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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxazosin
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Accession:CHEBI:4708 term browser browse the term
Definition:A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Synonyms:exact_synonym: 2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin;   1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin;   Formula=C23H25N5O5;   InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);   InChIKey=RUZYUOTYCVRMRZ-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1;   doxazosina;   doxazosine;   doxazosinum
 xref: Beilstein:731849;   CAS:74191-85-8;   DrugBank:DB00590;   Drug_Central:954;   HMDB:HMDB0014728;   KEGG:C06970;   KEGG:D07874;   LINCS:LSM-4335
 xref_mesh: MESH:D017292
 xref: PMID:17171413;   PMID:18559700;   Patent:DE2847623;   Patent:US4188390;   Reaxys:731849;   Wikipedia:Doxazosin



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doxazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ADRA1A adrenoceptor alpha 1A affects binding ISO
EXP
Doxazosin binds to ADRA1A protein CTD PMID:7536677 PMID:8183249 PMID:21544540 NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278
JBrowse link
G ADRA1B adrenoceptor alpha 1B affects binding EXP Doxazosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012
JBrowse link
G ADRA1D adrenoceptor alpha 1D affects binding EXP
ISO
Doxazosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr20:4,220,630...4,249,287
Ensembl chr20:4,220,630...4,249,287
JBrowse link
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases activity
decreases expression
EXP Doxazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Doxazosin results in increased activity of ADRA2A protein
Doxazosin results in decreased expression of ADRA2A protein
CTD PMID:10694191 PMID:10742289 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRB1 adrenoceptor beta 1 increases expression ISO Doxazosin results in increased expression of ADRB1 protein CTD PMID:18084315 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression ISO Doxazosin results in increased expression of ADRB2 protein CTD PMID:18084315 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
JBrowse link
G AKT1 AKT serine/threonine kinase 1 affects phosphorylation ISO Doxazosin affects the phosphorylation of AKT1 protein CTD PMID:18084315 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Doxazosin results in increased expression of BAX protein
SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]
CTD PMID:16007219 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP BCL2 inhibits the reaction [Doxazosin results in decreased expression of VEGFA] CTD PMID:12576871 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
EXP
ISO
Doxazosin results in increased activity of CASP3 protein
Doxazosin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:12771931 PMID:15221243 PMID:22845314 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Doxazosin results in decreased expression of CCNA2 protein CTD PMID:15371785 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Doxazosin results in increased expression of CDKN1A mRNA CTD PMID:12771931 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] CTD PMID:19575289 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CRP C-reactive protein decreases expression EXP Doxazosin results in decreased expression of CRP protein CTD PMID:16680063 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression ISO Doxazosin results in increased expression of DDIT3 protein CTD PMID:22845314 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G EPHA2 EPH receptor A2 multiple interactions ISO [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein; Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein; Lithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] CTD PMID:22845314 NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069
JBrowse link
G FASLG Fas ligand increases expression EXP Doxazosin results in increased expression of FASLG mRNA CTD PMID:12771931 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G KLF10 KLF transcription factor 10 increases expression EXP Doxazosin results in increased expression of KLF10 mRNA; Doxazosin results in increased expression of KLF10 protein CTD PMID:12771931 NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects phosphorylation ISO Doxazosin affects the phosphorylation of MAPK1 protein CTD PMID:18084315 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects phosphorylation ISO Doxazosin affects the phosphorylation of MAPK3 protein CTD PMID:18084315 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MSTN myostatin decreases expression ISO Doxazosin results in decreased expression of MSTN mRNA; Doxazosin results in decreased expression of MSTN protein CTD PMID:16968467 NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729
JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression EXP Doxazosin results in increased expression of NFKBIA mRNA; Doxazosin results in increased expression of NFKBIA protein CTD PMID:12771931 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NPPB natriuretic peptide B increases expression
multiple interactions
EXP
ISO
Doxazosin results in increased expression of NPPB protein
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
CTD PMID:15969258 PMID:18551024 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G PTK2 protein tyrosine kinase 2 decreases expression
increases cleavage
EXP
ISO
Doxazosin results in decreased expression of PTK2 protein
Doxazosin results in increased cleavage of PTK2 protein
CTD PMID:15221243 PMID:22845314 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 multiple interactions ISO [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein CTD PMID:22845314 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918
JBrowse link
G RB1 RB transcriptional corepressor 1 affects phosphorylation
decreases phosphorylation
ISO
EXP
Doxazosin affects the phosphorylation of RB1 protein
Doxazosin results in decreased phosphorylation of RB1 protein
CTD PMID:15371785 PMID:18084315 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G REN renin increases expression EXP Doxazosin results in increased expression of REN protein CTD PMID:7818152 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SERPINB5 serpin family B member 5 multiple interactions
increases response to substance
EXP SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]
SERPINB5 protein results in increased susceptibility to Doxazosin
CTD PMID:16007219 NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Doxazosin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SMAD4 SMAD family member 4 increases expression
multiple interactions
EXP Doxazosin results in increased expression of SMAD4 mRNA; Doxazosin results in increased expression of SMAD4 protein
SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]
CTD PMID:12771931 PMID:16007219 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression
EXP BCL2 inhibits the reaction [Doxazosin results in decreased expression of VEGFA]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]
Doxazosin results in decreased expression of VEGFA mRNA; Doxazosin results in decreased expression of VEGFA mRNA alternative form; Doxazosin results in decreased expression of VEGFA protein
CTD PMID:12576871 PMID:16007219 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

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  CHEBI ontology 26040
    role 25956
      application 25180
        pharmaceutical 24551
          drug 24548
            antineoplastic agent 20830
              doxazosin 32
                doxazosin mesylate 0
Path 2
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  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic group 23608
                              organic divalent group 23569
                                organodiyl group 23569
                                  carbonyl group 23563
                                    carbonyl compound 23563
                                      carboxylic acid 22717
                                        carboacyl group 20066
                                          univalent carboacyl group 20066
                                            carbamoyl group 19580
                                              carboxamide 19580
                                                monocarboxylic acid amide 16973
                                                  doxazosin 32
                                                    doxazosin mesylate 0
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