,310,308...19,334,768
Ensembl chr12:19,310,311...19,334,939 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C affects expression ISO Diclofenac affects the expression of EIF3C mRNA CTD PMID:24752500 NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 affects expression ISO Diclofenac affects the expression of EIF4A1 mRNA CTD PMID:24752500 NCBI chr10:54,883,093...54,888,602
Ensembl chr10:54,883,093...54,888,602 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression ISO Diclofenac affects the expression of EIF4A2 mRNA CTD PMID:24752500 NCBI chr11:91,268,730...91,276,738
Ensembl chr11:91,268,731...91,275,323 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression
decreases expression
affects expression 		EXP
ISO 		Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac results in decreased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA 		CTD PMID:18172885 PMID:24752500 PMID:35537566 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 affects expression ISO Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 NCBI chr11:93,726,322...93,746,387
Ensembl chr11:93,726,322...93,746,367 		JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 affects expression ISO Diclofenac affects the expression of EIF4G3 mRNA CTD PMID:24752500 NCBI chr 5:155,481,378...155,702,194
Ensembl chr 5:155,481,378...155,702,194 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 affects expression ISO Diclofenac affects the expression of EIF5 mRNA CTD PMID:24752500 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 affects expression ISO Diclofenac affects the expression of ELF2 mRNA CTD PMID:24752500 NCBI chr 2:137,445,787...137,536,512
Ensembl chr 2:137,445,788...137,470,355 		JBrowse link
G Elf3 E74 like ETS transcription factor 3 affects expression ISO Diclofenac affects the expression of ELF3 mRNA CTD PMID:24752500 NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects expression ISO Diclofenac affects the expression of ELOVL2 mRNA CTD PMID:24752500 NCBI chr17:23,750,350...23,790,601
Ensembl chr17:23,750,350...23,790,601 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Diclofenac results in increased expression of ELOVL6 mRNA CTD PMID:35537566 NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:220,738,064...220,845,549 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO Diclofenac results in increased expression of EME2 mRNA CTD PMID:26934552 NCBI chr10:14,413,661...14,420,489
Ensembl chr10:14,417,735...14,420,489 		JBrowse link
G Endog endonuclease G affects expression ISO Diclofenac affects the expression of ENDOG mRNA CTD PMID:24752500 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Eno1 enolase 1 increases expression ISO Diclofenac results in increased expression of ENO1 mRNA CTD PMID:26934552 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Diclofenac affects the expression of ENPP1 mRNA CTD PMID:24752500 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Diclofenac results in increased expression of ENPP2 mRNA CTD PMID:26934552 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 affects expression ISO Diclofenac affects the expression of ENTPD4 mRNA CTD PMID:24752500 NCBI chr15:51,040,665...51,068,450
Ensembl chr15:51,040,673...51,068,441 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 affects expression ISO Diclofenac affects the expression of ENTPD5 mRNA CTD PMID:24752500 NCBI chr 6:109,750,210...109,786,376
Ensembl chr 6:109,753,204...109,786,495 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 affects expression ISO Diclofenac affects the expression of ENTPD7 mRNA CTD PMID:24752500 NCBI chr 1:252,508,594...252,550,269
Ensembl chr 1:252,508,594...252,550,269 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Epc2 enhancer of polycomb homolog 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of EPC2 mRNA CTD PMID:37844793 NCBI chr 3:54,276,187...54,376,373
Ensembl chr 3:54,276,239...54,376,916 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Diclofenac results in decreased expression of EPHX1 mRNA CTD PMID:17202759 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Epn2 epsin 2 affects expression ISO Diclofenac affects the expression of EPN2 mRNA CTD PMID:24752500 NCBI chr10:46,697,238...46,759,128
Ensembl chr10:46,697,238...46,759,092 		JBrowse link
G Epn3 epsin 3 affects expression ISO Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 NCBI chr10:79,935,857...79,946,121
Ensembl chr10:79,935,857...79,944,235 		JBrowse link
G Epo erythropoietin affects expression ISO Diclofenac affects the expression of EPO mRNA CTD PMID:24752500 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ERBB4 mRNA CTD PMID:37844793 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Ereg epiregulin increases expression ISO Diclofenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 affects expression ISO Diclofenac affects the expression of ERN1 mRNA CTD PMID:24752500 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Diclofenac results in increased expression of ERO1A mRNA CTD PMID:26934552 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039 		JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO Diclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase decreases expression ISO Diclofenac results in decreased expression of ETNPPL mRNA CTD PMID:26934552 NCBI chr 2:221,847,210...221,868,827
Ensembl chr 2:221,847,250...221,866,357 		JBrowse link
G Evi5 ecotropic viral integration site 5 decreases expression ISO Diclofenac results in decreased expression of EVI5 mRNA CTD PMID:35537566 NCBI chr14:2,020,524...2,166,593
Ensembl chr14:2,020,581...2,166,593 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 decreases expression ISO Diclofenac results in decreased expression of EXTL1 mRNA CTD PMID:35537566 NCBI chr 5:151,857,629...151,872,830
Ensembl chr 5:151,857,629...151,872,830 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Diclofenac results in decreased expression of EYA4 mRNA CTD PMID:26934552 NCBI chr 1:23,991,431...24,235,132
Ensembl chr 1:23,991,431...24,235,131 		JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression ISO Diclofenac results in increased expression of F13A1 mRNA CTD PMID:26934552 NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948 		JBrowse link
G Faap24 FA core complex associated protein 24 increases expression ISO Diclofenac results in increased expression of FAAP24 mRNA CTD PMID:26934552 NCBI chr 1:97,188,678...97,194,899
Ensembl chr 1:97,188,678...97,194,882 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein 		CTD PMID:19022234 PMID:23506792 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP
ISO 		Diclofenac results in decreased expression of FABP2 mRNA CTD PMID:19022234 PMID:26934552 NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686 		JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FABP3 mRNA CTD PMID:37844793 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Diclofenac results in decreased expression of FABP4 mRNA CTD PMID:35537566 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Diclofenac results in increased expression of FABP5 mRNA CTD PMID:26934552 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Diclofenac results in decreased expression of FADS1 mRNA CTD PMID:26934552 NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615 		JBrowse link
G Fam209 family with sequence similarity 209 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FAM209 mRNA CTD PMID:37844793 NCBI chr 3:181,658,479...181,660,164
Ensembl chr 3:181,658,461...181,660,164 		JBrowse link
G Fancb FA complementation group B affects expression ISO Diclofenac affects the expression of FANCB mRNA CTD PMID:24752500 NCBI chr  X:33,035,387...33,051,993
Ensembl chr  X:33,035,387...33,051,808 		JBrowse link
G Fancc FA complementation group C affects expression ISO Diclofenac affects the expression of FANCC mRNA CTD PMID:24752500 NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,687,017...1,835,096 		JBrowse link
G Fance FA complementation group E increases expression ISO Diclofenac results in increased expression of FANCE mRNA CTD PMID:26934552 NCBI chr20:6,371,153...6,388,366
Ensembl chr20:6,377,234...6,388,365 		JBrowse link
G Fancf FA complementation group F affects expression ISO Diclofenac affects the expression of FANCF mRNA CTD PMID:24752500 NCBI chr 1:110,585,054...110,587,870
Ensembl chr 1:110,576,389...110,587,863 		JBrowse link
G Fancg FA complementation group G affects expression ISO Diclofenac affects the expression of FANCG mRNA CTD PMID:24752500 NCBI chr 5:62,027,494...62,037,202
Ensembl chr 5:62,027,500...62,035,787 		JBrowse link
G Fancl FA complementation group L affects expression ISO Diclofenac affects the expression of FANCL mRNA CTD PMID:24752500 NCBI chr14:104,449,403...104,515,297
Ensembl chr14:104,394,590...104,515,297 		JBrowse link
G Fancm FA complementation group M affects expression ISO Diclofenac affects the expression of FANCM mRNA CTD PMID:24752500 NCBI chr 6:88,862,898...88,916,701
Ensembl chr 6:88,863,306...88,921,652 		JBrowse link
G Fas Fas cell surface death receptor affects expression
increases expression 		ISO Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand increases expression ISO Diclofenac results in increased expression of FASL mRNA CTD PMID:22285467 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Diclofenac results in decreased expression of FASN mRNA CTD PMID:19022234 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fastk Fas-activated serine/threonine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTK mRNA CTD PMID:37844793 NCBI chr 4:11,624,697...11,628,769
Ensembl chr 4:11,624,689...11,629,867 		JBrowse link
G Fastkd2 FAST kinase domains 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTKD2 mRNA CTD PMID:37844793 NCBI chr 9:72,659,961...72,681,986
Ensembl chr 9:72,661,764...72,721,338 		JBrowse link
G Fbxo33 F-box protein 33 increases expression ISO Diclofenac results in increased expression of FBXO33 mRNA CTD PMID:35537566 NCBI chr 6:82,635,509...82,669,441
Ensembl chr 6:82,635,521...82,667,440 		JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO Diclofenac results in decreased expression of FBXO5 mRNA CTD PMID:35537566 NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:44,601,412...44,607,781 		JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression ISO Diclofenac results in increased expression of FCER1G mRNA CTD PMID:26934552 NCBI chr13:86,181,908...86,186,766
Ensembl chr13:86,181,908...86,186,859 		JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression ISO Diclofenac results in increased expression of FCGR3 mRNA CTD PMID:26934552 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO Diclofenac results in decreased expression of FCGR2B mRNA CTD PMID:35537566 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Diclofenac results in increased expression of FEN1 mRNA CTD PMID:26934552 NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016 		JBrowse link
G Fer FER tyrosine kinase affects expression ISO Diclofenac affects the expression of FER mRNA CTD PMID:24752500 NCBI chr 9:110,967,317...111,274,315
Ensembl chr 9:110,967,390...111,274,315 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 increases expression EXP Diclofenac results in increased expression of FERMT1 mRNA CTD PMID:30723492 NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:140,624,434...140,666,419 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions
increases expression 		EXP
ISO 		[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA 		CTD PMID:25772430 PMID:26934552 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Diclofenac results in decreased expression of FGF1 mRNA CTD PMID:26934552 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO Diclofenac results in decreased expression of FGF15 mRNA CTD PMID:38815664 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Fgf3 fibroblast growth factor 3 increases expression ISO Diclofenac results in increased expression of FGF3 mRNA CTD PMID:26934552 NCBI chr 1:209,430,457...209,434,832
Ensembl chr 1:209,430,457...209,434,832 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Diclofenac affects the expression of FGFR1 mRNA CTD PMID:24752500 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855 		JBrowse link
G Fgfr1op2 FGFR1 oncogene partner 2 decreases expression ISO Diclofenac results in decreased expression of FGFR1OP2 mRNA CTD PMID:26934552 NCBI chr 4:181,222,298...181,243,318
Ensembl chr 4:181,222,323...181,243,322 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions
decreases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] CTD PMID:25772430 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170 		JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Diclofenac results in increased expression of FGL1 mRNA CTD PMID:26934552 NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429 		JBrowse link
G Fmod fibromodulin decreases expression ISO Diclofenac results in decreased expression of FMOD mRNA CTD PMID:26934552 NCBI chr13:48,045,567...48,056,184
Ensembl chr13:47,990,774...48,056,183 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein CTD PMID:26934552 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fnbp1 formin binding protein 1 affects expression ISO Diclofenac affects the expression of FNBP1 mRNA CTD PMID:24752500 NCBI chr 3:34,706,814...34,826,770
Ensembl chr 3:34,706,814...34,822,117 		JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression ISO Diclofenac results in increased expression of FNDC3B mRNA CTD PMID:26934552 NCBI chr 2:112,240,108...112,546,113
Ensembl chr 2:112,243,202...112,546,306 		JBrowse link
G Fnip1 folliculin interacting protein 1 decreases expression ISO Diclofenac results in decreased expression of FNIP1 mRNA CTD PMID:26934552 NCBI chr10:39,068,432...39,151,552
Ensembl chr10:39,068,445...39,151,552 		JBrowse link
G Fnip2 folliculin interacting protein 2 decreases expression ISO Diclofenac results in decreased expression of FNIP2 mRNA CTD PMID:26934552 NCBI chr 2:166,894,726...167,006,490
Ensembl chr 2:166,897,075...167,006,055 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
affects expression 		ISO Diclofenac results in increased expression of FOS mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA 		CTD PMID:12730611 PMID:24752500 PMID:37844793 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Diclofenac results in increased expression of FOSL2 mRNA CTD PMID:26934552 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406 		JBrowse link
G Foxa1 forkhead box A1 affects expression ISO Diclofenac affects the expression of FOXA1 mRNA CTD PMID:24752500 NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191 		JBrowse link
G Foxa3 forkhead box A3 increases expression ISO Diclofenac results in increased expression of FOXA3 mRNA CTD PMID:26934552 NCBI chr 1:87,790,111...87,800,259
Ensembl chr 1:87,790,012...87,800,953 		JBrowse link
G Foxo1 forkhead box O1 affects expression ISO Diclofenac affects the expression of FOXO1 mRNA CTD PMID:24752500 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Foxo3 forkhead box O3 affects expression
decreases expression 		ISO Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Diclofenac results in increased expression of FPR2 mRNA CTD PMID:26934552 NCBI chr 1:67,449,637...67,458,272
Ensembl chr 1:67,449,637...67,458,272 		JBrowse link
G Frat2 FRAT regulator of WNT signaling pathway 2 decreases expression ISO Diclofenac results in decreased expression of FRAT2 mRNA CTD PMID:35537566 NCBI chr 1:250,603,450...250,605,779
Ensembl chr 1:250,603,088...250,606,921 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 affects expression ISO Diclofenac affects the expression of FRS2 mRNA CTD PMID:24752500 NCBI chr 7:54,597,182...54,678,656
Ensembl chr 7:54,597,182...54,678,774 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase affects expression ISO Diclofenac affects the expression of FTCD mRNA CTD PMID:24752500 NCBI chr20:12,054,710...12,068,219
Ensembl chr20:12,054,711...12,068,237 		JBrowse link
G Fyb1 FYN binding protein 1 increases expression ISO Diclofenac results in increased expression of FYB1 mRNA CTD PMID:26934552 NCBI chr 2:57,360,084...57,508,609
Ensembl chr 2:57,360,096...57,508,608 		JBrowse link
G Fzd3 frizzled class receptor 3 affects expression ISO Diclofenac affects the expression of FZD3 mRNA CTD PMID:24752500 NCBI chr15:43,596,962...43,664,047
Ensembl chr15:43,596,965...43,663,960 		JBrowse link
G Fzd4 frizzled class receptor 4 affects expression ISO Diclofenac affects the expression of FZD4 mRNA CTD PMID:24752500 NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372 		JBrowse link
G Fzd5 frizzled class receptor 5 affects expression ISO Diclofenac affects the expression of FZD5 mRNA CTD PMID:24752500 NCBI chr 9:73,606,860...73,614,039
Ensembl chr 9:73,606,860...73,618,612 		JBrowse link
G Fzd6 frizzled class receptor 6 affects expression ISO Diclofenac affects the expression of FZD6 mRNA CTD PMID:24752500 NCBI chr 7:71,939,916...71,971,685
Ensembl chr 7:71,939,973...71,971,680 		JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO Diclofenac affects the expression of FZD7 mRNA CTD PMID:24752500 NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:68,411,259...68,432,585 		JBrowse link
G Gab1 GRB2-associated binding protein 1 affects expression ISO Diclofenac affects the expression of GAB1 mRNA CTD PMID:24752500 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617 		JBrowse link
G Gab2 GRB2-associated binding protein 2 affects expression ISO Diclofenac affects the expression of GAB2 mRNA CTD PMID:24752500 NCBI chr 1:160,841,066...161,036,940
Ensembl chr 1:160,841,066...161,036,940 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 decreases expression ISO Diclofenac results in decreased expression of GABRA5 mRNA CTD PMID:26934552 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:117,404,494...117,516,635 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases expression
affects expression 		ISO
EXP 		Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA 		CTD PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Diclofenac results in increased expression of GADD45G mRNA CTD PMID:26934552 NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369 		JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression EXP Diclofenac results in increased expression of GALNT3 mRNA CTD PMID:30723492 NCBI chr 3:71,150,559...71,187,321
Ensembl chr 3:71,150,571...71,174,323 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of GAPDH mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of GAPDH mRNA] CTD PMID:38945390 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 affects expression
decreases expression 		ISO Diclofenac affects the expression of GARS1 mRNA
Diclofenac results in decreased expression of GARS1 mRNA 		CTD PMID:24752500 PMID:35537566 NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase affects expression ISO Diclofenac affects the expression of GART mRNA CTD PMID:24752500 NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086 		JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Diclofenac results in decreased expression of GAS1 mRNA CTD PMID:26934552 NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657 		JBrowse link
G Gata4 GATA binding protein 4 affects expression ISO Diclofenac affects the expression of GATA4 mRNA CTD PMID:24752500 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609 		JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Diclofenac results in increased expression of GATA6 mRNA CTD PMID:26934552 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322 		JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Diclofenac results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802 		JBrowse link
G Gbp4 guanylate binding protein 4 increases expression ISO Diclofenac results in increased expression of GBP3 mRNA CTD PMID:26934552 NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120 		JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673 		JBrowse link
G Gck glucokinase affects expression ISO Diclofenac affects the expression of GCK mRNA CTD PMID:26934552 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
affects expression
affects response to substance 		EXP
ISO 		Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac 		CTD PMID:17202759 PMID:19481141 PMID:24752500 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression ISO Diclofenac affects the expression of GCLM mRNA CTD PMID:24752500 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein 		CTD PMID:15555568 PMID:18076062 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gdf6 growth differentiation factor 6 increases expression EXP Diclofenac results in increased expression of GDF6 mRNA CTD PMID:30723492 NCBI chr 5:27,793,561...27,809,884
Ensembl chr 5:27,793,552...27,811,825 		JBrowse link
G Gdf9 growth differentiation factor 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of GDF9 mRNA CTD PMID:37844793 NCBI chr10:38,090,021...38,100,801
Ensembl chr10:38,089,878...38,100,797 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 increases expression ISO Diclofenac results in increased expression of GFPT1 mRNA CTD PMID:26934552 NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein CTD PMID:23939143 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Ghr growth hormone receptor affects expression ISO Diclofenac affects the expression of GHR protein CTD PMID:26934552 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Git2 GIT ArfGAP 2 affects expression ISO Diclofenac affects the expression of GIT2 mRNA CTD PMID:24752500 NCBI chr12:47,490,350...47,531,232
Ensembl chr12:47,490,369...47,533,250 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Diclofenac results in increased expression of GJA1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gja3 gap junction protein, alpha 3 increases expression ISO Diclofenac results in increased expression of GJA3 mRNA CTD PMID:26934552 NCBI chr15:35,296,946...35,322,405
Ensembl chr15:35,295,523...35,322,809 		JBrowse link
G Gldc glycine decarboxylase affects expression ISO Diclofenac affects the expression of GLDC mRNA CTD PMID:24752500 NCBI chr 1:237,296,753...237,375,620
Ensembl chr 1:237,296,753...237,375,604 		JBrowse link
G Glyctk glycerate kinase affects expression ISO Diclofenac affects the expression of GLYCTK mRNA CTD PMID:24752500 NCBI chr 8:115,676,071...115,681,403
Ensembl chr 8:115,676,072...115,681,091 		JBrowse link
G Gna13 G protein subunit alpha 13 affects expression ISO Diclofenac affects the expression of GNA13 mRNA CTD PMID:24752500 NCBI chr10:94,837,271...94,870,290
Ensembl chr10:94,836,444...94,874,968 		JBrowse link
G Gnaq G protein subunit alpha q affects expression ISO Diclofenac affects the expression of GNAQ mRNA CTD PMID:24752500 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742 		JBrowse link
G Gnas GNAS complex locus affects expression ISO Diclofenac affects the expression of GNAS mRNA CTD PMID:24752500 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Gnat1 G protein subunit alpha transducin 1 increases expression ISO Diclofenac results in increased expression of GNAT1 mRNA CTD PMID:26934552 NCBI chr 8:117,229,575...117,234,311
Ensembl chr 8:117,229,575...117,234,311 		JBrowse link
G Gnb5 G protein subunit beta 5 affects expression ISO Diclofenac affects the expression of GNB5 mRNA CTD PMID:24752500 NCBI chr 8:84,956,629...84,985,576
Ensembl chr 8:84,953,815...84,986,888 		JBrowse link
G Gng4 G protein subunit gamma 4 affects expression ISO Diclofenac affects the expression of GNG4 mRNA CTD PMID:24752500 NCBI chr17:93,432,791...93,481,709
Ensembl chr17:93,433,195...93,481,709 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression
increases secretion 		ISO Diclofenac affects the expression of GOT1 mRNA
Diclofenac results in increased secretion of GOT1 protein 		CTD PMID:24752500 PMID:36442613 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] CTD PMID:25772430 NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Diclofenac affects the expression of GPLD1 mRNA CTD PMID:24752500 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975 		JBrowse link
G Gpr176 G protein-coupled receptor 176 decreases expression ISO Diclofenac results in decreased expression of GPR176 mRNA CTD PMID:35537566 NCBI chr 3:125,690,750...125,791,172
Ensembl chr 3:125,690,751...125,791,172 		JBrowse link
G Gpr20 G protein-coupled receptor 20 decreases expression EXP Diclofenac results in decreased expression of GPR20 mRNA CTD PMID:30723492 NCBI chr 7:107,490,419...107,500,993
Ensembl chr 7:107,490,713...107,500,966 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases secretion
increases expression
increases activity 		EXP
ISO 		[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased secretion of GPT protein
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of GPT protein; eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]; Sodium Selenite inhibits the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of GPT protein] 		CTD PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 More... NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Diclofenac results in decreased expression of GPT2 mRNA CTD PMID:35537566 NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions 		EXP
ISO 		Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of GPX1 mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of GPX1 mRNA] 		CTD PMID:25772430 PMID:29027214 PMID:38945390 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO Diclofenac affects the expression of GPX2 mRNA CTD PMID:24752500 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of GPX3 mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of GPX3 mRNA] CTD PMID:38945390 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Sodium Selenite co-treated with Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of GPX4 mRNA CTD PMID:38945390 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Grb10 growth factor receptor bound protein 10 affects expression ISO Diclofenac affects the expression of GRB10 mRNA CTD PMID:24752500 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of GRID2 mRNA CTD PMID:37844793 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:93,745,277...95,219,868 		JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases expression ISO Diclofenac results in increased expression of GRM7 mRNA CTD PMID:26934552 NCBI chr 4:145,286,714...146,169,099
Ensembl chr 4:145,286,924...146,169,201 		JBrowse link
G Gsdmd gasdermin D increases cleavage
multiple interactions 		EXP Diclofenac results in increased cleavage of GSDMD protein
diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein] 		CTD PMID:38582345 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression ISO Diclofenac affects the expression of GSK3B mRNA CTD PMID:24752500 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsn gelsolin decreases expression ISO Diclofenac results in decreased expression of GSN mRNA CTD PMID:26934552 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Diclofenac results in decreased activity of GSTA1 protein CTD PMID:27183920 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases activity
decreases expression 		ISO Diclofenac results in decreased activity of GSTA4 protein
Diclofenac results in decreased expression of GSTA4 mRNA 		CTD PMID:26934552 PMID:27183920 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
Diclofenac results in increased expression of GSTA5 protein 		CTD PMID:25772430 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
decreases expression 		ISO Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA 		CTD PMID:26934552 PMID:27183920 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity ISO Diclofenac results in decreased activity of GSTM2 protein CTD PMID:27183920 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects activity ISO Diclofenac affects the activity of GSTM4 protein CTD PMID:27183920 NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Diclofenac results in increased expression of GSTM3 mRNA CTD PMID:26934552 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
affects activity
affects metabolic processing 		ISO [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite 		CTD PMID:24185126 PMID:24246759 PMID:27183920 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression
affects activity 		ISO Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein 		CTD PMID:24752500 PMID:27183920 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 affects expression ISO Diclofenac affects the expression of GTF2H4 mRNA CTD PMID:24752500 NCBI chr20:3,076,110...3,081,805
Ensembl chr20:3,076,088...3,081,760 		JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression ISO Diclofenac affects the expression of GTF2H5 mRNA CTD PMID:24752500 NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:49,061,959...49,070,039 		JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Diclofenac results in decreased expression of GTPBP2 mRNA CTD PMID:35537566 NCBI chr 9:22,311,532...22,321,405
Ensembl chr 9:22,311,158...22,321,441 		JBrowse link
G Gucy2g guanylate cyclase 2G increases expression EXP Diclofenac results in increased expression of GUCY2G mRNA CTD PMID:30723492 NCBI chr 1:264,241,830...264,285,615
Ensembl chr 1:264,244,515...264,285,615 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hamp hepcidin antimicrobial peptide affects expression
decreases secretion 		ISO Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein 		CTD PMID:24038040 PMID:26934552 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Hat1 histone acetyltransferase 1 affects expression ISO Diclofenac affects the expression of HAT1 mRNA CTD PMID:24752500 NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
increases secretion 		ISO
EXP 		Diclofenac results in increased expression of HAVCR1 mRNA
diacerein inhibits the reaction [Diclofenac results in increased secretion of HAVCR1 protein] 		CTD PMID:23506792 PMID:38582345 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Diclofenac results in increased expression of HBA-A2 protein CTD PMID:14565772 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141 		JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Diclofenac results in increased expression of HBB protein CTD PMID:14565772 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects expression
decreases expression
increases expression 		ISO Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in decreased expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA 		CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases expression ISO Diclofenac results in increased expression of HCK mRNA CTD PMID:26934552 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935 		JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA 		CTD PMID:19192274 PMID:26934552 NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 affects expression
decreases expression 		ISO Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA 		CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression ISO Diclofenac results in decreased expression of HES6 mRNA CTD PMID:26934552 NCBI chr 9:99,449,375...99,451,343
Ensembl chr 9:99,449,371...99,451,096 		JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression ISO Diclofenac results in decreased expression of HHEX mRNA CTD PMID:26934552 NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Diclofenac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO Diclofenac results in decreased expression of H2BC21 mRNA CTD PMID:26934552 NCBI chr17:47,488,627...47,489,008 JBrowse link
G Hk1 hexokinase 1 increases expression ISO Diclofenac results in increased expression of HK1 mRNA CTD PMID:26934552 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
affects expression 		EXP
ISO 		Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA 		CTD PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of HMGCR mRNA; Sodium Selenite inhibits the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of HMGCR mRNA] CTD PMID:38945390 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Diclofenac results in decreased expression of HMGCS2 mRNA CTD PMID:26934552 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
affects expression 		ISO
EXP 		1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in decreased expression of HMOX1 protein
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of HMOX1 mRNA; [Sodium Selenite co-treated with Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; diacerein inhibits the reaction [Diclofenac results in decreased expression of HMOX1 protein]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein 		CTD PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO Diclofenac results in decreased expression of HMX3 mRNA CTD PMID:35537566 NCBI chr 1:195,743,411...195,745,375
Ensembl chr 1:195,743,271...195,746,444 		JBrowse link
G Hnf1a HNF1 homeobox A affects expression ISO Diclofenac affects the expression of HNF1A mRNA CTD PMID:24752500 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Diclofenac results in decreased expression of HNF4A mRNA CTD PMID:19022234 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression ISO Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066 		JBrowse link
G Hoatz HOATZ cilia and flagella associated protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HOATZ mRNA CTD PMID:37844793 NCBI chr 8:60,284,745...60,306,687
Ensembl chr 8:60,283,904...60,305,377 		JBrowse link
G Hp haptoglobin decreases expression
increases expression 		ISO Diclofenac results in decreased expression of HP mRNA
Diclofenac results in increased expression of HP mRNA 		CTD PMID:26934552 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
multiple interactions
increases expression 		ISO Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA 		CTD PMID:19501039 PMID:25526675 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of HRAS mRNA CTD PMID:24752500 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 decreases expression ISO Diclofenac results in decreased expression of HS3ST3B1 mRNA CTD PMID:35537566 NCBI chr10:49,060,693...49,093,185
Ensembl chr10:49,060,693...49,093,185 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Diclofenac results in increased expression of HS6ST2 mRNA CTD PMID:26934552 NCBI chr  X:135,887,224...136,182,388
Ensembl chr  X:135,888,472...136,182,353 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Diclofenac results in decreased expression of HSD3B2 mRNA CTD PMID:26934552 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Diclofenac results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] CTD PMID:23939143 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
affects expression 		EXP
ISO 		Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1A mRNA
Diclofenac results in increased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA 		CTD PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 PMID:37844793 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression
multiple interactions 		ISO Diclofenac results in increased expression of HSPA1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1B mRNA 		CTD PMID:26934552 PMID:37844793 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		EXP
ISO 		Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein 		CTD PMID:25014874 PMID:25772430 PMID:27313093 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression 		EXP
ISO 		Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA 		CTD PMID:23939143 PMID:26934552 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Diclofenac results in decreased expression of HSPB1 mRNA CTD PMID:26934552 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Diclofenac results in increased expression of HSPB8 mRNA CTD PMID:26934552 NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of IARS1 mRNA CTD PMID:35537566 NCBI chr17:15,147,357...15,193,716
Ensembl chr17:15,147,357...15,193,652 		JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase increases expression ISO Diclofenac results in increased expression of IBTK mRNA CTD PMID:26934552 NCBI chr 8:95,505,630...95,579,435
Ensembl chr 8:95,505,630...95,578,301 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
increases expression
affects expression 		EXP
ISO 		Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA 		CTD PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Diclofenac results in increased expression of ID2 mRNA CTD PMID:26934552 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Diclofenac results in increased expression of ID3 mRNA CTD PMID:26934552 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO Diclofenac results in increased expression of IER3 mRNA CTD PMID:26934552 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Diclofenac results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781 		JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Diclofenac results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Diclofenac results in decreased expression of IFI44 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877 		JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Diclofenac results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Diclofenac results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Diclofenac results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521 		JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Diclofenac results in increased expression of IFITM2 mRNA CTD PMID:26934552 NCBI chr 1:205,481,168...205,482,348 JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression ISO Diclofenac results in increased expression of IFITM3 mRNA CTD PMID:26934552 NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression 		EXP
ISO 		3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA 		CTD PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Diclofenac results in decreased expression of IFRD1 mRNA CTD PMID:35537566 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression ISO Diclofenac affects the expression of IGF1R mRNA CTD PMID:24752500 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA CTD PMID:37844793 NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 affects expression
increases expression 		ISO Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Diclofenac results in decreased expression of IGFBP2 mRNA CTD PMID:26934552 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Diclofenac affects the expression of IGFBP3 mRNA CTD PMID:24752500 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] CTD PMID:25935278 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Diclofenac results in increased expression of IKBKE mRNA CTD PMID:26934552 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression ISO Diclofenac affects the expression of IKBKG mRNA CTD PMID:24752500 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il10 interleukin 10 increases response to substance
multiple interactions 		ISO
EXP 		IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein] 		CTD PMID:15122773 PMID:23939143 PMID:31042592 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression EXP Diclofenac results in increased expression of IL12RB1 mRNA CTD PMID:30723492 NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,654,207...18,666,824 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Diclofenac results in increased expression of IL13RA1 mRNA CTD PMID:26934552 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Il16 interleukin 16 decreases expression ISO Diclofenac results in decreased expression of IL16 mRNA CTD PMID:35537566 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023 		JBrowse link
G Il17a interleukin 17A increases expression
multiple interactions 		ISO
EXP 		Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein] 		CTD PMID:22285467 PMID:25450234 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression 		EXP diacerein inhibits the reaction [Diclofenac results in increased expression of IL18 protein] CTD PMID:38582345 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il18bp interleukin 18 binding protein increases expression ISO Diclofenac results in increased expression of IL18BP mRNA CTD PMID:26934552 NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:165,784,069...165,786,955 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression 		ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of IL1A mRNA 		CTD PMID:19362101 PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO
EXP 		Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; diacerein inhibits the reaction [Diclofenac results in increased expression of IL1B protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] 		CTD PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 affects expression
increases expression 		ISO Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO
EXP 		Diclofenac results in increased expression of IL1R2 mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
decreases expression
increases secretion
multiple interactions 		ISO Diclofenac results in increased expression of IL1RN mRNA
Diclofenac results in decreased expression of IL1RN mRNA
Diclofenac results in increased secretion of IL1RN protein
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein] 		CTD PMID:9491209 PMID:26934552 PMID:35537566 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Diclofenac results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il24 interleukin 24 increases expression ISO Diclofenac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Diclofenac results in increased expression of IL2RG mRNA CTD PMID:26934552 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161 		JBrowse link
G Il33 interleukin 33 increases expression
decreases expression 		ISO Diclofenac results in increased expression of IL33 mRNA
Diclofenac results in decreased expression of IL33 mRNA 		CTD PMID:26934552 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Il4 interleukin 4 increases response to substance ISO IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] CTD PMID:15663561 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression 		ISO
EXP 		[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein] 		CTD PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Diclofenac affects the expression of IMMT mRNA CTD PMID:26934552 NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:105,438,712...105,477,368 		JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO
EXP 		Diclofenac results in increased expression of INHBB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609 		JBrowse link
G Inka2 inka box actin regulator 2 increases expression ISO Diclofenac results in increased expression of INKA2 mRNA CTD PMID:35537566 NCBI chr 2:195,873,617...195,888,983
Ensembl chr 2:195,873,497...195,893,605 		JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO Diclofenac results in decreased expression of INMT mRNA CTD PMID:26934552 NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755 		JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL3 mRNA CTD PMID:37844793 NCBI chr16:18,432,668...18,434,539 JBrowse link
G Insl6 insulin-like 6 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL6 mRNA CTD PMID:37844793 NCBI chr 1:236,483,530...236,487,065
Ensembl chr 1:236,483,530...236,487,065 		JBrowse link
G Insr insulin receptor affects expression ISO Diclofenac affects the expression of INSR mRNA CTD PMID:24752500 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Iqcf1 IQ motif containing F1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of IQCF1 mRNA CTD PMID:37844793 NCBI chr 8:116,008,081...116,011,950
Ensembl chr 8:116,009,452...116,011,949 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO Diclofenac results in increased expression of IRAK4 mRNA CTD PMID:26934552 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Diclofenac results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Irgm immunity-related GTPase M increases expression ISO Diclofenac results in increased expression of IRGM1 mRNA CTD PMID:26934552 NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,732,961...33,743,228 		JBrowse link
G Irs1 insulin receptor substrate 1 affects expression ISO Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 PMID:26934552 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Diclofenac results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Diclofenac results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Diclofenac results in increased expression of ISYNA1 mRNA CTD PMID:26934552 NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,873,121...18,875,955 		JBrowse link
G Itga2 integrin subunit alpha 2 affects expression ISO Diclofenac affects the expression of ITGA2 mRNA CTD PMID:24752500 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itgal integrin subunit alpha L increases expression ISO Diclofenac results in increased expression of ITGAL mRNA CTD PMID:26934552 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Diclofenac results in increased expression of ITGAM mRNA CTD PMID:27671914 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Diclofenac results in decreased expression of ITGAX mRNA CTD PMID:35537566 NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151 		JBrowse link
G Itgb1 integrin subunit beta 1 affects expression ISO Diclofenac affects the expression of ITGB1 mRNA CTD PMID:24752500 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Diclofenac results in increased expression of ITGB2 mRNA CTD PMID:26934552 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] CTD PMID:19691487 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression ISO Diclofenac results in increased expression of ITIH3 mRNA CTD PMID:26934552 NCBI chr16:6,108,378...6,123,609
Ensembl chr16:6,108,382...6,123,374 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression ISO Diclofenac results in increased expression of ITIH4 mRNA CTD PMID:26934552 NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160 		JBrowse link
G Itm2a integral membrane protein 2A increases expression ISO Diclofenac results in increased expression of ITM2A mRNA CTD PMID:17379860 NCBI chr  X:76,559,183...76,565,144
Ensembl chr  X:76,559,181...76,565,437 		JBrowse link
G Jade2 jade family PHD finger 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE2 mRNA CTD PMID:37844793 NCBI chr10:36,576,187...36,625,129
Ensembl chr10:36,576,187...36,623,532 		JBrowse link
G Jade3 jade family PHD finger 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE3 mRNA CTD PMID:37844793 NCBI chr  X:4,222,369...4,424,164
Ensembl chr  X:4,223,425...4,398,627 		JBrowse link
G Jdp2 Jun dimerization protein 2 decreases expression ISO Diclofenac results in decreased expression of JDP2 mRNA CTD PMID:35537566 NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:110,992,806...111,033,392 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression 		ISO Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of JUNB mRNA CTD PMID:37844793 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP 		Diclofenac results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148 		JBrowse link
G Kat6b lysine acetyltransferase 6B affects expression ISO Diclofenac affects the expression of KAT6B mRNA CTD PMID:24752500 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343 		JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 increases expression EXP Diclofenac results in increased expression of KBTBD11 mRNA CTD PMID:30723492 NCBI chr16:81,318,596...81,340,334
Ensembl chr16:81,313,093...81,340,390 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression EXP Diclofenac results in increased expression of KHDC3 mRNA CTD PMID:30723492 NCBI chr 8:82,722,980...82,724,884
Ensembl chr 8:82,722,980...82,724,884 		JBrowse link
G Kif5c kinesin family member 5C increases expression EXP Diclofenac results in increased expression of KIF5C mRNA CTD PMID:30723492 NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of KIT mRNA CTD PMID:37844793 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812 		JBrowse link
G Klf4 KLF transcription factor 4 decreases expression ISO Diclofenac results in decreased expression of KLF4 mRNA CTD PMID:35537566 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592 		JBrowse link
G Klhl33 kelch-like family member 33 decreases expression ISO Diclofenac results in decreased expression of KLHL33 mRNA CTD PMID:35537566 NCBI chr15:26,579,473...26,589,766
Ensembl chr15:26,580,639...26,590,387 		JBrowse link
G Klk1 kallikrein 1 increases expression ISO Diclofenac results in increased expression of KLK1 protein CTD PMID:23506792 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:103,779,164...103,783,270 		JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 increases expression EXP Diclofenac results in increased expression of KNDC1 mRNA CTD PMID:30723492 NCBI chr 1:204,119,597...204,167,967
Ensembl chr 1:204,119,659...204,167,965 		JBrowse link
G Kng1 kininogen 1 increases expression
multiple interactions 		EXP Diclofenac results in increased expression of KNG1 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein] 		CTD PMID:25772430 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148 		JBrowse link
G Kras KRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 decreases expression ISO Diclofenac results in decreased expression of LAX1 mRNA CTD PMID:26934552 NCBI chr13:47,686,840...47,697,396
Ensembl chr13:47,686,849...47,697,460 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression
decreases expression
affects expression 		ISO Diclofenac results in increased expression of LBP protein
Diclofenac results in decreased expression of LBP mRNA
Diclofenac affects the expression of LBP mRNA 		CTD PMID:26934552 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lcn2 lipocalin 2 increases expression
increases secretion
multiple interactions 		EXP
ISO 		Diclofenac results in increased expression of LCN2 mRNA
Diclofenac results in increased secretion of LCN2 protein
diacerein inhibits the reaction [Diclofenac results in increased secretion of LCN2 protein]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA] 		CTD PMID:23939143 PMID:26934552 PMID:38582345 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Diclofenac results in increased expression of LCP2 mRNA CTD PMID:26934552 NCBI chr10:19,146,846...19,193,750
Ensembl chr10:19,146,554...19,193,744 		JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Diclofenac results in increased expression of LDHA protein CTD PMID:25772430 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 increases expression ISO Diclofenac results in increased expression of LEAP2 mRNA CTD PMID:26934552 NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073 		JBrowse link
G Lepr leptin receptor affects expression
increases expression 		ISO Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein 		CTD PMID:26934552 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lgals3 galectin 3 increases expression ISO Diclofenac results in increased expression of LGALS3 mRNA CTD PMID:26934552 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Lgmn legumain increases expression ISO Diclofenac results in increased expression of LGMN mRNA CTD PMID:26934552 NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328 		JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 increases expression ISO Diclofenac results in increased expression of LGR4 mRNA CTD PMID:35537566 NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:116,901,968...117,004,153 		JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Diclofenac results in decreased expression of LHX2 mRNA CTD PMID:35537566 NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:42,535,744...42,553,645 		JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO Diclofenac results in decreased expression of LIFR mRNA CTD PMID:26934552 NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364 		JBrowse link
G Lipc lipase C, hepatic type decreases expression ISO Diclofenac results in decreased expression of LIPC mRNA CTD PMID:26934552 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression ISO Diclofenac results in increased expression of LITAF mRNA CTD PMID:26934552 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930 		JBrowse link
G Lmnb1 lamin B1 increases expression ISO Diclofenac results in increased expression of LMNB1 mRNA CTD PMID:35537566 NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283 		JBrowse link
G Lmo4 LIM domain only 4 decreases expression ISO Diclofenac results in decreased expression of LMO4 mRNA CTD PMID:35537566 NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:235,924,403...235,941,275 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Diclofenac results in decreased expression of LPAR4 mRNA CTD PMID:26934552 NCBI chr  X:76,106,319...76,119,807
Ensembl chr  X:76,106,071...76,119,808 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Diclofenac results in increased expression of LPL mRNA CTD PMID:26934552 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Diclofenac results in increased expression of LRG1 mRNA CTD PMID:26934552 NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337 		JBrowse link
G Lrp8 LDL receptor related protein 8 increases expression ISO Diclofenac results in increased expression of LRP8 mRNA CTD PMID:35537566 NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:127,792,299...127,864,207 		JBrowse link
G Ltc4s leukotriene C4 synthase increases expression EXP Diclofenac results in increased expression of LTC4S mRNA CTD PMID:30723492 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Lxn latexin increases expression ISO Diclofenac results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:154,037,604...154,043,473
Ensembl chr 2:154,037,292...154,043,488 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression
increases expression 		ISO Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA 		CTD PMID:19192274 PMID:26934552 NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443 		JBrowse link
G Ly75 lymphocyte antigen 75 increases expression ISO Diclofenac results in increased expression of LY75 mRNA CTD PMID:26934552 NCBI chr 3:65,173,395...65,260,878
Ensembl chr 3:65,173,395...65,260,878 		JBrowse link
G Lyz2 lysozyme 2 increases expression ISO Diclofenac results in increased expression of LYZ2 mRNA CTD PMID:26934552 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 affects expression ISO Diclofenac affects the expression of MAGI1 mRNA CTD PMID:24752500 NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833 		JBrowse link
G Malsu1 mitochondrial assembly of ribosomal large subunit 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MALSU1 mRNA CTD PMID:37844793 NCBI chr 4:79,381,963...79,390,786
Ensembl chr 4:79,374,393...79,411,608 		JBrowse link
G Maoa monoamine oxidase A affects expression ISO Diclofenac affects the expression of MAOA mRNA CTD PMID:24752500 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Maob monoamine oxidase B affects expression ISO Diclofenac affects the expression of MAOB mRNA CTD PMID:24752500 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects expression ISO Diclofenac affects the expression of MAP2K3 mRNA CTD PMID:24752500 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 affects expression ISO Diclofenac affects the expression of MAP2K5 mRNA CTD PMID:24752500 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 affects expression ISO Diclofenac affects the expression of MAP2K6 mRNA CTD PMID:24752500 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Diclofenac results in increased expression of MAP3K1 mRNA CTD PMID:26934552 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP Diclofenac results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects expression ISO Diclofenac affects the expression of MAP3K7 mRNA CTD PMID:24752500 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 affects expression ISO Diclofenac affects the expression of MAP4K4 mRNA CTD PMID:24752500 NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:49,696,700...49,822,353 		JBrowse link
G Map7d1 MAP7 domain containing 1 increases expression ISO Diclofenac results in increased expression of MAP7D1 mRNA CTD PMID:26934552 NCBI chr 5:143,812,467...143,837,597
Ensembl chr 5:143,811,924...143,837,021 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]
Diclofenac analog results in increased phosphorylation of MAPK1 protein; Diclofenac results in increased phosphorylation of MAPK1 protein 		CTD PMID:24104198 PMID:26609140 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression ISO Diclofenac affects the expression of MAPK13 mRNA CTD PMID:24752500 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression ISO Diclofenac affects the expression of MAPK14 mRNA CTD PMID:24752500 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]
Diclofenac analog results in increased phosphorylation of MAPK3 protein; Diclofenac results in increased phosphorylation of MAPK3 protein 		CTD PMID:24104198 PMID:26609140 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects expression ISO Diclofenac affects the expression of MAPK8 mRNA CTD PMID:24752500 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Diclofenac results in increased expression of MAPK8IP3 mRNA CTD PMID:26934552 NCBI chr10:14,422,936...14,463,387
Ensembl chr10:14,422,936...14,462,812 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Diclofenac results in increased expression of MAPKAPK3 mRNA CTD PMID:26934552 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228 		JBrowse link
G Marchf1 membrane associated ring-CH-type finger 1 increases expression ISO Diclofenac results in increased expression of MARCHF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr16:28,022,159...28,880,872
Ensembl chr16:28,022,159...28,881,054 		JBrowse link
G Marco macrophage receptor with collagenous structure increases expression
decreases expression 		ISO Diclofenac results in increased expression of MARCO mRNA
Diclofenac results in decreased expression of MARCO mRNA 		CTD PMID:26934552 NCBI chr13:34,169,011...34,210,340
Ensembl chr13:34,169,011...34,201,255 		JBrowse link
G Mastl microtubule associated serine/threonine kinase-like decreases expression ISO Diclofenac results in decreased expression of MASTL mRNA CTD PMID:26934552 PMID:35537566 NCBI chr17:90,158,592...90,195,550
Ensembl chr17:90,160,068...90,195,564 		JBrowse link
G Mbl1 mannose binding lectin 1 increases expression ISO Diclofenac results in increased expression of MBL1 mRNA CTD PMID:26934552 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,060,703...17,069,271 		JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression ISO Diclofenac results in decreased expression of MCAM mRNA CTD PMID:35537566 NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:53,376,197...53,384,406 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 affects expression ISO Diclofenac affects the expression of MCM7 mRNA CTD PMID:24752500 NCBI chr12:22,155,921...22,163,320
Ensembl chr12:22,155,921...22,163,771 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression EXP Diclofenac results in increased expression of MCTP1 mRNA CTD PMID:30723492 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression EXP Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mecom MDS1 and EVI1 complex locus decreases expression ISO Diclofenac results in decreased expression of MECOM mRNA CTD PMID:26934552 NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:114,837,840...115,393,038 		JBrowse link
G Med10 mediator complex subunit 10 affects expression ISO Diclofenac affects the expression of MED10 mRNA CTD PMID:24752500 NCBI chr 1:35,298,494...35,310,163
Ensembl chr 1:35,298,495...35,304,154 		JBrowse link
G Med13 mediator complex subunit 13 affects expression ISO Diclofenac affects the expression of MED13 mRNA CTD PMID:24752500 NCBI chr10:71,584,354...71,674,614
Ensembl chr10:71,584,354...71,673,901 		JBrowse link
G Med13l mediator complex subunit 13L affects expression ISO Diclofenac affects the expression of MED13L mRNA CTD PMID:24752500 NCBI chr12:43,468,556...43,665,819
Ensembl chr12:43,468,556...43,665,819 		JBrowse link
G Med14 mediator complex subunit 14 affects expression ISO Diclofenac affects the expression of MED14 mRNA CTD PMID:24752500 NCBI chr  X:12,709,406...12,800,642
Ensembl chr  X:12,709,472...12,800,640 		JBrowse link
G Med17 mediator complex subunit 17 affects expression ISO Diclofenac affects the expression of MED17 mRNA CTD PMID:24752500 NCBI chr 8:20,382,995...20,401,993
Ensembl chr 8:20,382,995...20,401,993 		JBrowse link
G Med30 mediator complex subunit 30 affects expression ISO Diclofenac affects the expression of MED30 mRNA CTD PMID:24752500 NCBI chr 7:85,894,638...85,916,373
Ensembl chr 7:85,894,605...85,917,973 		JBrowse link
G Med31 mediator complex subunit 31 affects expression ISO Diclofenac affects the expression of MED31 mRNA CTD PMID:24752500 NCBI chr10:57,335,507...57,338,889
Ensembl chr10:57,335,507...57,338,889 		JBrowse link
G Med6 mediator complex subunit 6 affects expression ISO Diclofenac affects the expression of MED6 mRNA CTD PMID:24752500 NCBI chr 6:107,001,664...107,015,130
Ensembl chr 6:106,990,116...107,015,130 		JBrowse link
G Mef2a myocyte enhancer factor 2a affects expression ISO Diclofenac affects the expression of MEF2A mRNA CTD PMID:24752500 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162 		JBrowse link
G Meig1 meiosis/spermiogenesis associated 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MEIG1 mRNA CTD PMID:37844793 NCBI chr17:79,718,630...79,737,604
Ensembl chr17:79,723,811...79,737,533 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression
increases expression 		ISO Diclofenac results in decreased expression of MET mRNA
Diclofenac results in increased expression of MET mRNA 		CTD PMID:19192274 PMID:32816093 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mfn1 mitofusin 1 decreases expression
multiple interactions 		EXP Diclofenac results in decreased expression of MFN1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein] 		CTD PMID:27792760 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions 		EXP Diclofenac results in decreased expression of MFN2 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein] 		CTD PMID:27792760 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression ISO Diclofenac results in increased expression of MFSD2A mRNA CTD PMID:35537566 NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916 		JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Diclofenac results in decreased expression of MGLL mRNA CTD PMID:26934552 NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Diclofenac results in increased expression of MGMT mRNA CTD PMID:35537566 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Mir122 microRNA 122 increases expression ISO
EXP 		Diclofenac results in increased expression of MIR122
Diclofenac results in increased expression of MIR122 mRNA 		CTD PMID:25527335 PMID:30925002 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Mir192 microRNA 192 increases expression EXP Diclofenac results in increased expression of MIR192 mRNA CTD PMID:30925002 NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:212,994,209...212,994,318 		JBrowse link
G Mirlet7d microRNA let-7d decreases expression EXP Diclofenac results in decreased expression of MIRLET7D mRNA CTD PMID:30723492 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,322,260...16,322,357 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of MKNK2 mRNA CTD PMID:24752500 NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,690,421...9,701,529 		JBrowse link
G Mkrn2 makorin, ring finger protein, 2 decreases expression ISO Diclofenac results in decreased expression of MKRN2 mRNA CTD PMID:35537566 NCBI chr 4:150,334,164...150,352,271
Ensembl chr 4:150,334,142...150,352,263 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Diclofenac results in decreased expression of MME mRNA CTD PMID:26934552 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Diclofenac results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478 		JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO Diclofenac results in increased expression of MMP16 mRNA CTD PMID:26934552 NCBI chr 5:36,109,265...36,353,252
Ensembl chr 5:36,109,265...36,353,252 		JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP Diclofenac results in increased expression of MMP8 mRNA CTD PMID:30723492 NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729 		JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO Diclofenac results in increased expression of MNDA mRNA CTD PMID:26934552 NCBI chr13:88,550,224...88,567,892
Ensembl chr13:88,550,228...88,566,537 		JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Diclofenac results in increased expression of MPEG1 mRNA CTD PMID:26934552 NCBI chr 1:218,876,848...218,881,364
Ensembl chr 1:218,876,069...218,908,715 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
increases activity 		EXP
ISO 		Diclofenac inhibits the reaction [Carrageenan results in increased activity of MPO protein]; sodium nitrate inhibits the reaction [Diclofenac results in increased activity of MPO protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein]
Diclofenac results in increased expression of MPO mRNA
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Diclofenac 		CTD PMID:17275683 PMID:24412305 PMID:27671914 PMID:28754375 PMID:31926916 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Diclofenac affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Mras muscle RAS oncogene homolog affects expression ISO Diclofenac affects the expression of MRAS mRNA CTD PMID:24752500 NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911 		JBrowse link
G Mrpl15 mitochondrial ribosomal protein L15 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL15 mRNA CTD PMID:37844793 NCBI chr 5:19,527,745...19,539,061
Ensembl chr 5:19,524,588...19,538,004 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL20 mRNA CTD PMID:37844793 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728 		JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL32 mRNA CTD PMID:37844793 NCBI chr17:55,260,651...55,263,517
Ensembl chr17:55,260,270...55,263,517 		JBrowse link
G Mrpl36 mitochondrial ribosomal protein L36 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL36 mRNA CTD PMID:37844793 NCBI chr 1:31,794,025...31,797,446
Ensembl chr 1:31,790,887...31,797,808 		JBrowse link
G Mrpl52 mitochondrial ribosomal protein L52 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL52 mRNA CTD PMID:37844793 NCBI chr15:31,852,927...31,856,160
Ensembl chr15:31,852,760...31,856,162 		JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL54 mRNA CTD PMID:37844793 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:9,103,525...9,106,045 		JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPL57 mRNA CTD PMID:37844793 NCBI chr15:36,086,457...36,087,319
Ensembl chr15:36,086,457...36,087,298 		JBrowse link
G Mrps11 mitochondrial ribosomal protein S11 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS11 mRNA CTD PMID:37844793 NCBI chr 1:142,117,045...142,126,644
Ensembl chr 1:142,116,937...142,126,644 		JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS14 mRNA CTD PMID:37844793 NCBI chr13:74,962,597...74,968,344
Ensembl chr13:74,962,515...74,970,975 		JBrowse link
G Mrps16 mitochondrial ribosomal protein S16 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS16 mRNA CTD PMID:37844793 NCBI chr15:3,967,809...3,970,211
Ensembl chr15:3,968,054...3,970,185 		JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS18C mRNA CTD PMID:37844793 NCBI chr14:9,116,688...9,122,943 JBrowse link
G Mrps22 mitochondrial ribosomal protein S22 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS22 mRNA CTD PMID:37844793 NCBI chr 8:108,063,468...108,076,638
Ensembl chr 8:108,063,471...108,076,638 		JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MRPS33 mRNA CTD PMID:37844793 NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:69,563,503...69,572,177 		JBrowse link
G Ms4a14 membrane spanning 4-domains A14 increases expression EXP Diclofenac results in increased expression of MS4A14 mRNA CTD PMID:30723492 NCBI chr 1:217,374,325...217,389,839
Ensembl chr 1:217,374,328...217,389,839 		JBrowse link
G Mt1a metallothionein 1A increases expression
multiple interactions 		ISO Diclofenac results in increased expression of MT1 mRNA
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of MT1 mRNA; [Sodium Selenite co-treated with Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of MT1 mRNA 		CTD PMID:26934552 PMID:38945390 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 increases expression
multiple interactions 		ISO Diclofenac results in increased expression of MT2 mRNA
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of MT2 mRNA; [Sodium Selenite co-treated with Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of MT2 mRNA 		CTD PMID:26934552 PMID:38945390 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mtbp MDM2 binding protein decreases expression ISO Diclofenac results in decreased expression of MTBP mRNA CTD PMID:35537566 NCBI chr 7:88,862,939...88,945,491
Ensembl chr 7:88,862,927...88,945,493 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase affects expression
decreases expression 		ISO Diclofenac affects the expression of MTHFD2 mRNA
Diclofenac results in decreased expression of MTHFD2 mRNA 		CTD PMID:24752500 PMID:35537566 NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like increases expression EXP Diclofenac results in increased expression of MTHFD2L mRNA CTD PMID:30723492 NCBI chr14:17,374,139...17,455,508
Ensembl chr14:17,374,144...17,454,322 		JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO Diclofenac results in increased expression of MTSS1 mRNA CTD PMID:26934552 NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:92,378,238...92,517,303 		JBrowse link
G Mup4 major urinary protein 4 decreases expression ISO Diclofenac results in decreased expression of MUP4 mRNA CTD PMID:26934552 NCBI chr 5:79,756,142...79,759,496 JBrowse link
G Mvp major vault protein increases expression ISO Diclofenac results in increased expression of MVP mRNA CTD PMID:26934552 NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:191,025,268...191,052,873 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Diclofenac results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904 		JBrowse link
G Mxd1 max dimerization protein 1 affects expression ISO Diclofenac affects the expression of MXD1 mRNA CTD PMID:24752500 NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
affects expression 		EXP
ISO 		Diclofenac results in increased expression of MYC mRNA
Diclofenac results in decreased expression of MYC mRNA
Diclofenac affects the expression of MYC mRNA 		CTD PMID:19022234 PMID:24752500 PMID:35537566 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO Diclofenac results in increased expression of MYD88 mRNA CTD PMID:26934552 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D affects expression ISO Diclofenac affects the expression of NAPEPLD mRNA CTD PMID:24752500 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of NARS1 mRNA CTD PMID:35537566 NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Diclofenac results in increased expression of NCF1 mRNA CTD PMID:26934552 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 increases expression ISO Diclofenac results in increased expression of NCF4 mRNA CTD PMID:26934552 NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:111,706,520...111,723,898 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of NCOA1 mRNA CTD PMID:37844793 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 affects expression ISO Diclofenac affects the expression of NCOA3 mRNA CTD PMID:24752500 NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631 		JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of NDUFA7 mRNA CTD PMID:37844793 NCBI chr 7:15,311,446...15,324,226
Ensembl chr 7:15,311,286...15,334,138 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase increases expression ISO Diclofenac results in increased expression of NEDD4L mRNA CTD PMID:26934552 NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824 		JBrowse link
G Nek6 NIMA-related kinase 6 increases expression ISO Diclofenac results in increased expression of NEK6 mRNA CTD PMID:26934552 NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases stability
decreases expression
multiple interactions 		ISO
EXP 		Diclofenac results in increased stability of NFE2L2 protein
Diclofenac results in decreased expression of NFE2L2 protein
diacerein inhibits the reaction [Diclofenac results in decreased expression of NFE2L2 protein]
NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA] 		CTD PMID:24752500 PMID:38582345 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression
decreases expression 		ISO Diclofenac results in increased expression of NFIL3 mRNA
Diclofenac results in decreased expression of NFIL3 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression 		ISO
EXP 		Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Diclofenac results in decreased expression of NFKB1 mRNA 		CTD PMID:15489888 PMID:29027214 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression 		ISO
EXP 		Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]
Diclofenac results in decreased expression of NFKBIA mRNA 		CTD PMID:15489888 PMID:18172885 PMID:19393675 PMID:25935278 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfkbiz NFKB inhibitor zeta decreases expression
increases expression 		ISO Diclofenac results in decreased expression of NFKBIZ mRNA
Diclofenac results in increased expression of NFKBIZ mRNA 		CTD PMID:26934552 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Diclofenac results in increased expression of TNFRSF10B mRNA CTD PMID:35537566 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO Diclofenac results in increased expression of NHERF1 mRNA CTD PMID:26934552 NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Diclofenac results in decreased expression of NHERF2 mRNA CTD PMID:26934552 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:14,167,005...14,177,593 		JBrowse link
G Nhsl2 NHS-like 2 increases expression ISO Diclofenac results in increased expression of NHSL2 mRNA CTD PMID:35537566 NCBI chr  X:71,009,940...71,249,427
Ensembl chr  X:71,009,949...71,241,289 		JBrowse link
G Nipal1 NIPA-like domain containing 1 increases expression ISO Diclofenac results in increased expression of NIPAL1 mRNA CTD PMID:26934552 NCBI chr14:35,891,645...35,915,658
Ensembl chr14:35,891,647...35,915,658 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:56,277,134...56,323,880 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions 		ISO
EXP 		Diclofenac results in increased expression of NLRP3 mRNA
diacerein inhibits the reaction [Diclofenac results in increased expression of NLRP3 protein] 		CTD PMID:24747151 PMID:28138970 PMID:38582345 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Diclofenac results in increased expression of NNMT mRNA CTD PMID:26934552 NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases expression 		EXP
ISO 		3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA]
Diclofenac results in decreased expression of NOS2 mRNA 		CTD PMID:15135310 PMID:16944022 PMID:17275683 PMID:19393675 PMID:23395999 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nova1 NOVA alternative splicing regulator 1 decreases expression ISO Diclofenac results in decreased expression of NOVA1 mRNA CTD PMID:26934552 NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:69,506,983...69,632,437 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO Diclofenac results in decreased expression of NOX1 mRNA CTD PMID:35537566 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
affects expression
increases expression 		ISO
EXP 		Diclofenac results in increased activity of NQO1 protein
Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
Diclofenac affects the expression of NQO1 mRNA
Diclofenac results in increased expression of NQO1 mRNA 		CTD PMID:8572925 PMID:18172885 PMID:24752500 PMID:29281794 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 affects expression ISO Diclofenac affects the expression of NR0B2 mRNA CTD PMID:24752500 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression
multiple interactions 		ISO Diclofenac results in increased expression of NR1D1 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of NR1D1 mRNA 		CTD PMID:35537566 PMID:37844793 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity 		ISO Diclofenac results in increased expression of NR1I2 mRNA
Diclofenac results in increased activity of NR1I2 protein 		CTD PMID:19022234 PMID:28728110 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO Diclofenac affects the expression of NR1I3 mRNA CTD PMID:19022234 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects expression ISO Diclofenac affects the expression of NR2F1 mRNA CTD PMID:24752500 NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 affects expression ISO Diclofenac affects the expression of NR2F2 mRNA CTD PMID:24752500 NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:133,420,227...133,431,975 		JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 affects expression ISO Diclofenac affects the expression of NR2F6 mRNA CTD PMID:24752500 NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,080,003...18,087,449 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression
multiple interactions 		ISO Diclofenac affects the expression of NR3C1 mRNA
Diclofenac binds to and affects the activity of NR3C1 protein 		CTD PMID:24752500 PMID:29777833 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Nr6a1 nuclear receptor subfamily 6, group A, member 1 affects expression ISO Diclofenac affects the expression of NR6A1 mRNA CTD PMID:24752500 NCBI chr 3:42,904,832...43,094,622
Ensembl chr 3:42,904,832...43,092,951 		JBrowse link
G Nras NRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of NRAS mRNA CTD PMID:24752500 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Diclofenac results in decreased expression of NREP mRNA CTD PMID:26934552 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742 		JBrowse link
G Nrg4 neuregulin 4 increases expression ISO Diclofenac results in increased expression of NRG4 mRNA CTD PMID:26934552 NCBI chr 8:64,483,559...64,555,671
Ensembl chr 8:64,488,722...64,573,439 		JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Diclofenac results in increased expression of NRP1 mRNA CTD PMID:26934552 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Diclofenac results in increased expression of NT5E mRNA CTD PMID:35537566 NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO Diclofenac results in decreased expression of NUPR1 mRNA CTD PMID:35537566 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Nxpe4 neurexophilin and PC-esterase domain family member 4 increases expression ISO Diclofenac results in increased expression of NXPE4 mRNA CTD PMID:26934552 NCBI chr 8:57,399,199...57,640,629
Ensembl chr 8:57,631,895...57,644,186 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Diclofenac results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of OCA2 mRNA CTD PMID:37844793 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:116,251,796...116,581,838 		JBrowse link
G Ocln occludin decreases expression ISO
EXP 		Diclofenac results in decreased expression of OCLN mRNA CTD PMID:29027214 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Diclofenac results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:85,402,151...85,439,342
Ensembl chr13:85,402,169...85,439,342 		JBrowse link
G Olr1271 olfactory receptor 1271 decreases expression ISO Diclofenac results in decreased expression of OR8D1B mRNA CTD PMID:35537566 NCBI chr 8:48,024,543...48,029,052
Ensembl chr 8:48,024,562...48,029,042 		JBrowse link
G Ooep oocyte expressed protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of OOEP mRNA CTD PMID:37844793 NCBI chr 8:88,103,675...88,104,848
Ensembl chr 8:88,102,840...88,104,876 		JBrowse link
G Oosp1 oocyte secreted protein 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of OOSP1 mRNA CTD PMID:37844793
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression
multiple interactions 		ISO
EXP 		Diclofenac results in decreased expression of OPA1 mRNA
Diclofenac results in decreased expression of OPA1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] 		CTD PMID:26934552 PMID:27792760 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955 		JBrowse link
G Opcml opioid binding protein/cell adhesion molecule-like increases expression ISO Diclofenac results in increased expression of OPCML mRNA CTD PMID:26934552 NCBI chr 8:34,451,629...35,562,897
Ensembl chr 8:34,451,500...35,558,966 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
increases expression 		EXP
ISO 		[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ORM1 protein
Diclofenac results in increased expression of ORM1 mRNA 		CTD PMID:25772430 PMID:26934552 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Oxtr oxytocin receptor multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of OXTR mRNA CTD PMID:37844793 NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:147,154,374...147,170,750 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein] CTD PMID:25450234 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094 		JBrowse link
G P2rx5 purinergic receptor P2X 5 increases expression EXP Diclofenac results in increased expression of P2RX5 mRNA CTD PMID:30723492 NCBI chr10:58,276,329...58,291,108
Ensembl chr10:58,276,257...58,287,935 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
increases expression 		EXP
ISO 		Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]
Diclofenac results in increased expression of P2RX7 mRNA 		CTD PMID:25935278 PMID:26934552 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 increases expression ISO Diclofenac results in increased expression of P4HA2 mRNA CTD PMID:17379860 NCBI chr10:38,743,894...38,772,741
Ensembl chr10:38,743,894...38,772,993 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
increases expression 		EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of P4HB protein
Diclofenac results in increased expression of P4HB protein 		CTD PMID:25772430 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 affects expression ISO Diclofenac affects the expression of PAK2 mRNA CTD PMID:24752500 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression EXP Diclofenac results in increased expression of PAQR8 mRNA CTD PMID:30723492 NCBI chr 9:30,808,921...30,858,599
Ensembl chr 9:30,808,923...30,861,043 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression ISO Diclofenac affects the expression of PARP1 mRNA CTD PMID:24752500 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pax6 paired box 6 increases expression ISO Diclofenac results in increased expression of PAX6 mRNA CTD PMID:26934552 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Pcdhb17 protocadherin beta 17 increases expression EXP Diclofenac results in increased expression of PCDHB17 mRNA CTD PMID:30723492 NCBI chr18:29,470,868...29,475,832
Ensembl chr18:29,466,240...29,494,665 		JBrowse link
G Pcdhga8 protocadherin gamma subfamily A, 8 increases expression EXP Diclofenac results in increased expression of PCDHGA8 mRNA CTD PMID:30723492 NCBI chr18:29,805,113...29,919,095 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO Diclofenac affects the expression of PCK1 mRNA CTD PMID:24752500 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Diclofenac results in decreased expression of PCK2 mRNA CTD PMID:35537566 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pcna proliferating cell nuclear antigen affects expression ISO Diclofenac affects the expression of PCNA protein CTD PMID:23506792 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Diclofenac results in increased expression of PCSK9 mRNA CTD PMID:26934552 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of PDCD4 mRNA
Diclofenac results in increased expression of PDCD4 mRNA 		CTD PMID:21873647 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189 		JBrowse link
G Pde9a phosphodiesterase 9A increases expression EXP Diclofenac results in increased expression of PDE9A mRNA CTD PMID:30723492 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO Diclofenac results in decreased expression of PDGFRB mRNA CTD PMID:26934552 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Diclofenac results in increased expression of PDIA6 mRNA CTD PMID:26934552 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091 		JBrowse link
G Pdilt protein disulfide isomerase-like, testis expressed decreases expression ISO Diclofenac results in decreased expression of PDILT mRNA CTD PMID:26934552 NCBI chr 1:183,268,812...183,562,825
Ensembl chr 1:183,268,813...183,300,022 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression ISO Diclofenac results in decreased expression of PDK4 mRNA CTD PMID:26934552 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 affects expression ISO Diclofenac affects the expression of PDPK1 mRNA CTD PMID:24752500 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pfkl phosphofructokinase, liver type multiple interactions ISO [Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of PFKL mRNA; Sodium Selenite inhibits the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of PFKL mRNA] CTD PMID:38945390 NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966 		JBrowse link
G Pgk2 phosphoglycerate kinase 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PGK2 mRNA CTD PMID:37844793 NCBI chr 9:27,976,913...27,978,479
Ensembl chr 9:27,973,459...28,079,866 		JBrowse link
G Phf10 PHD finger protein 10 decreases expression ISO Diclofenac results in decreased expression of PHF10 mRNA CTD PMID:35537566 NCBI chr 1:64,625,373...64,642,110
Ensembl chr 1:64,624,465...64,642,049 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Diclofenac results in decreased expression of PHLDA1 mRNA CTD PMID:26934552 NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Diclofenac results in increased expression of PHLDA3 mRNA CTD PMID:35537566 NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621 		JBrowse link
G Phyhipl phytanoyl-CoA 2-hydroxylase interacting protein-like decreases expression ISO Diclofenac results in decreased expression of PHYHIPL mRNA CTD PMID:26934552 NCBI chr20:18,023,831...18,064,903
Ensembl chr20:17,934,683...18,065,756 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Diclofenac results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha affects expression ISO Diclofenac affects the expression of PIK3C2A mRNA CTD PMID:24752500 NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression ISO Diclofenac affects the expression of PIK3CA mRNA CTD PMID:24752500 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta affects expression ISO Diclofenac affects the expression of PIK3CD mRNA CTD PMID:24752500 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression
increases expression 		ISO Diclofenac affects the expression of PIK3R1 mRNA
Diclofenac results in increased expression of PIK3R1 mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 affects expression ISO Diclofenac affects the expression of PIK3R2 mRNA CTD PMID:24752500 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 affects expression ISO Diclofenac affects the expression of PIK3R3 mRNA CTD PMID:24752500 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pirb paired Ig-like receptor B increases expression ISO
EXP 		Diclofenac results in increased expression of PIRB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 1:74,414,556...74,433,015
Ensembl chr 1:74,331,291...74,422,116 		JBrowse link
G Pklr pyruvate kinase L/R increases expression
multiple interactions 		ISO Diclofenac results in increased expression of PKLR mRNA
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of PKLR mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of PKLR mRNA] 		CTD PMID:26934552 PMID:38945390 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 increases expression EXP Diclofenac results in increased expression of PKNOX2 mRNA CTD PMID:30723492 NCBI chr 8:44,789,464...45,051,933
Ensembl chr 8:44,789,467...44,979,754 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA affects expression ISO Diclofenac affects the expression of PLA2G12A mRNA CTD PMID:24752500 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964 		JBrowse link
G Pla2g4c phospholipase A2 group IVC increases expression ISO Diclofenac results in increased expression of PLA2G4C mRNA CTD PMID:26934552 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:83,382,068...83,410,037 		JBrowse link
G Pla2g7 phospholipase A2 group VII increases expression ISO Diclofenac results in increased expression of PLA2G7 mRNA CTD PMID:26934552 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747 		JBrowse link
G Plac8 placenta associated 8 increases expression ISO Diclofenac results in increased expression of PLAC8 mRNA CTD PMID:26934552 NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572 		JBrowse link
G Plau plasminogen activator, urokinase increases expression
decreases expression 		ISO Diclofenac results in increased expression of PLAU protein
Diclofenac results in decreased expression of PLAU mRNA 		CTD PMID:23506792 PMID:35537566 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plcg1 phospholipase C, gamma 1 affects expression ISO Diclofenac affects the expression of PLCG1 mRNA CTD PMID:24752500 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO Diclofenac results in increased expression of PLD1 mRNA CTD PMID:26934552 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245 		JBrowse link
G Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 decreases expression ISO Diclofenac results in decreased expression of PLEKHH2 mRNA CTD PMID:35537566 NCBI chr 6:15,783,179...15,893,479
Ensembl chr 6:15,784,645...15,893,537 		JBrowse link
G Plk3 polo-like kinase 3 affects expression ISO Diclofenac affects the expression of PLK3 mRNA CTD PMID:26934552 NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO Diclofenac results in increased expression of PLSCR1 mRNA CTD PMID:26934552 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:101,664,056...101,684,614 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Diclofenac results in increased expression of PMAIP1 mRNA CTD PMID:26934552 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases expression ISO Diclofenac results in increased expression of PNLIPRP2 mRNA CTD PMID:26934552 NCBI chr 1:267,883,906...267,902,572
Ensembl chr 1:267,883,906...267,902,572 		JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit affects expression ISO Diclofenac affects the expression of POLE3 mRNA CTD PMID:24752500 NCBI chr 5:80,989,508...80,992,742
Ensembl chr 5:80,989,511...80,992,742
Ensembl chr 7:80,989,511...80,992,742 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit affects expression ISO Diclofenac affects the expression of POLE4 mRNA CTD PMID:24752500 NCBI chr 4:116,723,040...116,728,873
Ensembl chr 4:116,716,719...116,728,851 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit affects expression ISO Diclofenac affects the expression of POLG mRNA CTD PMID:24752500 NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:142,792,119...142,808,838 		JBrowse link
G Polh DNA polymerase eta affects expression ISO Diclofenac affects the expression of POLH mRNA CTD PMID:24752500 NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:22,275,946...22,310,577 		JBrowse link
G Polq DNA polymerase theta affects expression ISO Diclofenac affects the expression of POLQ mRNA CTD PMID:24752500 NCBI chr11:77,179,190...77,281,270
Ensembl chr11:77,179,209...77,281,268 		JBrowse link
G Polr2f RNA polymerase II, I and III subunit F affects expression ISO Diclofenac affects the expression of POLR2F mRNA CTD PMID:24752500 NCBI chr 7:112,592,977...112,604,681
Ensembl chr 7:112,593,027...112,604,666 		JBrowse link
G Polr2h-ps1 polymerase (RNA) II (DNA directed) polypeptide H, pseudogene 1 decreases expression EXP Diclofenac results in decreased expression of POLR2H-PS1 mRNA CTD PMID:30723492 NCBI chr10:105,353,439...105,357,591 JBrowse link
G Polr3a RNA polymerase III subunit A affects expression ISO Diclofenac affects the expression of POLR3A mRNA CTD PMID:24752500 NCBI chr16:56,066...95,060
Ensembl chr16:56,066...95,060 		JBrowse link
G Polr3d RNA polymerase III subunit D affects expression ISO Diclofenac affects the expression of POLR3D mRNA CTD PMID:24752500 NCBI chr15:51,921,283...51,925,952
Ensembl chr15:51,921,283...51,925,691 		JBrowse link
G Polr3g RNA polymerase III subunit G increases expression ISO Diclofenac results in increased expression of POLR3G mRNA CTD PMID:35537566 NCBI chr 2:13,680,893...13,721,802
Ensembl chr 2:13,680,895...13,721,802 		JBrowse link
G Pomk protein-O-mannose kinase increases expression ISO Diclofenac results in increased expression of POMK mRNA CTD PMID:26934552 NCBI chr16:72,788,842...72,801,122
Ensembl chr16:72,794,831...72,801,103 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein CTD PMID:29512227 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance
increases oxidation 		ISO POR affects the susceptibility to Diclofenac
POR results in increased oxidation of Diclofenac 		CTD PMID:25820915 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Diclofenac results in decreased expression of POU2AF1 mRNA CTD PMID:26934552 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 affects expression ISO Diclofenac affects the expression of POU2F1 mRNA CTD PMID:24752500 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356 		JBrowse link
G Pou2f2 POU class 2 homeobox 2 increases expression ISO Diclofenac results in increased expression of POU2F2 mRNA CTD PMID:26934552 NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564 		JBrowse link
G Pou2f3 POU class 2 homeobox 3 increases expression ISO Diclofenac results in increased expression of POU2F3 mRNA CTD PMID:26934552 NCBI chr 8:52,392,363...52,474,756
Ensembl chr 8:52,392,497...52,474,756 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
increases activity 		ISO Diclofenac affects the expression of PPARG mRNA
Diclofenac inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]
Diclofenac results in increased activity of PPARG protein 		CTD PMID:12065695 PMID:15273253 PMID:24752500 PMID:28728110 PMID:30138673 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects expression
increases expression 		ISO Diclofenac affects the expression of PPARGC1A mRNA
Diclofenac results in increased expression of PPARGC1A mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression ISO Diclofenac results in decreased expression of PPARGC1B mRNA CTD PMID:26934552 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466 		JBrowse link
G Ppbp pro-platelet basic protein increases expression ISO Diclofenac results in increased expression of PPBP mRNA CTD PMID:26934552 NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Diclofenac CTD PMID:20668000 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta affects expression ISO Diclofenac affects the expression of PPP1CB mRNA CTD PMID:24752500 NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924 		JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B affects expression ISO Diclofenac affects the expression of PPP1R14B mRNA CTD PMID:24752500 NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A affects expression
decreases expression 		ISO Diclofenac affects the expression of PPP1R15A mRNA
Diclofenac results in decreased expression of PPP1R15A mRNA 		CTD PMID:24752500 PMID:35537566 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Ppp1r7 protein phosphatase 1, regulatory subunit 7 affects expression ISO Diclofenac affects the expression of PPP1R7 mRNA CTD PMID:24752500 NCBI chr 9:101,333,472...101,358,589
Ensembl chr 9:101,333,497...101,360,959 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta affects expression ISO Diclofenac affects the expression of PPP2R1B mRNA CTD PMID:24752500 NCBI chr 8:60,092,540...60,125,512
Ensembl chr 8:60,081,553...60,125,795 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha affects expression ISO Diclofenac affects the expression of PPP2R2A mRNA CTD PMID:24752500 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405 		JBrowse link
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma affects expression ISO Diclofenac affects the expression of PPP2R2C mRNA CTD PMID:24752500 NCBI chr14:78,071,274...78,156,212
Ensembl chr14:78,071,274...78,156,212 		JBrowse link
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha affects expression ISO Diclofenac affects the expression of PPP2R5A mRNA CTD PMID:24752500 NCBI chr13:105,462,371...105,506,767
Ensembl chr13:105,462,371...105,506,767 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma affects expression ISO Diclofenac affects the expression of PPP2R5C mRNA CTD PMID:24752500 NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:135,324,067...135,419,597 		JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Diclofenac results in decreased expression of PRDM1 mRNA CTD PMID:35537566 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088 		JBrowse link
G Prg4 proteoglycan 4 increases expression ISO Diclofenac results in increased expression of PRG4 mRNA CTD PMID:26934552 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:65,037,363...65,054,508 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Diclofenac affects the expression of PRKACB mRNA CTD PMID:24752500 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315 		JBrowse link
G Prkca protein kinase C, alpha affects expression ISO Diclofenac affects the expression of PRKCA mRNA CTD PMID:24752500 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkci protein kinase C, iota affects expression ISO Diclofenac affects the expression of PRKCI mRNA CTD PMID:24752500 NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:114,250,398...114,310,784 		JBrowse link
G Prkd3 protein kinase D3 affects expression ISO Diclofenac affects the expression of PRKD3 mRNA CTD PMID:24752500 NCBI chr 6:21,784,665...21,860,600
Ensembl chr 6:21,784,673...21,860,600 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Diclofenac results in decreased expression of PRKG2 mRNA CTD PMID:35537566 NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,864,186...10,972,614 		JBrowse link
G Prl prolactin decreases expression ISO Diclofenac results in decreased expression of PRL mRNA CTD PMID:26934552 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Prm1 protamine 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PRM1 mRNA CTD PMID:37844793 NCBI chr10:5,378,740...5,379,235 JBrowse link
G Procr protein C receptor increases expression ISO Diclofenac results in increased expression of PROCR mRNA CTD PMID:26934552 NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989 		JBrowse link
G Prok2 prokineticin 2 increases expression ISO Diclofenac results in increased expression of PROK2 mRNA CTD PMID:26934552 NCBI chr 4:133,903,210...133,918,126
Ensembl chr 4:133,903,210...133,917,933 		JBrowse link
G Pros1 protein S increases expression ISO Diclofenac results in increased expression of PROS1 mRNA CTD PMID:26934552 NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852 		JBrowse link
G Prss3 serine protease 3 decreases expression ISO Diclofenac results in decreased expression of PRSS3 mRNA CTD PMID:26934552 NCBI chr 4:71,169,749...71,173,223
Ensembl chr 4:71,169,749...71,173,223 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO Diclofenac results in increased expression of PRTN3 mRNA CTD PMID:26934552 NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 affects expression ISO Diclofenac affects the expression of PSAT1 mRNA CTD PMID:24752500 NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression EXP Diclofenac results in decreased expression of PSMB4 mRNA CTD PMID:18172885 NCBI chr 2:185,131,787...185,134,561
Ensembl chr 2:185,131,786...185,135,287 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO Diclofenac results in increased expression of PSMD2 mRNA CTD PMID:26934552 NCBI chr11:93,752,761...93,763,388
Ensembl chr11:93,752,763...93,763,388 		JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 decreases expression ISO Diclofenac results in decreased expression of PSMD9 mRNA CTD PMID:26934552 NCBI chr12:38,998,027...39,018,340
Ensembl chr12:38,998,030...39,018,679 		JBrowse link
G Psmf1 proteasome inhibitor subunit 1 affects expression ISO Diclofenac affects the expression of PSMF1 mRNA CTD PMID:24752500 NCBI chr 3:160,695,744...160,720,915
Ensembl chr 3:160,695,745...160,720,915 		JBrowse link
G Pten phosphatase and tensin homolog affects expression
increases expression 		ISO Diclofenac affects the expression of PTEN mRNA
Diclofenac results in increased expression of PTEN mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptges prostaglandin E synthase decreases expression
multiple interactions 		EXP Diclofenac results in decreased expression of PTGES mRNA
[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone 		CTD PMID:19393675 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995 		JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PTGES2 mRNA CTD PMID:37844793 NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:36,088,246...36,097,694 		JBrowse link
G Ptgfr prostaglandin F receptor decreases expression ISO Diclofenac results in decreased expression of PTGFR mRNA CTD PMID:26934552 NCBI chr 2:243,390,820...243,426,647
Ensembl chr 2:243,393,350...243,425,623 		JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PTGIS mRNA CTD PMID:37844793 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgr1 prostaglandin reductase 1 decreases activity ISO Diclofenac results in decreased activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
multiple interactions
decreases expression
increases expression 		ISO
EXP 		Diclofenac analog results in decreased activity of PTGS1 protein; Diclofenac results in decreased activity of PTGS1 protein
[thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein
Diclofenac results in decreased expression of PTGS1 protein
Diclofenac results in increased expression of PTGS1 mRNA 		CTD PMID:9258749 PMID:12242329 PMID:16141368 PMID:19031110 PMID:26934552 More... NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
decreases activity 		ISO
EXP 		Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Diclofenac results in decreased expression of PTGS2 mRNA
Diclofenac results in increased expression of PTGS2 mRNA
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
Diclofenac results in decreased activity of PTGS2 protein
Diclofenac results in increased expression of PTGS2 mRNA; Diclofenac results in increased expression of PTGS2 protein
Acetaminophen inhibits the reaction [Diclofenac results in increased expression of PTGS2 protein]; Diclofenac binds to and results in decreased activity of PTGS2 protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein] 		CTD PMID:9258749 PMID:9851595 PMID:10594327 PMID:12242329 PMID:12925531 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression ISO Diclofenac affects the expression of PTK2 mRNA CTD PMID:24752500 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression ISO Diclofenac results in increased expression of PTPN1 mRNA CTD PMID:26934552 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 increases expression ISO Diclofenac results in increased expression of PTPN2 mRNA CTD PMID:26934552 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO Diclofenac results in increased expression of PTPRC mRNA CTD PMID:26934552 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J increases expression ISO Diclofenac results in increased expression of PTPRJ mRNA CTD PMID:26934552 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:96,861,785...97,017,656 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein] CTD PMID:25450234 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 increases expression ISO Diclofenac results in increased expression of QSOX1 mRNA CTD PMID:26934552 NCBI chr13:70,500,060...70,537,711
Ensembl chr13:70,500,060...70,537,733 		JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 increases expression ISO Diclofenac results in increased expression of RAB11FIP3 mRNA CTD PMID:26934552 NCBI chr10:15,507,151...15,591,173
Ensembl chr10:15,507,151...15,591,173 		JBrowse link
G Rabl2 RAB, member of RAS oncogene family like 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of RABL2 mRNA CTD PMID:37844793 NCBI chr 7:122,531,787...122,540,500
Ensembl chr 7:122,531,792...122,540,395 		JBrowse link
G Rack1 receptor for activated C kinase 1 affects expression ISO Diclofenac affects the expression of RACK1 mRNA CTD PMID:24752500 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948 		JBrowse link
G Rad50 RAD50 double strand break repair protein affects expression ISO Diclofenac affects the expression of RAD50 mRNA CTD PMID:24752500 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100 		JBrowse link
G Rad51 RAD51 recombinase affects expression
increases expression 		ISO
EXP 		Diclofenac affects the expression of RAD51 mRNA
Diclofenac results in increased expression of RAD51 mRNA 		CTD PMID:24752500 PMID:30723492 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469 		JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO Diclofenac affects the expression of RASA1 mRNA CTD PMID:24752500 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161 		JBrowse link
G Rasgef1b RasGEF domain family, member 1B decreases expression ISO Diclofenac results in decreased expression of RASGEF1B mRNA CTD PMID:35537566 NCBI chr14:10,164,366...10,684,184
Ensembl chr14:10,644,521...10,697,296 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO Diclofenac affects the expression of RB1 mRNA CTD PMID:24752500 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression
decreases expression 		ISO Diclofenac results in increased expression of RBBP8 mRNA
Diclofenac results in decreased expression of RBBP8 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985 		JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression ISO Diclofenac results in increased expression of RBM3 mRNA CTD PMID:26934552 NCBI chr  X:17,020,863...17,024,341
Ensembl chr  X:17,020,864...17,024,841 		JBrowse link
G Rbx1 ring-box 1 decreases expression ISO Diclofenac results in decreased expression of RBX1 mRNA CTD PMID:26934552 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191 		JBrowse link
G Rcan1 regulator of calcineurin 1 decreases expression ISO Diclofenac results in decreased expression of RCAN1 mRNA CTD PMID:35537566 NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236 		JBrowse link
G Reep6 receptor accessory protein 6 increases expression ISO Diclofenac results in increased expression of REEP6 mRNA CTD PMID:35537566 NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression ISO Diclofenac results in increased expression of REG3B mRNA CTD PMID:26934552 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:112,419,776...112,423,014 		JBrowse link
G Reg3g regenerating family member 3 gamma increases expression ISO Diclofenac results in increased expression of REG3G mRNA CTD PMID:26934552 NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:112,482,183...112,484,738 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects expression 		ISO
EXP 		Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]
Diclofenac results in increased expression of RELA protein
Diclofenac affects the expression of RELA mRNA
diacerein inhibits the reaction [Diclofenac results in increased expression of RELA protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] 		CTD PMID:15489888 PMID:19393675 PMID:24752500 PMID:25935278 PMID:38582345 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Reln reelin decreases expression ISO Diclofenac results in decreased expression of RELN mRNA CTD PMID:26934552 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Ret ret proto-oncogene increases expression ISO Diclofenac results in increased expression of RET mRNA CTD PMID:26934552 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit affects expression ISO Diclofenac affects the expression of REV3L mRNA CTD PMID:24752500 NCBI chr20:44,686,482...44,844,668
Ensembl chr20:44,686,940...44,844,668 		JBrowse link
G Rgn regucalcin increases expression EXP Diclofenac results in increased expression of RGN mRNA CTD PMID:19022234 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Diclofenac results in decreased expression of RGS16 mRNA CTD PMID:35537566 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Diclofenac results in decreased expression of RGS2 mRNA CTD PMID:35537566 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Diclofenac results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884 		JBrowse link
G Rhob ras homolog family member B affects expression ISO Diclofenac affects the expression of RHOB mRNA CTD PMID:24752500 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772 		JBrowse link
G Rhoj ras homolog family member J decreases expression ISO Diclofenac results in decreased expression of RHOJ mRNA CTD PMID:35537566 NCBI chr 6:99,771,104...99,853,366
Ensembl chr 6:99,771,252...99,853,999 		JBrowse link
G Rhoq ras homolog family member Q affects expression ISO Diclofenac affects the expression of RHOQ mRNA CTD PMID:24752500 NCBI chr 6:13,368,499...13,403,929
Ensembl chr 1:115,757,909...115,759,467 		JBrowse link
G Rhot2 ras homolog family member T2 affects expression ISO Diclofenac affects the expression of RHOT2 mRNA CTD PMID:24752500 NCBI chr10:15,363,467...15,369,263
Ensembl chr10:15,361,726...15,369,006 		JBrowse link
G Ric8a RIC8 guanine nucleotide exchange factor A decreases expression ISO Diclofenac results in decreased expression of RIC8A mRNA CTD PMID:35537566 NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102 		JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO Diclofenac results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995 		JBrowse link
G Rnase6 ribonuclease A family member 6 increases expression EXP Diclofenac results in increased expression of RNASE6 mRNA CTD PMID:30723492 NCBI chr15:26,827,896...26,830,807
Ensembl chr15:26,827,009...26,830,825 		JBrowse link
G Rnasel ribonuclease L increases expression ISO Diclofenac results in increased expression of RNASEL mRNA CTD PMID:26934552 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:68,446,882...68,459,557 		JBrowse link
G Rnd1 Rho family GTPase 1 decreases expression ISO Diclofenac results in decreased expression of RND1 mRNA CTD PMID:35537566 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392 		JBrowse link
G Rnf145 ring finger protein 145 increases expression ISO Diclofenac results in increased expression of RNF145 mRNA CTD PMID:35537566 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,507,772...29,552,151 		JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Diclofenac results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 affects expression ISO Diclofenac affects the expression of ROCK1 mRNA CTD PMID:24752500 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 affects expression ISO Diclofenac affects the expression of ROCK2 mRNA CTD PMID:24752500 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771 		JBrowse link
G Ropn1 rhophilin associated tail protein 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ROPN1 mRNA CTD PMID:37844793 NCBI chr11:79,603,053...79,632,344
Ensembl chr11:79,603,055...79,632,344 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like increases expression ISO Diclofenac results in increased expression of ROPN1L mRNA CTD PMID:35537566 NCBI chr 2:84,153,529...84,164,216
Ensembl chr 2:84,153,529...84,164,415 		JBrowse link
G Rora RAR-related orphan receptor A decreases expression ISO Diclofenac results in decreased expression of RORA mRNA CTD PMID:26934552 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO Diclofenac results in increased expression of RORC mRNA CTD PMID:22285467 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Rpa1 replication protein A1 affects expression ISO Diclofenac affects the expression of RPA1 mRNA CTD PMID:24752500 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279 		JBrowse link
G Rpa2 replication protein A2 affects expression ISO Diclofenac affects the expression of RPA2 mRNA CTD PMID:24752500 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:150,260,723...150,271,546 		JBrowse link
G Rpap3 RNA polymerase II associated protein 3 increases expression ISO Diclofenac results in increased expression of RPAP3 mRNA CTD PMID:26934552 NCBI chr 7:130,689,923...130,719,411
Ensembl chr 7:130,689,929...130,719,247 		JBrowse link
G Rpl39l1 ribosomal protein L39 like 1 increases expression ISO Diclofenac results in increased expression of RPL39L mRNA CTD PMID:26934552 NCBI chr10:5,962,506...5,966,621
Ensembl chr10:5,962,515...5,966,621 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 affects expression ISO Diclofenac affects the expression of RPS6KA1 mRNA CTD PMID:24752500 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases expression ISO Diclofenac results in decreased expression of RPS6KA5 mRNA CTD PMID:26934552 NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856 		JBrowse link
G Rps6kl1 ribosomal protein S6 kinase-like 1 increases expression EXP Diclofenac results in increased expression of RPS6KL1 mRNA CTD PMID:30723492 NCBI chr 6:110,514,322...110,530,955
Ensembl chr 6:110,514,017...110,530,929 		JBrowse link
G Rras2 RAS related 2 affects expression ISO Diclofenac affects the expression of RRAS2 mRNA CTD PMID:24752500 NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Diclofenac results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP Diclofenac results in decreased expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Diclofenac affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G RT1-M6-1 RT1 class I, locus M6, gene 1 increases expression EXP Diclofenac results in increased expression of RT1-M6-1 mRNA CTD PMID:30723492 NCBI chr20:1,571,471...1,574,387
Ensembl chr20:1,571,442...1,575,632 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP Diclofenac results in increased expression of RUNX2 mRNA CTD PMID:30723492 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Diclofenac results in increased expression of S100A8 mRNA CTD PMID:24747151 PMID:26934552 PMID:28138970 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Diclofenac results in increased expression of S100A9 mRNA CTD PMID:24747151 PMID:26934552 PMID:27671914 PMID:28138970 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G Saa4 serum amyloid A4 increases expression
decreases expression 		ISO Diclofenac results in increased expression of SAA4 mRNA
Diclofenac results in decreased expression of SAA4 mRNA 		CTD PMID:26934552 NCBI chr 1:106,383,856...106,388,158
Ensembl chr 1:106,383,856...106,387,354 		JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 increases expression ISO Diclofenac results in increased expression of SARM1 mRNA CTD PMID:26934552 NCBI chr10:63,867,503...63,890,872
Ensembl chr10:63,867,503...63,890,872 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 affects expression ISO Diclofenac affects the expression of SARS1 mRNA CTD PMID:24752500 NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 affects expression ISO Diclofenac affects the expression of SAT1 mRNA CTD PMID:24752500 NCBI chr  X:44,008,089...44,011,376
Ensembl chr  X:44,006,781...44,011,374 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 affects expression ISO Diclofenac affects the expression of SAT2 mRNA CTD PMID:24752500 NCBI chr10:54,839,531...54,841,651
Ensembl chr10:54,839,189...54,841,958 		JBrowse link
G Scara5 scavenger receptor class A, member 5 increases expression ISO Diclofenac results in increased expression of SCARA5 mRNA CTD PMID:26934552 NCBI chr15:44,055,576...44,160,593
Ensembl chr15:44,055,630...44,160,585 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Diclofenac results in increased expression of SCD1 mRNA CTD PMID:26934552 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Diclofenac results in decreased activity of SCN5A protein CTD PMID:33617802 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Sele selectin E increases expression ISO Diclofenac results in increased expression of SELE mRNA CTD PMID:26934552 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Selenof selenoprotein F multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SELENOF mRNA CTD PMID:37844793 NCBI chr 2:236,302,439...236,335,216
Ensembl chr 2:236,302,683...236,335,210 		JBrowse link
G Sell selectin L decreases expression
increases expression 		ISO Diclofenac results in decreased expression of SELL protein
Diclofenac results in increased expression of SELL mRNA 		CTD PMID:12147693 PMID:26934552 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Selp selectin P decreases expression
multiple interactions 		EXP Diclofenac results in decreased expression of SELP protein
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein] 		CTD PMID:14716214 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Sema4b semaphorin 4B increases expression ISO Diclofenac results in increased expression of SEMA4B mRNA CTD PMID:26934552 NCBI chr 1:143,545,727...143,587,037
Ensembl chr 1:143,537,690...143,587,037 		JBrowse link
G Serpina10 serpin family A member 10 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of SERPINA10 mRNA
Diclofenac results in increased expression of SERPINA10 mRNA 		CTD PMID:26934552 NCBI chr 6:128,520,894...128,529,332
Ensembl chr 6:128,520,896...128,529,332 		JBrowse link
G Serpina12 serpin family A member 12 increases expression EXP Diclofenac results in increased expression of SERPINA12 mRNA CTD PMID:30723492 NCBI chr 6:128,717,334...128,732,049
Ensembl chr 6:128,717,334...128,732,049 		JBrowse link
G Serpina3n serpin family A member 3N multiple interactions
increases expression 		EXP
ISO 		[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINA3N protein
Diclofenac results in increased expression of SERPINA3N mRNA 		CTD PMID:25772430 PMID:26934552 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
affects expression 		EXP
ISO 		Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA]
Diclofenac results in increased expression of SERPINE1 mRNA
Diclofenac affects the expression of SERPINE1 mRNA 		CTD PMID:23939143 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serpine2 serpin family E member 2 decreases expression ISO Diclofenac results in decreased expression of SERPINE2 mRNA CTD PMID:26934552 NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202 		JBrowse link
G Serpinf2 serpin family F member 2 increases expression ISO Diclofenac results in increased expression of SERPINF2 mRNA CTD PMID:26934552 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996 		JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Diclofenac results in decreased expression of SERPINH1 mRNA CTD PMID:26934552 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976 		JBrowse link
G Sfn stratifin increases expression ISO Diclofenac results in increased expression of SFN mRNA CTD PMID:17379860 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995 		JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Diclofenac results in increased expression of SFPQ mRNA CTD PMID:26934552 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
decreases expression 		EXP
ISO 		Diclofenac results in increased expression of SGK1 mRNA
Diclofenac results in decreased expression of SGK1 mRNA 		CTD PMID:30723492 PMID:35537566 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231 		JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 decreases expression ISO Diclofenac results in decreased expression of SGK2 mRNA CTD PMID:26934552 NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:172,063,776...172,089,011 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 affects expression ISO Diclofenac affects the expression of SH3GLB1 mRNA CTD PMID:24752500 NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140 		JBrowse link
G Shisa6 shisa family member 6 decreases expression ISO Diclofenac results in decreased expression of SHISA6 mRNA CTD PMID:26934552 NCBI chr10:51,396,806...51,691,156
Ensembl chr10:51,396,806...51,691,156 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 affects expression ISO Diclofenac affects the expression of SHMT1 mRNA CTD PMID:24752500 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326 		JBrowse link
G Shprh SNF2 histone linker PHD RING helicase decreases expression ISO Diclofenac results in decreased expression of SHPRH mRNA CTD PMID:26934552 NCBI chr 1:7,349,073...7,422,804
Ensembl chr 1:7,320,395...7,422,794 		JBrowse link
G Siglech sialic acid binding Ig-like lectin H increases expression EXP Diclofenac results in increased expression of SIGLECH mRNA CTD PMID:30723492 NCBI chr 1:115,729,491...115,739,959
Ensembl chr 1:115,729,491...115,739,959 		JBrowse link
G Sik1 salt-inducible kinase 1 increases expression ISO Diclofenac results in increased expression of SIK1 mRNA CTD PMID:35537566 NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698 		JBrowse link
G Sin3a SIN3 transcription regulator family member A affects expression ISO Diclofenac affects the expression of SIN3A mRNA CTD PMID:24752500 NCBI chr 8:66,377,471...66,432,150
Ensembl chr 8:66,381,657...66,434,542 		JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 increases expression EXP Diclofenac results in increased expression of SKA1 mRNA CTD PMID:30723492 NCBI chr18:70,069,957...70,080,303
Ensembl chr18:70,069,957...70,080,398 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO Diclofenac results in decreased activity of SLC10A1 protein CTD PMID:39023798 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression ISO Diclofenac results in increased expression of SLC10A2 mRNA CTD PMID:26934552 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases expression ISO Diclofenac results in increased expression of SLC10A6 mRNA CTD PMID:26934552 NCBI chr14:6,385,348...6,407,532
Ensembl chr14:6,385,537...6,408,894 		JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression ISO Diclofenac results in increased expression of SLC13A3 mRNA CTD PMID:26934552 NCBI chr 3:174,561,174...174,623,893
Ensembl chr 3:174,561,168...174,623,895 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 decreases expression ISO Diclofenac results in decreased expression of SLC15A2 mRNA CTD PMID:26934552 NCBI chr11:77,519,565...77,548,609
Ensembl chr11:77,519,529...77,548,606 		JBrowse link
G Slc16a5 solute carrier family 16 member 5 increases expression ISO Diclofenac results in increased expression of SLC16A5 mRNA CTD PMID:26934552 NCBI chr10:101,206,371...101,220,300
Ensembl chr10:101,206,398...101,220,300 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Diclofenac results in increased expression of SLC17A6 mRNA CTD PMID:26934552 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects expression ISO Diclofenac affects the expression of SLC19A1 mRNA CTD PMID:24752500 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 increases expression ISO Diclofenac results in increased expression of SLC19A2 mRNA CTD PMID:35537566 NCBI chr13:79,135,118...79,149,316
Ensembl chr13:79,135,059...79,149,315 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression
decreases expression 		ISO Diclofenac results in increased expression of SLC1A4 mRNA
Diclofenac results in decreased expression of SLC1A4 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Diclofenac results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 multiple interactions EXP Diclofenac inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] CTD PMID:16079298 NCBI chr 1:214,339,594...214,394,681
Ensembl chr 1:214,339,599...214,394,681 		JBrowse link
G Slc22a21 solute carrier family 22 (organic cation transporter), member 21 increases expression ISO Diclofenac results in increased expression of SLC22A21 mRNA CTD PMID:26934552 NCBI chr10:38,605,665...38,633,376
Ensembl chr10:38,604,886...38,631,209 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Diclofenac results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Diclofenac results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity
multiple interactions 		ISO Diclofenac results in decreased activity of SLC22A7 protein
Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] 		CTD PMID:12388633 PMID:15901346 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] CTD PMID:11306713 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Diclofenac results in increased expression of SLC23A1 mRNA CTD PMID:26934552 NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid] CTD PMID:17092984 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343 		JBrowse link
G Slc25a22 solute carrier family 25 member 22 decreases expression ISO Diclofenac results in decreased expression of SLC25A22 mRNA CTD PMID:26934552 NCBI chr 1:205,954,713...205,966,188
Ensembl chr 1:205,958,032...205,965,877 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression ISO Diclofenac results in decreased expression of SLC25A30 mRNA CTD PMID:26934552 NCBI chr15:57,486,346...57,508,981
Ensembl chr15:57,486,350...57,502,690 		JBrowse link
G Slc25a33 solute carrier family 25 member 33 decreases expression ISO Diclofenac results in decreased expression of SLC25A33 mRNA CTD PMID:26934552 NCBI chr 5:165,478,070...165,518,186
Ensembl chr 5:165,478,072...165,502,973 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression ISO Diclofenac results in decreased expression of SLC29A1 mRNA CTD PMID:26934552 NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression ISO Diclofenac results in decreased expression of SLC2A2 mRNA CTD PMID:26934552 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 increases expression ISO Diclofenac results in increased expression of SLC30A5 mRNA CTD PMID:26934552 NCBI chr 2:33,679,800...33,710,025
Ensembl chr 2:33,679,800...33,712,596 		JBrowse link
G Slc36a4 solute carrier family 36 member 4 increases expression ISO Diclofenac results in increased expression of SLC36A4 mRNA CTD PMID:26934552 NCBI chr 8:20,801,256...20,834,046
Ensembl chr 8:20,801,289...20,834,044 		JBrowse link
G Slc37a1 solute carrier family 37 member 1 increases expression ISO Diclofenac results in increased expression of SLC37A1 mRNA CTD PMID:26934552 NCBI chr20:9,361,733...9,435,227
Ensembl chr20:9,379,664...9,435,229 		JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases expression ISO Diclofenac results in decreased expression of SLC38A7 mRNA CTD PMID:35537566 NCBI chr19:9,215,336...9,231,592
Ensembl chr19:9,215,383...9,231,589 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression ISO Diclofenac results in increased expression of SLC39A14 mRNA CTD PMID:26934552 NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases expression ISO Diclofenac results in increased expression of SLC3A1 mRNA CTD PMID:26934552 NCBI chr 6:15,361,037...15,396,695
Ensembl chr 6:15,361,046...15,394,775 		JBrowse link
G Slc41a1 solute carrier family 41 member 1 increases expression ISO Diclofenac results in increased expression of SLC41A1 mRNA CTD PMID:26934552 NCBI chr13:45,822,999...45,843,364
Ensembl chr13:45,822,999...45,843,657 		JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression ISO Diclofenac results in increased expression of SLC41A2 mRNA CTD PMID:26934552 NCBI chr 7:22,271,298...22,378,764
Ensembl chr 7:22,271,313...22,378,764 		JBrowse link
G Slc43a1 solute carrier family 43 member 1 increases expression ISO Diclofenac results in increased expression of SLC43A1 mRNA CTD PMID:26934552 NCBI chr 3:90,327,250...90,353,438
Ensembl chr 3:90,327,149...90,353,438 		JBrowse link
G Slc45a4 solute carrier family 45, member 4 decreases expression ISO Diclofenac results in decreased expression of SLC45A4 mRNA CTD PMID:26934552 NCBI chr 7:107,370,826...107,459,163
Ensembl chr 7:107,371,273...107,398,284 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 decreases expression ISO Diclofenac results in decreased expression of SLC46A2 mRNA CTD PMID:26934552 NCBI chr 5:79,594,003...79,603,074
Ensembl chr 5:79,595,150...79,603,114 		JBrowse link
G Slc46a3 solute carrier family 46, member 3 decreases expression ISO Diclofenac results in decreased expression of SLC46A3 mRNA CTD PMID:35537566 NCBI chr12:12,176,776...12,193,256
Ensembl chr12:12,176,807...12,193,255 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) increases expression ISO Diclofenac results in increased expression of SLC4A1 mRNA CTD PMID:26934552 NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO Diclofenac results in increased expression of SLC4A4 mRNA CTD PMID:26934552 NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Diclofenac results in decreased expression of SLC6A9 mRNA CTD PMID:35537566 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression ISO Diclofenac results in decreased expression of SLC7A1 mRNA CTD PMID:35537566 NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression 		ISO Diclofenac results in decreased expression of SLC7A11 mRNA
Diclofenac results in increased expression of SLC7A11 mRNA 		CTD PMID:19192274 PMID:32816093 PMID:33785417 PMID:35537566 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slc7a3 solute carrier family 7 member 3 increases expression ISO Diclofenac results in increased expression of SLC7A3 mRNA CTD PMID:26934552 NCBI chr  X:70,250,089...70,256,610
Ensembl chr  X:70,250,099...70,256,059 		JBrowse link
G Slc7a4 solute carrier family 7, member 4 increases expression ISO Diclofenac results in increased expression of SLC7A4 mRNA CTD PMID:26934552 NCBI chr11:96,939,456...96,943,127
Ensembl chr11:96,939,444...96,943,802 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 decreases expression ISO Diclofenac results in decreased expression of SLC7A5 mRNA CTD PMID:35537566 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412 		JBrowse link
G Slc7a8 solute carrier family 7 member 8 increases expression ISO Diclofenac results in increased expression of SLC7A8 mRNA CTD PMID:19192274 PMID:26934552 NCBI chr15:32,153,016...32,212,715
Ensembl chr15:32,153,018...32,212,715 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Diclofenac results in decreased expression of SLCO1A4 mRNA CTD PMID:26934552 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921 		JBrowse link
G Slirp SRA stem-loop interacting RNA binding protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SLIRP mRNA CTD PMID:37844793 NCBI chr 6:112,819,684...112,828,715
Ensembl chr 6:112,819,448...112,828,715 		JBrowse link
G Slitrk5 SLIT and NTRK-like family, member 5 increases expression EXP Diclofenac results in increased expression of SLITRK5 mRNA CTD PMID:30723492 NCBI chr15:95,261,397...95,270,465
Ensembl chr15:95,261,005...95,276,090 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Diclofenac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Smad1 SMAD family member 1 increases expression ISO Diclofenac results in increased expression of SMAD1 mRNA CTD PMID:26934552 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad4 SMAD family member 4 affects expression ISO Diclofenac affects the expression of SMAD4 mRNA CTD PMID:24752500 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smarca5 SNF2 related chromatin remodeling ATPase 5 increases expression ISO Diclofenac results in increased expression of SMARCA5 mRNA CTD PMID:26934552 NCBI chr19:44,172,465...44,208,967
Ensembl chr19:44,175,733...44,208,957 		JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 increases expression ISO Diclofenac results in increased expression of SMARCB1 mRNA CTD PMID:26934552 NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055 		JBrowse link
G Snca synuclein alpha increases expression ISO Diclofenac results in increased expression of SNCA mRNA CTD PMID:26934552 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Snx10 sorting nexin 10 increases expression ISO Diclofenac results in increased expression of SNX10 mRNA CTD PMID:26934552 NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651 		JBrowse link
G Soat2 sterol O-acyltransferase 2 decreases expression ISO Diclofenac results in decreased expression of SOAT2 mRNA CTD PMID:35537566 NCBI chr 7:135,160,424...135,173,521
Ensembl chr 7:135,160,402...135,173,513 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Diclofenac results in increased expression of SOCS3 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 affects expression ISO Diclofenac affects the expression of SOCS6 mRNA CTD PMID:24752500 NCBI chr18:84,386,587...84,413,927
Ensembl chr18:84,384,573...84,414,053 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 affects expression ISO Diclofenac affects the expression of SOCS7 mRNA CTD PMID:24752500 NCBI chr10:82,848,525...82,885,201
Ensembl chr10:82,848,612...82,885,201 		JBrowse link
G Sod1 superoxide dismutase 1 increases secretion
multiple interactions
decreases activity
increases expression 		ISO
EXP 		Diclofenac results in increased secretion of SOD1 protein
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of SOD1 mRNA; Sodium Selenite promotes the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in decreased expression of SOD1 mRNA]
Diclofenac results in decreased activity of SOD1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]
Diclofenac results in increased expression of SOD1 mRNA 		CTD PMID:24038040 PMID:28535741 PMID:29027214 PMID:38945390 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
affects expression 		EXP
ISO 		Diclofenac results in increased expression of SOD2 mRNA; Diclofenac results in increased expression of SOD2 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOD2 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SOD2 mRNA]; rebamipide promotes the reaction [Diclofenac results in increased expression of SOD2 protein]
Diclofenac affects the expression of SOD2 mRNA 		CTD PMID:19022234 PMID:22653900 PMID:23939143 PMID:24752500 PMID:25772430 More... NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases secretion 		ISO Acetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein] CTD PMID:12763371 NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 affects expression ISO Diclofenac affects the expression of SOS1 mRNA CTD PMID:24752500 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of SOS2 mRNA CTD PMID:24752500 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Sox8 SRY-box transcription factor 8 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SOX8 mRNA CTD PMID:37844793 NCBI chr10:15,089,357...15,094,345
Ensembl chr10:15,089,357...15,094,345 		JBrowse link
G Spaca6 sperm acrosome associated 6 increases expression EXP Diclofenac results in increased expression of SPACA6 mRNA CTD PMID:30723492 NCBI chr 1:67,345,996...67,365,210
Ensembl chr 1:67,346,893...67,362,087 		JBrowse link
G Spata17 spermatogenesis associated 17 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SPATA17 mRNA CTD PMID:37844793 NCBI chr13:101,137,415...101,316,221
Ensembl chr13:101,137,415...101,316,376 		JBrowse link
G Spata19 spermatogenesis associated 19 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SPATA19 mRNA CTD PMID:37844793 NCBI chr 8:34,057,130...34,079,097
Ensembl chr 8:34,073,316...34,079,096 		JBrowse link
G Spata25 spermatogenesis associated 25 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SPATA25 mRNA CTD PMID:37844793 NCBI chr 3:173,981,863...173,983,818
Ensembl chr 3:173,981,866...173,983,818 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO Diclofenac results in decreased expression of SPDL1 mRNA CTD PMID:35537566 NCBI chr10:19,773,456...19,798,341
Ensembl chr10:19,773,457...19,798,297 		JBrowse link
G Spem1 spermatid maturation 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SPEM1 mRNA CTD PMID:37844793 NCBI chr10:55,040,178...55,041,479
Ensembl chr10:55,040,195...55,041,479 		JBrowse link
G Spink2 serine peptidase inhibitor, Kazal type 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SPINK2 mRNA CTD PMID:37844793 NCBI chr14:31,321,976...31,328,622
Ensembl chr14:31,322,010...31,328,622 		JBrowse link
G Spmip10 sperm microtubule inner protein 10 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TEX43 mRNA CTD PMID:37844793 NCBI chr18:52,268,703...52,272,037
Ensembl chr18:52,268,665...52,272,041 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 increases expression EXP Diclofenac results in increased expression of SPRY3 mRNA CTD PMID:30723492 NCBI chr12:21,777,090...21,786,280
Ensembl chr12:21,776,005...21,786,804 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 decreases expression ISO Diclofenac results in decreased expression of SPRY4 mRNA CTD PMID:26934552 NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,687,039...30,704,173 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Diclofenac results in increased expression of SQLE mRNA CTD PMID:26934552 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of SRC mRNA CTD PMID:24752500 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO Diclofenac results in decreased expression of SRD5A1 mRNA CTD PMID:26934552 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
multiple interactions 		ISO Diclofenac results in increased expression of SREBF2 mRNA
[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of SREBF2 mRNA; Sodium Selenite inhibits the reaction [[Cadmium co-treated with Arsenic co-treated with Mercury co-treated with Diclofenac co-treated with flumequine] results in increased expression of SREBF2 mRNA] 		CTD PMID:26934552 PMID:38945390 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression
multiple interactions 		ISO Diclofenac results in increased expression of SRXN1 mRNA
Diclofenac results in increased expression of SRXN1 protein
NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA] 		CTD PMID:24752500 PMID:27358234 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression ISO Diclofenac results in increased expression of ST6GAL1 mRNA CTD PMID:26934552 NCBI chr11:91,031,481...91,158,111
Ensembl chr11:91,032,450...91,040,415 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
affects expression 		ISO Diclofenac results in decreased expression of STAT1 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac affects the expression of STAT1 mRNA 		CTD PMID:19192274 PMID:22285467 PMID:24752500 PMID:26609140 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
affects expression 		ISO Diclofenac results in increased expression of STAT3 mRNA
Diclofenac affects the expression of STAT3 mRNA 		CTD PMID:22285467 PMID:23506792 PMID:24752500 PMID:26934552 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Diclofenac results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B affects expression ISO Diclofenac affects the expression of STAT5B mRNA CTD PMID:24752500 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects expression ISO Diclofenac affects the expression of STAT6 mRNA CTD PMID:24752500 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Steap4 STEAP4 metalloreductase increases expression
decreases expression 		ISO Diclofenac results in increased expression of STEAP4 mRNA
Diclofenac results in decreased expression of STEAP4 mRNA 		CTD PMID:26934552 NCBI chr 4:27,032,096...27,054,769
Ensembl chr 4:27,009,584...27,067,105 		JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP Diclofenac results in increased expression of STIL mRNA CTD PMID:30723492 NCBI chr 5:133,757,598...133,810,493
Ensembl chr 5:133,760,417...133,810,494 		JBrowse link
G Stk31 serine threonine kinase 31 decreases expression ISO Diclofenac results in decreased expression of STK31 mRNA CTD PMID:26934552 NCBI chr 4:79,701,470...79,797,085
Ensembl chr 4:79,694,606...79,797,354 		JBrowse link
G Stmn1 stathmin 1 affects expression ISO Diclofenac affects the expression of STMN1 mRNA CTD PMID:24752500 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842 		JBrowse link
G Sts steroid sulfatase increases expression ISO Diclofenac results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104 		JBrowse link
G Sucnr1 succinate receptor 1 decreases expression ISO Diclofenac results in decreased expression of SUCNR1 mRNA CTD PMID:26934552 NCBI chr 2:146,368,858...146,380,360
Ensembl chr 2:146,368,858...146,380,360 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SULT1E1 mRNA CTD PMID:37844793 NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase affects expression ISO Diclofenac affects the expression of SUV39H1 mRNA CTD PMID:24752500 NCBI chr  X:17,093,059...17,105,942
Ensembl chr  X:17,092,986...17,105,942 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 affects expression ISO Diclofenac affects the expression of SUV39H1 mRNA CTD PMID:24752500 NCBI chr  X:146,828,818...146,831,485 JBrowse link
G Syce3 synaptonemal complex central element protein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SYCE3 mRNA CTD PMID:37844793 NCBI chr 7:122,336,427...122,362,608
Ensembl chr 7:122,336,427...122,344,820 		JBrowse link
G Sycp3 synaptonemal complex protein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of SYCP3 mRNA CTD PMID:37844793 NCBI chr 7:24,761,476...24,775,933
Ensembl chr 7:24,761,463...24,776,501 		JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Diclofenac results in decreased expression of SYNE1 mRNA CTD PMID:35537566 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721 		JBrowse link
G Syne4 spectrin repeat containing nuclear envelope family member 4 increases expression EXP Diclofenac results in increased expression of SYNE4 mRNA CTD PMID:30723492 NCBI chr 1:94,696,866...94,701,230
Ensembl chr 1:94,696,609...94,701,230 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TAC1 mRNA CTD PMID:37844793 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Taf3 TATA-box binding protein associated factor 3 affects expression ISO Diclofenac affects the expression of TAF3 mRNA CTD PMID:24752500 NCBI chr17:73,365,162...73,518,053 JBrowse link
G Taf9b TATA-box binding protein associated factor 9b affects expression ISO Diclofenac affects the expression of TAF9B mRNA CTD PMID:24752500 NCBI chr  X:75,354,823...75,366,166
Ensembl chr  X:75,354,825...75,366,414 		JBrowse link
G Tank TRAF family member-associated NFKB activator affects expression ISO Diclofenac affects the expression of TANK mRNA CTD PMID:24752500 NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:66,537,175...66,598,864 		JBrowse link
G Tarbp2 Tarbp2 subunit of RISC loading complex multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TARBP2 mRNA CTD PMID:37844793 NCBI chr 7:135,527,710...135,532,826
Ensembl chr 7:135,527,589...135,533,323 		JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Diclofenac results in decreased expression of TARDBP mRNA CTD PMID:26934552 NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204 		JBrowse link
G Tas1r3 taste 1 receptor member 3 increases expression EXP Diclofenac results in increased expression of TAS1R3 mRNA CTD PMID:30723492 NCBI chr 5:171,750,937...171,754,993
Ensembl chr 5:171,750,937...171,754,993 		JBrowse link
G Tasor transcription activation suppressor affects expression ISO Diclofenac affects the expression of TASOR mRNA CTD PMID:24752500 NCBI chr16:2,612,942...2,669,870
Ensembl chr16:2,613,505...2,669,867 		JBrowse link
G Tbc1d21 TBC1 domain family, member 21 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TBC1D21 mRNA CTD PMID:37844793 NCBI chr 8:67,657,409...67,669,558
Ensembl chr 8:67,657,410...67,669,558 		JBrowse link
G Tbc1d31 TBC1 domain family, member 31 decreases expression ISO Diclofenac results in decreased expression of TBC1D31 mRNA CTD PMID:35537566 NCBI chr 7:91,316,905...91,396,434
Ensembl chr 7:91,316,921...91,396,434 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Diclofenac results in decreased expression of TBX21 mRNA CTD PMID:22285467 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Diclofenac results in increased expression of TBX3 mRNA CTD PMID:26934552 NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171 		JBrowse link
G Tcf3 transcription factor 3 affects expression ISO Diclofenac affects the expression of TCF3 mRNA CTD PMID:24752500 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 affects expression ISO Diclofenac affects the expression of TCF7L2 mRNA CTD PMID:24752500 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Tdrd7 tudor domain containing 7 affects expression ISO Diclofenac affects the expression of TDRD7 mRNA CTD PMID:24752500 NCBI chr 5:65,034,317...65,108,165
Ensembl chr 5:65,034,341...65,108,161 		JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 decreases expression ISO Diclofenac results in decreased expression of TECPR1 mRNA CTD PMID:35537566 NCBI chr12:15,504,456...15,534,541
Ensembl chr12:15,505,343...15,534,116 		JBrowse link
G Tekt4 tektin 4 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TEKT4 mRNA CTD PMID:37844793 NCBI chr10:14,992,284...14,997,460
Ensembl chr10:14,992,262...14,997,461 		JBrowse link
G Tex12 testis expressed 12 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TEX12 mRNA CTD PMID:37844793 NCBI chr 8:59,804,662...59,809,595
Ensembl chr 8:59,804,662...59,813,423 		JBrowse link
G Tfdp1 transcription factor Dp-1 affects expression ISO Diclofenac affects the expression of TFDP1 mRNA CTD PMID:24752500 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996 		JBrowse link
G Tff3 trefoil factor 3 increases expression ISO Diclofenac results in increased expression of TFF3 mRNA CTD PMID:26934552 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Diclofenac results in increased expression of TFRC mRNA CTD PMID:26934552 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Diclofenac results in increased expression of TGFA mRNA CTD PMID:19022234 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Diclofenac results in decreased expression of TGFB2 mRNA CTD PMID:17379860 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tgm1 transglutaminase 1 increases expression ISO Diclofenac results in increased expression of TGM1 mRNA CTD PMID:26934552 NCBI chr15:33,160,985...33,175,632
Ensembl chr15:33,160,987...33,174,463 		JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain increases expression ISO Diclofenac results in increased expression of TIFA mRNA CTD PMID:26934552 NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:218,909,915...218,956,224 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
increases expression 		EXP
ISO 		Diclofenac results in decreased expression of TIMP1 mRNA
Diclofenac results in increased expression of TIMP1 mRNA 		CTD PMID:19022234 PMID:26934552 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tirap TIR domain containing adaptor protein increases expression ISO Diclofenac results in increased expression of TIRAP mRNA CTD PMID:26934552 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312 		JBrowse link
G Tjp1 tight junction protein 1 affects expression ISO Diclofenac affects the expression of TJP1 mRNA CTD PMID:24752500 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tk1 thymidine kinase 1 affects expression ISO Diclofenac affects the expression of TK1 mRNA CTD PMID:24752500 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228 		JBrowse link
G Tk2 thymidine kinase 2 affects expression ISO Diclofenac affects the expression of TK2 mRNA CTD PMID:24752500 NCBI chr19:713,043...737,345
Ensembl chr19:715,318...738,355 		JBrowse link
G Tlcd1 TLC domain containing 1 increases expression ISO Diclofenac results in increased expression of TLCD1 mRNA CTD PMID:35537566 NCBI chr10:63,572,541...63,574,574
Ensembl chr10:63,572,518...63,574,567 		JBrowse link
G Tlk1 tousled-like kinase 1 decreases expression ISO Diclofenac results in decreased expression of TLK1 mRNA CTD PMID:26934552 NCBI chr 3:75,928,303...76,035,246
Ensembl chr 3:75,928,303...76,035,059 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression
increases expression 		ISO
EXP 		Diclofenac results in decreased expression of TLR2 mRNA
Diclofenac results in increased expression of TLR2 mRNA 		CTD PMID:19192274 PMID:26934552 PMID:29027214 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression 		EXP diacerein inhibits the reaction [Diclofenac results in increased expression of TLR4 protein] CTD PMID:38582345 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression ISO Diclofenac results in increased expression of TM7SF2 mRNA CTD PMID:35537566 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
G Tmem176a transmembrane protein 176A increases expression
decreases expression 		ISO Diclofenac results in increased expression of TMEM176A mRNA
Diclofenac results in decreased expression of TMEM176A mRNA 		CTD PMID:26934552 NCBI chr 4:79,101,946...79,109,499
Ensembl chr 4:79,101,857...79,111,175 		JBrowse link
G Tnc tenascin C decreases expression ISO Diclofenac results in decreased expression of TNC mRNA CTD PMID:35537566 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases response to substance 		ISO
EXP 		Diclofenac results in increased expression of TNF mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
TNF protein results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of TNF mRNA; Diclofenac results in increased expression of TNF protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
[Diclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] 		CTD PMID:15135310 PMID:15489888 PMID:17328244 PMID:19022234 PMID:19362101 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO Diclofenac results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979 		JBrowse link
G Tnfaip8l2 TNF alpha induced protein 8 like 2 increases expression ISO Diclofenac results in increased expression of TNFAIP8L2 mRNA CTD PMID:26934552 NCBI chr 2:185,399,442...185,415,798
Ensembl chr 2:185,397,029...185,418,455 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression
increases expression 		ISO Diclofenac affects the expression of TNFRSF1A mRNA
Diclofenac results in increased expression of TNFRSF1A mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tnfsf18 TNF superfamily member 18 decreases expression ISO Diclofenac results in decreased expression of TNFSF18 mRNA CTD PMID:35537566 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:76,366,771...76,376,608 		JBrowse link
G Tnks1bp1 tankyrase 1 binding protein 1 decreases expression ISO Diclofenac results in decreased expression of TNKS1BP1 mRNA CTD PMID:35537566 NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:90,542,033...90,566,713 		JBrowse link
G Tnp1 transition protein 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TNP1 mRNA CTD PMID:37844793 NCBI chr 9:82,043,669...82,044,278
Ensembl chr 9:82,043,672...82,044,278 		JBrowse link
G Tnp2 transition protein 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TNP2 mRNA CTD PMID:37844793 NCBI chr10:5,386,735...5,387,463
Ensembl chr10:5,383,885...5,387,467 		JBrowse link
G Togaram2 TOG array regulator of axonemal microtubules 2 increases expression EXP Diclofenac results in increased expression of TOGARAM2 mRNA CTD PMID:30723492 NCBI chr 6:29,491,183...29,549,004
Ensembl chr 6:29,491,040...29,548,977 		JBrowse link
G Tox thymocyte selection-associated high mobility group box increases expression EXP Diclofenac results in increased expression of TOX mRNA CTD PMID:30723492 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:24,672,487...24,968,754 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
affects expression 		ISO
EXP 		Diclofenac promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]
Diclofenac results in increased expression of TP53 mRNA
Diclofenac results in increased expression of TP53 mRNA; Diclofenac results in increased expression of TP53 protein
Diclofenac affects the expression of TP53 mRNA 		CTD PMID:15458769 PMID:24752500 PMID:29027214 PMID:32087850 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Diclofenac results in increased expression of TRP53INP1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484 		JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Diclofenac results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:94,642,585...94,724,241 		JBrowse link
G Tppp2 tubulin polymerization-promoting protein family member 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of TPPP2 mRNA CTD PMID:37844793 NCBI chr15:27,087,457...27,090,869 JBrowse link
G Tpsb2 tryptase beta 2 increases expression EXP Diclofenac results in increased expression of TPSB2 mRNA CTD PMID:30723492 NCBI chr10:14,886,310...14,888,102
Ensembl chr10:14,886,360...14,888,100 		JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 increases expression EXP Diclofenac results in increased expression of TRAF3IP3 mRNA CTD PMID:30723492 NCBI chr13:107,223,499...107,248,358
Ensembl chr13:107,223,502...107,248,155 		JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 increases expression ISO Diclofenac results in increased expression of TRAT1 mRNA CTD PMID:26934552 NCBI chr11:65,498,742...65,540,823
Ensembl chr11:65,498,742...65,542,381 		JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO Diclofenac results in decreased expression of TRIB3 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802 		JBrowse link
G Trim46 tripartite motif-containing 46 decreases expression ISO Diclofenac results in decreased expression of TRIM46 mRNA CTD PMID:35537566 NCBI chr 2:176,939,253...176,952,285
Ensembl chr 2:176,939,253...176,958,364 		JBrowse link
G Trrap transformation/transcription domain-associated protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of TRRAP mRNA CTD PMID:37844793 NCBI chr12:14,851,758...14,941,444
Ensembl chr12:14,851,758...14,941,407 		JBrowse link
G Tsc1 TSC complex subunit 1 affects expression ISO Diclofenac affects the expression of TSC1 mRNA CTD PMID:24752500 NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Diclofenac results in decreased expression of TSC22D1 mRNA CTD PMID:26934552 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322 		JBrowse link
G Tsc22d2 TSC22 domain family, member 2 increases expression ISO Diclofenac results in increased expression of TSC22D2 mRNA CTD PMID:26934552 NCBI chr 2:144,796,760...144,847,930
Ensembl chr 2:144,796,841...144,843,559 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression
decreases expression 		ISO Diclofenac results in increased expression of TSC22D3 mRNA
Diclofenac results in decreased expression of TSC22D3 mRNA 		CTD PMID:26934552 PMID:35537566 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519 		JBrowse link
G Tsks testis-specific serine kinase substrate increases expression EXP Diclofenac results in increased expression of TSKS mRNA CTD PMID:30723492 NCBI chr 1:104,550,790...104,578,147
Ensembl chr 1:104,550,897...104,578,145 		JBrowse link
G Tspan4 tetraspanin 4 increases expression ISO Diclofenac results in increased expression of TSPAN4 mRNA CTD PMID:26934552 NCBI chr 1:206,001,731...206,021,414
Ensembl chr 1:206,001,731...206,021,413 		JBrowse link
G Tspan8 tetraspanin 8 increases expression ISO Diclofenac results in increased expression of TSPAN8 mRNA CTD PMID:26934552 NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401 		JBrowse link
G Tspear thrombospondin-type laminin G domain and EAR repeats increases expression EXP Diclofenac results in increased expression of TSPEAR mRNA CTD PMID:30723492 NCBI chr20:10,771,365...10,944,285
Ensembl chr20:10,771,371...10,943,708 		JBrowse link
G Ttr transthyretin increases expression ISO Diclofenac results in increased expression of TTR protein CTD PMID:23506792 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969 		JBrowse link
G Tuba1a tubulin, alpha 1A affects expression ISO Diclofenac affects the expression of TUBA1A mRNA CTD PMID:24752500 NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035 		JBrowse link
G Tuba1c tubulin, alpha 1C affects expression ISO Diclofenac affects the expression of TUBA1C mRNA CTD PMID:24752500 NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:132,070,536...132,079,311 		JBrowse link
G Tubb3 tubulin, beta 3 class III affects expression ISO Diclofenac affects the expression of TUBB3 mRNA CTD PMID:24752500 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb affects expression ISO Diclofenac affects the expression of TUBB4B mRNA CTD PMID:24752500 NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719 		JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions 		ISO
EXP 		Diclofenac results in increased expression of TXN mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXN1 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TXN1 mRNA]; Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA] 		CTD PMID:19022234 PMID:23939143 PMID:25772430 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txn2 thioredoxin 2 increases expression EXP Diclofenac results in increased expression of TXN2 mRNA CTD PMID:19022234 NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Diclofenac results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression
multiple interactions 		ISO
EXP 		Diclofenac affects the expression of TXNRD1 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXNRD1 protein 		CTD PMID:24752500 PMID:25772430 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Tyr tyrosinase decreases expression ISO Diclofenac results in decreased expression of TYR protein CTD PMID:21079976 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp increases expression ISO Diclofenac results in increased expression of TYROBP mRNA CTD PMID:26934552 NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:94,800,117...94,804,299 		JBrowse link
G Ubc ubiquitin C affects expression ISO Diclofenac affects the expression of UBC mRNA CTD PMID:26934552 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of UBE2B mRNA CTD PMID:37844793 NCBI chr10:36,749,365...36,764,335
Ensembl chr10:36,749,369...36,765,587 		JBrowse link
G Uck2 uridine-cytidine kinase 2 affects expression ISO Diclofenac affects the expression of UCK2 mRNA CTD PMID:24752500 NCBI chr13:81,913,732...81,971,036
Ensembl chr13:81,916,818...81,971,091 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Diclofenac results in increased expression of UCP2 mRNA CTD PMID:26934552 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
decreases expression
decreases activity 		ISO
EXP 		Diclofenac results in increased expression of UGT1A1 mRNA
Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]
Diclofenac results in decreased expression of UGT1A1 mRNA
Diclofenac results in decreased activity of UGT1A1 protein 		CTD PMID:15334623 PMID:15593333 PMID:18227147 PMID:19022234 PMID:33290829 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity
increases glucuronidation 		ISO Diclofenac results in decreased activity of UGT1A3 protein
UGT1A3 protein results in increased glucuronidation of Diclofenac 		CTD PMID:15117964 PMID:15334623 PMID:15843492 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone] CTD PMID:22265884 PMID:33290829 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions 		ISO UGT1A9 protein results in increased glucuronidation of Diclofenac
Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone] 		CTD PMID:15988124 PMID:33290829 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 PMID:22265884 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
affects glucuronidation
affects response to substance
increases metabolic processing
increases glucuronidation 		ISO [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [UGT2B7 protein polymorphism affects the glucuronidation of Diclofenac] which affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]
UGT2B7 protein polymorphism affects the susceptibility to Diclofenac
UGT2B7 protein results in increased metabolism of Diclofenac
UGT2B7 protein results in increased glucuronidation of Diclofenac 		CTD PMID:15608137 PMID:15843492 PMID:15988124 PMID:19740398 PMID:22265884 More... NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 increases expression ISO Diclofenac results in increased expression of ULK2 mRNA CTD PMID:26934552 NCBI chr10:46,951,038...47,029,844
Ensembl chr10:46,951,038...47,029,844 		JBrowse link
G Ung uracil-DNA glycosylase affects expression
increases expression 		ISO Diclofenac affects the expression of UNG mRNA
Diclofenac results in increased expression of UNG mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257 		JBrowse link
G Upp2 uridine phosphorylase 2 decreases expression ISO Diclofenac results in decreased expression of UPP2 mRNA CTD PMID:26934552 NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191 		JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of UQCC2 mRNA CTD PMID:37844793 NCBI chr20:5,204,682...5,217,080
Ensembl chr17:12,088,037...12,088,606
Ensembl chr20:12,088,037...12,088,606 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression ISO Diclofenac results in increased expression of USP28 mRNA CTD PMID:26934552 NCBI chr 8:58,222,258...58,282,711
Ensembl chr 8:58,222,220...58,282,750 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Diclofenac results in increased expression of VCAM1 mRNA CTD PMID:26934552 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vcan versican decreases expression ISO Diclofenac results in decreased expression of VCAN mRNA CTD PMID:26934552 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955 		JBrowse link
G Vcl vinculin affects expression ISO Diclofenac affects the expression of VCL mRNA CTD PMID:24752500 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression ISO Diclofenac affects the expression of VEGFA mRNA CTD PMID:24752500 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Diclofenac results in decreased expression of VEGFC mRNA CTD PMID:35537566 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
G Vim vimentin decreases expression ISO Diclofenac results in decreased expression of VIM protein CTD PMID:19628293 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Diclofenac results in decreased expression of VLDLR mRNA CTD PMID:26934552 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 increases expression ISO Diclofenac results in increased expression of VSIG4 mRNA CTD PMID:26934552 NCBI chr  X:65,154,422...65,179,708
Ensembl chr  X:65,154,424...65,179,708 		JBrowse link
G Vwce von Willebrand factor C and EGF domains decreases expression ISO Diclofenac results in decreased expression of VWCE mRNA CTD PMID:26934552 NCBI chr 1:216,703,742...216,753,284
Ensembl chr 1:216,707,351...216,738,337 		JBrowse link
G Wdr11 WD repeat domain 11 decreases expression ISO Diclofenac results in decreased expression of WDR11 mRNA CTD PMID:35537566 NCBI chr 1:193,595,606...193,641,149
Ensembl chr 1:193,595,535...193,641,142 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Diclofenac results in increased expression of WIPI1 mRNA CTD PMID:26934552 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Diclofenac results in increased expression of XBP1 mRNA CTD PMID:26934552 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects expression
increases expression 		ISO Diclofenac affects the expression of XIAP mRNA
Diclofenac results in increased expression of XIAP mRNA 		CTD PMID:24752500 PMID:26934552 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta affects expression ISO Diclofenac affects the expression of YWHAB mRNA CTD PMID:24752500 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta affects expression ISO Diclofenac affects the expression of YWHAQ mRNA CTD PMID:24752500 NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875 		JBrowse link
G Zar1 zygote arrest 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ZAR1 mRNA CTD PMID:37844793 NCBI chr14:35,547,467...35,551,757
Ensembl chr14:35,547,467...35,551,611 		JBrowse link
G Zbp1 Z-DNA binding protein 1 increases expression ISO Diclofenac results in increased expression of ZBP1 mRNA CTD PMID:26934552 NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:182,411,665...182,422,839 		JBrowse link
G Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 increases expression ISO Diclofenac results in increased expression of ZDHHC23 mRNA CTD PMID:35537566 NCBI chr11:70,224,581...70,240,971
Ensembl chr11:70,225,045...70,240,102 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Diclofenac results in decreased expression of ZEB1 protein CTD PMID:19628293 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
G Zfp346 zinc finger protein 346 decreases expression ISO Diclofenac results in decreased expression of ZFP346 mRNA CTD PMID:35537566 NCBI chr17:9,498,933...9,528,824
Ensembl chr17:9,498,933...9,528,783 		JBrowse link
G Zfp420 zinc finger protein 420 decreases expression ISO Diclofenac results in decreased expression of ZFP420 mRNA CTD PMID:35537566 NCBI chr 1:94,259,715...94,271,102
Ensembl chr 1:94,259,809...94,271,101 		JBrowse link
G Zfp786 zinc finger protein 786 increases expression EXP Diclofenac results in increased expression of ZFP786 mRNA CTD PMID:30723492 NCBI chr 4:78,156,173...78,171,888
Ensembl chr 4:78,158,757...78,172,425 		JBrowse link
G Znrd2 zinc ribbon domain containing 2 increases expression ISO Diclofenac results in increased expression of ZNRD2 mRNA CTD PMID:35537566 NCBI chr 1:212,447,010...212,448,793
Ensembl chr 1:212,447,010...212,448,793 		JBrowse link
G Zp1 zona pellucida glycoprotein 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ZP1 mRNA CTD PMID:37844793 NCBI chr 1:216,984,343...216,993,882
Ensembl chr 1:216,985,768...216,992,148 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ZP2 mRNA CTD PMID:37844793 NCBI chr 1:183,944,840...183,956,619
Ensembl chr 1:183,939,880...183,963,075 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ZP3 mRNA CTD PMID:37844793 NCBI chr12:26,327,161...26,334,126
Ensembl chr12:26,327,161...26,334,126 		JBrowse link
4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions 		ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] 		CTD PMID:24246759 PMID:24552538 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions 		EXP
ISO 		TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein] 		CTD PMID:23939143 PMID:29777833 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
5-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA 		CTD PMID:15555568 PMID:18076062 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      biological role 20827
        xenobiotic 19528
          diclofenac 1219
            3'-hydroxy-4'-methoxydiclofenac 0
            3'-hydroxydiclofenac 0
            4',5-dihydroxydiclofenac 0
            4'-hydroxydiclofenac 14
            4'-hydroxydiclofenac quinone imine 0
            5-hydroxydiclofenac 8
            5-hydroxydiclofenac quinone imine 0
            aceclofenac 4
            diclofenac beta-D-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      monocarboxylic acid 18307
                                        acetic acid 11173
                                          phenylacetic acid 1372
                                            diclofenac 1219
                                              3'-hydroxy-4'-methoxydiclofenac 0
                                              3'-hydroxydiclofenac 0
                                              4',5-dihydroxydiclofenac 0
                                              4'-hydroxydiclofenac 14
                                              4'-hydroxydiclofenac quinone imine 0
                                              5-hydroxydiclofenac 8
                                              5-hydroxydiclofenac quinone imine 0
                                              aceclofenac 4
                                              diclofenac beta-D-glucosiduronic acid 0
paths to the root