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ONTOLOGY REPORT - ANNOTATIONS


Term:N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
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Accession:CHEBI:47322 term browser browse the term
Definition:A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
Synonyms:related_synonym: CKI 7;   Formula=C11H12ClN3O2S;   InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2;   InChIKey=OGKYMFFYOWUTKV-UHFFFAOYSA-N;   SMILES=NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
 xref: CAS:120615-25-0 "ChemIDplus";   DrugBank:DB03693
 xref_mesh: MESH:C058815
 xref: PDBeChem:CKI;   Patent:US4943581;   Reaxys:13642444 "Reaxys"


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N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6480464
G Tbx3 T-box transcription factor 3 JBrowse link 12 42,479,518 42,494,588 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        refrigerant 16994
          ammonia 16561
            organic amino compound 16560
              primary amino compound 6635
                N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              oxoacid 18076
                                chalcogen oxoacid 11397
                                  sulfur oxoacid 10987
                                    sulfonic acid 7240
                                      sulfonic acid derivative 7240
                                        sulfonamide 3125
                                          N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.