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ONTOLOGY REPORT - ANNOTATIONS


Term:imipenem
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Accession:CHEBI:471744 term browser browse the term
Definition:A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.
Synonyms:exact_synonym: (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
 related_synonym: (5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid;   (5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid;   (5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure;   Formula=C12H17N3O4S;   Imipenem anhydrous;   InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1;   InChIKey=ZSKVGTPCRGIANV-ZXFLCMHBSA-N;   N-formimidoyl thienamycin;   N-formimidoylthienamycin;   SMILES=[H]C(=N)NCCSC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])C1)C(O)=O;   imipenemum
 alt_id: CHEBI:5879
 xref: Beilstein:434624 "Beilstein";   CAS:64221-86-9 "ChemIDplus";   CAS:64221-86-9 "KEGG COMPOUND";   DrugBank:DB01598;   Drug_Central:1426 "DrugCentral";   KEGG:C06665;   KEGG:D04515;   LINCS:LSM-6568;   PMID:1384868 "Europe PMC";   PMID:17361077 "Europe PMC";   PMID:24112243 "Europe PMC";   PMID:24247132 "Europe PMC";   PMID:2457043 "Europe PMC";   PMID:24903189 "Europe PMC";   PMID:25216543 "Europe PMC";   PMID:25351714 "Europe PMC";   PMID:9131470 "Europe PMC";   Patent:BE848545;   Patent:US4194047;   Reaxys:434624 "Reaxys";   Wikipedia:Imipenem


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imipenem hydrate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcg5 ATP binding cassette subfamily G member 5 JBrowse link 6 7,935,771 7,961,207 RGD:6480464
G Abcg8 ATP binding cassette subfamily G member 8 JBrowse link 6 7,961,413 7,980,708 RGD:6480464
G Baat bile acid CoA:amino acid N-acyltransferase JBrowse link 5 64,768,397 64,777,368 RGD:6480464
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6480464
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 JBrowse link 8 130,548,418 130,550,388 RGD:6480464
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 14 86,345,946 86,560,694 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 JBrowse link 13 53,750,470 53,870,288 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc27a5 solute carrier family 27 member 5 JBrowse link 1 65,576,599 65,587,192 RGD:6480464
G Slc51a solute carrier family 51 subunit alpha JBrowse link 11 71,533,078 71,547,476 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 1 164,623,313 164,671,612 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      biological role 19693
        antimicrobial agent 17227
          antibacterial agent 12937
            antibacterial drug 3095
              imipenem 19
                imipenem hydrate 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic group 18426
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18306
                                    carbonyl compound 18306
                                      carboxylic acid 17973
                                        carboacyl group 17082
                                          univalent carboacyl group 17082
                                            carbamoyl group 16811
                                              carboxamide 16811
                                                lactam 7820
                                                  beta-lactam 787
                                                    beta-lactam antibiotic 775
                                                      carbapenems 21
                                                        imipenem 19
                                                          imipenem hydrate 19
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.