Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,4-dioxane
go back to main search page
Accession:CHEBI:47032 term browser browse the term
Definition:A dioxane with oxygen atoms at positions 1 and 4.
Synonyms:related_synonym: 1,4-DIETHYLENE DIOXIDE;   1,4-Dioxan;   1,4-dioxacyclohexane;   Formula=C4H8O2;   InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2;   InChIKey=RYHBNJHYFVUHQT-UHFFFAOYSA-N;   SMILES=C1COCCO1;   di(ethylene oxide);   glycol ethylene ether;   p-Dioxane;   tetrahydro-1,4-dioxin;   tetrahydro-p-dioxin;   tetrahydro-para-dioxin
 alt_id: CHEBI:34064;   CHEBI:41951;   CHEBI:46925
 xref: Beilstein:102551;   CAS:123-91-1;   DrugBank:DB03316;   KEGG:C14440;   LINCS:LSM-37087
 xref_mesh: MESH:C025223
 xref: PDBeChem:DIO;   PMID:14550759;   PMID:18044507;   PMID:20598439;   PPDB:1638;   Reaxys:102551;   Wikipedia:1\,4-Dioxane



show annotations for term's descendants           Sort by:
 
1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 1,4-dioxane results in increased expression of AAAS mRNA CTD PMID:33693819 NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 1,4-dioxane results in increased expression of AOX1 mRNA CTD PMID:33693819 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression ISO 1,4-dioxane results in decreased expression of ATP6V0D2 mRNA CTD PMID:33693819 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO 1,4-dioxane results in increased expression of BTG2 mRNA CTD PMID:33693819 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 1,4-dioxane results in increased expression of CCNG1 mRNA CTD PMID:33693819 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cpq carboxypeptidase Q decreases expression ISO 1,4-dioxane results in decreased expression of CPQ mRNA CTD PMID:33693819 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:15490126 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression
EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
1,4-dioxane results in increased activity of CYP2E1 protein
1,4-dioxane results in increased expression of CYP2E1 mRNA
CTD PMID:15490126 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression ISO 1,4-dioxane results in decreased expression of CYP2G1 mRNA CTD PMID:33693819 NCBI chr 1:82,145,635...82,156,862
Ensembl chr 1:82,145,073...82,156,828
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression ISO 1,4-dioxane results in increased expression of DDIAS mRNA CTD PMID:33693819 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
JBrowse link
G Dglucy D-glutamate cyclase increases expression ISO 1,4-dioxane results in increased expression of DGLUCY mRNA CTD PMID:33693819 NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 1,4-dioxane results in increased expression of EDA2R mRNA CTD PMID:33693819 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,4-dioxane results in increased expression of EGR1 mRNA CTD PMID:33693819 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 1,4-dioxane results in increased expression of EPHX1 mRNA CTD PMID:33693819 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 1,4-dioxane results in decreased expression of ERBB4 mRNA CTD PMID:33693819 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression ISO 1,4-dioxane results in increased expression of FITM1 mRNA CTD PMID:33693819 NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015
JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 decreases expression ISO 1,4-dioxane results in decreased expression of FRAS1 mRNA CTD PMID:33693819 NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO 1,4-dioxane results in increased expression of GSTA1 mRNA CTD PMID:33693819 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO 1,4-dioxane results in increased expression of GSTM1 mRNA CTD PMID:33693819 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO 1,4-dioxane results in increased expression of GSTM2 mRNA CTD PMID:33693819 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO 1,4-dioxane results in increased expression of GSTM3 mRNA CTD PMID:33693819 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO 1,4-dioxane results in increased expression of GSTP1 mRNA CTD PMID:33693819 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 1,4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO 1,4-dioxane results in increased expression of HES1 mRNA CTD PMID:33693819 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hexb hexosaminidase subunit beta decreases expression ISO 1,4-dioxane results in decreased expression of HEXB mRNA CTD PMID:33693819 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO 1,4-dioxane results in increased expression of ID1 mRNA CTD PMID:33693819 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO 1,4-dioxane results in decreased expression of NAALADL2 mRNA CTD PMID:33693819 NCBI chr 2:106,639,146...107,992,218 JBrowse link
G Ncmap noncompact myelin associated protein decreases expression ISO 1,4-dioxane results in decreased expression of NCMAP mRNA CTD PMID:33693819 NCBI chr 5:147,608,042...147,623,266
Ensembl chr 5:147,610,677...147,618,775
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO 1,4-dioxane results in increased expression of PHLDA3 mRNA CTD PMID:33693819 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO 1,4-dioxane results in increased expression of PIM1 mRNA CTD PMID:33693819 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO 1,4-dioxane results in decreased expression of PPP1R10 mRNA CTD PMID:33693819 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611
JBrowse link
G Pygo1 pygopus family PHD finger 1 decreases expression ISO 1,4-dioxane results in decreased expression of PYGO1 mRNA CTD PMID:33693819 NCBI chr 8:73,666,467...73,684,641
Ensembl chr 8:73,665,593...73,684,869
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Rcan2 regulator of calcineurin 2 decreases expression ISO 1,4-dioxane results in decreased expression of RCAN2 mRNA CTD PMID:33693819 NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856
JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression ISO 1,4-dioxane results in decreased expression of RGS1 mRNA CTD PMID:33693819 NCBI chr13:56,018,529...56,022,939
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression ISO 1,4-dioxane results in decreased expression of RSRP1 mRNA CTD PMID:33693819 NCBI chr 5:147,147,774...147,151,523
Ensembl chr 5:147,147,784...147,151,523
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO 1,4-dioxane results in decreased expression of H2-AB1 mRNA CTD PMID:33693819 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO 1,4-dioxane results in increased expression of SERPINA7 mRNA CTD PMID:33693819 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Slc17a8 solute carrier family 17 member 8 increases expression ISO 1,4-dioxane results in increased expression of SLC17A8 mRNA CTD PMID:33693819 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO 1,4-dioxane results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression ISO 1,4-dioxane results in decreased expression of SUGCT mRNA CTD PMID:33693819 NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a decreases expression ISO 1,4-dioxane results in decreased expression of SULT1C2 mRNA CTD PMID:33693819 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO 1,4-dioxane results in increased expression of TGIF1 mRNA CTD PMID:33693819 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO 1,4-dioxane results in decreased expression of TSC22D3 mRNA CTD PMID:33693819 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO 1,4-dioxane results in decreased expression of UGT1A1 mRNA CTD PMID:33693819 NCBI chr 9:88,801,344...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            1,4-dioxane 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    saturated organic heteromonocyclic parent 9797
                                      dioxane 53
                                        1,4-dioxane 53
paths to the root