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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefixime
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Accession:CHEBI:472657 term browser browse the term
Definition:A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.
Synonyms:exact_synonym: 7beta-{(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido}-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (-)-cefixim;   (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Formula=C16H15N5O7S2;   InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1;   InChIKey=OKBVVJOGVLARMR-QSWIMTSFSA-N;   SMILES=[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC(O)=O)\\c1csc(N)n1)C(O)=O;   cefixima;   cefiximum
 alt_id: CHEBI:3487
 xref: Beilstein:6025058;   CAS:79350-37-1;   DrugBank:DB00671;   Drug_Central:537;   KEGG:C06881;   KEGG:D00258
 xref_mesh: MESH:D020682
 xref: PMID:17116681;   PMID:29017833;   Patent:EP30630;   Patent:US4409214


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cefixime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab8a RAB8A, member RAS oncogene family multiple interactions
increases uptake
ISO [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime
RAB8A protein results in increased uptake of Cefixime
CTD PMID:19074526 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678
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G Slc15a1 solute carrier family 15 member 1 multiple interactions
increases uptake
ISO [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime
SLC15A1 protein results in increased uptake of Cefixime
CTD PMID:19074526 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          antibacterial agent 13571
            antibacterial drug 3190
              cefixime 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                lactam 8307
                                                  beta-lactam 795
                                                    beta-lactam antibiotic 780
                                                      cephem 545
                                                        cephalosporin 544
                                                          cefixime 2
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