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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diselenide
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Accession:CHEBI:47026 term browser browse the term
Definition:Compounds having the structure RSe2R, with R =/= H.
Synonyms:related_synonym: diselenides


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selenocystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO selenocystine results in increased expression of BAX protein CTD PMID:35863474 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO selenocystine results in decreased expression of BCL2 protein CTD PMID:35863474 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [selenocystine results in decreased expression of CASP3 protein] CTD PMID:35863474 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO selenocystine results in decreased expression of CASP8 protein CTD PMID:35863474 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression ISO selenocystine results in decreased expression of CASP9 protein CTD PMID:35863474 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression ISO selenocystine results in decreased expression of CAT protein CTD PMID:35863474 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK1 protein] CTD PMID:23838314 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK3 protein] CTD PMID:23838314 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization		 ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
selenocystine affects the localization of NFE2L2 protein		 CTD PMID:22807314 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
affects expression
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]
selenocystine affects the expression of NQO1 mRNA
selenocystine results in increased expression of NQO1 protein		 CTD PMID:22807314 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of selenocystine CTD PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO selenocystine results in decreased expression of SOD1 protein CTD PMID:35863474 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO selenocystine results in decreased expression of SOD2 protein CTD PMID:35863474 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases response to substance
multiple interactions
increases expression		 ISO TXNRD1 protein results in decreased susceptibility to selenocystine
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
selenocystine results in increased expression of TXNRD1 mRNA; selenocystine results in increased expression of TXNRD1 protein		 CTD PMID:20920480 PMID:22807314 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions
decreases activity		 ISO selenocystine inhibits the reaction [Zinc binds to XPA protein]
selenocystine results in decreased activity of XPA protein		 CTD PMID:15265038 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19810
      atom 19810
        nonmetal atom 19744
          selenium atom 3246
            selenium molecular entity 3246
              diselenide 17
                selenocystine 17
                selenohomocystine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      p-block molecular entity 19755
                        chalcogen molecular entity 19543
                          selenium molecular entity 3246
                            diselenide 17
                              selenocystine 17
                              selenohomocystine 0
paths to the root