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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylenediaminetetraacetic acid
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Accession:CHEBI:4735 term browser browse the term
Synonyms:exact_synonym: (ethane-1,2-diyldinitrilo)tetraacetic acid
 related_synonym: (ethylenedinitrilo)tetraacetic acid;   2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetic acid;   2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid;   2-([2-[bis(carboxymethyl)amino]ethyl](carboxymethyl)amino)acetic acid;   EDTA;   EDTA (chelating agent);   Formula=C10H16N2O8;   H4edta;   InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);   InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N;   N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine);   N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycine];   SMILES=OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O;   acide edetique;   acido edetico;   acidum edeticum;   edathamil;   edetic acid;   ethylene-N,N'-biscarboxymethyl-N,N'-diglycine;   ethylenediamine-N,N,N',N'-tetraacetic acid;   ethylenedinitrilotetraacetic acid;   {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
 alt_id: CHEBI:42189
 xref: CAS:60-00-4;   Chemspider:5826;   DrugBank:DB00974;   Drug_Central:987;   HMDB:HMDB0015109;   KEGG:C00284;   KEGG:D00052;   KNApSAcK:C00062378
 xref_mesh: MESH:D004492
 xref: PDBeChem:EDT;   PMID:33351441;   PMID:34135967;   PMID:34152137;   PMID:34277313;   PMID:34370848;   PMID:34481414;   PMID:35006635;   PMID:35305029;   PMID:35343279;   PMID:35859250;   PMID:35936934;   PMID:35964552;   PMID:36187868;   PMID:36200920;   PMID:36229181;   PMID:36265367;   PMID:36297869;   PMID:36314569;   PMID:36348502;   PMID:36540522;   PMID:36566396;   PMID:36597320;   PPDB:1337;   Reaxys:1716295;   Wikipedia:Ethylenediaminetetraacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:64755


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ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
multiple interactions		 ISO Edetic Acid results in decreased activity of ACE protein
Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein]		 CTD PMID:28544013 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Aplp1 amyloid beta precursor like protein 1 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] CTD PMID:24855651 NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein] CTD PMID:24855651 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aspa aspartoacylase decreases activity ISO Edetic Acid results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein] CTD PMID:18369157 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase multiple interactions ISO CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl] CTD PMID:22824865 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein] CTD PMID:29158198 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dspp dentin sialophosphoprotein affects localization EXP Edetic Acid affects the localization of DSPP protein CTD PMID:23525114 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672 		JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein] CTD PMID:12885774 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Edetic Acid results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP Edetic Acid results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] CTD PMID:11238657 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Edetic Acid results in increased expression of ITGAM protein CTD PMID:8595612 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mbp myelin basic protein affects expression EXP Edetic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein] CTD PMID:18369157 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Edetic Acid results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]] CTD PMID:14998373 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt3 metallothionein 3 increases alkylation
affects metabolic processing		 ISO Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid		 CTD PMID:12383939 PMID:14983064 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258 		JBrowse link
G Optc opticin multiple interactions ISO Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237 		JBrowse link
G Pgp phosphoglycolate phosphatase decreases activity ISO Edetic Acid results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein] CTD PMID:21615740 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plg plasminogen multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Prl prolactin multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prlr prolactin receptor multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prnp prion protein multiple interactions ISO Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Edetic Acid inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 2:176,077,081...176,078,325 JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Sell selectin L decreases expression ISO Edetic Acid results in decreased expression of SELL protein CTD PMID:8595612 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 increases expression
multiple interactions		 ISO Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]		 CTD PMID:22341971 PMID:22926781 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions EXP Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein] CTD PMID:17069801 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Srr serine racemase multiple interactions ISO Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid] CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Edetic Acid results in increased expression of TNF protein CTD PMID:29953848 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]] CTD PMID:17442041 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
multiple interactions		 ISO Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]		 CTD PMID:16774913 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd3 thioredoxin reductase 3 increases activity
multiple interactions		 ISO Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]		 CTD PMID:16774913 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      chemical role 19529
        ligand 6751
          chelator 6738
            ethylenediaminetetraacetic acid 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            inorganic hydride 18191
                              pnictogen hydride 18181
                                nitrogen hydride 18092
                                  azane 17895
                                    ammonia 17894
                                      organic amino compound 17894
                                        polyamine 9032
                                          diamine 8967
                                            primary diamine 5707
                                              alkane-alpha,omega-diamine 3785
                                                ethylenediamine 3759
                                                  ethylenediamine derivative 3578
                                                    ethylenediaminetetraacetic acid 53
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