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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diclofenac
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Accession:CHEBI:47381 term browser browse the term
Definition:A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Synonyms:exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
 related_synonym: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID;   Formula=C14H11Cl2NO2;   InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19);   InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N;   SMILES=C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl;   [2-(2,6-dichloroanilino)phenyl]acetic acid;   diclofenac acid;   diclofenaco;   diclofenacum;   diclofenamic acid
 alt_id: CHEBI:4507;   CHEBI:47380
 xref: Beilstein:2146636;   CAS:15307-86-5;   DrugBank:DB00586;   Drug_Central:865;   HMDB:HMDB0014724;   KEGG:C01690;   KEGG:D07816;   LINCS:LSM-2160
 xref_mesh: MESH:D004008
 xref: PDBeChem:DIF;   PMID:11322639;   PMID:1502708;   PMID:23777257;   PMID:27967303;   PMID:7838674;   Patent:NL6604752;   Patent:US3558690;   Reaxys:2146636;   VSDB:1933;   Wikipedia:Diclofenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:48311


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diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Aacs acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:36,512,393...36,555,694
Ensembl chr12:36,512,393...36,555,694
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein
CTD PMID:24014644, PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases response to substance
decreases activity
ISO Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein
CTD PMID:15458769, PMID:19022234, PMID:28193520 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression EXP Diclofenac results in decreased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity
ISO Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein
CTD PMID:19022234, PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac
CTD PMID:19022234, PMID:22646477, PMID:25450747 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACPP mRNA CTD PMID:26934552 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects expression ISO Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Actn1 actinin, alpha 1 affects expression EXP Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Acvr1 activin A receptor type 1 affects expression ISO Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr1b activin A receptor type 1B affects expression ISO Diclofenac affects the expression of ACVR1B mRNA CTD PMID:24752500 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr2b activin A receptor type 2B affects expression ISO Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr15:49,485,604...49,521,638
Ensembl chr15:49,485,611...49,505,553
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression ISO Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy9 adenylate cyclase 9 affects expression
decreases expression
ISO Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adk adenosine kinase increases expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA
CTD PMID:19022234 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151, PMID:28138970 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Aggf1 angiogenic factor with G patch and FHA domains 1 affects expression ISO Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 2:25,068,804...25,095,429
Ensembl chr 2:25,069,620...25,095,106
JBrowse link
G Ago2 argonaute RISC catalytic component 2 affects expression ISO Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ago3 argonaute RISC catalytic component 3 affects expression ISO Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Ago4 argonaute RISC component 4 affects expression ISO Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 5:144,501,875...144,557,165
Ensembl chr 5:144,504,938...144,556,889
JBrowse link
G Agrp agouti related neuropeptide increases expression EXP Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression ISO Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 affects expression ISO Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin affects binding
multiple interactions
decreases expression
increases expression
ISO
EXP
Diclofenac binds to ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased expression of ALB protein
Diclofenac results in increased expression of ALB mRNA
CTD PMID:9353694, PMID:19022234, PMID:28400101 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Diclofenac results in increased expression of ALDH18A1 mRNA CTD PMID:26934552 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Diclofenac results in increased expression of ALOX15 mRNA CTD PMID:23939143 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Ang angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Aoc3 amine oxidase, copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apcs amyloid P component, serum multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein
CTD PMID:25772430, PMID:26934552 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoa4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor affects expression ISO Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Ar androgen receptor affects activity ISO Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Arhgap20 Rho GTPase activating protein 20 increases expression EXP Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr 8:56,179,581...56,264,343
Ensembl chr 8:56,179,637...56,264,263
JBrowse link
G Arhgap26 Rho GTPase activating protein 26 affects expression ISO Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr18:31,807,052...32,557,176
Ensembl chr18:31,812,109...32,207,801
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects expression ISO Diclofenac affects the expression of ARHGEF3 mRNA CTD PMID:24752500 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression ISO Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr20:21,713,900...21,881,193
Ensembl chr20:21,564,975...21,880,715
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression EXP Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:105,535,670...105,539,575
Ensembl chr  X:105,537,602...105,539,375
Ensembl chr  X:105,537,602...105,539,375
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects expression ISO Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression ISO Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Ash2l ASH2 like histone lysine methyltransferase complex subunit affects expression ISO Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr16:71,011,315...71,033,171
Ensembl chr16:71,011,332...71,032,790
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression
decreases activity
EXP Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein
CTD PMID:11588175 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Asl argininosuccinate lyase affects expression ISO Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression
ISO Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA
CTD PMID:19192274, PMID:26934552 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf4 activating transcription factor 4 affects expression
increases expression
ISO Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA
CTD PMID:24752500, PMID:27313093 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein
CTD PMID:25772430 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein
CTD PMID:25772430 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein
CTD PMID:25772430 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Azin1 antizyme inhibitor 1 affects expression ISO Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 3:53,699,409...54,269,612
Ensembl chr 3:54,253,949...54,267,292
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects expression ISO Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization
ISO
EXP
Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein
CTD PMID:18191430, PMID:29027214 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO
EXP
Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects expression
ISO Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA
CTD PMID:14609740, PMID:24752500 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 affects expression ISO Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA
CTD PMID:18191430, PMID:24752500 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Diclofenac results in decreased expression of BMP6 mRNA CTD PMID:26934552 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 affects expression ISO Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G C1qa complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qb complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1qc complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C4b complement C4B (Chido blood group) increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Ca13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression
increases secretion
ISO
EXP
Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein
CTD PMID:24038040, PMID:26934552 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calm1 calmodulin 1 affects expression ISO Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calml3 calmodulin-like 3 increases expression EXP Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr17:70,070,458...70,073,697
Ensembl chr17:70,072,156...70,073,530
JBrowse link
G Calr calreticulin affects expression
decreases expression
EXP Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA
CTD PMID:18246545 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn10 calpain 10 affects expression ISO Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 9:100,104,000...100,112,833
Ensembl chr 9:100,104,000...100,112,832
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 multiple interactions
affects expression
ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA
CTD PMID:16388830, PMID:24752500 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
CTD PMID:12826271, PMID:14599462, PMID:14609740, PMID:16388830, PMID:24770551, PMID:26609140, PMID:27313093, PMID:31042592 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 affects expression ISO Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases activity
affects expression
multiple interactions
EXP
ISO
Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]
CTD PMID:14609740, PMID:20237495, PMID:24752500, PMID:27313093 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO
EXP
[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA
CTD PMID:14609740, PMID:16388830, PMID:25014874, PMID:27313093, PMID:29027214 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
EXP
ISO
Diclofenac results in increased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]
CTD PMID:17274466, PMID:23994749, PMID:31042592, PMID:31332906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbl Cbl proto-oncogene affects expression ISO Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbs cystathionine beta synthase affects expression ISO Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression
EXP
ISO
[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA
CTD PMID:22285467, PMID:23939143, PMID:24104198, PMID:25051504, PMID:27671914, PMID:31042592 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA] CTD PMID:23939143 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccn1 cellular communication network factor 1 affects expression
increases expression
ISO Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA
CTD PMID:19192274, PMID:24752500 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression
ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein
CTD PMID:15188006, PMID:15489888, PMID:19022234, PMID:26934552 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 affects expression ISO Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 affects expression ISO Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 affects expression ISO Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnf cyclin F affects expression ISO Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccnh cyclin H affects expression ISO Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd28 Cd28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd5l Cd5 molecule-like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr 1:73,717,207...73,719,600
Ensembl chr 1:73,719,005...73,719,529
JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 affects expression ISO Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA
CTD PMID:19022234, PMID:19628293, PMID:24752500 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression ISO Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression EXP Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects expression ISO Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP
Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234, PMID:26934552 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression ISO Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression
ISO
EXP
Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA
CTD PMID:19022234, PMID:24752500 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cfh complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects expression
ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA
CTD PMID:20237495, PMID:24752500 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 6:26,797,126...26,809,132
Ensembl chr 6:26,797,126...26,809,129
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Diclofenac results in increased expression of CHAC1 mRNA CTD PMID:26934552 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Chdh choline dehydrogenase affects expression ISO Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr16:6,078,083...6,109,386
Ensembl chr16:6,078,122...6,109,382
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chka choline kinase alpha affects expression ISO Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chkb choline kinase beta affects expression ISO Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr 7:130,404,818...130,408,813
Ensembl chr 7:130,404,832...130,408,187
JBrowse link
G Chl1 cell adhesion molecule L1-like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Chst4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr19:41,630,060...41,642,373
Ensembl chr19:41,631,715...41,640,367
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]
CTD PMID:15489888, PMID:25935278 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO
EXP
Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein
CTD PMID:23506792, PMID:25772430 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 affects expression ISO Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]
CTD PMID:26934552, PMID:31042592 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr19:52,465,074...52,499,433
Ensembl chr19:52,465,087...52,499,433
JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
JBrowse link
G Cplx1 complexin 1 increases expression EXP Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598
JBrowse link
G Cplx4 complexin 4 increases expression EXP Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:61,657,216...61,672,641
Ensembl chr18:61,656,758...61,672,663
JBrowse link
G Cpne8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr 7:131,623,180...131,798,236
Ensembl chr 7:131,623,181...131,798,236
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 affects expression ISO Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr 7:60,385,688...60,417,661
Ensembl chr 7:60,385,688...60,416,925
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO
EXP
Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:113,824,886...113,872,097
Ensembl chr13:113,824,892...113,872,097
JBrowse link
G Cr2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr13:113,890,274...113,927,824
Ensembl chr13:113,890,272...113,927,877
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 4:64,869,285...64,981,519
Ensembl chr 4:64,869,026...64,981,384
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 affects expression ISO Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 2:189,596,657...189,602,243
Ensembl chr 2:189,595,415...189,602,143
JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]
CTD PMID:25772430, PMID:27313093 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression
increases secretion
ISO Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein
CTD PMID:26934552 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 affects expression ISO Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 increases expression EXP Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 3:51,883,559...52,120,290
Ensembl chr 3:51,883,559...52,120,290
JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 affects expression ISO Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:104,882,726...104,909,746
Ensembl chr  X:104,882,704...104,909,739
JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects expression ISO Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr 3:94,530,586...94,603,378
Ensembl chr 3:94,530,586...94,607,588
JBrowse link
G Ctbp2 C-terminal binding protein 2 affects expression ISO Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
JBrowse link
G Cth cystathionine gamma-lyase affects expression ISO Diclofenac affects the expression of CTH mRNA CTD PMID:24752500 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctps1 CTP synthase 1 affects expression ISO Diclofenac affects the expression of CTPS mRNA CTD PMID:24752500 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 affects expression ISO Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
G Ctsc cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Ctss cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cul3 cullin 3 affects expression ISO Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Cul7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 9:16,629,491...16,643,527
Ensembl chr 9:16,629,401...16,643,182
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23939143 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein
CTD PMID:22285467, PMID:23939143, PMID:24747151, PMID:26934552, PMID:27671914 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
decreases expression
ISO Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA
CTD PMID:26934552, PMID:27671914 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein
CTD PMID:18420780, PMID:21784029 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac
CTD PMID:21784029, PMID:23397584, PMID:28960974 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 affects expression ISO Diclofenac affects the expression of CYP2A5 mRNA CTD PMID:26934552 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Diclofenac results in increased expression of CYP2B9 mRNA CTD PMID:26934552 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Diclofenac results in decreased expression of CYP2C55 mRNA CTD PMID:26934552 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation
increases response to substance
multiple interactions
EXP
ISO
CYP2C6V1 protein results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac
CTD PMID:11911841, PMID:15486075, PMID:18511451, PMID:23397584, PMID:28762043 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Diclofenac results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584, PMID:24246759 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diclofenac results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19022234, PMID:29027214 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA
CTD PMID:26934552, PMID:28960974 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA
CTD PMID:26934552, PMID:28960974 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP7A1 mRNA CTD PMID:26934552 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dap death-associated protein increases expression ISO Diclofenac results in increased expression of DAP mRNA CTD PMID:26934552 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 affects expression ISO Diclofenac affects the expression of DBT mRNA CTD PMID:24752500 NCBI chr 2:219,563,783...219,592,651
Ensembl chr 2:219,563,783...219,592,650
JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 affects expression ISO Diclofenac affects the expression of DCTPP1 mRNA CTD PMID:24752500 NCBI chr 1:198,703,459...198,706,852
Ensembl chr 1:198,703,461...198,706,852
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases response to substance
increases expression
ISO
EXP
DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein
CTD PMID:18172885, PMID:20668000, PMID:24752500, PMID:27313093, PMID:27358234 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Diclofenac results in increased expression of DDIT4 mRNA CTD PMID:26934552 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 affects expression ISO Diclofenac affects the expression of DDR1 mRNA CTD PMID:24752500 NCBI chr20:3,553,430...3,574,959
Ensembl chr20:3,552,929...3,575,780
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Diclofenac results in decreased expression of DDT mRNA CTD PMID:26934552 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Ddx5 DEAD-box helicase 5 affects expression ISO Diclofenac affects the expression of DDX5 mRNA CTD PMID:24752500 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Diclofenac results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Diclofenac results in increased expression of DECR1 protein CTD PMID:25772430 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Derl1 derlin 1 increases expression ISO Diclofenac results in increased expression of DERL1 mRNA CTD PMID:26934552 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Derl3 derlin 3 increases expression ISO Diclofenac results in increased expression of DERL3 mRNA CTD PMID:26934552 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression ISO Diclofenac affects the expression of DFFA mRNA CTD PMID:24752500 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Diclofenac results in increased expression of DHCR24 mRNA CTD PMID:26934552 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhfr dihydrofolate reductase affects expression ISO Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects expression ISO Diclofenac affects the expression of DKK1 mRNA CTD PMID:24752500 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects expression ISO Diclofenac affects the expression of DNAJA1 mRNA CTD PMID:24752500 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 affects expression ISO Diclofenac affects the expression of DNAJA2 mRNA CTD PMID:24752500 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 affects expression
decreases expression
ISO Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Diclofenac affects the expression of DNAJB1 mRNA CTD PMID:24752500 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 affects expression ISO Diclofenac affects the expression of DNAJB14 mRNA CTD PMID:24752500 NCBI chr 2:243,108,443...243,151,933
Ensembl chr 2:243,018,975...243,151,933
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 affects expression ISO Diclofenac affects the expression of DNAJB4 mRNA CTD PMID:24752500 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 affects expression ISO Diclofenac affects the expression of DNAJB6 mRNA CTD PMID:24752500 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnajb7 DnaJ heat shock protein family (Hsp40) member B7 increases expression EXP Diclofenac results in increased expression of DNAJB7 mRNA CTD PMID:30723492 NCBI chr 7:122,642,740...122,644,054
Ensembl chr 7:122,642,740...122,644,054
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression
increases expression
ISO Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 affects expression
increases expression
ISO Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 3:67,538,289...67,578,308
Ensembl chr 3:67,538,289...67,578,306
JBrowse link
G Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 affects expression ISO Diclofenac affects the expression of DNAJC11 mRNA CTD PMID:24752500 NCBI chr 5:169,109,907...169,154,725
Ensembl chr 5:169,109,907...169,154,720
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression
decreases expression
ISO Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA
CTD PMID:26934552 NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 affects expression ISO Diclofenac affects the expression of DNAJC15 mRNA CTD PMID:24752500 NCBI chr15:59,990,131...60,056,710
Ensembl chr15:59,990,131...60,056,710
JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 affects expression ISO Diclofenac affects the expression of DNAJC18 mRNA CTD PMID:24752500 NCBI chr18:28,466,892...28,501,013
Ensembl chr18:28,466,311...28,495,937
JBrowse link
G Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 affects expression ISO Diclofenac affects the expression of DNAJC21 mRNA CTD PMID:24752500 NCBI chr 2:60,419,446...60,446,656
Ensembl chr 2:60,419,525...60,446,510
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Diclofenac results in increased expression of DNAJC3 mRNA CTD PMID:26934552 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 affects expression ISO Diclofenac affects the expression of DNAJC5 mRNA CTD PMID:24752500 NCBI chr 3:177,012,714...177,047,787
Ensembl chr 3:177,013,604...177,043,902
JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 affects expression ISO Diclofenac affects the expression of DNAJC6 mRNA CTD PMID:24752500 NCBI chr 5:120,330,372...120,492,515
Ensembl chr 5:120,340,646...120,492,487
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 affects expression ISO Diclofenac affects the expression of DNAJC7 mRNA CTD PMID:24752500 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829
JBrowse link
G Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 affects expression ISO Diclofenac affects the expression of DNAJC8 mRNA CTD PMID:24752500 NCBI chr 5:150,725,674...150,743,732
Ensembl chr 5:150,725,654...150,743,730
JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 affects expression ISO Diclofenac affects the expression of DNAJC9 mRNA CTD PMID:24752500 NCBI chr15:4,356,512...4,360,788
Ensembl chr15:4,356,261...4,360,564
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects expression ISO Diclofenac affects the expression of DPYSL2 mRNA CTD PMID:24752500 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Diclofenac results in increased expression of DRD1 mRNA CTD PMID:26934552 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Dtymk deoxythymidylate kinase affects expression ISO Diclofenac affects the expression of DTYMK mRNA CTD PMID:24752500 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression
decreases expression
ISO Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Diclofenac affects the expression of DUT mRNA CTD PMID:24752500 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 increases expression EXP Diclofenac results in increased expression of DYNC1I1 mRNA CTD PMID:30723492 NCBI chr 4:30,807,755...31,121,097
Ensembl chr 4:30,807,879...31,121,090
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Diclofenac affects the expression of E2F1 mRNA CTD PMID:24752500 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Diclofenac affects the expression of E2F2 mRNA CTD PMID:24752500 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G E2f5 E2F transcription factor 5 affects expression ISO Diclofenac affects the expression of E2F5 mRNA CTD PMID:24752500 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Diclofenac results in decreased expression of ECM1 mRNA CTD PMID:26934552 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Ect2 epithelial cell transforming 2 increases expression ISO Diclofenac results in increased expression of ECT2 mRNA CTD PMID:26934552 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Diclofenac results in increased expression of EDEM1 mRNA CTD PMID:26934552 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Diclofenac results in decreased expression of EDIL3 mRNA CTD PMID:26934552 NCBI chr 2:17,616,116...18,128,514
Ensembl chr 2:17,616,401...18,128,512
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor increases expression ISO Diclofenac results in increased expression of EGF protein CTD PMID:23506792 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Diclofenac results in increased expression of EGFR mRNA CTD PMID:26934552 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression
affects expression
ISO Diclofenac results in increased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA
CTD PMID:15509713, PMID:26934552 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Diclofenac affects the expression of EIF1 mRNA CTD PMID:24752500 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression ISO Diclofenac results in increased expression of EIF1A mRNA CTD PMID:26934552 NCBI chr18:40,586,315...40,598,661
Ensembl chr18:40,586,315...40,597,671
JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked affects expression ISO Diclofenac affects the expression of EIF1AX mRNA CTD PMID:24752500 NCBI chr  X:37,579,959...37,595,300
Ensembl chr  X:37,579,957...37,595,486
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A affects expression ISO Diclofenac affects the expression of EIF2A mRNA CTD PMID:24752500 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects expression
decreases expression
ISO Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity
ISO Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein
CTD PMID:24752500, PMID:26609140, PMID:26934552 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Diclofenac affects the expression of EIF2AK4 mRNA CTD PMID:24752500 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha affects expression ISO Diclofenac affects the expression of EIF2B1 mRNA CTD PMID:24752500 NCBI chr12:37,444,136...37,452,391
Ensembl chr12:37,444,072...37,465,398
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects expression
multiple interactions
ISO Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein
CTD PMID:24752500, PMID:27313093 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta affects expression ISO Diclofenac affects the expression of EIF2S2 mRNA CTD PMID:24752500 NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A affects expression ISO Diclofenac affects the expression of EIF3A mRNA CTD PMID:24752500 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B affects expression ISO Diclofenac affects the expression of EIF3B mRNA CTD PMID:24752500 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C affects expression ISO Diclofenac affects the expression of EIF3C mRNA CTD PMID:24752500 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 affects expression ISO Diclofenac affects the expression of EIF4A1 mRNA CTD PMID:24752500 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression ISO Diclofenac affects the expression of EIF4A2 mRNA CTD PMID:24752500 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression
affects expression
EXP
ISO
Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA
CTD PMID:18172885, PMID:24752500 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 affects expression ISO Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 affects expression ISO Diclofenac affects the expression of EIF4G3 mRNA CTD PMID:24752500 NCBI chr 5:156,343,663...156,564,037
Ensembl chr 5:156,396,695...156,564,037
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 affects expression ISO Diclofenac affects the expression of EIF5 mRNA CTD PMID:24752500 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Elf2 E74 like ETS transcription factor 2 affects expression ISO Diclofenac affects the expression of ELF2 mRNA CTD PMID:24752500 NCBI chr 2:140,310,374...140,399,312
Ensembl chr 2:140,310,375...140,387,505
JBrowse link
G Elf3 E74 like ETS transcription factor 3 affects expression ISO Diclofenac affects the expression of ELF3 mRNA CTD PMID:24752500 NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects expression ISO Diclofenac affects the expression of ELOVL2 mRNA CTD PMID:24752500 NCBI chr17:21,382,461...21,422,413
Ensembl chr17:21,382,455...21,422,407
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO Diclofenac results in increased expression of EME2 mRNA CTD PMID:26934552 NCBI chr10:14,253,552...14,257,017
Ensembl chr10:14,254,252...14,256,930
JBrowse link
G Endog endonuclease G affects expression ISO Diclofenac affects the expression of ENDOG mRNA CTD PMID:24752500 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Eno1 enolase 1 increases expression ISO Diclofenac results in increased expression of ENO1 mRNA CTD PMID:26934552 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Diclofenac affects the expression of ENPP1 mRNA CTD PMID:24752500 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Diclofenac results in increased expression of ENPP2 mRNA CTD PMID:26934552 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 affects expression ISO Diclofenac affects the expression of ENTPD4 mRNA CTD PMID:24752500 NCBI chr15:51,222,954...51,250,787
Ensembl chr15:51,222,954...51,250,787
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 affects expression ISO Diclofenac affects the expression of ENTPD5 mRNA CTD PMID:24752500 NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579
JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 affects expression ISO Diclofenac affects the expression of ENTPD7 mRNA CTD PMID:24752500 NCBI chr 1:263,448,633...263,490,308
Ensembl chr 1:263,448,633...263,490,308
Ensembl chr 1:263,448,633...263,490,308
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Diclofenac results in decreased expression of EPHX1 mRNA CTD PMID:17202759 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Epn2 epsin 2 affects expression ISO Diclofenac affects the expression of EPN2 mRNA CTD PMID:24752500 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Epn3 epsin 3 affects expression ISO Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 NCBI chr10:82,220,762...82,231,200
Ensembl chr10:82,220,762...82,229,140
JBrowse link
G Epo erythropoietin affects expression ISO Diclofenac affects the expression of EPO mRNA CTD PMID:24752500 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 affects expression ISO Diclofenac affects the expression of ERN1 mRNA CTD PMID:24752500 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Diclofenac results in increased expression of ERO1A mRNA CTD PMID:26934552 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO Diclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase decreases expression ISO Diclofenac results in decreased expression of ETNPPL mRNA CTD PMID:26934552 NCBI chr 2:235,738,377...235,760,351
Ensembl chr 2:235,738,416...235,760,352
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Diclofenac results in decreased expression of EYA4 mRNA CTD PMID:26934552 NCBI chr 1:23,237,617...23,611,580
Ensembl chr 1:23,409,408...23,610,164
JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression ISO Diclofenac results in increased expression of F13A1 mRNA CTD PMID:26934552 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G Faap24 FA core complex associated protein 24 increases expression ISO Diclofenac results in increased expression of FAAP24 mRNA CTD PMID:26934552 NCBI chr 1:91,657,263...91,663,485
Ensembl chr 1:91,657,263...91,663,467
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
increases expression
ISO Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein
CTD PMID:19022234, PMID:23506792 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP
ISO
Diclofenac results in decreased expression of FABP2 mRNA CTD PMID:19022234, PMID:26934552 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Diclofenac results in increased expression of FABP5 mRNA CTD PMID:26934552 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Diclofenac results in decreased expression of FADS1 mRNA CTD PMID:26934552 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fancb FA complementation group B affects expression ISO Diclofenac affects the expression of FANCB mRNA CTD PMID:24752500 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Fancc FA complementation group C affects expression ISO Diclofenac affects the expression of FANCC mRNA CTD PMID:24752500 NCBI chr17:826,512...955,703
Ensembl chr17:833,509...955,615
JBrowse link
G Fance FA complementation group E increases expression ISO Diclofenac results in increased expression of FANCE mRNA CTD PMID:26934552 NCBI chr20:7,888,927...7,906,142
Ensembl chr20:7,895,083...7,906,142
JBrowse link
G Fancf FA complementation group F affects expression ISO Diclofenac affects the expression of FANCF mRNA CTD PMID:24752500 NCBI chr 1:107,229,516...107,232,321
Ensembl chr 1:107,231,292...107,232,305
JBrowse link
G Fancg FA complementation group G affects expression ISO Diclofenac affects the expression of FANCG mRNA CTD PMID:24752500 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819
JBrowse link
G Fancl FA complementation group L affects expression ISO Diclofenac affects the expression of FANCL mRNA CTD PMID:24752500 NCBI chr14:110,675,306...110,740,880
Ensembl chr14:110,676,090...110,740,317
JBrowse link
G Fancm FA complementation group M affects expression ISO Diclofenac affects the expression of FANCM mRNA CTD PMID:24752500 NCBI chr 6:86,823,195...86,877,067
Ensembl chr 6:86,823,684...86,876,633
JBrowse link
G Fas Fas cell surface death receptor affects expression
increases expression
ISO Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO Diclofenac results in increased expression of FASL mRNA CTD PMID:22285467 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Diclofenac results in decreased expression of FASN mRNA CTD PMID:19022234 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig increases expression ISO Diclofenac results in increased expression of FCER1G mRNA CTD PMID:26934552 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa increases expression ISO Diclofenac results in increased expression of FCGR3 mRNA CTD PMID:26934552 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Diclofenac results in increased expression of FEN1 mRNA CTD PMID:26934552 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fer FER tyrosine kinase affects expression ISO Diclofenac affects the expression of FER mRNA CTD PMID:24752500 NCBI chr 9:111,557,804...111,868,583
Ensembl chr 9:111,597,037...111,862,670
JBrowse link
G Fermt1 fermitin family member 1 increases expression EXP Diclofenac results in increased expression of FERMT1 mRNA CTD PMID:30723492 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735
JBrowse link
G Fgb fibrinogen beta chain multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA
CTD PMID:25772430, PMID:26934552 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Diclofenac results in decreased expression of FGF1 mRNA CTD PMID:26934552 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf3 fibroblast growth factor 3 increases expression ISO Diclofenac results in increased expression of FGF3 mRNA CTD PMID:26934552 NCBI chr 1:218,003,018...218,006,942
Ensembl chr 1:218,003,018...218,006,942
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Diclofenac affects the expression of FGFR1 mRNA CTD PMID:24752500 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr1op2 FGFR1 oncogene partner 2 decreases expression ISO Diclofenac results in decreased expression of FGFR1OP2 mRNA CTD PMID:26934552 NCBI chr 4:180,887,182...180,908,206
Ensembl chr 4:180,887,182...180,908,198
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions
decreases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] CTD PMID:25772430 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Diclofenac results in increased expression of FGL1 mRNA CTD PMID:26934552 NCBI chr16:54,153,086...54,188,120
Ensembl chr16:54,153,054...54,188,181
JBrowse link
G Fmod fibromodulin decreases expression ISO Diclofenac results in decreased expression of FMOD mRNA CTD PMID:26934552 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein CTD PMID:26934552 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fnbp1 formin binding protein 1 affects expression ISO Diclofenac affects the expression of FNBP1 mRNA CTD PMID:24752500 NCBI chr 3:9,865,657...9,936,333
Ensembl chr 3:9,861,237...9,936,405
JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression ISO Diclofenac results in increased expression of FNDC3B mRNA CTD PMID:26934552 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Fnip1 folliculin interacting protein 1 decreases expression ISO Diclofenac results in decreased expression of FNIP1 mRNA CTD PMID:26934552 NCBI chr10:39,786,687...39,870,188 JBrowse link
G Fnip2 folliculin interacting protein 2 decreases expression ISO Diclofenac results in decreased expression of FNIP2 mRNA CTD PMID:26934552 NCBI chr 2:178,223,561...178,334,925
Ensembl chr 2:178,225,915...178,334,900
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression
ISO Diclofenac results in increased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA
CTD PMID:12730611, PMID:24752500 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Diclofenac results in increased expression of FOSL2 mRNA CTD PMID:26934552 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Foxa1 forkhead box A1 affects expression ISO Diclofenac affects the expression of FOXA1 mRNA CTD PMID:24752500 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa3 forkhead box A3 increases expression ISO Diclofenac results in increased expression of FOXA3 mRNA CTD PMID:26934552 NCBI chr 1:79,921,292...79,930,219
Ensembl chr 1:79,920,752...79,930,263
JBrowse link
G Foxo1 forkhead box O1 affects expression ISO Diclofenac affects the expression of FOXO1 mRNA CTD PMID:24752500 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 affects expression
decreases expression
ISO Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Diclofenac results in increased expression of FPR2 mRNA CTD PMID:26934552 NCBI chr 1:59,800,558...59,809,507
Ensembl chr 1:59,800,984...59,802,401
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 affects expression ISO Diclofenac affects the expression of FRS2 mRNA CTD PMID:24752500 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase affects expression ISO Diclofenac affects the expression of FTCD mRNA CTD PMID:24752500 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Fyb1 FYN binding protein 1 increases expression ISO Diclofenac results in increased expression of FYB mRNA CTD PMID:26934552 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G Fzd3 frizzled class receptor 3 affects expression ISO Diclofenac affects the expression of FZD3 mRNA CTD PMID:24752500 NCBI chr15:48,601,259...48,670,257
Ensembl chr15:48,601,266...48,670,257
JBrowse link
G Fzd4 frizzled class receptor 4 affects expression ISO Diclofenac affects the expression of FZD4 mRNA CTD PMID:24752500 NCBI chr 1:153,589,471...153,598,376
Ensembl chr 1:153,589,471...153,598,375
JBrowse link
G Fzd5 frizzled class receptor 5 affects expression ISO Diclofenac affects the expression of FZD5 mRNA CTD PMID:24752500 NCBI chr 9:71,443,784...71,445,541
Ensembl chr 9:71,443,588...71,445,739
JBrowse link
G Fzd6 frizzled class receptor 6 affects expression ISO Diclofenac affects the expression of FZD6 mRNA CTD PMID:24752500 NCBI chr 7:77,898,329...77,931,034
Ensembl chr 7:77,899,322...77,931,029
JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO Diclofenac affects the expression of FZD7 mRNA CTD PMID:24752500 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
G Gab1 GRB2-associated binding protein 1 affects expression ISO Diclofenac affects the expression of GAB1 mRNA CTD PMID:24752500 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Gab2 GRB2-associated binding protein 2 affects expression ISO Diclofenac affects the expression of GAB2 mRNA CTD PMID:24752500 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 decreases expression ISO Diclofenac results in decreased expression of GABRA5 mRNA CTD PMID:26934552 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases expression
affects expression
ISO
EXP
Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA
CTD PMID:18172885, PMID:19022234, PMID:24752500, PMID:26934552 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Diclofenac results in increased expression of GADD45G mRNA CTD PMID:26934552 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression EXP Diclofenac results in increased expression of GALNT3 mRNA CTD PMID:30723492 NCBI chr 3:52,174,469...52,212,395
Ensembl chr 3:52,175,547...52,212,412
JBrowse link
G Gars glycyl-tRNA synthetase affects expression ISO Diclofenac affects the expression of GARS1 mRNA CTD PMID:24752500 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase affects expression ISO Diclofenac affects the expression of GART mRNA CTD PMID:24752500 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Diclofenac results in decreased expression of GAS1 mRNA CTD PMID:26934552 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gata4 GATA binding protein 4 affects expression ISO Diclofenac affects the expression of GATA4 mRNA CTD PMID:24752500 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Diclofenac results in increased expression of GATA6 mRNA CTD PMID:26934552 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Diclofenac results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression ISO Diclofenac results in increased expression of GBP3 mRNA CTD PMID:26934552 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Gck glucokinase affects expression ISO Diclofenac affects the expression of GCK mRNA CTD PMID:26934552 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
affects expression
affects response to substance
EXP
ISO
Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac
CTD PMID:17202759, PMID:19481141, PMID:24752500 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression ISO Diclofenac affects the expression of GCLM mRNA CTD PMID:24752500 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein
CTD PMID:15555568, PMID:18076062 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf6 growth differentiation factor 6 increases expression EXP Diclofenac results in increased expression of GDF6 mRNA CTD PMID:30723492 NCBI chr 5:23,056,345...23,072,666
Ensembl chr 5:23,056,347...23,074,599
JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 increases expression ISO Diclofenac results in increased expression of GFPT1 mRNA CTD PMID:26934552 NCBI chr 4:118,852,046...118,901,583
Ensembl chr 4:118,852,062...118,901,591
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein CTD PMID:23939143 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ghr growth hormone receptor affects expression ISO Diclofenac affects the expression of GHR protein CTD PMID:26934552 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
JBrowse link
G Git2 GIT ArfGAP 2 affects expression ISO Diclofenac affects the expression of GIT2 mRNA CTD PMID:24752500 NCBI chr12:47,590,110...47,630,991
Ensembl chr12:47,590,154...47,631,119
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Diclofenac results in increased expression of GJA1 mRNA CTD PMID:26934552 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja3 gap junction protein, alpha 3 increases expression ISO Diclofenac results in increased expression of GJA3 mRNA CTD PMID:26934552 NCBI chr15:37,298,607...37,325,370
Ensembl chr15:37,299,738...37,325,178
JBrowse link
G Gldc glycine decarboxylase affects expression ISO Diclofenac affects the expression of GLDC mRNA CTD PMID:24752500 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093
JBrowse link
G Glyctk glycerate kinase affects expression ISO Diclofenac affects the expression of GLYCTK mRNA CTD PMID:24752500 NCBI chr 8:114,846,210...114,853,374
Ensembl chr 8:114,848,084...114,853,103
JBrowse link
G Gna13 G protein subunit alpha 13 affects expression ISO Diclofenac affects the expression of GNA13 mRNA CTD PMID:24752500 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gnaq G protein subunit alpha q affects expression ISO Diclofenac affects the expression of GNAQ mRNA CTD PMID:24752500 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnas GNAS complex locus affects expression ISO Diclofenac affects the expression of GNAS mRNA CTD PMID:24752500 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnat1 G protein subunit alpha transducin 1 increases expression ISO Diclofenac results in increased expression of GNAT1 mRNA CTD PMID:26934552 NCBI chr 8:116,433,302...116,438,038
Ensembl chr 8:116,433,302...116,438,038
JBrowse link
G Gnb5 G protein subunit beta 5 affects expression ISO Diclofenac affects the expression of GNB5 mRNA CTD PMID:24752500 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184
JBrowse link
G Gng4 G protein subunit gamma 4 affects expression ISO Diclofenac affects the expression of GNG4 mRNA CTD PMID:24752500 NCBI chr17:90,266,571...90,316,278
Ensembl chr17:90,266,794...90,315,492
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression ISO Diclofenac affects the expression of GOT1 mRNA CTD PMID:24752500 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] CTD PMID:25772430 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Diclofenac affects the expression of GPLD1 mRNA CTD PMID:24752500 NCBI chr17:42,085,027...42,131,344
Ensembl chr17:42,085,028...42,127,678
JBrowse link
G Gpr20 G protein-coupled receptor 20 decreases expression EXP Diclofenac results in decreased expression of GPR20 mRNA CTD PMID:30723492 NCBI chr 7:114,943,675...114,953,977
Ensembl chr 7:114,944,282...114,945,344
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
increases activity
EXP
ISO
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]
CTD PMID:23939143, PMID:24747151, PMID:26934552, PMID:27671914, PMID:30925002, PMID:31813902 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP
ISO
Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein CTD PMID:25772430, PMID:29027214 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO Diclofenac affects the expression of GPX2 mRNA CTD PMID:24752500 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grb10 growth factor receptor bound protein 10 affects expression ISO Diclofenac affects the expression of GRB10 mRNA CTD PMID:24752500 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases expression ISO Diclofenac results in increased expression of GRM7 mRNA CTD PMID:26934552 NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression ISO Diclofenac affects the expression of GSK3B mRNA CTD PMID:24752500 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsn gelsolin decreases expression ISO Diclofenac results in decreased expression of GSN mRNA CTD PMID:26934552 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Diclofenac results in decreased activity of GSTA1 protein CTD PMID:27183920 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases activity ISO Diclofenac results in decreased activity of GSTA4 protein CTD PMID:27183920 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
Diclofenac results in increased expression of GSTA5 protein
CTD PMID:25772430 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
decreases expression
ISO Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA
CTD PMID:26934552, PMID:27183920 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity ISO Diclofenac results in decreased activity of GSTM2 protein CTD PMID:27183920 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects activity ISO Diclofenac affects the activity of GSTM4 protein CTD PMID:27183920 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Diclofenac results in increased expression of GSTM3 mRNA CTD PMID:26934552 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
affects activity
affects metabolic processing
ISO [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite
CTD PMID:24185126, PMID:24246759, PMID:27183920 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression
affects activity
ISO Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein
CTD PMID:24752500, PMID:27183920 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 affects expression ISO Diclofenac affects the expression of GTF2H4 mRNA CTD PMID:24752500 NCBI chr20:3,582,688...3,588,373
Ensembl chr20:3,582,742...3,588,375
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression ISO Diclofenac affects the expression of GTF2H5 mRNA CTD PMID:24752500 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
G Hamp hepcidin antimicrobial peptide affects expression
decreases secretion
ISO Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein
CTD PMID:24038040, PMID:26934552 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hat1 histone acetyltransferase 1 affects expression ISO Diclofenac affects the expression of HAT1 mRNA CTD PMID:24752500 NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Diclofenac results in increased expression of HAVCR1 mRNA CTD PMID:23506792 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Diclofenac results in increased expression of HBA-A2 protein CTD PMID:14565772 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Diclofenac results in increased expression of HBB protein CTD PMID:14565772 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects expression
increases expression
ISO Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases expression ISO Diclofenac results in increased expression of HCK mRNA CTD PMID:26934552 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression
increases expression
ISO Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA
CTD PMID:19192274, PMID:26934552 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 affects expression
decreases expression
ISO Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression ISO Diclofenac results in decreased expression of HES6 mRNA CTD PMID:26934552 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression ISO Diclofenac results in decreased expression of HHEX mRNA CTD PMID:26934552 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Diclofenac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression ISO Diclofenac results in decreased expression of H2BC21 mRNA CTD PMID:26934552 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378
JBrowse link
G Hk1 hexokinase 1 increases expression ISO Diclofenac results in increased expression of HK1 mRNA CTD PMID:26934552 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
affects expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA
CTD PMID:23939143, PMID:24747151, PMID:24752500, PMID:26934552 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Diclofenac results in decreased expression of HMGCS2 mRNA CTD PMID:26934552 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
affects expression
ISO
EXP
1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein
CTD PMID:12763371, PMID:18172885, PMID:18227147, PMID:19022234, PMID:19952508, PMID:23939143, PMID:27313093, PMID:29027214 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A affects expression ISO Diclofenac affects the expression of HNF1A mRNA CTD PMID:24752500 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Diclofenac results in decreased expression of HNF4A mRNA CTD PMID:19022234 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression ISO Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hp haptoglobin decreases expression
increases expression
ISO Diclofenac results in decreased expression of HP mRNA
Diclofenac results in increased expression of HP mRNA
CTD PMID:26934552 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
multiple interactions
increases expression
ISO Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA
CTD PMID:19501039, PMID:25526675 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of HRAS mRNA CTD PMID:24752500 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Diclofenac results in increased expression of HS6ST2 mRNA CTD PMID:26934552 NCBI chr  X:138,675,326...138,972,774
Ensembl chr  X:138,677,580...138,972,684
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression ISO Diclofenac results in decreased expression of HSD3B2 mRNA CTD PMID:26934552 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] CTD PMID:23939143 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
affects expression
EXP
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
Diclofenac results in increased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA
CTD PMID:19022234, PMID:23939143, PMID:25014874, PMID:26934552 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diclofenac results in increased expression of HSPA1B mRNA CTD PMID:26934552 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
EXP
ISO
Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein
CTD PMID:25014874, PMID:25772430, PMID:27313093 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression
EXP
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA
CTD PMID:23939143, PMID:26934552 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Diclofenac results in decreased expression of HSPB1 mRNA CTD PMID:26934552 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Diclofenac results in increased expression of HSPB8 mRNA CTD PMID:26934552 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase increases expression ISO Diclofenac results in increased expression of IBTK mRNA CTD PMID:26934552 NCBI chr 8:93,323,454...93,397,044
Ensembl chr 8:93,324,476...93,390,305
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
increases expression
affects expression
EXP
ISO
Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA
CTD PMID:14716214, PMID:18460984, PMID:24752500, PMID:26934552 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Diclofenac results in increased expression of ID2 mRNA CTD PMID:26934552 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Diclofenac results in increased expression of ID3 mRNA CTD PMID:26934552 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Diclofenac results in increased expression of IER3 mRNA CTD PMID:26934552 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Diclofenac results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Diclofenac results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Diclofenac results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Diclofenac results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Diclofenac results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Diclofenac results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Diclofenac results in increased expression of IFITM2 mRNA CTD PMID:26934552 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression ISO Diclofenac results in increased expression of IFITM3 mRNA CTD PMID:26934552 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP
ISO
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA
CTD PMID:19393675, PMID:22285467, PMID:23395999, PMID:23939143, PMID:26609140 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression ISO Diclofenac affects the expression of IGF1R mRNA CTD PMID:24752500 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 affects expression
increases expression
ISO Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Diclofenac results in decreased expression of IGFBP2 mRNA CTD PMID:26934552 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Diclofenac affects the expression of IGFBP3 mRNA CTD PMID:24752500 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] CTD PMID:25935278 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Diclofenac results in increased expression of IKBKE mRNA CTD PMID:26934552 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression ISO Diclofenac affects the expression of IKBKG mRNA CTD PMID:24752500 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il10 interleukin 10 increases response to substance
multiple interactions
ISO
EXP
IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]
CTD PMID:15122773, PMID:23939143, PMID:31042592 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression EXP Diclofenac results in increased expression of IL12RB1 mRNA CTD PMID:30723492 NCBI chr16:20,370,722...20,383,576
Ensembl chr16:20,371,338...20,383,337
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Diclofenac results in increased expression of IL13RA1 mRNA CTD PMID:26934552 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Il17a interleukin 17A increases expression
multiple interactions
ISO
EXP
Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]
CTD PMID:22285467, PMID:25450234 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18bp interleukin 18 binding protein increases expression ISO Diclofenac results in increased expression of IL18BP mRNA CTD PMID:26934552 NCBI chr 1:167,091,521...167,095,727
Ensembl chr 1:167,091,522...167,093,560
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
CTD PMID:15135310, PMID:15705740, PMID:19393675, PMID:22285467, PMID:23395999, PMID:23939143, PMID:24747151, PMID:25051504, PMID:25450234, PMID:25935278, PMID:28138970, PMID:29027214, PMID:31042592, PMID:31926916 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 affects expression
increases expression
ISO Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO
EXP
Diclofenac results in increased expression of IL1R2 mRNA CTD PMID:26934552, PMID:30723492 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
increases secretion
multiple interactions
ISO Diclofenac results in increased expression of IL1RN mRNA
Diclofenac results in increased secretion of IL1RN protein
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]
CTD PMID:9491209, PMID:26934552 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Diclofenac results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Diclofenac results in increased expression of IL2RG mRNA CTD PMID:26934552 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865
JBrowse link
G Il33 interleukin 33 increases expression
decreases expression
ISO Diclofenac results in increased expression of IL33 mRNA
Diclofenac results in decreased expression of IL33 mRNA
CTD PMID:26934552 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 increases response to substance ISO IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] CTD PMID:15663561 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
ISO
EXP
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
CTD PMID:19192274, PMID:19362101, PMID:23506792, PMID:23939143, PMID:24412305, PMID:25450234, PMID:25935278, PMID:27671914, PMID:29777833, PMID:31048000 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Diclofenac affects the expression of IMMT mRNA CTD PMID:26934552 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO
EXP
Diclofenac results in increased expression of INHBB mRNA CTD PMID:26934552, PMID:30723492 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO Diclofenac results in decreased expression of INMT mRNA CTD PMID:26934552 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
JBrowse link
G Insr insulin receptor affects expression ISO Diclofenac affects the expression of INSR mRNA CTD PMID:24752500 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO Diclofenac results in increased expression of IRAK4 mRNA CTD PMID:26934552 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Diclofenac results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irgm immunity-related GTPase M increases expression ISO Diclofenac results in increased expression of IRGM1 mRNA CTD PMID:26934552 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Irs1 insulin receptor substrate 1 affects expression ISO Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500, PMID:26934552 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Diclofenac results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Diclofenac results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Diclofenac results in increased expression of ISYNA1 mRNA CTD PMID:26934552 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Itga2 integrin subunit alpha 2 affects expression ISO Diclofenac affects the expression of ITGA2 mRNA CTD PMID:24752500 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgal integrin subunit alpha L increases expression ISO Diclofenac results in increased expression of ITGAL mRNA CTD PMID:26934552 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Diclofenac results in increased expression of ITGAM mRNA CTD PMID:27671914 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb1 integrin subunit beta 1 affects expression ISO Diclofenac affects the expression of ITGB1 mRNA CTD PMID:24752500 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Diclofenac results in increased expression of ITGB2 mRNA CTD PMID:26934552 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] CTD PMID:19691487 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression ISO Diclofenac results in increased expression of ITIH3 mRNA CTD PMID:26934552 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression ISO Diclofenac results in increased expression of ITIH4 mRNA CTD PMID:26934552 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Itm2a integral membrane protein 2A increases expression ISO Diclofenac results in increased expression of ITM2A mRNA CTD PMID:17379860 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression
ISO Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP
Diclofenac results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kat6b lysine acetyltransferase 6B affects expression ISO Diclofenac affects the expression of KAT6B mRNA CTD PMID:24752500 NCBI chr15:2,811,933...2,966,833
Ensembl chr15:2,813,537...2,966,576
JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 increases expression EXP Diclofenac results in increased expression of KBTBD11 mRNA CTD PMID:30723492 NCBI chr16:79,696,395...79,716,129
Ensembl chr16:79,696,891...79,700,992
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression EXP Diclofenac results in increased expression of KHDC3 mRNA CTD PMID:30723492 NCBI chr 8:79,781,941...79,783,845
Ensembl chr 8:79,781,983...79,783,592
JBrowse link
G Kif5c kinesin family member 5C increases expression EXP Diclofenac results in increased expression of KIF5C mRNA CTD PMID:30723492 NCBI chr 3:35,014,157...35,257,417
Ensembl chr 3:35,014,538...35,257,407
JBrowse link
G Klk1 kallikrein 1 increases expression ISO Diclofenac results in increased expression of KLK1 protein CTD PMID:23506792 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 increases expression EXP Diclofenac results in increased expression of KNDC1 mRNA CTD PMID:30723492 NCBI chr 1:212,229,751...212,279,254
Ensembl chr 1:212,230,259...212,277,694
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein] CTD PMID:25772430 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 decreases expression ISO Diclofenac results in decreased expression of LAX1 mRNA CTD PMID:26934552 NCBI chr13:50,164,563...50,175,119
Ensembl chr13:50,164,563...50,175,112
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression
decreases expression
affects expression
ISO Diclofenac results in increased expression of LBP protein
Diclofenac results in decreased expression of LBP mRNA
Diclofenac affects the expression of LBP mRNA
CTD PMID:26934552 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lce1d late cornified envelope 1D decreases expression ISO Diclofenac results in decreased expression of LCE1D mRNA CTD PMID:26934552
G Lcn2 lipocalin 2 increases expression
multiple interactions
EXP
ISO
Diclofenac results in increased expression of LCN2 mRNA
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]
CTD PMID:23939143, PMID:26934552 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Diclofenac results in increased expression of LCP2 mRNA CTD PMID:26934552 NCBI chr10:18,996,523...19,043,289
Ensembl chr10:18,996,523...19,043,286
JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Diclofenac results in increased expression of LDHA protein CTD PMID:25772430 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Lepr leptin receptor affects expression
increases expression
ISO Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein
CTD PMID:26934552 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lgals3 galectin 3 increases expression ISO Diclofenac results in increased expression of LGALS3 mRNA CTD PMID:26934552 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lgmn legumain increases expression ISO Diclofenac results in increased expression of LGMN mRNA CTD PMID:26934552 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO Diclofenac results in decreased expression of LIFR mRNA CTD PMID:26934552 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G Lipc lipase C, hepatic type decreases expression ISO Diclofenac results in decreased expression of LIPC mRNA CTD PMID:26934552 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression ISO Diclofenac results in increased expression of LITAF mRNA CTD PMID:26934552 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Diclofenac results in decreased expression of LPAR4 mRNA CTD PMID:26934552 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Diclofenac results in increased expression of LPL mRNA CTD PMID:26934552 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Diclofenac results in increased expression of LRG1 mRNA CTD PMID:26934552 NCBI chr 9:10,952,424...10,954,664
Ensembl chr 9:10,952,374...10,954,681
JBrowse link
G Ltc4s leukotriene C4 synthase increases expression EXP Diclofenac results in increased expression of LTC4S mRNA CTD PMID:30723492 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Lxn latexin increases expression ISO Diclofenac results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:164,628,565...164,634,434
Ensembl chr 2:164,628,566...164,634,434
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression
increases expression
ISO Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA
CTD PMID:19192274, PMID:26934552 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Ly75 lymphocyte antigen 75 increases expression ISO Diclofenac results in increased expression of LY75 mRNA CTD PMID:26934552 NCBI chr 3:46,369,749...46,457,182
Ensembl chr 3:46,365,165...46,457,201
JBrowse link
G Lyz2 lysozyme 2 increases expression ISO Diclofenac results in increased expression of LYZ2 mRNA CTD PMID:26934552 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 affects expression ISO Diclofenac affects the expression of MAGI1 mRNA CTD PMID:24752500 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Maoa monoamine oxidase A affects expression ISO Diclofenac affects the expression of MAOA mRNA CTD PMID:24752500 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B affects expression ISO Diclofenac affects the expression of MAOB mRNA CTD PMID:24752500 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects expression ISO Diclofenac affects the expression of MAP2K3 mRNA CTD PMID:24752500 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 affects expression ISO Diclofenac affects the expression of MAP2K5 mRNA CTD PMID:24752500 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 affects expression ISO Diclofenac affects the expression of MAP2K6 mRNA CTD PMID:24752500 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Diclofenac results in increased expression of MAP3K1 mRNA CTD PMID:26934552 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP Diclofenac results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects expression ISO Diclofenac affects the expression of MAP3K7 mRNA CTD PMID:24752500 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 affects expression ISO Diclofenac affects the expression of MAP4K4 mRNA CTD PMID:24752500 NCBI chr 9:46,657,444...46,782,545
Ensembl chr 9:46,657,575...46,782,545
JBrowse link
G Map7d1 MAP7 domain containing 1 increases expression ISO Diclofenac results in increased expression of MAP7D1 mRNA CTD PMID:26934552 NCBI chr 5:144,250,416...144,274,981
Ensembl chr 5:144,250,419...144,274,981
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]
Diclofenac analog results in increased phosphorylation of MAPK1 protein; Diclofenac results in increased phosphorylation of MAPK1 protein
CTD PMID:24104198, PMID:26609140 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression ISO Diclofenac affects the expression of MAPK13 mRNA CTD PMID:24752500 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression ISO Diclofenac affects the expression of MAPK14 mRNA CTD PMID:24752500 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]
Diclofenac analog results in increased phosphorylation of MAPK3 protein; Diclofenac results in increased phosphorylation of MAPK3 protein
CTD PMID:24104198, PMID:26609140 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects expression ISO Diclofenac affects the expression of MAPK8 mRNA CTD PMID:24752500 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Diclofenac results in increased expression of MAPK8IP3 mRNA CTD PMID:26934552 NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Diclofenac results in increased expression of MAPKAPK3 mRNA CTD PMID:26934552 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
JBrowse link
G Marchf1 membrane associated ring-CH-type finger 1 increases expression ISO Diclofenac results in increased expression of MARCHF1 mRNA CTD PMID:26934552 NCBI chr16:24,998,709...25,856,327
Ensembl chr16:25,001,666...25,192,675
JBrowse link
G Marco macrophage receptor with collagenous structure increases expression
decreases expression
ISO Diclofenac results in increased expression of MARCO mRNA
Diclofenac results in decreased expression of MARCO mRNA
CTD PMID:26934552 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like decreases expression ISO Diclofenac results in decreased expression of MASTL mRNA CTD PMID:26934552 NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825
JBrowse link
G Mbl1 mannose binding lectin 1 increases expression ISO Diclofenac results in increased expression of MBL1 mRNA CTD PMID:26934552 NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 affects expression ISO Diclofenac affects the expression of MCM7 mRNA CTD PMID:24752500 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression EXP Diclofenac results in increased expression of MCTP1 mRNA CTD PMID:30723492 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression EXP Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mecom MDS1 and EVI1 complex locus decreases expression ISO Diclofenac results in decreased expression of MECOM mRNA CTD PMID:26934552 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Med10 mediator complex subunit 10 affects expression ISO Diclofenac affects the expression of MED10 mRNA CTD PMID:24752500 NCBI chr 1:36,107,249...36,118,887
Ensembl chr 1:36,107,232...36,112,993
JBrowse link
G Med13 mediator complex subunit 13 affects expression ISO Diclofenac affects the expression of MED13 mRNA CTD PMID:24752500 NCBI chr10:73,702,327...73,787,084
Ensembl chr10:73,702,327...73,787,083
JBrowse link
G Med13l mediator complex subunit 13L affects expression ISO Diclofenac affects the expression of MED13L mRNA CTD PMID:24752500 NCBI chr12:43,421,317...43,576,859
Ensembl chr12:43,421,308...43,576,804
JBrowse link
G Med14 mediator complex subunit 14 affects expression ISO Diclofenac affects the expression of MED14 mRNA CTD PMID:24752500 NCBI chr  X:10,964,035...11,082,403
Ensembl chr  X:10,963,809...11,082,565
JBrowse link
G Med17 mediator complex subunit 17 affects expression ISO Diclofenac affects the expression of MED17 mRNA CTD PMID:24752500 NCBI chr 8:13,522,257...13,835,302
Ensembl chr 8:13,819,563...13,835,168
JBrowse link
G Med30 mediator complex subunit 30 affects expression ISO Diclofenac affects the expression of MED30 mRNA CTD PMID:24752500 NCBI chr 7:92,234,584...92,260,019
Ensembl chr 7:92,234,597...92,256,100
JBrowse link
G Med31 mediator complex subunit 31 affects expression ISO Diclofenac affects the expression of MED31 mRNA CTD PMID:24752500 NCBI chr10:58,780,987...58,784,369
Ensembl chr10:58,780,597...58,784,374
JBrowse link
G Med6 mediator complex subunit 6 affects expression ISO Diclofenac affects the expression of MED6 mRNA CTD PMID:24752500 NCBI chr 6:105,302,558...105,316,024
Ensembl chr 6:105,302,558...105,316,024
JBrowse link
G Mef2a myocyte enhancer factor 2a affects expression ISO Diclofenac affects the expression of MEF2A mRNA CTD PMID:24752500 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Diclofenac results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mfn1 mitofusin 1 decreases expression
multiple interactions
EXP Diclofenac results in decreased expression of MFN1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein]
CTD PMID:27792760 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Diclofenac results in decreased expression of MFN2 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein]
CTD PMID:27792760 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Diclofenac results in decreased expression of MGLL mRNA CTD PMID:26934552 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir122 microRNA 122 increases expression ISO
EXP
Diclofenac results in increased expression of MIR122
Diclofenac results in increased expression of MIR122 mRNA
CTD PMID:25527335, PMID:30925002 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir192 microRNA 192 increases expression EXP Diclofenac results in increased expression of MIR192 mRNA CTD PMID:30925002 NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
JBrowse link
G Mirlet7d microRNA let-7d decreases expression EXP Diclofenac results in decreased expression of MIRLET7D mRNA CTD PMID:30723492 NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of MKNK2 mRNA CTD PMID:24752500 NCBI chr 7:11,908,107...11,919,161
Ensembl chr 7:11,908,107...11,919,156
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Diclofenac results in decreased expression of MME mRNA CTD PMID:26934552 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Diclofenac results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO Diclofenac results in increased expression of MMP16 mRNA CTD PMID:26934552 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP Diclofenac results in increased expression of MMP8 mRNA CTD PMID:30723492 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO Diclofenac results in increased expression of MNDA mRNA CTD PMID:26934552 NCBI chr13:92,073,664...92,091,335
Ensembl chr13:92,073,668...92,089,980
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Diclofenac results in increased expression of MPEG1 mRNA CTD PMID:26934552 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
increases activity
EXP
ISO
Diclofenac inhibits the reaction [Carrageenan results in increased activity of MPO protein]; sodium nitrate inhibits the reaction [Diclofenac results in increased activity of MPO protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein]
Diclofenac results in increased expression of MPO mRNA
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Diclofenac
CTD PMID:17275683, PMID:24412305, PMID:27671914, PMID:28754375, PMID:31926916 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Diclofenac affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Mras muscle RAS oncogene homolog affects expression ISO Diclofenac affects the expression of MRAS mRNA CTD PMID:24752500 NCBI chr 8:107,629,028...107,656,851
Ensembl chr 8:107,629,028...107,681,512
JBrowse link
G Ms4a14 membrane spanning 4-domains A14 increases expression EXP Diclofenac results in increased expression of MS4A14 mRNA CTD PMID:30723492 NCBI chr 1:227,471,441...227,486,953
Ensembl chr 1:227,471,436...227,486,976
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Diclofenac results in increased expression of MT1 mRNA CTD PMID:26934552 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Diclofenac results in increased expression of MT2 mRNA CTD PMID:26934552 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase affects expression ISO Diclofenac affects the expression of MTHFD2 mRNA CTD PMID:24752500 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like increases expression EXP Diclofenac results in increased expression of MTHFD2L mRNA CTD PMID:30723492 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO Diclofenac results in increased expression of MTSS1 mRNA CTD PMID:26934552 NCBI chr 7:98,820,799...98,960,878
Ensembl chr 7:98,820,812...98,960,837
JBrowse link
G Mvp major vault protein increases expression ISO Diclofenac results in increased expression of MVP mRNA CTD PMID:26934552 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Diclofenac results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Mxd1 max dimerization protein 1 affects expression ISO Diclofenac affects the expression of MXD1 mRNA CTD PMID:24752500 NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
affects expression
EXP
ISO
Diclofenac results in increased expression of MYC mRNA
Diclofenac affects the expression of MYC mRNA
CTD PMID:19022234, PMID:24752500 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO Diclofenac results in increased expression of MYD88 mRNA CTD PMID:26934552 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D affects expression ISO Diclofenac affects the expression of NAPEPLD mRNA CTD PMID:24752500 NCBI chr 4:9,965,323...10,004,650
Ensembl chr 4:9,966,891...10,002,247
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Diclofenac results in increased expression of NCF1 mRNA CTD PMID:26934552 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf4 neutrophil cytosolic factor 4 increases expression ISO Diclofenac results in increased expression of NCF4 mRNA CTD PMID:26934552 NCBI chr 7:119,481,711...119,499,426
Ensembl chr 7:119,482,272...119,499,425
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 affects expression ISO Diclofenac affects the expression of NCOA3 mRNA CTD PMID:24752500 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase increases expression ISO Diclofenac results in increased expression of NEDD4L mRNA CTD PMID:26934552 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
JBrowse link
G Nek6 NIMA-related kinase 6 increases expression ISO Diclofenac results in increased expression of NEK6 mRNA CTD PMID:26934552 NCBI chr 3:22,811,927...22,888,598
Ensembl chr 3:22,811,927...22,888,598
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases stability
multiple interactions
ISO Diclofenac results in increased stability of NFE2L2 protein
NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA]
CTD PMID:24752500 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Diclofenac results in increased expression of NFIL3 mRNA CTD PMID:26934552 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression
ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Diclofenac results in decreased expression of NFKB1 mRNA
CTD PMID:15489888, PMID:29027214 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]
Diclofenac results in decreased expression of NFKBIA mRNA
CTD PMID:15489888, PMID:18172885, PMID:19393675, PMID:25935278 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbiz NFKB inhibitor zeta decreases expression
increases expression
ISO Diclofenac results in decreased expression of NFKBIZ mRNA
Diclofenac results in increased expression of NFKBIZ mRNA
CTD PMID:26934552 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nipal1 NIPA-like domain containing 1 increases expression ISO Diclofenac results in increased expression of NIPAL1 mRNA CTD PMID:26934552 NCBI chr14:38,104,027...38,128,038
Ensembl chr14:38,104,047...38,128,024
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 NCBI chr10:57,692,474...57,747,608
Ensembl chr10:57,692,474...57,822,498
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Diclofenac results in increased expression of NLRP3 mRNA CTD PMID:24747151, PMID:28138970 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Diclofenac results in increased expression of NNMT mRNA CTD PMID:26934552 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases expression
EXP
ISO
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA]
Diclofenac results in decreased expression of NOS2 mRNA
CTD PMID:15135310, PMID:16944022, PMID:17275683, PMID:19393675, PMID:23395999, PMID:23939143, PMID:29027214 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 decreases expression ISO Diclofenac results in decreased expression of NOVA1 mRNA CTD PMID:26934552 NCBI chr 6:66,960,126...67,085,836
Ensembl chr 6:66,963,510...67,085,390
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
affects expression
increases expression
ISO
EXP
Diclofenac results in increased activity of NQO1 protein
Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
Diclofenac affects the expression of NQO1 mRNA
Diclofenac results in increased expression of NQO1 mRNA
CTD PMID:8572925, PMID:18172885, PMID:24752500, PMID:29281794 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 affects expression ISO Diclofenac affects the expression of NR0B2 mRNA CTD PMID:24752500 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity
ISO Diclofenac results in increased expression of NR1I2 mRNA
Diclofenac results in increased activity of NR1I2 protein
CTD PMID:19022234, PMID:28728110 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO Diclofenac affects the expression of NR1I3 mRNA CTD PMID:19022234 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects expression ISO Diclofenac affects the expression of NR2F1 mRNA CTD PMID:24752500 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 affects expression ISO Diclofenac affects the expression of NR2F2 mRNA CTD PMID:24752500 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 affects expression ISO Diclofenac affects the expression of NR2F6 mRNA CTD PMID:24752500 NCBI chr16:19,769,968...19,777,414
Ensembl chr16:19,769,968...19,777,414
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression
multiple interactions
ISO Diclofenac affects the expression of NR3C1 mRNA
Diclofenac binds to and affects the activity of NR3C1 protein
CTD PMID:24752500, PMID:29777833 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr6a1 nuclear receptor subfamily 6, group A, member 1 affects expression ISO Diclofenac affects the expression of NR6A1 mRNA CTD PMID:24752500 NCBI chr 3:23,029,222...23,218,050
Ensembl chr 3:23,033,775...23,066,658
JBrowse link
G Nras NRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of NRAS mRNA CTD PMID:24752500 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Diclofenac results in decreased expression of NREP mRNA CTD PMID:26934552 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Nrg4 neuregulin 4 increases expression ISO Diclofenac results in increased expression of NRG4 mRNA CTD PMID:26934552 NCBI chr 8:59,782,789...59,849,433
Ensembl chr 8:59,782,974...59,849,490
JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Diclofenac results in increased expression of NRP1 mRNA CTD PMID:26934552 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nxpe4 neurexophilin and PC-esterase domain family member 4 increases expression ISO Diclofenac results in increased expression of NXPE4 mRNA CTD PMID:26934552 NCBI chr 8:52,717,341...52,734,448 JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Diclofenac results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Ocln occludin decreases expression ISO
EXP
Diclofenac results in decreased expression of OCLN mRNA CTD PMID:29027214 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Diclofenac results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:88,995,301...89,032,487
Ensembl chr13:88,995,316...89,032,487
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased expression of OPA1 mRNA
Diclofenac results in decreased expression of OPA1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein]
CTD PMID:26934552, PMID:27792760 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Opcml opioid binding protein/cell adhesion molecule-like increases expression ISO Diclofenac results in increased expression of OPCML mRNA CTD PMID:26934552 NCBI chr 8:28,842,202...29,967,300
Ensembl chr 8:29,453,643...29,962,825
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ORM1 protein
Diclofenac results in increased expression of ORM1 mRNA
CTD PMID:25772430, PMID:26934552 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein] CTD PMID:25450234 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G P2rx5 purinergic receptor P2X 5 increases expression EXP Diclofenac results in increased expression of P2RX5 mRNA CTD PMID:30723492 NCBI chr10:59,725,438...59,737,126
Ensembl chr10:59,725,398...59,737,126
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
increases expression
EXP
ISO
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]
Diclofenac results in increased expression of P2RX7 mRNA
CTD PMID:25935278, PMID:26934552 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 increases expression ISO Diclofenac results in increased expression of P4HA2 mRNA CTD PMID:17379860 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of P4HB protein
Diclofenac results in increased expression of P4HB protein
CTD PMID:25772430 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 affects expression ISO Diclofenac affects the expression of PAK2 mRNA CTD PMID:24752500 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression EXP Diclofenac results in increased expression of PAQR8 mRNA CTD PMID:30723492 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression ISO Diclofenac affects the expression of PARP1 mRNA CTD PMID:24752500 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pax6 paired box 6 increases expression ISO Diclofenac results in increased expression of PAX6 mRNA CTD PMID:26934552 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pcdhga8 protocadherin gamma subfamily A, 8 increases expression EXP Diclofenac results in increased expression of PCDHGA8 mRNA CTD PMID:30723492 NCBI chr18:30,874,873...30,971,113
Ensembl chr18:30,875,011...30,877,434
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO Diclofenac affects the expression of PCK1 mRNA CTD PMID:24752500 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen affects expression ISO Diclofenac affects the expression of PCNA protein CTD PMID:23506792 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Diclofenac results in increased expression of PCSK9 mRNA CTD PMID:26934552 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression
ISO Diclofenac results in decreased expression of PDCD4 mRNA
Diclofenac results in increased expression of PDCD4 mRNA
CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pde9a phosphodiesterase 9A increases expression EXP Diclofenac results in increased expression of PDE9A mRNA CTD PMID:30723492 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO Diclofenac results in decreased expression of PDGFRB mRNA CTD PMID:26934552 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Diclofenac results in increased expression of PDIA6 mRNA CTD PMID:26934552 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pdilt protein disulfide isomerase-like, testis expressed decreases expression ISO Diclofenac results in decreased expression of PDILT mRNA CTD PMID:26934552 NCBI chr 1:189,207,164...189,238,796
Ensembl chr 1:189,207,165...189,238,776
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression ISO Diclofenac results in decreased expression of PDK4 mRNA CTD PMID:26934552 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 affects expression ISO Diclofenac affects the expression of PDPK1 mRNA CTD PMID:24752500 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Diclofenac results in decreased expression of PHLDA1 mRNA CTD PMID:26934552 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha affects expression ISO Diclofenac affects the expression of PIK3C2A mRNA CTD PMID:24752500 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression ISO Diclofenac affects the expression of PIK3CA mRNA CTD PMID:24752500 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta affects expression ISO Diclofenac affects the expression of PIK3CD mRNA CTD PMID:24752500 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression
increases expression
ISO Diclofenac affects the expression of PIK3R1 mRNA
Diclofenac results in increased expression of PIK3R1 mRNA
CTD PMID:24752500, PMID:26934552 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 affects expression ISO Diclofenac affects the expression of PIK3R2 mRNA CTD PMID:24752500 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 affects expression ISO Diclofenac affects the expression of PIK3R3 mRNA CTD PMID:24752500 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pirb paired Ig-like receptor B increases expression ISO
EXP
Diclofenac results in increased expression of PIRB mRNA CTD PMID:26934552, PMID:30723492 NCBI chr 1:64,074,097...64,081,568
Ensembl chr 1:64,074,231...64,081,438