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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
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Accession:CHEBI:47322 term browser browse the term
Definition:A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
Synonyms:related_synonym: CKI 7;   Formula=C11H12ClN3O2S;   InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2;   InChIKey=OGKYMFFYOWUTKV-UHFFFAOYSA-N;   SMILES=NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
 xref: CAS:120615-25-0;   DrugBank:DB03693
 xref_mesh: MESH:C058815
 xref: PDBeChem:CKI;   Patent:US4943581;   Reaxys:13642444


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N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein] CTD PMID:15520213 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15520213 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased activity of CSNK1A1 protein CTD PMID:15520213 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased expression of TBX3 mRNA CTD PMID:15255957 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in increased expression of TNFRSF10A protein CTD PMID:15520213 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein]; N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        refrigerant 17694
          ammonia 17278
            organic amino compound 17278
              primary amino compound 7952
                N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
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Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11099
                                    sulfonic acid 7363
                                      sulfonic acid derivative 7363
                                        sulfonamide 3191
                                          N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
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