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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diclofenac
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Accession:CHEBI:47381 term browser browse the term
Definition:A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Synonyms:exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
 related_synonym: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID;   Formula=C14H11Cl2NO2;   InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19);   InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N;   SMILES=C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl;   [2-(2,6-dichloroanilino)phenyl]acetic acid;   diclofenac acid;   diclofenaco;   diclofenacum;   diclofenamic acid
 alt_id: CHEBI:4507;   CHEBI:47380
 xref: Beilstein:2146636;   CAS:15307-86-5;   DrugBank:DB00586;   Drug_Central:865;   HMDB:HMDB0014724;   KEGG:C01690;   KEGG:D07816;   LINCS:LSM-2160
 xref_mesh: MESH:D004008
 xref: PDBeChem:DIF;   PMID:11322639;   PMID:1502708;   PMID:23777257;   PMID:27967303;   PMID:7838674;   Patent:NL6604752;   Patent:US3558690;   Reaxys:2146636;   VSDB:1933;   Wikipedia:Diclofenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:48311


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diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Aacs acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954 		JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of AARS1 mRNA CTD PMID:35537566 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein		 CTD PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases response to substance
decreases activity		 ISO Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein		 CTD PMID:15458769 PMID:19022234 PMID:28193520 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases expression EXP Diclofenac results in decreased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity		 ISO Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein		 CTD PMID:19022234 PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions		 ISO
EXP		 Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac		 CTD PMID:19022234 PMID:22646477 PMID:25450747 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Diclofenac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001 		JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACP3 mRNA CTD PMID:26934552 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects expression ISO Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Actn1 actinin, alpha 1 affects expression EXP Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Acvr1 activin A receptor type 1 affects expression ISO Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Acvr1b activin A receptor type 1B affects expression ISO Diclofenac affects the expression of ACVR1B mRNA CTD PMID:24752500 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Acvr2b activin A receptor type 2B affects expression ISO Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr15:42,900,629...42,921,684
Ensembl chr15:42,900,636...42,921,712 		JBrowse link
G Adcy6 adenylate cyclase 6 affects expression ISO Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy9 adenylate cyclase 9 affects expression
decreases expression		 ISO Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression EXP Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Diclofenac results in decreased expression of ADH7 mRNA CTD PMID:35537566 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Adk adenosine kinase increases expression
decreases expression		 ISO
EXP		 Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA		 CTD PMID:19022234 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO Diclofenac results in increased expression of AEN mRNA CTD PMID:35537566 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151 PMID:28138970 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aggf1 angiogenic factor with G patch and FHA domains 1 affects expression ISO Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 affects expression ISO Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 affects expression ISO Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 affects expression ISO Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
G Agrp agouti related neuropeptide increases expression EXP Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression ISO Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Akna AT-hook transcription factor decreases expression ISO Diclofenac results in decreased expression of AKNA mRNA CTD PMID:35537566 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 affects expression ISO Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Alb albumin affects binding
increases expression
decreases expression
multiple interactions
decreases secretion		 ISO
EXP		 Diclofenac binds to ALB protein
Diclofenac results in increased expression of ALB mRNA
Diclofenac results in decreased expression of ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased secretion of ALB protein		 CTD PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression
decreases expression		 ISO Diclofenac results in increased expression of ALDH18A1 mRNA
Diclofenac results in decreased expression of ALDH18A1 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Diclofenac results in increased expression of ALOX15 mRNA CTD PMID:23939143 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Amh anti-Mullerian hormone increases expression ISO Diclofenac results in increased expression of AMH mRNA CTD PMID:35537566 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Amotl2 angiomotin like 2 decreases expression ISO Diclofenac results in decreased expression of AMOTL2 mRNA CTD PMID:35537566 NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910 		JBrowse link
G Ang angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Aoc3 amine oxidase, copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apcs amyloid P component, serum multiple interactions
increases expression		 EXP
ISO		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein		 CTD PMID:25772430 PMID:26934552 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Apoa4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Aqp9 aquaporin 9 decreases expression ISO Diclofenac results in decreased expression of AQP9 mRNA CTD PMID:35537566 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Aqr aquarius intron-binding spliceosomal factor affects expression ISO Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044 		JBrowse link
G Ar androgen receptor affects activity ISO Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Arhgap20 Rho GTPase activating protein 20 increases expression EXP Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739 		JBrowse link
G Arhgap26 Rho GTPase activating protein 26 affects expression ISO Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects expression
decreases expression		 ISO Diclofenac affects the expression of ARHGEF3 mRNA
Diclofenac results in decreased expression of ARHGEF3 mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945 		JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression ISO Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697 		JBrowse link
G Arid5a AT-rich interaction domain 5A decreases expression ISO Diclofenac results in decreased expression of ARID5A mRNA CTD PMID:35537566 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597 		JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433 		JBrowse link
G Arl11 ADP-ribosylation factor like GTPase 11 decreases expression ISO Diclofenac results in decreased expression of ARL11 mRNA CTD PMID:35537566 NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596 		JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression EXP Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:97,898,969...97,902,874
Ensembl chr  X:97,898,883...97,903,299 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects expression ISO Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Diclofenac results in increased expression of ARRDC3 mRNA CTD PMID:35537566 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression ISO Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754 		JBrowse link
G Ash2l ASH2 like histone lysine methyltransferase complex subunit affects expression ISO Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr16:66,242,205...66,264,064
Ensembl chr16:66,242,212...66,264,061 		JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression
decreases activity		 EXP Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein		 CTD PMID:11588175 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Asl argininosuccinate lyase affects expression ISO Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression		 ISO Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA		 CTD PMID:19192274 PMID:26934552 PMID:35537566 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf4 activating transcription factor 4 affects expression
decreases expression
increases expression		 ISO Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in decreased expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA		 CTD PMID:24752500 PMID:27313093 PMID:35537566 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Diclofenac results in decreased expression of ATF5 mRNA CTD PMID:35537566 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707 		JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
increases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein		 CTD PMID:25772430 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions
increases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein		 CTD PMID:25772430 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein		 CTD PMID:25772430 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119 		JBrowse link
G Azin1 antizyme inhibitor 1 affects expression ISO Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578 		JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects expression ISO Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization		 ISO
EXP		 Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein		 CTD PMID:18191430 PMID:29027214 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member decreases expression ISO Diclofenac results in decreased expression of BCAR3 mRNA CTD PMID:35537566 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO
EXP		 Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects expression		 ISO Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA		 CTD PMID:14609740 PMID:24752500 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression ISO Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases activity		 ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA		 CTD PMID:18191430 PMID:24752500 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of BMP6 mRNA
Diclofenac results in increased expression of BMP6 mRNA		 CTD PMID:26934552 PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brd3os BRD3 opposite strand decreases expression ISO Diclofenac results in decreased expression of BRD3OS mRNA CTD PMID:35537566 NCBI chr 3:10,770,229...10,771,860 JBrowse link
G Brdt bromodomain testis associated decreases expression ISO Diclofenac results in decreased expression of BRDT mRNA CTD PMID:35537566 NCBI chr14:2,387,372...2,445,857
Ensembl chr14:2,387,796...2,445,842 		JBrowse link
G Brip1 BRCA1 interacting helicase 1 affects expression ISO Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G C1qa complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C4b complement C4B increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091 		JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calm1 calmodulin 1 affects expression ISO Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calml3 calmodulin-like 3 increases expression EXP Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175 		JBrowse link
G Calr calreticulin affects expression
decreases expression		 EXP Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA		 CTD PMID:18246545 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Capn10 calpain 10 affects expression ISO Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Car1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression
increases secretion		 ISO
EXP		 Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein		 CTD PMID:24038040 PMID:26934552 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of CARS1 mRNA CTD PMID:35537566 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 multiple interactions
affects expression		 ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA		 CTD PMID:16388830 PMID:24752500 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]		 CTD PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 affects expression ISO Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 increases activity
affects expression
multiple interactions		 EXP
ISO		 Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]		 CTD PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO
EXP		 [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA		 CTD PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
decreases activity
multiple interactions		 EXP
ISO		 Diclofenac results in increased activity of CAT protein
Diclofenac results in decreased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein]		 CTD PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbl Cbl proto-oncogene affects expression ISO Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbs cystathionine beta synthase affects expression ISO Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccdc137 coiled-coil domain containing 137 increases expression ISO Diclofenac results in increased expression of CCDC137 mRNA CTD PMID:35537566 NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression		 EXP
ISO		 [Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA		 CTD PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 EXP
ISO		 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]
Diclofenac results in decreased expression of CCL3 mRNA		 CTD PMID:23939143 PMID:35537566 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369 		JBrowse link
G Ccn1 cellular communication network factor 1 affects expression
increases expression		 ISO Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA		 CTD PMID:19192274 PMID:24752500 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression		 ISO
EXP		 Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein		 CTD PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 affects expression ISO Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 affects expression ISO Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccnf cyclin F affects expression ISO Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Ccnh cyclin H affects expression ISO Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd200r1l CD200 receptor 1-like decreases expression ISO Diclofenac results in decreased expression of CD200R4 mRNA CTD PMID:35537566 NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680 		JBrowse link
G Cd244 CD244 molecule decreases expression ISO Diclofenac results in decreased expression of CD244 mRNA CTD PMID:35537566 NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492 		JBrowse link
G Cd28 Cd28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd44 CD44 molecule increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd5l Cd5 molecule-like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cd9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr 1:70,035,921...70,038,990 JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdc7 cell division cycle 7 affects expression ISO Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778 		JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023 		JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
decreases expression		 ISO
EXP		 Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA		 CTD PMID:19022234 PMID:19628293 PMID:24752500 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression ISO Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression EXP Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects expression ISO Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234 PMID:26934552 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression ISO Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression		 ISO
EXP		 Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA		 CTD PMID:19022234 PMID:24752500 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression ISO Diclofenac results in decreased expression of CEBPG mRNA CTD PMID:35537566 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569 		JBrowse link
G Cep162 centrosomal protein 162 decreases expression ISO Diclofenac results in decreased expression of CEP162 mRNA CTD PMID:35537566 NCBI chr 8:88,149,726...88,208,249
Ensembl chr 8:88,149,726...88,206,830 		JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cfh complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects expression		 ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA		 CTD PMID:20237495 PMID:24752500 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression
decreases expression		 ISO Diclofenac results in increased expression of CHAC1 mRNA
Diclofenac results in decreased expression of CHAC1 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Chdh choline dehydrogenase affects expression ISO Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chka choline kinase alpha affects expression ISO Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chkb choline kinase beta affects expression ISO Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Chl1 cell adhesion molecule L1-like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP		 Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]		 CTD PMID:15489888 PMID:25935278 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Clec4a C-type lectin domain family 4, member A increases expression ISO Diclofenac results in increased expression of CLEC4N mRNA CTD PMID:26934552 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402 		JBrowse link
G Clu clusterin increases expression
multiple interactions		 ISO
EXP		 Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein		 CTD PMID:23506792 PMID:25772430 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 affects expression ISO Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions		 ISO
EXP		 Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]		 CTD PMID:26934552 PMID:31042592 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 increases expression ISO Diclofenac results in increased expression of COX4I2 mRNA CTD PMID:35537566 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO Diclofenac results in decreased expression of COX6A2 mRNA CTD PMID:35537566 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274 		JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cplx1 complexin 1 increases expression EXP Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr14:1,184,677...1,216,392 JBrowse link
G Cplx4 complexin 4 increases expression EXP Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:59,481,360...59,504,716
Ensembl chr18:59,481,986...59,497,778 		JBrowse link
G Cpne8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377 		JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 affects expression ISO Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO
EXP		 Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 affects expression ISO Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression		 EXP
ISO		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]		 CTD PMID:25772430 PMID:27313093 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression
increases secretion		 ISO Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein		 CTD PMID:26934552 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 affects expression ISO Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 increases expression EXP Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950 		JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 affects expression ISO Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:97,253,559...97,279,476
Ensembl chr  X:97,253,586...97,279,476 		JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects expression ISO Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196 		JBrowse link
G Ctbp2 C-terminal binding protein 2 affects expression ISO Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Cth cystathionine gamma-lyase affects expression
decreases expression		 ISO Diclofenac affects the expression of CTH mRNA
Diclofenac results in decreased expression of CTH mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctps1 CTP synthase 1 affects expression ISO Diclofenac affects the expression of CTPS1 mRNA CTD PMID:24752500 NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180 		JBrowse link
G Ctps2 CTP synthase 2 affects expression ISO Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:31,645,873...31,786,733
Ensembl chr  X:31,645,873...31,786,733 		JBrowse link
G Ctsc cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ctse cathepsin E decreases expression ISO Diclofenac results in decreased expression of CTSE mRNA CTD PMID:35537566 NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502 		JBrowse link
G Ctss cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cul3 cullin 3 affects expression ISO Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Cul7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23939143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 EXP
ISO		 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein		 CTD PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
decreases expression		 ISO Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA		 CTD PMID:26934552 PMID:27671914 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787 		JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity		 ISO Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein		 CTD PMID:18420780 PMID:21784029 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions		 ISO Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac		 CTD PMID:21784029 PMID:23397584 PMID:28960974 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity
affects expression		 ISO Diclofenac results in decreased activity of CYP2A4 protein
Diclofenac affects the expression of CYP2A4 mRNA		 CTD PMID:18420780 PMID:26934552 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Diclofenac results in decreased expression of CYP2C55 mRNA CTD PMID:26934552 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation
decreases activity
increases response to substance
multiple interactions		 EXP
ISO		 CYP2C6V1 protein results in increased hydroxylation of Diclofenac
Diclofenac results in decreased activity of CYP2C29 protein
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac		 CTD PMID:11911841 PMID:15486075 PMID:18420780 PMID:18511451 PMID:23397584 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584 PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
increases expression
multiple interactions
increases response to substance		 ISO Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Diclofenac
Diclofenac results in increased expression of CYP3A4 mRNA
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
CYP3A4 protein results in increased susceptibility to Diclofenac		 CTD PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diclofenac results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19022234 PMID:29027214 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases expression		 ISO Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA		 CTD PMID:26934552 PMID:28960974 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760 		JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 decreases expression ISO Diclofenac results in decreased expression of CYP4F39 mRNA CTD PMID:35537566 NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression		 ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA		 CTD PMID:26934552 PMID:28960974 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP7A1 mRNA CTD PMID:26934552 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dap death-associated protein increases expression ISO Diclofenac results in increased expression of DAP mRNA CTD PMID:26934552 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 affects expression ISO Diclofenac affects the expression of DBT mRNA CTD PMID:24752500 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609 		JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 affects expression ISO Diclofenac affects the expression of DCTPP1 mRNA CTD PMID:24752500 NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases response to substance
decreases expression
increases expression		 ISO
EXP		 DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in decreased expression of DDIT3 mRNA
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein		 CTD PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Diclofenac results in increased expression of DDIT4 mRNA CTD PMID:26934552 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 affects expression ISO Diclofenac affects the expression of DDR1 mRNA CTD PMID:24752500 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Diclofenac results in decreased expression of DDT mRNA CTD PMID:26934552 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Ddx5 DEAD-box helicase 5 affects expression ISO Diclofenac affects the expression of DDX5 mRNA CTD PMID:24752500 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Diclofenac results in increased expression of DECR1 protein CTD PMID:25772430 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dennd2d DENN domain containing 2D decreases expression ISO Diclofenac results in decreased expression of DENND2D mRNA CTD PMID:35537566 NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270 		JBrowse link
G Derl1 derlin 1 increases expression ISO Diclofenac results in increased expression of DERL1 mRNA CTD PMID:26934552 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl3 derlin 3 increases expression ISO Diclofenac results in increased expression of DERL3 mRNA CTD PMID:26934552 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression ISO Diclofenac affects the expression of DFFA mRNA CTD PMID:24752500 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Diclofenac results in increased expression of DHCR24 mRNA CTD PMID:26934552 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhfr dihydrofolate reductase affects expression ISO Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 decreases expression ISO Diclofenac results in decreased expression of DHRS3 mRNA CTD PMID:35537566 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects expression ISO Diclofenac affects the expression of DKK1 mRNA CTD PMID:24752500 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects expression ISO Diclofenac affects the expression of DNAJA1 mRNA CTD PMID:24752500 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 affects expression ISO Diclofenac affects the expression of DNAJA2 mRNA CTD PMID:24752500 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 affects expression
decreases expression		 ISO Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Diclofenac affects the expression of DNAJB1 mRNA CTD PMID:24752500 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 affects expression ISO Diclofenac affects the expression of DNAJB14 mRNA CTD PMID:24752500 NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 affects expression ISO Diclofenac affects the expression of DNAJB4 mRNA CTD PMID:24752500 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 affects expression ISO Diclofenac affects the expression of DNAJB6 mRNA CTD PMID:24752500 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659 		JBrowse link
G Dnajb7 DnaJ heat shock protein family (Hsp40) member B7 increases expression EXP Diclofenac results in increased expression of DNAJB7 mRNA CTD PMID:30723492 NCBI chr 7:112,932,736...112,934,050
Ensembl chr 7:112,932,616...112,945,537 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression
increases expression		 ISO Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 affects expression
increases expression		 ISO Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 affects expression ISO Diclofenac affects the expression of DNAJC11 mRNA CTD PMID:24752500 NCBI chr 5:162,442,042...162,487,966
Ensembl chr 5:162,442,026...162,488,169 		JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression
decreases expression		 ISO Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA		 CTD PMID:26934552 NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521 		JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 affects expression ISO Diclofenac affects the expression of DNAJC15 mRNA CTD PMID:24752500 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675 		JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 affects expression ISO Diclofenac affects the expression of DNAJC18 mRNA CTD PMID:24752500 NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344 		JBrowse link
G Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 affects expression ISO Diclofenac affects the expression of DNAJC21 mRNA CTD PMID:24752500 NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Diclofenac results in increased expression of DNAJC3 mRNA CTD PMID:26934552 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 affects expression ISO Diclofenac affects the expression of DNAJC5 mRNA CTD PMID:24752500 NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935 		JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 affects expression ISO Diclofenac affects the expression of DNAJC6 mRNA CTD PMID:24752500 NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 affects expression ISO Diclofenac affects the expression of DNAJC7 mRNA CTD PMID:24752500 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575 		JBrowse link
G Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 affects expression ISO Diclofenac affects the expression of DNAJC8 mRNA CTD PMID:24752500 NCBI chr 5:144,745,055...144,763,106
Ensembl chr 5:144,745,036...144,763,108 		JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 affects expression ISO Diclofenac affects the expression of DNAJC9 mRNA CTD PMID:24752500 NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118 		JBrowse link
G Dnd1 DND microRNA-mediated repression inhibitor 1 increases expression ISO Diclofenac results in increased expression of DND1 mRNA CTD PMID:35537566 NCBI chr18:28,378,692...28,381,316
Ensembl chr18:28,378,692...28,381,316 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Diclofenac results in decreased expression of DNER mRNA CTD PMID:35537566 NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects expression ISO Diclofenac affects the expression of DPYSL2 mRNA CTD PMID:24752500 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Diclofenac results in increased expression of DRD1 mRNA CTD PMID:26934552 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Dtymk deoxythymidylate kinase affects expression ISO Diclofenac affects the expression of DTYMK mRNA CTD PMID:24752500 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression
decreases expression		 ISO Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Diclofenac affects the expression of DUT mRNA CTD PMID:24752500 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 increases expression EXP Diclofenac results in increased expression of DYNC1I1 mRNA CTD PMID:30723492 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Diclofenac affects the expression of E2F1 mRNA CTD PMID:24752500 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Diclofenac affects the expression of E2F2 mRNA CTD PMID:24752500 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f5 E2F transcription factor 5 affects expression ISO Diclofenac affects the expression of E2F5 mRNA CTD PMID:24752500 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Ebln1 endogenous Bornavirus like nucleoprotein 1 increases expression EXP Diclofenac results in increased expression of IGKV8-24 mRNA CTD PMID:30723492 NCBI chr10:78,938,645...78,940,651 JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Diclofenac results in decreased expression of ECM1 mRNA CTD PMID:26934552 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Ect2 epithelial cell transforming 2 increases expression ISO Diclofenac results in increased expression of ECT2 mRNA CTD PMID:26934552 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Diclofenac results in increased expression of EDEM1 mRNA CTD PMID:26934552 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Diclofenac results in decreased expression of EDIL3 mRNA CTD PMID:26934552 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Diclofenac results in decreased expression of EEF2K mRNA CTD PMID:35537566 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164 		JBrowse link
G Egf epidermal growth factor increases expression ISO Diclofenac results in increased expression of EGF protein CTD PMID:23506792 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Diclofenac results in increased expression of EGFR mRNA CTD PMID:26934552 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression
affects expression		 ISO Diclofenac results in increased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA		 CTD PMID:15509713 PMID:26934552 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Diclofenac affects the expression of EIF1 mRNA CTD PMID:24752500 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 		JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression ISO Diclofenac results in increased expression of EIF1A mRNA CTD PMID:26934552 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696 		JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked affects expression ISO Diclofenac affects the expression of EIF1AX mRNA CTD PMID:24752500 NCBI chr  X:35,498,698...35,513,402
Ensembl chr  X:35,498,517...35,513,335 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A affects expression ISO Diclofenac affects the expression of EIF2A mRNA CTD PMID:24752500 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects expression
decreases expression		 ISO Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity		 ISO Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein		 CTD PMID:24752500 PMID:26609140 PMID:26934552 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Diclofenac affects the expression of EIF2AK4 mRNA CTD PMID:24752500 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha affects expression ISO Diclofenac affects the expression of EIF2B1 mRNA CTD PMID:24752500 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects expression
multiple interactions		 ISO Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:24752500 PMID:27313093 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta affects expression ISO Diclofenac affects the expression of EIF2S2 mRNA CTD PMID:24752500 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A affects expression ISO Diclofenac affects the expression of EIF3A mRNA CTD PMID:24752500 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B affects expression ISO Diclofenac affects the expression of EIF3B mRNA CTD PMID:24752500 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C affects expression ISO Diclofenac affects the expression of EIF3C mRNA CTD PMID:24752500 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 affects expression ISO Diclofenac affects the expression of EIF4A1 mRNA CTD PMID:24752500 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression ISO Diclofenac affects the expression of EIF4A2 mRNA CTD PMID:24752500 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression
decreases expression
affects expression		 EXP
ISO		 Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac results in decreased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA		 CTD PMID:18172885 PMID:24752500 PMID:35537566 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 affects expression ISO Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 affects expression ISO Diclofenac affects the expression of EIF4G3 mRNA CTD PMID:24752500 NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 affects expression ISO Diclofenac affects the expression of EIF5 mRNA CTD PMID:24752500 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 affects expression ISO Diclofenac affects the expression of ELF2 mRNA CTD PMID:24752500 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947 		JBrowse link
G Elf3 E74 like ETS transcription factor 3 affects expression ISO Diclofenac affects the expression of ELF3 mRNA CTD PMID:24752500 NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects expression ISO Diclofenac affects the expression of ELOVL2 mRNA CTD PMID:24752500 NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Diclofenac results in increased expression of ELOVL6 mRNA CTD PMID:35537566 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO Diclofenac results in increased expression of EME2 mRNA CTD PMID:26934552 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Endog endonuclease G affects expression ISO Diclofenac affects the expression of ENDOG mRNA CTD PMID:24752500 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Eno1 enolase 1 increases expression ISO Diclofenac results in increased expression of ENO1 mRNA CTD PMID:26934552 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Diclofenac affects the expression of ENPP1 mRNA CTD PMID:24752500 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Diclofenac results in increased expression of ENPP2 mRNA CTD PMID:26934552 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 affects expression ISO Diclofenac affects the expression of ENTPD4 mRNA CTD PMID:24752500 NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 affects expression ISO Diclofenac affects the expression of ENTPD5 mRNA CTD PMID:24752500 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 affects expression ISO Diclofenac affects the expression of ENTPD7 mRNA CTD PMID:24752500 NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Diclofenac results in decreased expression of EPHX1 mRNA CTD PMID:17202759 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Epn2 epsin 2 affects expression ISO Diclofenac affects the expression of EPN2 mRNA CTD PMID:24752500 NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642 		JBrowse link
G Epn3 epsin 3 affects expression ISO Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356 		JBrowse link
G Epo erythropoietin affects expression ISO Diclofenac affects the expression of EPO mRNA CTD PMID:24752500 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ereg epiregulin increases expression ISO Diclofenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 affects expression ISO Diclofenac affects the expression of ERN1 mRNA CTD PMID:24752500 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Diclofenac results in increased expression of ERO1A mRNA CTD PMID:26934552 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO Diclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase decreases expression ISO Diclofenac results in decreased expression of ETNPPL mRNA CTD PMID:26934552 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212 		JBrowse link
G Evi5 ecotropic viral integration site 5 decreases expression ISO Diclofenac results in decreased expression of EVI5 mRNA CTD PMID:35537566 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 decreases expression ISO Diclofenac results in decreased expression of EXTL1 mRNA CTD PMID:35537566 NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Diclofenac results in decreased expression of EYA4 mRNA CTD PMID:26934552 NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976 		JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression ISO Diclofenac results in increased expression of F13A1 mRNA CTD PMID:26934552 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G Faap24 FA core complex associated protein 24 increases expression ISO Diclofenac results in increased expression of FAAP24 mRNA CTD PMID:26934552 NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein		 CTD PMID:19022234 PMID:23506792 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP
ISO		 Diclofenac results in decreased expression of FABP2 mRNA CTD PMID:19022234 PMID:26934552 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Diclofenac results in decreased expression of FABP4 mRNA CTD PMID:35537566 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Diclofenac results in increased expression of FABP5 mRNA CTD PMID:26934552 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Diclofenac results in decreased expression of FADS1 mRNA CTD PMID:26934552 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fancb FA complementation group B affects expression ISO Diclofenac affects the expression of FANCB mRNA CTD PMID:24752500 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Fancc FA complementation group C affects expression ISO Diclofenac affects the expression of FANCC mRNA CTD PMID:24752500 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376 		JBrowse link
G Fance FA complementation group E increases expression ISO Diclofenac results in increased expression of FANCE mRNA CTD PMID:26934552 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631 		JBrowse link
G Fancf FA complementation group F affects expression ISO Diclofenac affects the expression of FANCF mRNA CTD PMID:24752500 NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923 		JBrowse link
G Fancg FA complementation group G affects expression ISO Diclofenac affects the expression of FANCG mRNA CTD PMID:24752500 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fancl FA complementation group L affects expression ISO Diclofenac affects the expression of FANCL mRNA CTD PMID:24752500 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fancm FA complementation group M affects expression ISO Diclofenac affects the expression of FANCM mRNA CTD PMID:24752500 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028 		JBrowse link
G Fas Fas cell surface death receptor affects expression
increases expression		 ISO Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO Diclofenac results in increased expression of FASL mRNA CTD PMID:22285467 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Diclofenac results in decreased expression of FASN mRNA CTD PMID:19022234 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxo33 F-box protein 33 increases expression ISO Diclofenac results in increased expression of FBXO33 mRNA CTD PMID:35537566 NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669 		JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO Diclofenac results in decreased expression of FBXO5 mRNA CTD PMID:35537566 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression ISO Diclofenac results in increased expression of FCER1G mRNA CTD PMID:26934552 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression ISO Diclofenac results in increased expression of FCGR3 mRNA CTD PMID:26934552 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO Diclofenac results in decreased expression of FCGR2B mRNA CTD PMID:35537566 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Diclofenac results in increased expression of FEN1 mRNA CTD PMID:26934552 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Fer FER tyrosine kinase affects expression ISO Diclofenac affects the expression of FER mRNA CTD PMID:24752500 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 increases expression EXP Diclofenac results in increased expression of FERMT1 mRNA CTD PMID:30723492 NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions
increases expression		 EXP
ISO		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA		 CTD PMID:25772430 PMID:26934552 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Diclofenac results in decreased expression of FGF1 mRNA CTD PMID:26934552 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf3 fibroblast growth factor 3 increases expression ISO Diclofenac results in increased expression of FGF3 mRNA CTD PMID:26934552 NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Diclofenac affects the expression of FGFR1 mRNA CTD PMID:24752500 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr1op2 FGFR1 oncogene partner 2 decreases expression ISO Diclofenac results in decreased expression of FGFR1OP2 mRNA CTD PMID:26934552 NCBI chr 4:179,491,602...179,512,630
Ensembl chr 4:179,491,599...179,512,630 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions
decreases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] CTD PMID:25772430 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Diclofenac results in increased expression of FGL1 mRNA CTD PMID:26934552 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093 		JBrowse link
G Fmod fibromodulin decreases expression ISO Diclofenac results in decreased expression of FMOD mRNA CTD PMID:26934552 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein CTD PMID:26934552 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fnbp1 formin binding protein 1 affects expression ISO Diclofenac affects the expression of FNBP1 mRNA CTD PMID:24752500 NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881 		JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression ISO Diclofenac results in increased expression of FNDC3B mRNA CTD PMID:26934552 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830 		JBrowse link
G Fnip1 folliculin interacting protein 1 decreases expression ISO Diclofenac results in decreased expression of FNIP1 mRNA CTD PMID:26934552 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824 		JBrowse link
G Fnip2 folliculin interacting protein 2 decreases expression ISO Diclofenac results in decreased expression of FNIP2 mRNA CTD PMID:26934552 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression		 ISO Diclofenac results in increased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA		 CTD PMID:12730611 PMID:24752500 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Diclofenac results in increased expression of FOSL2 mRNA CTD PMID:26934552 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Foxa1 forkhead box A1 affects expression ISO Diclofenac affects the expression of FOXA1 mRNA CTD PMID:24752500 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa3 forkhead box A3 increases expression ISO Diclofenac results in increased expression of FOXA3 mRNA CTD PMID:26934552 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155 		JBrowse link
G Foxo1 forkhead box O1 affects expression ISO Diclofenac affects the expression of FOXO1 mRNA CTD PMID:24752500 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 affects expression
decreases expression		 ISO Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Diclofenac results in increased expression of FPR2 mRNA CTD PMID:26934552 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019 		JBrowse link
G Frat2 FRAT regulator of WNT signaling pathway 2 decreases expression ISO Diclofenac results in decreased expression of FRAT2 mRNA CTD PMID:35537566 NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 affects expression ISO Diclofenac affects the expression of FRS2 mRNA CTD PMID:24752500 NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase affects expression ISO Diclofenac affects the expression of FTCD mRNA CTD PMID:24752500 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Fyb1 FYN binding protein 1 increases expression ISO Diclofenac results in increased expression of FYB1 mRNA CTD PMID:26934552 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629 		JBrowse link
G Fzd3 frizzled class receptor 3 affects expression ISO Diclofenac affects the expression of FZD3 mRNA CTD PMID:24752500 NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369 		JBrowse link
G Fzd4 frizzled class receptor 4 affects expression ISO Diclofenac affects the expression of FZD4 mRNA CTD PMID:24752500 NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724 		JBrowse link
G Fzd5 frizzled class receptor 5 affects expression ISO Diclofenac affects the expression of FZD5 mRNA CTD PMID:24752500 NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Fzd6 frizzled class receptor 6 affects expression ISO Diclofenac affects the expression of FZD6 mRNA CTD PMID:24752500 NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776 		JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO Diclofenac affects the expression of FZD7 mRNA CTD PMID:24752500 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
G Gab1 GRB2-associated binding protein 1 affects expression ISO Diclofenac affects the expression of GAB1 mRNA CTD PMID:24752500 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Gab2 GRB2-associated binding protein 2 affects expression ISO Diclofenac affects the expression of GAB2 mRNA CTD PMID:24752500 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 decreases expression ISO Diclofenac results in decreased expression of GABRA5 mRNA CTD PMID:26934552 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases expression
affects expression		 ISO
EXP		 Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA		 CTD PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Diclofenac results in increased expression of GADD45G mRNA CTD PMID:26934552 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression EXP Diclofenac results in increased expression of GALNT3 mRNA CTD PMID:30723492 NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 affects expression
decreases expression		 ISO Diclofenac affects the expression of GARS1 mRNA
Diclofenac results in decreased expression of GARS1 mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase affects expression ISO Diclofenac affects the expression of GART mRNA CTD PMID:24752500 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Diclofenac results in decreased expression of GAS1 mRNA CTD PMID:26934552 NCBI chr17:4,482,168...4,485,153 JBrowse link
G Gata4 GATA binding protein 4 affects expression ISO Diclofenac affects the expression of GATA4 mRNA CTD PMID:24752500 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Diclofenac results in increased expression of GATA6 mRNA CTD PMID:26934552 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Diclofenac results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gbp4 guanylate binding protein 4 increases expression ISO Diclofenac results in increased expression of GBP3 mRNA CTD PMID:26934552 NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879 		JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gck glucokinase affects expression ISO Diclofenac affects the expression of GCK mRNA CTD PMID:26934552 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
affects expression
affects response to substance		 EXP
ISO		 Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac		 CTD PMID:17202759 PMID:19481141 PMID:24752500 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression ISO Diclofenac affects the expression of GCLM mRNA CTD PMID:24752500 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein		 CTD PMID:15555568 PMID:18076062 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gdf6 growth differentiation factor 6 increases expression EXP Diclofenac results in increased expression of GDF6 mRNA CTD PMID:30723492 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 increases expression ISO Diclofenac results in increased expression of GFPT1 mRNA CTD PMID:26934552 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein CTD PMID:23939143 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ghr growth hormone receptor affects expression ISO Diclofenac affects the expression of GHR protein CTD PMID:26934552 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Git2 GIT ArfGAP 2 affects expression ISO Diclofenac affects the expression of GIT2 mRNA CTD PMID:24752500 NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Diclofenac results in increased expression of GJA1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja3 gap junction protein, alpha 3 increases expression ISO Diclofenac results in increased expression of GJA3 mRNA CTD PMID:26934552 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810 		JBrowse link
G Gldc glycine decarboxylase affects expression ISO Diclofenac affects the expression of GLDC mRNA CTD PMID:24752500 NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097 		JBrowse link
G Glyctk glycerate kinase affects expression ISO Diclofenac affects the expression of GLYCTK mRNA CTD PMID:24752500 NCBI chr 8:106,795,461...106,802,675
Ensembl chr 8:106,797,343...106,802,397 		JBrowse link
G Gna13 G protein subunit alpha 13 affects expression ISO Diclofenac affects the expression of GNA13 mRNA CTD PMID:24752500 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gnaq G protein subunit alpha q affects expression ISO Diclofenac affects the expression of GNAQ mRNA CTD PMID:24752500 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gnas GNAS complex locus affects expression ISO Diclofenac affects the expression of GNAS mRNA CTD PMID:24752500 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnat1 G protein subunit alpha transducin 1 increases expression ISO Diclofenac results in increased expression of GNAT1 mRNA CTD PMID:26934552 NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671 		JBrowse link
G Gnb5 G protein subunit beta 5 affects expression ISO Diclofenac affects the expression of GNB5 mRNA CTD PMID:24752500 NCBI chr 8:76,076,120...76,105,069
Ensembl chr 8:76,073,306...76,105,069 		JBrowse link
G Gng4 G protein subunit gamma 4 affects expression ISO Diclofenac affects the expression of GNG4 mRNA CTD PMID:24752500 NCBI chr17:86,448,708...86,497,560
Ensembl chr17:86,449,022...86,495,254 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression
increases secretion		 ISO Diclofenac affects the expression of GOT1 mRNA
Diclofenac results in increased secretion of GOT1 protein		 CTD PMID:24752500 PMID:36442613 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] CTD PMID:25772430 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Diclofenac affects the expression of GPLD1 mRNA CTD PMID:24752500 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
G Gpr176 G protein-coupled receptor 176 decreases expression ISO Diclofenac results in decreased expression of GPR176 mRNA CTD PMID:35537566 NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226 		JBrowse link
G Gpr20 G protein-coupled receptor 20 decreases expression EXP Diclofenac results in decreased expression of GPR20 mRNA CTD PMID:30723492 NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases secretion
increases expression
increases activity		 EXP
ISO		 [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased secretion of GPT protein
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]		 CTD PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 More... NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Diclofenac results in decreased expression of GPT2 mRNA CTD PMID:35537566 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP
ISO		 Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein CTD PMID:25772430 PMID:29027214 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO Diclofenac affects the expression of GPX2 mRNA CTD PMID:24752500 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Grb10 growth factor receptor bound protein 10 affects expression ISO Diclofenac affects the expression of GRB10 mRNA CTD PMID:24752500 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases expression ISO Diclofenac results in increased expression of GRM7 mRNA CTD PMID:26934552 NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression ISO Diclofenac affects the expression of GSK3B mRNA CTD PMID:24752500 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin decreases expression ISO Diclofenac results in decreased expression of GSN mRNA CTD PMID:26934552 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Diclofenac results in decreased activity of GSTA1 protein CTD PMID:27183920 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases activity ISO Diclofenac results in decreased activity of GSTA4 protein CTD PMID:27183920 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
Diclofenac results in increased expression of GSTA5 protein		 CTD PMID:25772430 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
decreases expression		 ISO Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA		 CTD PMID:26934552 PMID:27183920 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity ISO Diclofenac results in decreased activity of GSTM2 protein CTD PMID:27183920 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects activity ISO Diclofenac affects the activity of GSTM4 protein CTD PMID:27183920 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Diclofenac results in increased expression of GSTM3 mRNA CTD PMID:26934552 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
affects activity
affects metabolic processing		 ISO [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite		 CTD PMID:24185126 PMID:24246759 PMID:27183920 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression
affects activity		 ISO Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein		 CTD PMID:24752500 PMID:27183920 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 affects expression ISO Diclofenac affects the expression of GTF2H4 mRNA CTD PMID:24752500 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984 		JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression ISO Diclofenac affects the expression of GTF2H5 mRNA CTD PMID:24752500 NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939 		JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Diclofenac results in decreased expression of GTPBP2 mRNA CTD PMID:35537566 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hamp hepcidin antimicrobial peptide affects expression
decreases secretion		 ISO Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein		 CTD PMID:24038040 PMID:26934552 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hat1 histone acetyltransferase 1 affects expression ISO Diclofenac affects the expression of HAT1 mRNA CTD PMID:24752500 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Diclofenac results in increased expression of HAVCR1 mRNA CTD PMID:23506792 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Diclofenac results in increased expression of HBA-A2 protein CTD PMID:14565772 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Diclofenac results in increased expression of HBB protein CTD PMID:14565772 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects expression
decreases expression
increases expression		 ISO Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in decreased expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA		 CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases expression ISO Diclofenac results in increased expression of HCK mRNA CTD PMID:26934552 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA		 CTD PMID:19192274 PMID:26934552 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 affects expression
decreases expression		 ISO Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA		 CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression ISO Diclofenac results in decreased expression of HES6 mRNA CTD PMID:26934552 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559 		JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression ISO Diclofenac results in decreased expression of HHEX mRNA CTD PMID:26934552 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Diclofenac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Diclofenac results in decreased expression of H2BC21 mRNA CTD PMID:26934552 NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642 		JBrowse link
G Hk1 hexokinase 1 increases expression ISO Diclofenac results in increased expression of HK1 mRNA CTD PMID:26934552 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
affects expression		 EXP
ISO		 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA		 CTD PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Diclofenac results in decreased expression of HMGCS2 mRNA CTD PMID:26934552 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
affects expression		 ISO
EXP		 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein		 CTD PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO Diclofenac results in decreased expression of HMX3 mRNA CTD PMID:35537566 NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201 		JBrowse link
G Hnf1a HNF1 homeobox A affects expression ISO Diclofenac affects the expression of HNF1A mRNA CTD PMID:24752500 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Diclofenac results in decreased expression of HNF4A mRNA CTD PMID:19022234 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression ISO Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hp haptoglobin decreases expression
increases expression		 ISO Diclofenac results in decreased expression of HP mRNA
Diclofenac results in increased expression of HP mRNA		 CTD PMID:26934552 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
multiple interactions
increases expression		 ISO Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA		 CTD PMID:19501039 PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of HRAS mRNA CTD PMID:24752500 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 decreases expression ISO Diclofenac results in decreased expression of HS3ST3B1 mRNA CTD PMID:35537566 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Diclofenac results in increased expression of HS6ST2 mRNA CTD PMID:26934552 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Diclofenac results in decreased expression of HSD3B2 mRNA CTD PMID:26934552 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Diclofenac results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] CTD PMID:23939143 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
affects expression		 EXP
ISO		 Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
Diclofenac results in increased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA		 CTD PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diclofenac results in increased expression of HSPA1B mRNA CTD PMID:26934552 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP
ISO		 Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein		 CTD PMID:25014874 PMID:25772430 PMID:27313093 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression		 EXP
ISO		 Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA		 CTD PMID:23939143 PMID:26934552 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Diclofenac results in decreased expression of HSPB1 mRNA CTD PMID:26934552 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Diclofenac results in increased expression of HSPB8 mRNA CTD PMID:26934552 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of IARS1 mRNA CTD PMID:35537566 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237 		JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase increases expression ISO Diclofenac results in increased expression of IBTK mRNA CTD PMID:26934552 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
increases expression
affects expression		 EXP
ISO		 Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA		 CTD PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Diclofenac results in increased expression of ID2 mRNA CTD PMID:26934552 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Diclofenac results in increased expression of ID3 mRNA CTD PMID:26934552 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO Diclofenac results in increased expression of IER3 mRNA CTD PMID:26934552 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Diclofenac results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Diclofenac results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Diclofenac results in decreased expression of IFI44 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844 		JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Diclofenac results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Diclofenac results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Diclofenac results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Diclofenac results in increased expression of IFITM2 mRNA CTD PMID:26934552 NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression ISO Diclofenac results in increased expression of IFITM3 mRNA CTD PMID:26934552 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression		 EXP
ISO		 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA		 CTD PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Diclofenac results in decreased expression of IFRD1 mRNA CTD PMID:35537566 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression ISO Diclofenac affects the expression of IGF1R mRNA CTD PMID:24752500 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 affects expression
increases expression		 ISO Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Diclofenac results in decreased expression of IGFBP2 mRNA CTD PMID:26934552 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Diclofenac affects the expression of IGFBP3 mRNA CTD PMID:24752500 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] CTD PMID:25935278 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Diclofenac results in increased expression of IKBKE mRNA CTD PMID:26934552 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression ISO Diclofenac affects the expression of IKBKG mRNA CTD PMID:24752500 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il10 interleukin 10 increases response to substance
multiple interactions		 ISO
EXP		 IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]		 CTD PMID:15122773 PMID:23939143 PMID:31042592 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression EXP Diclofenac results in increased expression of IL12RB1 mRNA CTD PMID:30723492 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Diclofenac results in increased expression of IL13RA1 mRNA CTD PMID:26934552 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il16 interleukin 16 decreases expression ISO Diclofenac results in decreased expression of IL16 mRNA CTD PMID:35537566 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il17a interleukin 17A increases expression
multiple interactions		 ISO
EXP		 Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]		 CTD PMID:22285467 PMID:25450234 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18bp interleukin 18 binding protein increases expression ISO Diclofenac results in increased expression of IL18BP mRNA CTD PMID:26934552 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of IL1A mRNA		 CTD PMID:19362101 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]		 CTD PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 affects expression
increases expression		 ISO Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO
EXP		 Diclofenac results in increased expression of IL1R2 mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
decreases expression
increases secretion
multiple interactions		 ISO Diclofenac results in increased expression of IL1RN mRNA
Diclofenac results in decreased expression of IL1RN mRNA
Diclofenac results in increased secretion of IL1RN protein
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]		 CTD PMID:9491209 PMID:26934552 PMID:35537566 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Diclofenac results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il24 interleukin 24 increases expression ISO Diclofenac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Diclofenac results in increased expression of IL2RG mRNA CTD PMID:26934552 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il33 interleukin 33 increases expression
decreases expression		 ISO Diclofenac results in increased expression of IL33 mRNA
Diclofenac results in decreased expression of IL33 mRNA		 CTD PMID:26934552 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 increases response to substance ISO IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] CTD PMID:15663561 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression		 ISO
EXP		 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]		 CTD PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Diclofenac affects the expression of IMMT mRNA CTD PMID:26934552 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109 		JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO
EXP		 Diclofenac results in increased expression of INHBB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Inka2 inka box actin regulator 2 increases expression ISO Diclofenac results in increased expression of FAM212B mRNA CTD PMID:35537566 NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642 		JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO Diclofenac results in decreased expression of INMT mRNA CTD PMID:26934552 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493 		JBrowse link
G Insr insulin receptor affects expression ISO Diclofenac affects the expression of INSR mRNA CTD PMID:24752500 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO Diclofenac results in increased expression of IRAK4 mRNA CTD PMID:26934552 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Diclofenac results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Irgm immunity-related GTPase M increases expression ISO Diclofenac results in increased expression of IRGM1 mRNA CTD PMID:26934552 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Irs1 insulin receptor substrate 1 affects expression ISO Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 PMID:26934552 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Diclofenac results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Diclofenac results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Diclofenac results in increased expression of ISYNA1 mRNA CTD PMID:26934552 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979 		JBrowse link
G Itga2 integrin subunit alpha 2 affects expression ISO Diclofenac affects the expression of ITGA2 mRNA CTD PMID:24752500 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgal integrin subunit alpha L increases expression ISO Diclofenac results in increased expression of ITGAL mRNA CTD PMID:26934552 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Diclofenac results in increased expression of ITGAM mRNA CTD PMID:27671914 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Diclofenac results in decreased expression of ITGAX mRNA CTD PMID:35537566 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Itgb1 integrin subunit beta 1 affects expression ISO Diclofenac affects the expression of ITGB1 mRNA CTD PMID:24752500 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Diclofenac results in increased expression of ITGB2 mRNA CTD PMID:26934552 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] CTD PMID:19691487 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression ISO Diclofenac results in increased expression of ITIH3 mRNA CTD PMID:26934552 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression ISO Diclofenac results in increased expression of ITIH4 mRNA CTD PMID:26934552 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708 		JBrowse link
G Itm2a integral membrane protein 2A increases expression ISO Diclofenac results in increased expression of ITM2A mRNA CTD PMID:17379860 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Jdp2 Jun dimerization protein 2 decreases expression ISO Diclofenac results in decreased expression of JDP2 mRNA CTD PMID:35537566 NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression		 ISO Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP		 Diclofenac results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kat6b lysine acetyltransferase 6B affects expression ISO Diclofenac affects the expression of KAT6B mRNA CTD PMID:24752500 NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316 		JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 increases expression EXP Diclofenac results in increased expression of KBTBD11 mRNA CTD PMID:30723492 NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression EXP Diclofenac results in increased expression of KHDC3 mRNA CTD PMID:30723492 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G Kif5c kinesin family member 5C increases expression EXP Diclofenac results in increased expression of KIF5C mRNA CTD PMID:30723492 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413 		JBrowse link
G Klf4 KLF transcription factor 4 decreases expression ISO Diclofenac results in decreased expression of KLF4 mRNA CTD PMID:35537566 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klhl33 kelch-like family member 33 decreases expression ISO Diclofenac results in decreased expression of KLHL33 mRNA CTD PMID:35537566 NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438 		JBrowse link
G Klk1 kallikrein 1 increases expression ISO Diclofenac results in increased expression of KLK1 protein CTD PMID:23506792 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 increases expression EXP Diclofenac results in increased expression of KNDC1 mRNA CTD PMID:30723492 NCBI chr 1:194,689,962...194,738,353
Ensembl chr 1:194,690,135...194,738,362 		JBrowse link
G Kng1 kininogen 1 increases expression
multiple interactions		 EXP Diclofenac results in increased expression of KNG1 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein]		 CTD PMID:25772430 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kras KRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 decreases expression ISO Diclofenac results in decreased expression of LAX1 mRNA CTD PMID:26934552 NCBI chr13:45,134,825...45,145,381
Ensembl chr13:45,134,834...45,145,381 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression
decreases expression
affects expression		 ISO Diclofenac results in increased expression of LBP protein
Diclofenac results in decreased expression of LBP mRNA
Diclofenac affects the expression of LBP mRNA		 CTD PMID:26934552 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions		 EXP
ISO		 Diclofenac results in increased expression of LCN2 mRNA
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]		 CTD PMID:23939143 PMID:26934552 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Diclofenac results in increased expression of LCP2 mRNA CTD PMID:26934552 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559 		JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Diclofenac results in increased expression of LDHA protein CTD PMID:25772430 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 increases expression ISO Diclofenac results in increased expression of LEAP2 mRNA CTD PMID:26934552 NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244 		JBrowse link
G Lepr leptin receptor affects expression
increases expression		 ISO Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein		 CTD PMID:26934552 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lgals3 galectin 3 increases expression ISO Diclofenac results in increased expression of LGALS3 mRNA CTD PMID:26934552 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lgmn legumain increases expression ISO Diclofenac results in increased expression of LGMN mRNA CTD PMID:26934552 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 increases expression ISO Diclofenac results in increased expression of LGR4 mRNA CTD PMID:35537566 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899 		JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Diclofenac results in decreased expression of LHX2 mRNA CTD PMID:35537566 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO Diclofenac results in decreased expression of LIFR mRNA CTD PMID:26934552 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lipc lipase C, hepatic type decreases expression ISO Diclofenac results in decreased expression of LIPC mRNA CTD PMID:26934552 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression ISO Diclofenac results in increased expression of LITAF mRNA CTD PMID:26934552 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Lmnb1 lamin B1 increases expression ISO Diclofenac results in increased expression of LMNB1 mRNA CTD PMID:35537566 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Lmo4 LIM domain only 4 decreases expression ISO Diclofenac results in decreased expression of LMO4 mRNA CTD PMID:35537566 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Diclofenac results in decreased expression of LPAR4 mRNA CTD PMID:26934552 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Diclofenac results in increased expression of LPL mRNA CTD PMID:26934552 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Diclofenac results in increased expression of LRG1 mRNA CTD PMID:26934552 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813 		JBrowse link
G Lrp8 LDL receptor related protein 8 increases expression ISO Diclofenac results in increased expression of LRP8 mRNA CTD PMID:35537566 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352 		JBrowse link
G Ltc4s leukotriene C4 synthase increases expression EXP Diclofenac results in increased expression of LTC4S mRNA CTD PMID:30723492 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Lxn latexin increases expression ISO Diclofenac results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression
increases expression		 ISO Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA		 CTD PMID:19192274 PMID:26934552 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689 		JBrowse link
G Ly75 lymphocyte antigen 75 increases expression ISO Diclofenac results in increased expression of LY75 mRNA CTD PMID:26934552 NCBI chr 3:44,764,702...44,852,219
Ensembl chr 3:44,765,122...44,852,374 		JBrowse link
G Lyz2 lysozyme 2 increases expression ISO Diclofenac results in increased expression of LYZ2 mRNA CTD PMID:26934552 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 affects expression ISO Diclofenac affects the expression of MAGI1 mRNA CTD PMID:24752500 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691 		JBrowse link
G Maoa monoamine oxidase A affects expression ISO Diclofenac affects the expression of MAOA mRNA CTD PMID:24752500 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B affects expression ISO Diclofenac affects the expression of MAOB mRNA CTD PMID:24752500 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects expression ISO Diclofenac affects the expression of MAP2K3 mRNA CTD PMID:24752500 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 affects expression ISO Diclofenac affects the expression of MAP2K5 mRNA CTD PMID:24752500 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 affects expression ISO Diclofenac affects the expression of MAP2K6 mRNA CTD PMID:24752500 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Diclofenac results in increased expression of MAP3K1 mRNA CTD PMID:26934552 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP Diclofenac results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 affects expression ISO Diclofenac affects the expression of MAP3K7 mRNA CTD PMID:24752500 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 affects expression ISO Diclofenac affects the expression of MAP4K4 mRNA CTD PMID:24752500 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Map7d1 MAP7 domain containing 1 increases expression ISO Diclofenac results in increased expression of MAP7D1 mRNA CTD PMID:26934552 NCBI chr 5:138,527,944...138,552,537
Ensembl chr 5:138,527,401...138,552,499 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]
Diclofenac analog results in increased phosphorylation of MAPK1 protein; Diclofenac results in increased phosphorylation of MAPK1 protein		 CTD PMID:24104198 PMID:26609140 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression ISO Diclofenac affects the expression of MAPK13 mRNA CTD PMID:24752500 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression ISO Diclofenac affects the expression of MAPK14 mRNA CTD PMID:24752500 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]
Diclofenac analog results in increased phosphorylation of MAPK3 protein; Diclofenac results in increased phosphorylation of MAPK3 protein		 CTD PMID:24104198 PMID:26609140 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects expression ISO Diclofenac affects the expression of MAPK8 mRNA CTD PMID:24752500 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Diclofenac results in increased expression of MAPK8IP3 mRNA CTD PMID:26934552 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Diclofenac results in increased expression of MAPKAPK3 mRNA CTD PMID:26934552 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568 		JBrowse link
G Marchf1 membrane associated ring-CH-type finger 1 increases expression ISO Diclofenac results in increased expression of MARCHF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr16:23,255,551...24,114,290
Ensembl chr16:23,258,799...24,114,277 		JBrowse link
G Marco macrophage receptor with collagenous structure increases expression
decreases expression		 ISO Diclofenac results in increased expression of MARCO mRNA
Diclofenac results in decreased expression of MARCO mRNA		 CTD PMID:26934552 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521 		JBrowse link
G Mastl microtubule associated serine/threonine kinase-like decreases expression ISO Diclofenac results in decreased expression of MASTL mRNA CTD PMID:26934552 PMID:35537566 NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353 		JBrowse link
G Mbl1 mannose binding lectin 1 increases expression ISO Diclofenac results in increased expression of MBL1 mRNA CTD PMID:26934552 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression ISO Diclofenac results in decreased expression of MCAM mRNA CTD PMID:35537566 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 affects expression ISO Diclofenac affects the expression of MCM7 mRNA CTD PMID:24752500 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression EXP Diclofenac results in increased expression of MCTP1 mRNA CTD PMID:30723492 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression EXP Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mecom MDS1 and EVI1 complex locus decreases expression ISO Diclofenac results in decreased expression of MECOM mRNA CTD PMID:26934552 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Med10 mediator complex subunit 10 affects expression ISO Diclofenac affects the expression of MED10 mRNA CTD PMID:24752500 NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767 		JBrowse link
G Med13 mediator complex subunit 13 affects expression ISO Diclofenac affects the expression of MED13 mRNA CTD PMID:24752500 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242 		JBrowse link
G Med13l mediator complex subunit 13L affects expression ISO Diclofenac affects the expression of MED13L mRNA CTD PMID:24752500 NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473 		JBrowse link
G Med14 mediator complex subunit 14 affects expression ISO Diclofenac affects the expression of MED14 mRNA CTD PMID:24752500 NCBI chr  X:10,036,749...10,127,910
Ensembl chr  X:10,036,805...10,126,240 		JBrowse link
G Med17 mediator complex subunit 17 affects expression ISO Diclofenac affects the expression of MED17 mRNA CTD PMID:24752500 NCBI chr 8:12,101,594...12,120,592
Ensembl chr 8:12,101,594...12,120,592 		JBrowse link
G Med30 mediator complex subunit 30 affects expression ISO Diclofenac affects the expression of MED30 mRNA CTD PMID:24752500 NCBI chr 7:84,004,735...84,026,474
Ensembl chr 7:84,004,722...84,026,595 		JBrowse link
G Med31 mediator complex subunit 31 affects expression ISO Diclofenac affects the expression of MED31 mRNA CTD PMID:24752500 NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326 		JBrowse link
G Med6 mediator complex subunit 6 affects expression ISO Diclofenac affects the expression of MED6 mRNA CTD PMID:24752500 NCBI chr 6:101,270,410...101,283,929
Ensembl chr 6:101,270,410...101,283,876 		JBrowse link
G Mef2a myocyte enhancer factor 2a affects expression ISO Diclofenac affects the expression of MEF2A mRNA CTD PMID:24752500 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression
increases expression		 ISO Diclofenac results in decreased expression of MET mRNA
Diclofenac results in increased expression of MET mRNA		 CTD PMID:19192274 PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mfn1 mitofusin 1 decreases expression
multiple interactions		 EXP Diclofenac results in decreased expression of MFN1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein]		 CTD PMID:27792760 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions		 EXP Diclofenac results in decreased expression of MFN2 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein]		 CTD PMID:27792760 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression ISO Diclofenac results in increased expression of MFSD2A mRNA CTD PMID:35537566 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Diclofenac results in decreased expression of MGLL mRNA CTD PMID:26934552 NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Diclofenac results in increased expression of MGMT mRNA CTD PMID:35537566 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir122 microRNA 122 increases expression ISO
EXP		 Diclofenac results in increased expression of MIR122
Diclofenac results in increased expression of MIR122 mRNA		 CTD PMID:25527335 PMID:30925002 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir192 microRNA 192 increases expression EXP Diclofenac results in increased expression of MIR192 mRNA CTD PMID:30925002 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mirlet7d microRNA let-7d decreases expression EXP Diclofenac results in decreased expression of MIRLET7D mRNA CTD PMID:30723492 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of MKNK2 mRNA CTD PMID:24752500 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mkrn2 makorin, ring finger protein, 2 decreases expression ISO Diclofenac results in decreased expression of MKRN2 mRNA CTD PMID:35537566 NCBI chr 4:148,661,529...148,679,580
Ensembl chr 4:148,661,553...148,679,642 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Diclofenac results in decreased expression of MME mRNA CTD PMID:26934552 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Diclofenac results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO Diclofenac results in increased expression of MMP16 mRNA CTD PMID:26934552 NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388 		JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP Diclofenac results in increased expression of MMP8 mRNA CTD PMID:30723492 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO Diclofenac results in increased expression of MNDA mRNA CTD PMID:26934552 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201 		JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Diclofenac results in increased expression of MPEG1 mRNA CTD PMID:26934552 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
increases activity		 EXP
ISO		 Diclofenac inhibits the reaction [Carrageenan results in increased activity of MPO protein]; sodium nitrate inhibits the reaction [Diclofenac results in increased activity of MPO protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein]
Diclofenac results in increased expression of MPO mRNA
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Diclofenac		 CTD PMID:17275683 PMID:24412305 PMID:27671914 PMID:28754375 PMID:31926916 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Diclofenac affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Mras muscle RAS oncogene homolog affects expression ISO Diclofenac affects the expression of MRAS mRNA CTD PMID:24752500 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Ms4a14 membrane spanning 4-domains A14 increases expression EXP Diclofenac results in increased expression of MS4A14 mRNA CTD PMID:30723492 NCBI chr 1:207,949,423...207,964,937
Ensembl chr 1:207,949,426...207,964,937 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO Diclofenac results in increased expression of MT2 mRNA CTD PMID:26934552 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtbp MDM2 binding protein decreases expression ISO Diclofenac results in decreased expression of MTBP mRNA CTD PMID:35537566 NCBI chr 7:86,973,215...87,055,775
Ensembl chr 7:86,973,069...87,050,827 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase affects expression
decreases expression		 ISO Diclofenac affects the expression of MTHFD2 mRNA
Diclofenac results in decreased expression of MTHFD2 mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like increases expression EXP Diclofenac results in increased expression of MTHFD2L mRNA CTD PMID:30723492 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO Diclofenac results in increased expression of MTSS1 mRNA CTD PMID:26934552 NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968 		JBrowse link
G Mup4 major urinary protein 4 decreases expression ISO Diclofenac results in decreased expression of MUP4 mRNA CTD PMID:26934552 NCBI chr 5:74,961,143...74,964,686
Ensembl chr 5:74,842,319...75,061,474 		JBrowse link
G Mvp major vault protein increases expression ISO Diclofenac results in increased expression of MVP mRNA CTD PMID:26934552 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Diclofenac results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Mxd1 max dimerization protein 1 affects expression ISO Diclofenac affects the expression of MXD1 mRNA CTD PMID:24752500 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
affects expression		 EXP
ISO		 Diclofenac results in increased expression of MYC mRNA
Diclofenac results in decreased expression of MYC mRNA
Diclofenac affects the expression of MYC mRNA		 CTD PMID:19022234 PMID:24752500 PMID:35537566 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO Diclofenac results in increased expression of MYD88 mRNA CTD PMID:26934552 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D affects expression ISO Diclofenac affects the expression of NAPEPLD mRNA CTD PMID:24752500 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of NARS1 mRNA CTD PMID:35537566 NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Diclofenac results in increased expression of NCF1 mRNA CTD PMID:26934552 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 increases expression ISO Diclofenac results in increased expression of NCF4 mRNA CTD PMID:26934552 NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 affects expression ISO Diclofenac affects the expression of NCOA3 mRNA CTD PMID:24752500 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase increases expression ISO Diclofenac results in increased expression of NEDD4L mRNA CTD PMID:26934552 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137 		JBrowse link
G Nek6 NIMA-related kinase 6 increases expression ISO Diclofenac results in increased expression of NEK6 mRNA CTD PMID:26934552 NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases stability
multiple interactions		 ISO Diclofenac results in increased stability of NFE2L2 protein
NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA]		 CTD PMID:24752500 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression
decreases expression		 ISO Diclofenac results in increased expression of NFIL3 mRNA
Diclofenac results in decreased expression of NFIL3 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 ISO
EXP		 Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Diclofenac results in decreased expression of NFKB1 mRNA		 CTD PMID:15489888 PMID:29027214 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression		 ISO
EXP		 Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]
Diclofenac results in decreased expression of NFKBIA mRNA		 CTD PMID:15489888 PMID:18172885 PMID:19393675 PMID:25935278 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbiz NFKB inhibitor zeta decreases expression
increases expression		 ISO Diclofenac results in decreased expression of NFKBIZ mRNA
Diclofenac results in increased expression of NFKBIZ mRNA		 CTD PMID:26934552 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Diclofenac results in increased expression of TNFRSF10B mRNA CTD PMID:35537566 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO Diclofenac results in increased expression of NHERF1 mRNA CTD PMID:26934552 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Diclofenac results in decreased expression of NHERF2 mRNA CTD PMID:26934552 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Nhsl2 NHS-like 2 increases expression ISO Diclofenac results in increased expression of NHSL2 mRNA CTD PMID:35537566 NCBI chr  X:66,969,953...67,209,464
Ensembl chr  X:66,970,151...67,200,911 		JBrowse link
G Nipal1 NIPA-like domain containing 1 increases expression ISO Diclofenac results in increased expression of NIPAL1 mRNA CTD PMID:26934552 NCBI chr14:35,537,641...35,561,656
Ensembl chr14:35,540,324...35,561,659 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Diclofenac results in increased expression of NLRP3 mRNA CTD PMID:24747151 PMID:28138970 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Diclofenac results in increased expression of NNMT mRNA CTD PMID:26934552 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases expression		 EXP
ISO		 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA]
Diclofenac results in decreased expression of NOS2 mRNA		 CTD PMID:15135310 PMID:16944022 PMID:17275683 PMID:19393675 PMID:23395999 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nova1 NOVA alternative splicing regulator 1 decreases expression ISO Diclofenac results in decreased expression of NOVA1 mRNA CTD PMID:26934552 NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO Diclofenac results in decreased expression of NOX1 mRNA CTD PMID:35537566 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
affects expression
increases expression		 ISO
EXP		 Diclofenac results in increased activity of NQO1 protein
Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
Diclofenac affects the expression of NQO1 mRNA
Diclofenac results in increased expression of NQO1 mRNA		 CTD PMID:8572925 PMID:18172885 PMID:24752500 PMID:29281794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 affects expression ISO Diclofenac affects the expression of NR0B2 mRNA CTD PMID:24752500 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression ISO Diclofenac results in increased expression of NR1D1 mRNA CTD PMID:35537566 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity		 ISO Diclofenac results in increased expression of NR1I2 mRNA
Diclofenac results in increased activity of NR1I2 protein		 CTD PMID:19022234 PMID:28728110 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO Diclofenac affects the expression of NR1I3 mRNA CTD PMID:19022234 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects expression ISO Diclofenac affects the expression of NR2F1 mRNA CTD PMID:24752500 NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 affects expression ISO Diclofenac affects the expression of NR2F2 mRNA CTD PMID:24752500 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 affects expression ISO Diclofenac affects the expression of NR2F6 mRNA CTD PMID:24752500 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression
multiple interactions		 ISO Diclofenac affects the expression of NR3C1 mRNA
Diclofenac binds to and affects the activity of NR3C1 protein		 CTD PMID:24752500 PMID:29777833 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr6a1 nuclear receptor subfamily 6, group A, member 1 affects expression ISO Diclofenac affects the expression of NR6A1 mRNA CTD PMID:24752500 NCBI chr 3:22,495,109...22,683,132
Ensembl chr 3:22,496,943...22,683,131 		JBrowse link
G Nras NRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of NRAS mRNA CTD PMID:24752500 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Diclofenac results in decreased expression of NREP mRNA CTD PMID:26934552 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Nrg4 neuregulin 4 increases expression ISO Diclofenac results in increased expression of NRG4 mRNA CTD PMID:26934552 NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483 		JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Diclofenac results in increased expression of NRP1 mRNA CTD PMID:26934552 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Diclofenac results in increased expression of NT5E mRNA CTD PMID:35537566 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO Diclofenac results in decreased expression of NUPR1 mRNA CTD PMID:35537566 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Nxpe4 neurexophilin and PC-esterase domain family member 4 increases expression ISO Diclofenac results in increased expression of NXPE4 mRNA CTD PMID:26934552 NCBI chr 8:48,502,697...48,744,101
Ensembl chr 8:48,722,440...48,744,100 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Diclofenac results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Ocln occludin decreases expression ISO
EXP		 Diclofenac results in decreased expression of OCLN mRNA CTD PMID:29027214 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Diclofenac results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607 		JBrowse link
G Olr1271 olfactory receptor 1271 decreases expression ISO Diclofenac results in decreased expression of OR8D1B mRNA CTD PMID:35537566 NCBI chr 8:39,127,409...39,131,889
Ensembl chr 8:39,127,352...39,131,900 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression
multiple interactions		 ISO
EXP		 Diclofenac results in decreased expression of OPA1 mRNA
Diclofenac results in decreased expression of OPA1 protein
AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein]		 CTD PMID:26934552 PMID:27792760 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Opcml opioid binding protein/cell adhesion molecule-like increases expression ISO Diclofenac results in increased expression of OPCML mRNA CTD PMID:26934552 NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
increases expression		 EXP
ISO		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ORM1 protein
Diclofenac results in increased expression of ORM1 mRNA		 CTD PMID:25772430 PMID:26934552 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein] CTD PMID:25450234 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx5 purinergic receptor P2X 5 increases expression EXP Diclofenac results in increased expression of P2RX5 mRNA CTD PMID:30723492 NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
increases expression		 EXP
ISO		 Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]
Diclofenac results in increased expression of P2RX7 mRNA		 CTD PMID:25935278 PMID:26934552 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 increases expression ISO Diclofenac results in increased expression of P4HA2 mRNA CTD PMID:17379860 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
increases expression		 EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of P4HB protein
Diclofenac results in increased expression of P4HB protein		 CTD PMID:25772430 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 affects expression ISO Diclofenac affects the expression of PAK2 mRNA CTD PMID:24752500 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression EXP Diclofenac results in increased expression of PAQR8 mRNA CTD PMID:30723492 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression ISO Diclofenac affects the expression of PARP1 mRNA CTD PMID:24752500 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax6 paired box 6 increases expression ISO Diclofenac results in increased expression of PAX6 mRNA CTD PMID:26934552 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pcdhga8 protocadherin gamma subfamily A, 8 increases expression EXP Diclofenac results in increased expression of PCDHGA8 mRNA CTD PMID:30723492 NCBI chr18:29,553,882...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO Diclofenac affects the expression of PCK1 mRNA CTD PMID:24752500 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Diclofenac results in decreased expression of PCK2 mRNA CTD PMID:35537566 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pcna proliferating cell nuclear antigen affects expression ISO Diclofenac affects the expression of PCNA protein CTD PMID:23506792 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Diclofenac results in increased expression of PCSK9 mRNA CTD PMID:26934552 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of PDCD4 mRNA
Diclofenac results in increased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pde9a phosphodiesterase 9A increases expression EXP Diclofenac results in increased expression of PDE9A mRNA CTD PMID:30723492 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO Diclofenac results in decreased expression of PDGFRB mRNA CTD PMID:26934552 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Diclofenac results in increased expression of PDIA6 mRNA CTD PMID:26934552 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pdilt protein disulfide isomerase-like, testis expressed decreases expression ISO Diclofenac results in decreased expression of PDILT mRNA CTD PMID:26934552 NCBI chr 1:173,837,477...173,868,685
Ensembl chr 1:173,837,478...173,868,685 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression ISO Diclofenac results in decreased expression of PDK4 mRNA CTD PMID:26934552 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 affects expression ISO Diclofenac affects the expression of PDPK1 mRNA CTD PMID:24752500 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Phf10 PHD finger protein 10 decreases expression ISO Diclofenac results in decreased expression of PHF10 mRNA CTD PMID:35537566 NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Diclofenac results in decreased expression of PHLDA1 mRNA CTD PMID:26934552 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Diclofenac results in increased expression of PHLDA3 mRNA CTD PMID:35537566 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Phyhipl phytanoyl-CoA 2-hydroxylase interacting protein-like decreases expression ISO Diclofenac results in decreased expression of PHYHIPL mRNA CTD PMID:26934552 NCBI chr20:18,024,744...18,065,822
Ensembl chr20:18,024,666...18,065,478 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Diclofenac results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha affects expression ISO Diclofenac affects the expression of PIK3C2A mRNA CTD PMID:24752500 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression ISO Diclofenac affects the expression of PIK3CA mRNA CTD PMID:24752500 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta affects expression ISO Diclofenac affects the expression of PIK3CD mRNA CTD PMID:24752500 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression
increases expression		 ISO Diclofenac affects the expression of PIK3R1 mRNA
Diclofenac results in increased expression of PIK3R1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 affects expression ISO Diclofenac affects the expression of PIK3R2 mRNA CTD PMID:24752500 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 affects expression ISO Diclofenac affects the expression of PIK3R3 mRNA CTD PMID:24752500 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pirb paired Ig-like receptor B increases expression ISO
EXP		 Diclofenac results in increased expression of PIRB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Pklr pyruvate kinase L/R increases expression ISO Diclofenac results in increased expression of PKLR mRNA CTD PMID:26934552 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 increases expression EXP Diclofenac results in increased expression of PKNOX2 mRNA CTD PMID:30723492 NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA affects expression ISO Diclofenac affects the expression of PLA2G12A mRNA CTD PMID:24752500 NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740 		JBrowse link
G Pla2g4c phospholipase A2 group IVC increases expression ISO Diclofenac results in increased expression of PLA2G4C mRNA CTD PMID:26934552 NCBI chr 1:74,237,714...74,275,757
Ensembl chr 1:74,236,211...74,274,656 		JBrowse link
G Pla2g7 phospholipase A2 group VII increases expression ISO Diclofenac results in increased expression of PLA2G7 mRNA CTD PMID:26934552 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476 		JBrowse link
G Plac8 placenta associated 8 increases expression ISO Diclofenac results in increased expression of PLAC8 mRNA CTD PMID:26934552 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264 		JBrowse link
G Plau plasminogen activator, urokinase increases expression
decreases expression		 ISO Diclofenac results in increased expression of PLAU protein
Diclofenac results in decreased expression of PLAU mRNA		 CTD PMID:23506792 PMID:35537566 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plcg1 phospholipase C, gamma 1 affects expression ISO Diclofenac affects the expression of PLCG1 mRNA CTD PMID:24752500 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO Diclofenac results in increased expression of PLD1 mRNA CTD PMID:26934552 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 decreases expression ISO Diclofenac results in decreased expression of PLEKHH2 mRNA CTD PMID:35537566 NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794 		JBrowse link
G Plk3 polo-like kinase 3 affects expression ISO Diclofenac affects the expression of PLK3 mRNA CTD PMID:26934552 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO Diclofenac results in increased expression of PLSCR1 mRNA CTD PMID:26934552 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Diclofenac results in increased expression of PMAIP1 mRNA CTD PMID:26934552 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases expression ISO Diclofenac results in increased expression of PNLIPRP2 mRNA CTD PMID:26934552 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434 		JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit affects expression ISO Diclofenac affects the expression of POLE3 mRNA CTD PMID:24752500 NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit affects expression ISO Diclofenac affects the expression of POLE4 mRNA CTD PMID:24752500 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit affects expression ISO Diclofenac affects the expression of POLG mRNA CTD PMID:24752500 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567 		JBrowse link
G Polh DNA polymerase eta affects expression ISO Diclofenac affects the expression of POLH mRNA CTD PMID:24752500 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Polq DNA polymerase theta affects expression ISO Diclofenac affects the expression of POLQ mRNA CTD PMID:24752500 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Polr2f RNA polymerase II, I and III subunit F affects expression ISO Diclofenac affects the expression of POLR2F mRNA CTD PMID:24752500 NCBI chr 7:110,712,528...110,724,234
Ensembl chr 7:110,712,572...110,724,234 		JBrowse link
G Polr2h-ps1 polymerase (RNA) II (DNA directed) polypeptide H, pseudogene 1 decreases expression EXP Diclofenac results in decreased expression of POLR2H-PS1 mRNA CTD PMID:30723492 NCBI chr10:104,854,977...104,856,390 JBrowse link
G Polr3a RNA polymerase III subunit A affects expression ISO Diclofenac affects the expression of POLR3A mRNA CTD PMID:24752500 NCBI chr16:49,178...88,178
Ensembl chr16:49,521...88,172 		JBrowse link
G Polr3d RNA polymerase III subunit D affects expression ISO Diclofenac affects the expression of POLR3D mRNA CTD PMID:24752500 NCBI chr15:45,511,587...45,516,256
Ensembl chr15:45,511,589...45,516,353 		JBrowse link
G Polr3g RNA polymerase III subunit G increases expression ISO Diclofenac results in increased expression of POLR3G mRNA CTD PMID:35537566 NCBI chr 2:11,945,215...11,986,125
Ensembl chr 2:11,945,217...11,986,125 		JBrowse link
G Pomk protein-O-mannose kinase increases expression ISO Diclofenac results in increased expression of POMK mRNA CTD PMID:26934552 NCBI chr16:66,085,569...66,101,360
Ensembl chr16:66,088,000...66,098,388 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein CTD PMID:29512227 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance
increases oxidation		 ISO POR affects the susceptibility to Diclofenac
POR results in increased oxidation of Diclofenac		 CTD PMID:25820915 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Diclofenac results in decreased expression of POU2AF1 mRNA CTD PMID:26934552 NCBI chr 8:51,521,813...51,548,819
Ensembl chr 8:51,474,015...51,548,819 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 affects expression ISO Diclofenac affects the expression of POU2F1 mRNA CTD PMID:24752500 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363 		JBrowse link
G Pou2f2 POU class 2 homeobox 2 increases expression ISO Diclofenac results in increased expression of POU2F2 mRNA CTD PMID:26934552 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261 		JBrowse link
G Pou2f3 POU class 2 homeobox 3 increases expression ISO Diclofenac results in increased expression of POU2F3 mRNA CTD PMID:26934552 NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
increases activity		 ISO Diclofenac affects the expression of PPARG mRNA
Diclofenac inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]
Diclofenac results in increased activity of PPARG protein		 CTD PMID:12065695 PMID:15273253 PMID:24752500 PMID:28728110 PMID:30138673 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects expression
increases expression		 ISO Diclofenac affects the expression of PPARGC1A mRNA
Diclofenac results in increased expression of PPARGC1A mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression ISO Diclofenac results in decreased expression of PPARGC1B mRNA CTD PMID:26934552 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Ppbp pro-platelet basic protein increases expression ISO Diclofenac results in increased expression of PPBP mRNA CTD PMID:26934552 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Diclofenac CTD PMID:20668000 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta affects expression ISO Diclofenac affects the expression of PPP1CB mRNA CTD PMID:24752500 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824 		JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B affects expression ISO Diclofenac affects the expression of PPP1R14B mRNA CTD PMID:24752500 NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A affects expression
decreases expression		 ISO Diclofenac affects the expression of PPP1R15A mRNA
Diclofenac results in decreased expression of PPP1R15A mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ppp1r7 protein phosphatase 1, regulatory subunit 7 affects expression ISO Diclofenac affects the expression of PPP1R7 mRNA CTD PMID:24752500 NCBI chr 9:93,886,068...93,911,198
Ensembl chr 9:93,886,143...93,914,850 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta affects expression ISO Diclofenac affects the expression of PPP2R1B mRNA CTD PMID:24752500 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha affects expression ISO Diclofenac affects the expression of PPP2R2A mRNA CTD PMID:24752500 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma affects expression ISO Diclofenac affects the expression of PPP2R2C mRNA CTD PMID:24752500 NCBI chr14:73,846,547...73,931,489
Ensembl chr14:73,846,547...73,931,864 		JBrowse link
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha affects expression ISO Diclofenac affects the expression of PPP2R5A mRNA CTD PMID:24752500 NCBI chr13:102,931,264...102,975,661
Ensembl chr13:102,931,264...102,975,661 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma affects expression ISO Diclofenac affects the expression of PPP2R5C mRNA CTD PMID:24752500 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Diclofenac results in decreased expression of PRDM1 mRNA CTD PMID:35537566 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prg4 proteoglycan 4 increases expression ISO Diclofenac results in increased expression of PRG4 mRNA CTD PMID:26934552 NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Diclofenac affects the expression of PRKACB mRNA CTD PMID:24752500 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkca protein kinase C, alpha affects expression ISO Diclofenac affects the expression of PRKCA mRNA CTD PMID:24752500 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkci protein kinase C, iota affects expression ISO Diclofenac affects the expression of PRKCI mRNA CTD PMID:24752500 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkd3 protein kinase D3 affects expression ISO Diclofenac affects the expression of PRKD3 mRNA CTD PMID:24752500 NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Diclofenac results in decreased expression of PRKG2 mRNA CTD PMID:35537566 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888 		JBrowse link
G Prl prolactin decreases expression ISO Diclofenac results in decreased expression of PRL mRNA CTD PMID:26934552 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Procr protein C receptor increases expression ISO Diclofenac results in increased expression of PROCR mRNA CTD PMID:26934552 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
G Prok2 prokineticin 2 increases expression ISO Diclofenac results in increased expression of PROK2 mRNA CTD PMID:26934552 NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385 		JBrowse link
G Pros1 protein S increases expression ISO Diclofenac results in increased expression of PROS1 mRNA CTD PMID:26934552 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Prss3 serine protease 3 decreases expression ISO Diclofenac results in decreased expression of PRSS3 mRNA CTD PMID:26934552 NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO Diclofenac results in increased expression of PRTN3 mRNA CTD PMID:26934552 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 affects expression ISO Diclofenac affects the expression of PSAT1 mRNA CTD PMID:24752500 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression EXP Diclofenac results in decreased expression of PSMB4 mRNA CTD PMID:18172885 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO Diclofenac results in increased expression of PSMD2 mRNA CTD PMID:26934552 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 decreases expression ISO Diclofenac results in decreased expression of PSMD9 mRNA CTD PMID:26934552 NCBI chr12:33,337,182...33,357,468 JBrowse link
G Psmf1 proteasome inhibitor subunit 1 affects expression ISO Diclofenac affects the expression of PSMF1 mRNA CTD PMID:24752500 NCBI chr 3:140,235,371...140,260,546
Ensembl chr 3:140,235,373...140,260,546 		JBrowse link
G Pten phosphatase and tensin homolog affects expression
increases expression		 ISO Diclofenac affects the expression of PTEN mRNA
Diclofenac results in increased expression of PTEN mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptges prostaglandin E synthase decreases expression
multiple interactions		 EXP Diclofenac results in decreased expression of PTGES mRNA
[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone		 CTD PMID:19393675 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgfr prostaglandin F receptor decreases expression ISO Diclofenac results in decreased expression of PTGFR mRNA CTD PMID:26934552 NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650 		JBrowse link
G Ptgr1 prostaglandin reductase 1 decreases activity ISO Diclofenac results in decreased activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
multiple interactions
decreases expression
increases expression		 ISO
EXP		 Diclofenac analog results in decreased activity of PTGS1 protein; Diclofenac results in decreased activity of PTGS1 protein
[thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein
Diclofenac results in decreased expression of PTGS1 protein
Diclofenac results in increased expression of PTGS1 mRNA		 CTD PMID:9258749 PMID:12242329 PMID:16141368 PMID:19031110 PMID:26934552 More... NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
decreases activity		 ISO
EXP		 Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Diclofenac results in decreased expression of PTGS2 mRNA
Diclofenac results in increased expression of PTGS2 mRNA
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
Diclofenac results in decreased activity of PTGS2 protein
Diclofenac results in increased expression of PTGS2 mRNA; Diclofenac results in increased expression of PTGS2 protein
Acetaminophen inhibits the reaction [Diclofenac results in increased expression of PTGS2 protein]; Diclofenac binds to and results in decreased activity of PTGS2 protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]		 CTD PMID:9258749 PMID:9851595 PMID:10594327 PMID:12242329 PMID:12925531 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression ISO Diclofenac affects the expression of PTK2 mRNA CTD PMID:24752500 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression ISO Diclofenac results in increased expression of PTPN1 mRNA CTD PMID:26934552 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 increases expression ISO Diclofenac results in increased expression of PTPN2 mRNA CTD PMID:26934552 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO Diclofenac results in increased expression of PTPRC mRNA CTD PMID:26934552 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J increases expression ISO Diclofenac results in increased expression of PTPRJ mRNA CTD PMID:26934552 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein] CTD PMID:25450234 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 increases expression ISO Diclofenac results in increased expression of QSOX1 mRNA CTD PMID:26934552 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459 		JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 increases expression ISO Diclofenac results in increased expression of RAB11FIP3 mRNA CTD PMID:26934552 NCBI chr10:15,002,650...15,086,382
Ensembl chr10:15,002,926...15,118,479 		JBrowse link
G Rack1 receptor for activated C kinase 1 affects expression ISO Diclofenac affects the expression of RACK1 mRNA CTD PMID:24752500 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rad50 RAD50 double strand break repair protein affects expression ISO Diclofenac affects the expression of RAD50 mRNA CTD PMID:24752500 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rad51 RAD51 recombinase affects expression
increases expression		 ISO
EXP		 Diclofenac affects the expression of RAD51 mRNA
Diclofenac results in increased expression of RAD51 mRNA		 CTD PMID:24752500 PMID:30723492 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO Diclofenac affects the expression of RASA1 mRNA CTD PMID:24752500 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rasgef1b RasGEF domain family, member 1B decreases expression ISO Diclofenac results in decreased expression of RASGEF1B mRNA CTD PMID:35537566 NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO Diclofenac affects the expression of RB1 mRNA CTD PMID:24752500 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression
decreases expression		 ISO Diclofenac results in increased expression of RBBP8 mRNA
Diclofenac results in decreased expression of RBBP8 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression ISO Diclofenac results in increased expression of RBM3 mRNA CTD PMID:26934552 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580 		JBrowse link
G Rbx1 ring-box 1 decreases expression ISO Diclofenac results in decreased expression of RBX1 mRNA CTD PMID:26934552 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rcan1 regulator of calcineurin 1 decreases expression ISO Diclofenac results in decreased expression of RCAN1 mRNA CTD PMID:35537566 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Reep6 receptor accessory protein 6 increases expression ISO Diclofenac results in increased expression of REEP6 mRNA CTD PMID:35537566 NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression ISO Diclofenac results in increased expression of REG3B mRNA CTD PMID:26934552 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Reg3g regenerating family member 3 gamma increases expression ISO Diclofenac results in increased expression of REG3G mRNA CTD PMID:26934552 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects expression		 ISO
EXP		 Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]
Diclofenac affects the expression of RELA mRNA
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]		 CTD PMID:15489888 PMID:19393675 PMID:24752500 PMID:25935278 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Reln reelin decreases expression ISO Diclofenac results in decreased expression of RELN mRNA CTD PMID:26934552 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Ret ret proto-oncogene increases expression ISO Diclofenac results in increased expression of RET mRNA CTD PMID:26934552 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit affects expression ISO Diclofenac affects the expression of REV3L mRNA CTD PMID:24752500 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099 		JBrowse link
G Rgn regucalcin increases expression EXP Diclofenac results in increased expression of RGN mRNA CTD PMID:19022234 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Diclofenac results in decreased expression of RGS16 mRNA CTD PMID:35537566 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Diclofenac results in decreased expression of RGS2 mRNA CTD PMID:35537566 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Diclofenac results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rhob ras homolog family member B affects expression ISO Diclofenac affects the expression of RHOB mRNA CTD PMID:24752500 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rhoj ras homolog family member J decreases expression ISO Diclofenac results in decreased expression of RHOJ mRNA CTD PMID:35537566 NCBI chr 6:94,035,307...94,117,642
Ensembl chr 6:94,035,483...94,118,275 		JBrowse link
G Rhoq ras homolog family member Q affects expression ISO Diclofenac affects the expression of RHOQ mRNA CTD PMID:24752500 NCBI chr 6:7,613,632...7,652,047 JBrowse link
G Rhot2 ras homolog family member T2 affects expression ISO Diclofenac affects the expression of RHOT2 mRNA CTD PMID:24752500 NCBI chr10:14,858,954...14,864,751
Ensembl chr10:14,858,956...14,864,751 		JBrowse link
G Ric8a RIC8 guanine nucleotide exchange factor A decreases expression ISO Diclofenac results in decreased expression of RIC8A mRNA CTD PMID:35537566 NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467 		JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO Diclofenac results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Rnase6 ribonuclease A family member k6 increases expression EXP Diclofenac results in increased expression of RNASE6 mRNA CTD PMID:30723492 NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328 		JBrowse link
G Rnasel ribonuclease L increases expression ISO Diclofenac results in increased expression of RNASEL mRNA CTD PMID:26934552 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Rnd1 Rho family GTPase 1 decreases expression ISO Diclofenac results in decreased expression of RND1 mRNA CTD PMID:35537566 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399 		JBrowse link
G Rnf145 ring finger protein 145 increases expression ISO Diclofenac results in increased expression of RNF145 mRNA CTD PMID:35537566 NCBI chr10:29,006,391...29,050,788
Ensembl chr10:29,011,548...29,050,781 		JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Diclofenac results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 affects expression ISO Diclofenac affects the expression of ROCK1 mRNA CTD PMID:24752500 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 affects expression ISO Diclofenac affects the expression of ROCK2 mRNA CTD PMID:24752500 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like increases expression ISO Diclofenac results in increased expression of ROPN1L mRNA CTD PMID:35537566 NCBI chr 2:82,442,645...82,453,332
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
G Rora RAR-related orphan receptor A decreases expression ISO Diclofenac results in decreased expression of RORA mRNA CTD PMID:26934552 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO Diclofenac results in increased expression of RORC mRNA CTD PMID:22285467 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rpa1 replication protein A1 affects expression ISO Diclofenac affects the expression of RPA1 mRNA CTD PMID:24752500 NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rpa2 replication protein A2 affects expression ISO Diclofenac affects the expression of RPA2 mRNA CTD PMID:24752500 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpap3 RNA polymerase II associated protein 3 increases expression ISO Diclofenac results in increased expression of RPAP3 mRNA CTD PMID:26934552 NCBI chr 7:128,810,820...128,840,006
Ensembl chr 7:128,810,827...128,839,950 		JBrowse link
G Rpl39l1 ribosomal protein L39 like 1 increases expression ISO Diclofenac results in increased expression of RPL39L mRNA CTD PMID:26934552 NCBI chr10:5,455,712...5,459,828
Ensembl chr10:5,454,559...5,462,029 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 affects expression ISO Diclofenac affects the expression of RPS6KA1 mRNA CTD PMID:24752500 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases expression ISO Diclofenac results in decreased expression of RPS6KA5 mRNA CTD PMID:26934552 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rps6kl1 ribosomal protein S6 kinase-like 1 increases expression EXP Diclofenac results in increased expression of RPS6KL1 mRNA CTD PMID:30723492 NCBI chr 6:104,783,227...104,799,895
Ensembl chr 6:104,783,258...104,799,869 		JBrowse link
G Rras2 RAS related 2 affects expression ISO Diclofenac affects the expression of RRAS2 mRNA CTD PMID:24752500 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Diclofenac results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP Diclofenac results in decreased expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Diclofenac affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G RT1-M6-1 RT1 class I, locus M6, gene 1 increases expression EXP Diclofenac results in increased expression of RT1-M6-1 mRNA CTD PMID:30723492 NCBI chr20:1,566,220...1,569,151
Ensembl chr20:1,583,299...1,586,215 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP Diclofenac results in increased expression of RUNX2 mRNA CTD PMID:30723492 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Diclofenac results in increased expression of S100A8 mRNA CTD PMID:24747151 PMID:26934552 PMID:28138970 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Diclofenac results in increased expression of S100A9 mRNA CTD PMID:24747151 PMID:26934552 PMID:27671914 PMID:28138970 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Saa4 serum amyloid A4 increases expression
decreases expression		 ISO Diclofenac results in increased expression of SAA4 mRNA
Diclofenac results in decreased expression of SAA4 mRNA		 CTD PMID:26934552 NCBI chr 1:97,247,580...97,251,882 JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 increases expression ISO Diclofenac results in increased expression of SARM1 mRNA CTD PMID:26934552 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 affects expression ISO Diclofenac affects the expression of SARS1 mRNA CTD PMID:24752500 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 affects expression ISO Diclofenac affects the expression of SAT1 mRNA CTD PMID:24752500 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 affects expression ISO Diclofenac affects the expression of SAT2 mRNA CTD PMID:24752500 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224 		JBrowse link
G Scara5 scavenger receptor class A, member 5 increases expression ISO Diclofenac results in increased expression of SCARA5 mRNA CTD PMID:26934552 NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Diclofenac results in increased expression of SCD1 mRNA CTD PMID:26934552 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Diclofenac results in decreased activity of SCN5A protein CTD PMID:33617802 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sele selectin E increases expression ISO Diclofenac results in increased expression of SELE mRNA CTD PMID:26934552 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L decreases expression
increases expression		 ISO Diclofenac results in decreased expression of SELL protein
Diclofenac results in increased expression of SELL mRNA		 CTD PMID:12147693 PMID:26934552 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P decreases expression
multiple interactions		 EXP Diclofenac results in decreased expression of SELP protein
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]		 CTD PMID:14716214 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sema4b semaphorin 4B increases expression ISO Diclofenac results in increased expression of SEMA4B mRNA CTD PMID:26934552 NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775 		JBrowse link
G Serpina10 serpin family A member 10 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of SERPINA10 mRNA
Diclofenac results in increased expression of SERPINA10 mRNA		 CTD PMID:26934552 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544 		JBrowse link
G Serpina12 serpin family A member 12 increases expression EXP Diclofenac results in increased expression of SERPINA12 mRNA CTD PMID:30723492 NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N multiple interactions
increases expression		 EXP
ISO		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINA3N protein
Diclofenac results in increased expression of SERPINA3N mRNA		 CTD PMID:25772430 PMID:26934552 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
affects expression		 EXP
ISO		 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA]
Diclofenac results in increased expression of SERPINE1 mRNA
Diclofenac affects the expression of SERPINE1 mRNA		 CTD PMID:23939143 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 decreases expression ISO Diclofenac results in decreased expression of SERPINE2 mRNA CTD PMID:26934552 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Serpinf2 serpin family F member 2 increases expression ISO Diclofenac results in increased expression of SERPINF2 mRNA CTD PMID:26934552 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Diclofenac results in decreased expression of SERPINH1 mRNA CTD PMID:26934552 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Sfn stratifin increases expression ISO Diclofenac results in increased expression of SFN mRNA CTD PMID:17379860 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Diclofenac results in increased expression of SFPQ mRNA CTD PMID:26934552 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
decreases expression		 EXP
ISO		 Diclofenac results in increased expression of SGK1 mRNA
Diclofenac results in decreased expression of SGK1 mRNA		 CTD PMID:30723492 PMID:35537566 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 decreases expression ISO Diclofenac results in decreased expression of SGK2 mRNA CTD PMID:26934552 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 affects expression ISO Diclofenac affects the expression of SH3GLB1 mRNA CTD PMID:24752500 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Shisa6 shisa family member 6 decreases expression ISO Diclofenac results in decreased expression of SHISA6 mRNA CTD PMID:26934552 NCBI chr10:50,897,740...51,192,111
Ensembl chr10:50,903,333...51,192,063 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 affects expression ISO Diclofenac affects the expression of SHMT1 mRNA CTD PMID:24752500 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shprh SNF2 histone linker PHD RING helicase decreases expression ISO Diclofenac results in decreased expression of SHPRH mRNA CTD PMID:26934552 NCBI chr 1:5,528,827...5,602,537
Ensembl chr 1:5,528,888...5,602,527 		JBrowse link
G Sik1 salt-inducible kinase 1 increases expression ISO Diclofenac results in increased expression of SIK1 mRNA CTD PMID:35537566 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Sin3a SIN3 transcription regulator family member A affects expression ISO Diclofenac affects the expression of SIN3A mRNA CTD PMID:24752500 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 increases expression EXP Diclofenac results in increased expression of SKA1 mRNA CTD PMID:30723492 NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression ISO Diclofenac results in increased expression of SLC10A2 mRNA CTD PMID:26934552 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases expression ISO Diclofenac results in increased expression of SLC10A6 mRNA CTD PMID:26934552 NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression ISO Diclofenac results in increased expression of SLC13A3 mRNA CTD PMID:26934552 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 decreases expression ISO Diclofenac results in decreased expression of SLC15A2 mRNA CTD PMID:26934552 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slc16a5 solute carrier family 16 member 5 increases expression ISO Diclofenac results in increased expression of SLC16A5 mRNA CTD PMID:26934552 NCBI chr10:100,707,434...100,721,338
Ensembl chr10:100,707,434...100,721,338 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Diclofenac results in increased expression of SLC17A6 mRNA CTD PMID:26934552 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects expression ISO Diclofenac affects the expression of SLC19A1 mRNA CTD PMID:24752500 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 increases expression ISO Diclofenac results in increased expression of SLC19A2 mRNA CTD PMID:35537566 NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression
decreases expression		 ISO Diclofenac results in increased expression of SLC1A4 mRNA
Diclofenac results in decreased expression of SLC1A4 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Diclofenac results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a21 solute carrier family 22 (organic cation transporter), member 21 increases expression ISO Diclofenac results in increased expression of SLC22A21 mRNA CTD PMID:26934552 NCBI chr10:38,104,114...38,133,106
Ensembl chr10:38,104,122...38,130,671 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
multiple interactions		 ISO
EXP		 Diclofenac results in decreased activity of SLC22A9 protein
Diclofenac inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]		 CTD PMID:12388633 PMID:16079298 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Diclofenac results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity
multiple interactions		 ISO Diclofenac results in decreased activity of SLC22A7 protein
Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]		 CTD PMID:12388633 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] CTD PMID:11306713 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Diclofenac results in increased expression of SLC23A1 mRNA CTD PMID:26934552 NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid] CTD PMID:17092984 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Slc25a22 solute carrier family 25 member 22 decreases expression ISO Diclofenac results in decreased expression of SLC25A22 mRNA CTD PMID:26934552 NCBI chr 1:196,528,471...196,536,398
Ensembl chr 1:196,528,472...196,536,331 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression ISO Diclofenac results in decreased expression of SLC25A30 mRNA CTD PMID:26934552 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613 		JBrowse link
G Slc25a33 solute carrier family 25 member 33 decreases expression ISO Diclofenac results in decreased expression of SLC25A33 mRNA CTD PMID:26934552 NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression ISO Diclofenac results in decreased expression of SLC29A1 mRNA CTD PMID:26934552 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression ISO Diclofenac results in decreased expression of SLC2A2 mRNA CTD PMID:26934552 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 increases expression ISO Diclofenac results in increased expression of SLC30A5 mRNA CTD PMID:26934552 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934 		JBrowse link
G Slc36a4 solute carrier family 36 member 4 increases expression ISO Diclofenac results in increased expression of SLC36A4 mRNA CTD PMID:26934552 NCBI chr 8:12,519,613...12,552,671
Ensembl chr 8:12,519,943...12,552,031 		JBrowse link
G Slc37a1 solute carrier family 37 member 1 increases expression ISO Diclofenac results in increased expression of SLC37A1 mRNA CTD PMID:26934552 NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892 		JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases expression ISO Diclofenac results in decreased expression of SLC38A7 mRNA CTD PMID:35537566 NCBI chr19:9,209,203...9,225,472
Ensembl chr19:9,209,257...9,225,454 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression ISO Diclofenac results in increased expression of SLC39A14 mRNA CTD PMID:26934552 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases expression ISO Diclofenac results in increased expression of SLC3A1 mRNA CTD PMID:26934552 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907 		JBrowse link
G Slc41a1 solute carrier family 41 member 1 increases expression ISO Diclofenac results in increased expression of SLC41A1 mRNA CTD PMID:26934552 NCBI chr13:43,270,792...43,291,162
Ensembl chr13:43,270,792...43,291,162 		JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression ISO Diclofenac results in increased expression of SLC41A2 mRNA CTD PMID:26934552 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166 		JBrowse link
G Slc43a1 solute carrier family 43 member 1 increases expression ISO Diclofenac results in increased expression of SLC43A1 mRNA CTD PMID:26934552 NCBI chr 3:69,920,586...69,946,768
Ensembl chr 3:69,920,649...69,946,768 		JBrowse link
G Slc45a4 solute carrier family 45, member 4 decreases expression ISO Diclofenac results in decreased expression of SLC45A4 mRNA CTD PMID:26934552 NCBI chr 7:105,478,886...105,550,160
Ensembl chr 7:105,481,792...105,550,170 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 decreases expression ISO Diclofenac results in decreased expression of SLC46A2 mRNA CTD PMID:26934552 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Slc46a3 solute carrier family 46, member 3 decreases expression ISO Diclofenac results in decreased expression of SLC46A3 mRNA CTD PMID:35537566 NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) increases expression ISO Diclofenac results in increased expression of SLC4A1 mRNA CTD PMID:26934552 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO Diclofenac results in increased expression of SLC4A4 mRNA CTD PMID:26934552 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Diclofenac results in decreased expression of SLC6A9 mRNA CTD PMID:35537566 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression ISO Diclofenac results in decreased expression of SLC7A1 mRNA CTD PMID:35537566 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of SLC7A11 mRNA
Diclofenac results in increased expression of SLC7A11 mRNA		 CTD PMID:19192274 PMID:32816093 PMID:33785417 PMID:35537566 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a3 solute carrier family 7 member 3 increases expression ISO Diclofenac results in increased expression of SLC7A3 mRNA CTD PMID:26934552 NCBI chr  X:66,210,071...66,216,482
Ensembl chr  X:66,210,081...66,215,708 		JBrowse link
G Slc7a4 solute carrier family 7, member 4 increases expression ISO Diclofenac results in increased expression of SLC7A4 mRNA CTD PMID:26934552 NCBI chr11:83,435,093...83,439,078
Ensembl chr11:83,435,211...83,438,881 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 decreases expression ISO Diclofenac results in decreased expression of SLC7A5 mRNA CTD PMID:35537566 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Slc7a8 solute carrier family 7 member 8 increases expression ISO Diclofenac results in increased expression of SLC7A8 mRNA CTD PMID:19192274 PMID:26934552 NCBI chr15:28,183,013...28,242,717
Ensembl chr15:28,183,015...28,242,717 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Diclofenac results in decreased expression of SLCO1A4 mRNA CTD PMID:26934552 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546 		JBrowse link
G Slitrk5 SLIT and NTRK-like family, member 5 increases expression EXP Diclofenac results in increased expression of SLITRK5 mRNA CTD PMID:30723492 NCBI chr15:88,848,123...88,858,809
Ensembl chr15:88,847,535...88,856,836 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Diclofenac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Smad1 SMAD family member 1 increases expression ISO Diclofenac results in increased expression of SMAD1 mRNA CTD PMID:26934552 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad4 SMAD family member 4 affects expression ISO Diclofenac affects the expression of SMAD4 mRNA CTD PMID:24752500 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 increases expression ISO Diclofenac results in increased expression of SMARCA5 mRNA CTD PMID:26934552 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 increases expression ISO Diclofenac results in increased expression of SMARCB1 mRNA CTD PMID:26934552 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620 		JBrowse link
G Snca synuclein alpha increases expression ISO Diclofenac results in increased expression of SNCA mRNA CTD PMID:26934552 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Snx10 sorting nexin 10 increases expression ISO Diclofenac results in increased expression of SNX10 mRNA CTD PMID:26934552 NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996 		JBrowse link
G Soat2 sterol O-acyltransferase 2 decreases expression ISO Diclofenac results in decreased expression of SOAT2 mRNA CTD PMID:35537566 NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Diclofenac results in increased expression of SOCS3 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 affects expression ISO Diclofenac affects the expression of SOCS6 mRNA CTD PMID:24752500 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 affects expression ISO Diclofenac affects the expression of SOCS7 mRNA CTD PMID:24752500 NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830 		JBrowse link
G Sod1 superoxide dismutase 1 increases secretion
decreases activity
multiple interactions
increases expression		 ISO
EXP		 Diclofenac results in increased secretion of SOD1 protein
Diclofenac results in decreased activity of SOD1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]
Diclofenac results in increased expression of SOD1 mRNA		 CTD PMID:24038040 PMID:28535741 PMID:29027214 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
affects expression		 EXP
ISO		 Diclofenac results in increased expression of SOD2 mRNA; Diclofenac results in increased expression of SOD2 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOD2 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SOD2 mRNA]; rebamipide promotes the reaction [Diclofenac results in increased expression of SOD2 protein]
Diclofenac affects the expression of SOD2 mRNA		 CTD PMID:19022234 PMID:22653900 PMID:23939143 PMID:24752500 PMID:25772430 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases secretion		 ISO Acetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein] CTD PMID:12763371 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 affects expression ISO Diclofenac affects the expression of SOS1 mRNA CTD PMID:24752500 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of SOS2 mRNA CTD PMID:24752500 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Spaca6 sperm acrosome associated 6 increases expression EXP Diclofenac results in increased expression of SPACA6 mRNA CTD PMID:30723492 NCBI chr 1:58,672,128...58,689,309
Ensembl chr 1:58,677,797...58,688,562 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO Diclofenac results in decreased expression of SPDL1 mRNA CTD PMID:35537566 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 increases expression EXP Diclofenac results in increased expression of SPRY3 mRNA CTD PMID:30723492 NCBI chr12:16,663,188...16,673,124
Ensembl chr12:16,663,389...16,672,531 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 decreases expression ISO Diclofenac results in decreased expression of SPRY4 mRNA CTD PMID:26934552 NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Diclofenac results in increased expression of SQLE mRNA CTD PMID:26934552 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of SRC mRNA CTD PMID:24752500 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO Diclofenac results in decreased expression of SRD5A1 mRNA CTD PMID:26934552 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO Diclofenac results in increased expression of SREBF2 mRNA CTD PMID:26934552 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression
multiple interactions		 ISO Diclofenac results in increased expression of SRXN1 mRNA
Diclofenac results in increased expression of SRXN1 protein
NFE2L2 protein affects the reaction [Diclofenac results in increased expression of SRXN1 mRNA]		 CTD PMID:24752500 PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression ISO Diclofenac results in increased expression of ST6GAL1 mRNA CTD PMID:26934552 NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
affects expression		 ISO Diclofenac results in decreased expression of STAT1 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac affects the expression of STAT1 mRNA		 CTD PMID:19192274 PMID:22285467 PMID:24752500 PMID:26609140 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
affects expression		 ISO Diclofenac results in increased expression of STAT3 mRNA
Diclofenac affects the expression of STAT3 mRNA		 CTD PMID:22285467 PMID:23506792 PMID:24752500 PMID:26934552 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Diclofenac results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B affects expression ISO Diclofenac affects the expression of STAT5B mRNA CTD PMID:24752500 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects expression ISO Diclofenac affects the expression of STAT6 mRNA CTD PMID:24752500 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Steap4 STEAP4 metalloreductase increases expression
decreases expression		 ISO Diclofenac results in increased expression of STEAP4 mRNA
Diclofenac results in decreased expression of STEAP4 mRNA		 CTD PMID:26934552 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859 		JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP Diclofenac results in increased expression of STIL mRNA CTD PMID:30723492 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730 		JBrowse link
G Stk31 serine threonine kinase 31 decreases expression ISO Diclofenac results in decreased expression of STK31 mRNA CTD PMID:26934552 NCBI chr 4:78,370,691...78,467,599
Ensembl chr 4:78,370,649...78,466,240 		JBrowse link
G Stmn1 stathmin 1 affects expression ISO Diclofenac affects the expression of STMN1 mRNA CTD PMID:24752500 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Sts steroid sulfatase increases expression ISO Diclofenac results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sucnr1 succinate receptor 1 decreases expression ISO Diclofenac results in decreased expression of SUCNR1 mRNA CTD PMID:26934552 NCBI chr 2:144,219,066...144,230,568
Ensembl chr 2:144,219,122...144,230,034 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase affects expression ISO Diclofenac affects the expression of SUV39H1 mRNA CTD PMID:24752500 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 affects expression ISO Diclofenac affects the expression of SUV39H1 mRNA CTD PMID:24752500 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Diclofenac results in decreased expression of SYNE1 mRNA CTD PMID:35537566 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322 		JBrowse link
G Syne4 spectrin repeat containing nuclear envelope family member 4 increases expression EXP Diclofenac results in increased expression of SYNE4 mRNA CTD PMID:30723492 NCBI chr 1:85,569,409...85,573,775
Ensembl chr 1:85,569,545...85,573,760 		JBrowse link
G Taf3 TATA-box binding protein associated factor 3 affects expression ISO Diclofenac affects the expression of TAF3 mRNA CTD PMID:24752500 NCBI chr17:68,455,389...68,608,367
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Taf9b TATA-box binding protein associated factor 9b affects expression ISO Diclofenac affects the expression of TAF9B mRNA CTD PMID:24752500 NCBI chr  X:71,289,290...71,300,142
Ensembl chr  X:71,289,290...71,300,604 		JBrowse link
G Tank TRAF family member-associated NFKB activator affects expression ISO Diclofenac affects the expression of TANK mRNA CTD PMID:24752500 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Diclofenac results in decreased expression of TARDBP mRNA CTD PMID:26934552 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tas1r3 taste 1 receptor member 3 increases expression EXP Diclofenac results in increased expression of TAS1R3 mRNA CTD PMID:30723492 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742 		JBrowse link
G Tasor transcription activation suppressor affects expression ISO Diclofenac affects the expression of TASOR mRNA CTD PMID:24752500 NCBI chr16:2,606,807...2,669,902
Ensembl chr16:2,603,936...2,667,292 		JBrowse link
G Tbc1d31 TBC1 domain family, member 31 decreases expression ISO Diclofenac results in decreased expression of TBC1D31 mRNA CTD PMID:35537566 NCBI chr 7:89,427,354...89,506,894
Ensembl chr 7:89,426,780...89,506,894 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Diclofenac results in decreased expression of TBX21 mRNA CTD PMID:22285467 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Diclofenac results in increased expression of TBX3 mRNA CTD PMID:26934552 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tcf3 transcription factor 3 affects expression ISO Diclofenac affects the expression of TCF3 mRNA CTD PMID:24752500 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 affects expression ISO Diclofenac affects the expression of TCF7L2 mRNA CTD PMID:24752500 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tdrd7 tudor domain containing 7 affects expression ISO Diclofenac affects the expression of TDRD7 mRNA CTD PMID:24752500 NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544 		JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 decreases expression ISO Diclofenac results in decreased expression of TECPR1 mRNA CTD PMID:35537566 NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611 		JBrowse link
G Tfdp1 transcription factor Dp-1 affects expression ISO Diclofenac affects the expression of TFDP1 mRNA CTD PMID:24752500 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tff3 trefoil factor 3 increases expression ISO Diclofenac results in increased expression of TFF3 mRNA CTD PMID:26934552 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Diclofenac results in increased expression of TFRC mRNA CTD PMID:26934552 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Diclofenac results in increased expression of TGFA mRNA CTD PMID:19022234 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Diclofenac results in decreased expression of TGFB2 mRNA CTD PMID:17379860 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgm1 transglutaminase 1 increases expression ISO Diclofenac results in increased expression of TGM1 mRNA CTD PMID:26934552 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523 		JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain increases expression ISO Diclofenac results in increased expression of TIFA mRNA CTD PMID:26934552 NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
increases expression		 EXP
ISO		 Diclofenac results in decreased expression of TIMP1 mRNA
Diclofenac results in increased expression of TIMP1 mRNA		 CTD PMID:19022234 PMID:26934552 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tirap TIR domain containing adaptor protein increases expression ISO Diclofenac results in increased expression of TIRAP mRNA CTD PMID:26934552 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tjp1 tight junction protein 1 affects expression ISO Diclofenac affects the expression of TJP1 mRNA CTD PMID:24752500 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tk1 thymidine kinase 1 affects expression ISO Diclofenac affects the expression of TK1 mRNA CTD PMID:24752500 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tk2 thymidine kinase 2 affects expression ISO Diclofenac affects the expression of TK2 mRNA CTD PMID:24752500 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924 		JBrowse link
G Tlcd1 TLC domain containing 1 increases expression ISO Diclofenac results in increased expression of TLCD1 mRNA CTD PMID:35537566 NCBI chr10:63,074,469...63,076,502
Ensembl chr10:63,074,469...63,076,501 		JBrowse link
G Tlk1 tousled-like kinase 1 decreases expression ISO Diclofenac results in decreased expression of TLK1 mRNA CTD PMID:26934552 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression
increases expression		 ISO
EXP		 Diclofenac results in decreased expression of TLR2 mRNA
Diclofenac results in increased expression of TLR2 mRNA		 CTD PMID:19192274 PMID:26934552 PMID:29027214 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression ISO Diclofenac results in increased expression of TM7SF2 mRNA CTD PMID:35537566 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270 		JBrowse link
G Tmem176a transmembrane protein 176A increases expression
decreases expression		 ISO Diclofenac results in increased expression of TMEM176A mRNA
Diclofenac results in decreased expression of TMEM176A mRNA		 CTD PMID:26934552 NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620 		JBrowse link
G Tnc tenascin C decreases expression ISO Diclofenac results in decreased expression of TNC mRNA CTD PMID:35537566 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases response to substance		 ISO
EXP		 Diclofenac results in increased expression of TNF mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
TNF protein results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of TNF mRNA; Diclofenac results in increased expression of TNF protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
[Diclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]		 CTD PMID:15135310 PMID:15489888 PMID:17328244 PMID:19022234 PMID:19362101 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO Diclofenac results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfaip8l2 TNF alpha induced protein 8 like 2 increases expression ISO Diclofenac results in increased expression of TNFAIP8L2 mRNA CTD PMID:26934552 NCBI chr 2:182,710,433...182,726,724
Ensembl chr 2:182,709,378...182,726,760 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression
increases expression		 ISO Diclofenac affects the expression of TNFRSF1A mRNA
Diclofenac results in increased expression of TNFRSF1A mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf18 TNF superfamily member 18 decreases expression ISO Diclofenac results in decreased expression of TNFSF18 mRNA CTD PMID:35537566 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
G Tnks1bp1 tankyrase 1 binding protein 1 decreases expression ISO Diclofenac results in decreased expression of TNKS1BP1 mRNA CTD PMID:35537566 NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038 		JBrowse link
G Togaram2 TOG array regulator of axonemal microtubules 2 increases expression EXP Diclofenac results in increased expression of TOGARAM2 mRNA CTD PMID:30723492 NCBI chr 6:23,770,979...23,828,884
Ensembl chr 6:23,771,052...23,828,499 		JBrowse link
G Tox thymocyte selection-associated high mobility group box increases expression EXP Diclofenac results in increased expression of TOX mRNA CTD PMID:30723492 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
affects expression		 ISO
EXP		 Diclofenac promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]
Diclofenac results in increased expression of TP53 mRNA
Diclofenac results in increased expression of TP53 mRNA; Diclofenac results in increased expression of TP53 protein
Diclofenac affects the expression of TP53 mRNA		 CTD PMID:15458769 PMID:24752500 PMID:29027214 PMID:32087850 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Diclofenac results in increased expression of TRP53INP1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Diclofenac results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
G Tpsb2 tryptase beta 2 increases expression EXP Diclofenac results in increased expression of TPSB2 mRNA CTD PMID:30723492 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 increases expression EXP Diclofenac results in increased expression of TRAF3IP3 mRNA CTD PMID:30723492 NCBI chr13:104,694,802...104,719,655
Ensembl chr13:104,694,805...104,719,673 		JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 increases expression ISO Diclofenac results in increased expression of TRAT1 mRNA CTD PMID:26934552 NCBI chr11:52,035,750...52,077,805
Ensembl chr11:52,035,750...52,077,805 		JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO Diclofenac results in decreased expression of TRIB3 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Trim46 tripartite motif-containing 46 decreases expression ISO Diclofenac results in decreased expression of TRIM46 mRNA CTD PMID:35537566 NCBI chr 2:174,641,494...174,654,237
Ensembl chr 2:174,641,496...174,654,141 		JBrowse link
G Tsc1 TSC complex subunit 1 affects expression ISO Diclofenac affects the expression of TSC1 mRNA CTD PMID:24752500 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Diclofenac results in decreased expression of TSC22D1 mRNA CTD PMID:26934552 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Tsc22d2 TSC22 domain family, member 2 increases expression ISO Diclofenac results in increased expression of TSC22D2 mRNA CTD PMID:26934552 NCBI chr 2:142,646,778...142,697,977
Ensembl chr 2:142,644,744...142,693,606 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression
decreases expression		 ISO Diclofenac results in increased expression of TSC22D3 mRNA
Diclofenac results in decreased expression of TSC22D3 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
G Tsks testis-specific serine kinase substrate increases expression EXP Diclofenac results in increased expression of TSKS mRNA CTD PMID:30723492 NCBI chr 1:95,414,312...95,441,670
Ensembl chr 1:95,414,157...95,441,662 		JBrowse link
G Tspan4 tetraspanin 4 increases expression ISO Diclofenac results in increased expression of TSPAN4 mRNA CTD PMID:26934552 NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448 		JBrowse link
G Tspan8 tetraspanin 8 increases expression ISO Diclofenac results in increased expression of TSPAN8 mRNA CTD PMID:26934552 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
G Tspear thrombospondin-type laminin G domain and EAR repeats increases expression EXP Diclofenac results in increased expression of TSPEAR mRNA CTD PMID:30723492 NCBI chr20:10,771,806...10,837,419
Ensembl chr20:10,772,219...10,943,914 		JBrowse link
G Ttr transthyretin increases expression ISO Diclofenac results in increased expression of TTR protein CTD PMID:23506792 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Tuba1a tubulin, alpha 1A affects expression ISO Diclofenac affects the expression of TUBA1A mRNA CTD PMID:24752500 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba1c tubulin, alpha 1C affects expression ISO Diclofenac affects the expression of TUBA1C mRNA CTD PMID:24752500 NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr  X:130,192,016...130,199,647 		JBrowse link
G Tubb3 tubulin, beta 3 class III affects expression ISO Diclofenac affects the expression of TUBB3 mRNA CTD PMID:24752500 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb affects expression ISO Diclofenac affects the expression of TUBB4B mRNA CTD PMID:24752500 NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296 		JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions		 ISO
EXP		 Diclofenac results in increased expression of TXN mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXN1 protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TXN1 mRNA]; Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA]		 CTD PMID:19022234 PMID:23939143 PMID:25772430 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txn2 thioredoxin 2 increases expression EXP Diclofenac results in increased expression of TXN2 mRNA CTD PMID:19022234 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Diclofenac results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression
multiple interactions		 ISO
EXP		 Diclofenac affects the expression of TXNRD1 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXNRD1 protein		 CTD PMID:24752500 PMID:25772430 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tyr tyrosinase decreases expression ISO Diclofenac results in decreased expression of TYR protein CTD PMID:21079976 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp increases expression ISO Diclofenac results in increased expression of TYROBP mRNA CTD PMID:26934552 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Ubc ubiquitin C affects expression ISO Diclofenac affects the expression of UBC mRNA CTD PMID:26934552 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Uck2 uridine-cytidine kinase 2 affects expression ISO Diclofenac affects the expression of UCK2 mRNA CTD PMID:24752500 NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Diclofenac results in increased expression of UCP2 mRNA CTD PMID:26934552 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
decreases expression
decreases activity		 ISO
EXP		 Diclofenac results in increased expression of UGT1A1 mRNA
Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]
Diclofenac results in decreased expression of UGT1A1 mRNA
Diclofenac results in decreased activity of UGT1A1 protein		 CTD PMID:15334623 PMID:15593333 PMID:18227147 PMID:19022234 PMID:33290829 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity
increases glucuronidation		 ISO Diclofenac results in decreased activity of UGT1A3 protein
UGT1A3 protein results in increased glucuronidation of Diclofenac		 CTD PMID:15117964 PMID:15334623 PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone] CTD PMID:22265884 PMID:33290829 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of Diclofenac
Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]		 CTD PMID:15988124 PMID:33290829 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 PMID:22265884 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
affects glucuronidation
affects response to substance
increases metabolic processing
increases glucuronidation		 ISO [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [UGT2B7 protein polymorphism affects the glucuronidation of Diclofenac] which affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]
UGT2B7 protein polymorphism affects the susceptibility to Diclofenac
UGT2B7 protein results in increased metabolism of Diclofenac
UGT2B7 protein results in increased glucuronidation of Diclofenac		 CTD PMID:15608137 PMID:15843492 PMID:15988124 PMID:19740398 PMID:22265884 More... NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 increases expression ISO Diclofenac results in increased expression of ULK2 mRNA CTD PMID:26934552 NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407 		JBrowse link
G Ung uracil-DNA glycosylase affects expression
increases expression		 ISO Diclofenac affects the expression of UNG mRNA
Diclofenac results in increased expression of UNG mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Upp2 uridine phosphorylase 2 decreases expression ISO Diclofenac results in decreased expression of UPP2 mRNA CTD PMID:26934552 NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression ISO Diclofenac results in increased expression of USP28 mRNA CTD PMID:26934552 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Diclofenac results in increased expression of VCAM1 mRNA CTD PMID:26934552 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcan versican decreases expression ISO Diclofenac results in decreased expression of VCAN mRNA CTD PMID:26934552 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vcl vinculin affects expression ISO Diclofenac affects the expression of VCL mRNA CTD PMID:24752500 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression ISO Diclofenac affects the expression of VEGFA mRNA CTD PMID:24752500 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Diclofenac results in decreased expression of VEGFC mRNA CTD PMID:35537566 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vim vimentin decreases expression ISO Diclofenac results in decreased expression of VIM protein CTD PMID:19628293 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Diclofenac results in decreased expression of VLDLR mRNA CTD PMID:26934552 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 increases expression ISO Diclofenac results in increased expression of VSIG4 mRNA CTD PMID:26934552 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
G Vwce von Willebrand factor C and EGF domains decreases expression ISO Diclofenac results in decreased expression of VWCE mRNA CTD PMID:26934552 NCBI chr 1:207,280,714...207,327,215
Ensembl chr 1:207,282,356...207,312,986 		JBrowse link
G Wdr11 WD repeat domain 11 decreases expression ISO Diclofenac results in decreased expression of WDR11 mRNA CTD PMID:35537566 NCBI chr 1:184,165,260...184,210,834
Ensembl chr 1:184,165,571...184,210,846 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Diclofenac results in increased expression of WIPI1 mRNA CTD PMID:26934552 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Diclofenac results in increased expression of XBP1 mRNA CTD PMID:26934552 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects expression
increases expression		 ISO Diclofenac affects the expression of XIAP mRNA
Diclofenac results in increased expression of XIAP mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta affects expression ISO Diclofenac affects the expression of YWHAB mRNA CTD PMID:24752500 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta affects expression ISO Diclofenac affects the expression of YWHAQ mRNA CTD PMID:24752500 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273 		JBrowse link
G Zbp1 Z-DNA binding protein 1 increases expression ISO Diclofenac results in increased expression of ZBP1 mRNA CTD PMID:26934552 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
G Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 increases expression ISO Diclofenac results in increased expression of ZDHHC23 mRNA CTD PMID:35537566 NCBI chr11:56,718,702...56,735,063
Ensembl chr11:56,718,826...56,734,194 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Diclofenac results in decreased expression of ZEB1 protein CTD PMID:19628293 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zfp346 zinc finger protein 346 decreases expression ISO Diclofenac results in decreased expression of ZFP346 mRNA CTD PMID:35537566 NCBI chr17:9,493,787...9,523,681
Ensembl chr17:9,493,803...9,523,635 		JBrowse link
G Zfp420 zinc finger protein 420 decreases expression ISO Diclofenac results in decreased expression of ZFP420 mRNA CTD PMID:35537566 NCBI chr 1:85,092,810...85,143,682
Ensembl chr 1:85,093,085...85,106,693
Ensembl chr 1:85,093,085...85,106,693 		JBrowse link
G Zfp786 zinc finger protein 786 increases expression EXP Diclofenac results in increased expression of ZFP786 mRNA CTD PMID:30723492 NCBI chr 4:76,822,383...76,840,943
Ensembl chr 4:76,827,812...76,840,857 		JBrowse link
G Znrd2 zinc ribbon domain containing 2 increases expression ISO Diclofenac results in increased expression of ZNRD2 mRNA CTD PMID:35537566 NCBI chr 1:203,017,682...203,019,465
Ensembl chr 1:203,017,682...203,019,465 		JBrowse link
4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions		 ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]		 CTD PMID:24246759 PMID:24552538 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions		 EXP
ISO		 TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]		 CTD PMID:23939143 PMID:29777833 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
5-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA		 CTD PMID:15555568 PMID:18076062 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        xenobiotic 18731
          diclofenac 1114
            3'-hydroxy-4'-methoxydiclofenac 0
            3'-hydroxydiclofenac 0
            4',5-dihydroxydiclofenac 0
            4'-hydroxydiclofenac 14
            4'-hydroxydiclofenac quinone imine 0
            5-hydroxydiclofenac 8
            5-hydroxydiclofenac quinone imine 0
            aceclofenac 4
            diclofenac beta-D-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        acetic acid 11055
                                          phenylacetic acid 1273
                                            diclofenac 1114
                                              3'-hydroxy-4'-methoxydiclofenac 0
                                              3'-hydroxydiclofenac 0
                                              4',5-dihydroxydiclofenac 0
                                              4'-hydroxydiclofenac 14
                                              4'-hydroxydiclofenac quinone imine 0
                                              5-hydroxydiclofenac 8
                                              5-hydroxydiclofenac quinone imine 0
                                              aceclofenac 4
                                              diclofenac beta-D-glucosiduronic acid 0
paths to the root