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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
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Accession:CHEBI:47322 term browser browse the term
Definition:A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
Synonyms:related_synonym: CKI 7;   Formula=C11H12ClN3O2S;   InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2;   InChIKey=OGKYMFFYOWUTKV-UHFFFAOYSA-N;   SMILES=NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
 xref: CAS:120615-25-0;   DrugBank:DB03693
 xref_mesh: MESH:C058815
 xref: PDBeChem:CKI;   Patent:US4943581;   Reaxys:13642444



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N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein] CTD PMID:15520213 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15520213 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased activity of CSNK1A1 protein CTD PMID:15520213 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased expression of TBX3 mRNA CTD PMID:15255957 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in increased expression of TNFRSF10A protein CTD PMID:15520213 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein]; N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        NMR chemical shift reference compound 17992
          ammonia 17848
            organic amino compound 17848
              primary amino compound 9313
                N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18783
                                chalcogen oxoacid 13780
                                  sulfur oxoacid 13568
                                    sulfonic acid 11607
                                      sulfonic acid derivative 11607
                                        sulfonamide 5302
                                          N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
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