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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dioxane
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Accession:CHEBI:47032 term browser browse the term
Definition:A dioxane with oxygen atoms at positions 1 and 4.
Synonyms:related_synonym: 1,4-DIETHYLENE DIOXIDE;   1,4-Dioxan;   1,4-dioxacyclohexane;   Formula=C4H8O2;   InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2;   InChIKey=RYHBNJHYFVUHQT-UHFFFAOYSA-N;   SMILES=C1COCCO1;   di(ethylene oxide);   glycol ethylene ether;   p-Dioxane;   tetrahydro-1,4-dioxin;   tetrahydro-p-dioxin;   tetrahydro-para-dioxin
 alt_id: CHEBI:34064;   CHEBI:41951;   CHEBI:46925
 xref: Beilstein:102551;   CAS:123-91-1;   DrugBank:DB03316;   KEGG:C14440;   LINCS:LSM-37087
 xref_mesh: MESH:C025223
 xref: PDBeChem:DIO;   PMID:14550759;   PMID:18044507;   PMID:20598439;   PPDB:1638;   Reaxys:102551;   Wikipedia:1\,4-Dioxane

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1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 increases expression ISO 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:15490126 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression		 EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
1,4-dioxane results in increased activity of CYP2E1 protein
1,4-dioxane results in increased expression of CYP2E1 mRNA		 CTD PMID:15490126 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO 1,4-dioxane results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          metabolite 19350
            1,4-dioxane 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    saturated organic heteromonocyclic parent 5816
                                      dioxane 12
                                        1,4-dioxane 12
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