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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxepin
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Accession:CHEBI:4710 term browser browse the term
Definition:A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Synonyms:exact_synonym: 3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine
 related_synonym: 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine;   Formula=C19H21NO;   InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3;   InChIKey=ODQWQRRAPPTVAG-UHFFFAOYSA-N;   SMILES=[H]C(CCN(C)C)=C1c2ccccc2COc2ccccc12
 xref: Beilstein:1348849;   CAS:1668-19-5;   DrugBank:DB01142;   Drug_Central:956;   HMDB:HMDB0015273;   KEGG:C06971;   KEGG:D07875;   LINCS:LSM-2803
 xref_mesh: MESH:D004316
 xref: PMID:15014590;   PMID:19357442;   Reaxys:1348849;   Wikipedia:Doxepin


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doxepin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Doxepin CTD PMID:14550684 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase increases activity ISO Doxepin results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Doxepin results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]
CTD PMID:31743544 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Doxepin results in increased expression of ASNS mRNA CTD PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Doxepin results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Doxepin results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Doxepin results in increased expression of GDPD3 mRNA CTD PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Doxepin results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Doxepin results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31743544 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Doxepin results in increased expression of INHBE mRNA CTD PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Doxepin inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lss lanosterol synthase increases expression ISO Doxepin results in increased expression of LSS mRNA CTD PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Doxepin results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Doxepin results in increased expression of SERPINA3 mRNA CTD PMID:17567588 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Doxepin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Doxepin results in decreased expression of SLC2A3 mRNA CTD PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Doxepin results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tagln transgelin decreases expression ISO Doxepin results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:31743544 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        refrigerant 17418
          ammonia 16940
            organic amino compound 16939
              tertiary amino compound 8630
                doxepin 20
                  cis-doxepin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          doxepin 20
                                            cis-doxepin 0
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