dihydroxytetrahydrofuran - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dihydroxytetrahydrofuran	go back to main search page
Accession:	CHEBI:47019	browse the term
Synonyms:	related_synonym:	dihydroxytetrahydrofurans

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Rat (1143) Mouse (1150) Human (1171) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (6) Green Monkey (0) Naked Mole-rat (0) All
Genes (1171)

2',3'-dideoxyadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]

PMID:25813982 PMID:31300867

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

epidermal growth factor

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

2'-deoxyguanosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein]

PMID:9297556 PMID:9403342

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions

CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions

CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine]

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

multiple interactions

CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions

CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine]

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

O-6-methylguanine-DNA methyltransferase

decreases activity

Deoxyguanosine analog results in decreased activity of MGMT protein

NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects activity

Puromycin Aminonucleoside affects the activity of ACE protein

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

aminocarboxymuconate semialdehyde decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of ACMSD protein

NCBI chr 2:134,838,616...134,902,034
Ensembl chr 2:134,838,616...134,902,034

G

actin beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTB protein

NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902

G

actin gamma 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTG1 protein

NCBI chr17:81,509,971...81,512,799
Ensembl chr17:81,509,413...81,523,847

G

actin related protein 2

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR2 mRNA; Puromycin Aminonucleoside results in increased expression of ACTR2 protein

NCBI chr 2:65,227,831...65,271,253
Ensembl chr 2:65,227,788...65,271,253

G

actin related protein 3

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR3 protein

NCBI chr 2:113,889,934...113,962,596
Ensembl chr 2:113,890,063...113,962,596

G

angiotensinogen

affects expression
decreases expression
increases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of AGT protein
Puromycin Aminonucleoside results in decreased expression of AGT protein
Puromycin Aminonucleoside results in increased expression of AGT mRNA
[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGT mRNA

PMID:2236972 PMID:8446257 PMID:12495295

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

angiotensin II receptor type 2

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA
Puromycin Aminonucleoside results in increased expression of AGTR2 mRNA

NCBI chr X:116,170,744...116,174,974
Ensembl chr X:116,170,744...116,174,974

G

alanine--glyoxylate aminotransferase 2

increases expression

Puromycin Aminonucleoside results in increased expression of AGXT2 protein

NCBI chr 5:34,998,102...35,047,949
Ensembl chr 5:34,998,101...35,048,135

G

apoptosis inducing factor mitochondria associated 1

multiple interactions
affects localization

Dexamethasone inhibits the reaction [Puromycin Aminonucleoside affects the localization of AIFM1 protein]

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

albumin

affects transport
increases secretion
increases expression
affects localization
decreases expression

Puromycin Aminonucleoside affects the transport of ALB protein
Puromycin Aminonucleoside results in increased secretion of ALB protein
Puromycin Aminonucleoside results in increased expression of ALB mRNA; Puromycin Aminonucleoside results in increased expression of ALB protein
Puromycin Aminonucleoside affects the localization of ALB protein
Puromycin Aminonucleoside results in decreased expression of ALB protein

PMID:1453496 PMID:3301049 PMID:8413769 PMID:15798086 PMID:19264907 More...

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

aldehyde dehydrogenase 1 family member A2

increases expression

Puromycin Aminonucleoside results in increased expression of ALDH1A2 mRNA

NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866

G

angiopoietin 1

increases expression

Puromycin Aminonucleoside results in increased expression of ANGPT1 mRNA

NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

apolipoprotein A1

decreases response to substance
increases expression

APOA1 protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOA1 mRNA; Puromycin Aminonucleoside results in increased expression of APOA1 protein

PMID:7066357 PMID:7442475 PMID:7595070 PMID:8412754 PMID:8413767 More...

NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622

G

apolipoprotein A2

increases expression

Puromycin Aminonucleoside results in increased expression of APOA2 protein

NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631

G

apolipoprotein A4

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of APOA4 protein
Puromycin Aminonucleoside results in increased expression of APOA4 mRNA; Puromycin Aminonucleoside results in increased expression of APOA4 protein

PMID:7442475 PMID:8412754

NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304

G

apolipoprotein B

increases expression

Puromycin Aminonucleoside results in increased expression of APOB protein

PMID:2725289 PMID:7442475 PMID:8506949

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

G

apolipoprotein E

decreases response to substance
increases expression
affects expression

APOE protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOE protein
Puromycin Aminonucleoside affects the expression of APOE mRNA

PMID:7442475 PMID:8413767 PMID:12472773

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

aquaporin 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP2 protein

NCBI chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878

G

aquaporin 3 (Gill blood group)

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP3 protein

NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596

G

activity regulated cytoskeleton associated protein

increases expression

Puromycin Aminonucleoside results in increased expression of ARC mRNA

NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ATP1A1 protein
Puromycin Aminonucleoside results in increased expression of ATP1A1 mRNA

PMID:11675400 PMID:15075188

NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Puromycin Aminonucleoside results in increased expression of ATP1B1 mRNA

NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of ATP2A2 mRNA; Puromycin Aminonucleoside results in decreased expression of ATP2A2 protein

NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093

G

arginine vasopressin

increases expression

Puromycin Aminonucleoside results in increased expression of AVP protein

NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of BAX protein
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]
Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]

PMID:15113391 PMID:15987750 PMID:16152783 PMID:16396944

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

branched chain amino acid transaminase 2

decreases activity
decreases expression

Puromycin Aminonucleoside results in decreased activity of BCAT2 protein
Puromycin Aminonucleoside results in decreased expression of BCAT2 mRNA

NCBI chr19:48,795,064...48,811,029
Ensembl chr19:48,795,062...48,811,029

G

butyrylcholinesterase

increases activity

Puromycin Aminonucleoside results in increased activity of BCHE protein

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

BCL2 apoptosis regulator

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein
Puromycin Aminonucleoside results in increased expression of BCL2 protein

PMID:14993511 PMID:15113391 PMID:16152783

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

multiple interactions
decreases expression

[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]
Dinoprostone affects the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]

PMID:15987750 PMID:16396944

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

bone gamma-carboxyglutamate protein

increases expression

Puromycin Aminonucleoside results in increased expression of BGLAP protein

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

G

baculoviral IAP repeat containing 5

increases expression

Puromycin Aminonucleoside results in increased expression of BIRC5 mRNA; Puromycin Aminonucleoside results in increased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 7

multiple interactions
decreases expression

1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 protein]
Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA; Puromycin Aminonucleoside results in decreased expression of BMP7 protein

NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641

G

bone morphogenetic protein receptor type 2

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]; Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]

NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751

G

complement C3

multiple interactions
increases expression
decreases expression

cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of C3 protein]; mizoribine inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of C3 protein]

PMID:8919236 PMID:9250166

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

complement C5

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195

G

complement C9

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324

G

caspase 3

multiple interactions
increases activity

Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; L-161982 promotes the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

increases activity
decreases activity
decreases expression
affects activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of CAT protein
Puromycin Aminonucleoside results in decreased activity of CAT protein
Puromycin Aminonucleoside results in decreased expression of CAT mRNA
Puromycin Aminonucleoside affects the activity of CAT protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]; Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of CAT protein; sho-saiko-to-kyo-shokyo-ka-oren-bukuryo inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]

PMID:1744988 PMID:1942778 PMID:6246912 PMID:8289993 PMID:9355075 More...

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of CCL1 mRNA

NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233

G

C-C motif chemokine ligand 2

affects expression
increases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of CCL2 mRNA
Puromycin Aminonucleoside results in increased expression of CCL2 mRNA; Puromycin Aminonucleoside results in increased expression of CCL2 protein
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 protein]

PMID:10867541 PMID:12813006 PMID:16452496

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 3

affects expression

Puromycin Aminonucleoside affects the expression of CCL3 mRNA

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

G

C-C motif chemokine ligand 7

affects expression

Puromycin Aminonucleoside affects the expression of CCL7 mRNA

NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242

G

CD2 associated protein

multiple interactions
decreases expression

celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]

NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263

G

CD36 molecule (CD36 blood group)

multiple interactions
increases expression

Puromycin Aminonucleoside results in increased expression of and results in increased glycosylation of CD36 protein
Puromycin Aminonucleoside results in increased expression of CD36 mRNA

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD44 molecule (IN blood group)

increases expression

Puromycin Aminonucleoside results in increased expression of CD44 protein

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CDKN1A protein]

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

carbohydrate sulfotransferase 11

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHST11 mRNA

NCBI chr12:104,456,948...104,762,014
Ensembl chr12:104,455,295...104,762,014

G

chondroitin sulfate synthase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHSY1 mRNA

NCBI chr15:101,175,727...101,252,048
Ensembl chr15:101,175,727...101,252,048

G

claudin 6

affects localization

Puromycin Aminonucleoside affects the localization of CLDN6 protein

NCBI chr16:3,014,712...3,018,183
Ensembl chr16:3,014,712...3,020,071

G

chloride intracellular channel 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of CLIC5 protein

NCBI chr 6:45,880,827...46,129,819
Ensembl chr 6:45,880,827...46,080,348

G

collagen type I alpha 1 chain

multiple interactions
increases expression

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL1A1 mRNA]

PMID:9527400 PMID:16570917

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type III alpha 1 chain

increases expression

Puromycin Aminonucleoside results in increased expression of COL3A1 mRNA

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

collagen type IV alpha 1 chain

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202

G

corin, serine peptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of CORIN mRNA; Puromycin Aminonucleoside results in decreased expression of CORIN protein

NCBI chr 4:47,594,001...47,838,067
Ensembl chr 4:47,593,999...47,838,106

G

complement C3b/C4b receptor 1 (Knops blood group)

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]

NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765

G

catenin beta 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CTNNB1 protein

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cathepsin B

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSB protein

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin D

increases activity

Puromycin Aminonucleoside results in increased activity of CTSD protein

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

cathepsin H

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSH protein

NCBI chr15:78,921,058...78,945,046
Ensembl chr15:78,921,058...78,949,574

G

cathepsin L

decreases response to substance
multiple interactions
decreases activity
affects expression

CTSL gene mutant form results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased activity of and results in increased expression of CTSL protein
Puromycin Aminonucleoside results in decreased activity of CTSL protein
Puromycin Aminonucleoside affects the expression of CTSL mRNA; Puromycin Aminonucleoside affects the expression of CTSL protein

PMID:10394110 PMID:15197181

NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469

G

cytochrome P450 family 11 subfamily A member 1

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]

NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646

G

cytochrome P450 family 24 subfamily A member 1

increases expression

Puromycin Aminonucleoside results in increased expression of CYP24A1 mRNA

NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986

G

cytochrome P450 family 27 subfamily B member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CYP27B1 mRNA

NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986

G

dopa decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of DDC protein

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

dendrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of DDN protein

NCBI chr12:48,995,149...48,999,375
Ensembl chr12:48,995,149...48,999,375

G

desmin

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of DES protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein]

PMID:2183627 PMID:18509322

NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735

G

dynamin 3

increases expression

Puromycin Aminonucleoside results in increased expression of DNM3 mRNA

NCBI chr 1:171,841,498...172,418,466
Ensembl chr 1:171,817,887...172,418,466

G

endothelin converting enzyme 1

increases expression

Puromycin Aminonucleoside results in increased expression of ECE1 mRNA; Puromycin Aminonucleoside results in increased expression of ECE1 protein

NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572

G

enoyl-CoA hydratase, short chain 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ECHS1 protein

NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354

G

endothelin 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]

PMID:7756592 PMID:9175058 PMID:12972712

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin 3

multiple interactions

Puromycin Aminonucleoside promotes the reaction [EDN3 protein results in increased abundance of Cyclic GMP]

NCBI chr20:59,300,611...59,325,992
Ensembl chr20:59,300,443...59,325,992

G

endothelin receptor type A

increases expression

Puromycin Aminonucleoside results in increased expression of EDNRA mRNA

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

endothelin receptor type B

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA]

NCBI chr13:77,895,487...77,975,527
Ensembl chr13:77,895,481...77,975,529

G

electron transfer flavoprotein subunit alpha

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFA protein

NCBI chr15:76,215,353...76,311,469
Ensembl chr15:76,188,555...76,311,730

G

electron transfer flavoprotein subunit beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFB protein

NCBI chr19:51,345,155...51,366,388
Ensembl chr19:51,345,169...51,366,388

G

ezrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of EZR protein

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

Fas cell surface death receptor

multiple interactions
increases expression

Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]

PMID:14993511 PMID:16152783

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FASL protein
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein]

PMID:14993511 PMID:16152783

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

FAT atypical cadherin 1

increases expression

Puromycin Aminonucleoside results in increased expression of FAT1 mRNA; Puromycin Aminonucleoside results in increased expression of FAT1 protein

NCBI chr 4:186,587,794...186,726,696
Ensembl chr 4:186,587,794...186,726,722

G

fms related receptor tyrosine kinase 1

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of FLT1 protein
Puromycin Aminonucleoside affects the expression of FLT1 mRNA

PMID:11744811 PMID:14752241

NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145

G

fibronectin 1

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FN1 mRNA; Puromycin Aminonucleoside results in increased expression of FN1 protein
Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FN1 protein]

PMID:9527400 PMID:12813006

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]
Puromycin Aminonucleoside results in decreased expression of FSHB protein

PMID:12269381 PMID:16574160

NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261

G

G protein subunit alpha q

increases response to substance

GNAQ protein results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811

G

gonadotropin releasing hormone 1

multiple interactions

Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]

NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654

G

glutathione peroxidase 1

multiple interactions
increases expression

[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Puromycin Aminonucleoside results in increased expression of GPX1 mRNA

PMID:1942778 PMID:20685819

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of GPX3 mRNA

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein]

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

glutathione S-transferase pi 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of GSTP1 protein

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

guanylate cyclase activator 2B

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of GUCA2B protein
Puromycin Aminonucleoside affects the expression of GUCA2B mRNA

NCBI chr 1:42,153,410...42,155,820
Ensembl chr 1:42,153,410...42,155,820

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Puromycin Aminonucleoside results in decreased expression of HADH protein

NCBI chr 4:107,989,889...108,035,171
Ensembl chr 4:107,989,714...108,035,241

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity

Puromycin Aminonucleoside results in increased activity of HMGCR protein

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

heme oxygenase 1

multiple interactions
increases expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]
Puromycin Aminonucleoside results in increased expression of HMOX1 mRNA; Puromycin Aminonucleoside results in increased expression of HMOX1 protein

PMID:12806184 PMID:20685819

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heparanase

increases expression

Puromycin Aminonucleoside results in increased expression of HPSE mRNA; Puromycin Aminonucleoside results in increased expression of HPSE protein

NCBI chr 4:83,292,461...83,335,153
Ensembl chr 4:83,292,461...83,335,153

G

heparan sulfate-glucosamine 3-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS3ST1 mRNA

NCBI chr 4:11,393,150...11,434,327
Ensembl chr 4:11,393,150...11,429,564

G

heparan sulfate 6-O-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS6ST1 mRNA

NCBI chr 2:128,265,480...128,318,868
Ensembl chr 2:128,236,716...128,318,868

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Puromycin Aminonucleoside results in decreased activity of HSD11B2 protein

NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553

G

heat shock protein family A (Hsp70) member 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family A (Hsp70) member 8

affects localization

Puromycin Aminonucleoside affects the localization of HSPA8 protein

NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230

G

heat shock protein family D (Hsp60) member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPD1 protein

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

intercellular adhesion molecule 1

increases expression

Puromycin Aminonucleoside results in increased expression of ICAM1 protein

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 1 beta

increases expression

Puromycin Aminonucleoside results in increased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

integrin linked kinase

multiple interactions
increases activity

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased activity of ILK protein]

NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874

G

integrin subunit alpha 3

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of ITGA3 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGA3 protein
Puromycin Aminonucleoside affects the expression of ITGA3 protein

PMID:9249603 PMID:10845833 PMID:11274237 PMID:15197181

NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481

G

integrin subunit beta 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ITGB1 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGB1 protein
Puromycin Aminonucleoside results in increased expression of ITGB1 protein

PMID:11274237 PMID:12065681 PMID:14559718

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

kinase insert domain receptor

affects expression
increases expression
decreases expression

Puromycin Aminonucleoside affects the expression of KDR mRNA
Puromycin Aminonucleoside results in increased expression of KDR mRNA; Puromycin Aminonucleoside results in increased expression of KDR protein
Puromycin Aminonucleoside results in decreased expression of KDR mRNA

PMID:11744811 PMID:14752241 PMID:17667850

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

kirre like nephrin family adhesion molecule 1

multiple interactions
decreases expression

Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of KIRREL1 mRNA]

NCBI chr 1:157,993,645...158,100,262
Ensembl chr 1:157,993,273...158,100,262

G

keratin 7

decreases expression

Puromycin Aminonucleoside results in decreased expression of KRT7 mRNA; Puromycin Aminonucleoside results in decreased expression of KRT7 protein

NCBI chr12:52,233,243...52,255,853
Ensembl chr12:52,232,520...52,252,186

G

laminin subunit beta 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213

G

laminin subunit beta 2

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118

G

lipocalin 2

increases secretion

Puromycin Aminonucleoside results in increased secretion of LCN2 protein

NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453

G

galectin 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of LGALS1 protein

NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802

G

luteinizing hormone subunit beta

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
Puromycin Aminonucleoside results in decreased expression of LHB protein

PMID:12269381 PMID:16574160

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

mitogen-activated protein kinase 1

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

Puromycin Aminonucleoside binds to and results in increased activity of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

midkine

multiple interactions
decreases expression

Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]

NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837

G

membrane metalloendopeptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of MME protein

NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704

G

matrix metallopeptidase 2

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of MMP2 mRNA]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

moesin

increases expression

Puromycin Aminonucleoside results in increased expression of MSN protein

NCBI chr X:65,588,377...65,741,931
Ensembl chr X:65,588,377...65,741,931

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

Puromycin Aminonucleoside results in decreased expression of COX1 protein

NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445

G

myosin heavy chain 10

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of MYH10 protein
Puromycin Aminonucleoside affects the expression of MYH10 mRNA; Puromycin Aminonucleoside affects the expression of MYH10 protein

PMID:7671567 PMID:8918620

NCBI chr17:8,474,212...8,630,725
Ensembl chr17:8,474,207...8,631,376

G

myosin heavy chain 6

affects expression

Puromycin Aminonucleoside affects the expression of MYH6 mRNA

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

G

napsin A aspartic peptidase

increases expression

Puromycin Aminonucleoside results in increased expression of NAPSA mRNA; Puromycin Aminonucleoside results in increased expression of NAPSA protein

NCBI chr19:50,358,477...50,365,639
Ensembl chr19:50,358,472...50,365,830

G

N-deacetylase and N-sulfotransferase 1

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of NDST1 mRNA
Puromycin Aminonucleoside affects the expression of NDST1 mRNA

NCBI chr 5:150,497,779...150,558,211
Ensembl chr 5:150,485,818...150,558,211

G

nebulette

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEBL mRNA

NCBI chr10:20,779,973...21,293,050
Ensembl chr10:20,779,973...21,293,011

G

NEDD4 like E3 ubiquitin protein ligase

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEDD4L protein

NCBI chr18:58,044,226...58,401,540
Ensembl chr18:58,044,226...58,401,540

G

nitric oxide synthase 1

multiple interactions
increases expression

Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS1 protein
Puromycin Aminonucleoside results in increased expression of NOS1 mRNA

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

G

nitric oxide synthase 2

increases expression

Puromycin Aminonucleoside results in increased expression of NOS2 mRNA

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of NOS3 mRNA
Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS3 protein

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

NPHS2 stomatin family member, podocin

decreases expression
multiple interactions
affects expression

Puromycin Aminonucleoside results in decreased expression of NPHS2 protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein]
Puromycin Aminonucleoside affects the expression of NPHS2 mRNA; Puromycin Aminonucleoside affects the expression of NPHS2 protein

PMID:12065681 PMID:15363039 PMID:18509322

NCBI chr 1:179,550,539...179,575,948
Ensembl chr 1:179,550,539...179,575,952

G

natriuretic peptide A

affects metabolic processing
increases response to substance
increases expression
multiple interactions
affects expression

Puromycin Aminonucleoside affects the metabolism of NPPA protein
Puromycin Aminonucleoside results in increased susceptibility to NPPA protein
Puromycin Aminonucleoside results in increased expression of NPPA mRNA; Puromycin Aminonucleoside results in increased expression of NPPA protein
Puromycin Aminonucleoside inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]
Puromycin Aminonucleoside affects the expression of NPPA protein

PMID:2526952 PMID:12972712 PMID:15590761 PMID:19885019 PMID:20613715

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

affects expression

Puromycin Aminonucleoside affects the expression of NPPB mRNA

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

natriuretic peptide receptor 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR1 mRNA

NCBI chr 1:153,678,688...153,693,992
Ensembl chr 1:153,678,688...153,693,992

G

natriuretic peptide receptor 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR3 mRNA

NCBI chr 5:32,690,872...32,791,720
Ensembl chr 5:32,689,070...32,791,724

G

nuclear respiratory factor 1

affects expression

Puromycin Aminonucleoside affects the expression of NRF1 mRNA

NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082

G

optineurin

increases expression

Puromycin Aminonucleoside results in increased expression of OPTN protein

NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308

G

podoplanin

decreases expression

Puromycin Aminonucleoside results in decreased expression of PDPN mRNA; Puromycin Aminonucleoside results in decreased expression of PDPN protein

PMID:9327748 PMID:12032185

NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957

G

pleckstrin homology, MyTH4 and FERM domain containing H2

decreases expression

Puromycin Aminonucleoside results in decreased expression of PLEKHH2 protein

NCBI chr 2:43,637,260...43,767,987
Ensembl chr 2:43,637,260...43,767,987

G

phospholamban

increases expression

Puromycin Aminonucleoside results in increased expression of PLN mRNA

NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716

G

podocalyxin like

increases expression
affects metabolic processing

Puromycin Aminonucleoside results in increased expression of PODXL mRNA; Puromycin Aminonucleoside results in increased expression of PODXL protein
Puromycin Aminonucleoside affects the metabolism of PODXL protein

PMID:8780404 PMID:11274237

NCBI chr 7:131,500,271...131,556,628
Ensembl chr 7:131,500,262...131,558,217

G

DNA polymerase beta

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of POLB protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of POLB protein]

NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808

G

peroxisome proliferator activated receptor gamma

multiple interactions
increases expression

pioglitazone affects the reaction [Puromycin Aminonucleoside results in increased expression of PPARG protein]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein phosphatase 1 regulatory subunit 12A

increases phosphorylation
increases expression
multiple interactions

Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein
Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form
Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein]
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form]

PMID:16452496 PMID:18367845

NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460

G

peroxiredoxin 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of PRDX3 protein

NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812

G

prostaglandin-endoperoxide synthase 2

increases expression
affects response to substance
multiple interactions

Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA; Puromycin Aminonucleoside results in increased expression of PTGS2 protein
PTGS2 protein affects the susceptibility to Puromycin Aminonucleoside
celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]

PMID:16396944 PMID:17890881 PMID:19194550

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

parathyroid hormone

increases expression

Puromycin Aminonucleoside results in increased expression of PTH protein

NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181

G

protein tyrosine kinase 2

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of PTK2 protein

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

protein tyrosine phosphatase receptor type O

affects expression

Puromycin Aminonucleoside affects the expression of PTPRO mRNA; Puromycin Aminonucleoside affects the expression of PTPRO protein

NCBI chr12:15,322,508...15,598,331
Ensembl chr12:15,322,257...15,602,175

G

retinoic acid receptor alpha

increases expression

Puromycin Aminonucleoside results in increased expression of RARA mRNA; Puromycin Aminonucleoside results in increased expression of RARA protein

NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643

G

RB binding protein 7, chromatin remodeling factor

decreases expression

Puromycin Aminonucleoside results in decreased expression of RBBP7 protein

NCBI chr X:16,844,341...16,870,362
Ensembl chr X:16,839,283...16,870,362

G

renin

multiple interactions
increases expression
affects expression

Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein; Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein
Puromycin Aminonucleoside results in increased expression of REN protein
Puromycin Aminonucleoside affects the expression of REN protein

PMID:2236972 PMID:2267444 PMID:8446257 PMID:9171944

NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324

G

ras homolog family member A

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

sodium channel epithelial 1 subunit alpha

affects expression
multiple interactions
decreases expression
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1A mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1A protein
Puromycin Aminonucleoside results in decreased expression of SCNN1A mRNA
Puromycin Aminonucleoside affects the localization of SCNN1A protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr12:6,346,847...6,377,359
Ensembl chr12:6,346,843...6,377,730

G

sodium channel epithelial 1 subunit beta

affects expression
increases expression
decreases expression
multiple interactions
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1B protein
Puromycin Aminonucleoside affects the localization of SCNN1B protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr16:23,278,231...23,381,294
Ensembl chr16:23,278,231...23,381,294

G

sodium channel epithelial 1 subunit gamma

multiple interactions
increases expression
decreases expression

Puromycin Aminonucleoside affects the localization of and affects the expression of SCNN1G protein; Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1G protein
Puromycin Aminonucleoside results in increased expression of SCNN1G mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1G mRNA

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883

G

serpin family E member 1

multiple interactions
increases expression

pioglitazone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA]

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

solute carrier family 12 member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A1 protein

NCBI chr15:48,206,302...48,304,078
Ensembl chr15:48,178,438...48,304,078

G

solute carrier family 12 member 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A3 protein

NCBI chr16:56,865,207...56,915,850
Ensembl chr16:56,865,207...56,915,850

G

solute carrier family 22 member 2

affects expression

Puromycin Aminonucleoside affects the expression of SLC22A2 mRNA

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

solute carrier family 29 member 4

increases response to substance

SLC29A4 results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr 7:5,282,943...5,306,912
Ensembl chr 7:5,274,369...5,306,912

G

solute carrier family 5 member 3

increases expression

Puromycin Aminonucleoside results in increased expression of SLC5A3 mRNA

NCBI chr21:34,073,578...34,106,260
Ensembl chr21:34,073,578...34,106,260

G

solute carrier family 9 member A3

multiple interactions
decreases expression
affects expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
Puromycin Aminonucleoside affects the expression of SLC9A3 protein

PMID:12191963 PMID:12806184 PMID:15075188

NCBI chr 5:470,456...524,449
Ensembl chr 5:470,456...524,449

G

SMAD family member 1

increases expression

Puromycin Aminonucleoside results in increased expression of SMAD1 mRNA

NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176

G

superoxide dismutase 2

affects expression
decreases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of SOD2 protein
Puromycin Aminonucleoside results in decreased expression of SOD2 protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein

PMID:1942778 PMID:19264907

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

superoxide dismutase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SOD3 mRNA

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

G

sperm microtubule inner protein 11

decreases expression
decreases phosphorylation
multiple interactions
affects expression

Puromycin Aminonucleoside results in decreased expression of NPHS1; Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA; Puromycin Aminonucleoside results in decreased expression of NPHS1 protein
Puromycin Aminonucleoside results in decreased phosphorylation of NPHS1 protein
1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Mercuric Chloride promotes the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Puromycin Aminonucleoside affects the expression of and affects the localization of NPHS1 protein; Puromycin Aminonucleoside promotes the reaction [Mercuric Chloride results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]
Puromycin Aminonucleoside affects the expression of NPHS1 mRNA; Puromycin Aminonucleoside affects the expression of NPHS1 protein

PMID:10792613 PMID:11012881 PMID:12012391 PMID:12065681 PMID:12386277 More...

NCBI chr12:48,727,435...48,771,459
Ensembl chr12:48,727,435...48,765,790

G

secreted phosphoprotein 1

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 protein]; fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA]
Puromycin Aminonucleoside results in increased expression of SPP1 mRNA; Puromycin Aminonucleoside results in increased expression of SPP1 protein

PMID:14738908 PMID:16452496

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of SRC protein

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

synaptopodin

decreases expression

Puromycin Aminonucleoside results in decreased expression of SYNPO protein

NCBI chr 5:150,586,010...150,659,207
Ensembl chr 5:150,601,080...150,659,207

G

transgelin

increases expression

Puromycin Aminonucleoside results in increased expression of TAGLN mRNA; Puromycin Aminonucleoside results in increased expression of TAGLN protein

NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464

G

TEK receptor tyrosine kinase

decreases expression

Puromycin Aminonucleoside results in decreased expression of TEK mRNA

NCBI chr 9:27,109,225...27,230,174
Ensembl chr 9:27,109,141...27,230,174

G

transferrin

increases expression

Puromycin Aminonucleoside results in increased expression of TF mRNA

NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641

G

transcription factor A, mitochondrial

affects expression

Puromycin Aminonucleoside affects the expression of TFAM mRNA

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

G

transforming growth factor beta 1

multiple interactions
increases expression
affects expression

Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 protein]; Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA; Puromycin Aminonucleoside results in increased expression of TGFB1 protein
Puromycin Aminonucleoside affects the expression of TGFB1 mRNA

PMID:9527400 PMID:12397044 PMID:14738908 PMID:19194550 PMID:19594554

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TIMP1 mRNA]

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

tight junction protein 1

multiple interactions
increases expression
affects localization

Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TJP1 protein]
Puromycin Aminonucleoside affects the localization of TJP1 protein

PMID:15744817 PMID:15798086

NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915

G

tumor necrosis factor

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]

PMID:8384958 PMID:17457379

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

troponin C1, slow skeletal and cardiac type

decreases expression

Puromycin Aminonucleoside results in decreased expression of TNNC1 mRNA

NCBI chr 3:52,451,100...52,454,041
Ensembl chr 3:52,451,100...52,454,041

G

tumor protein p53

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
Puromycin Aminonucleoside results in increased expression of TRP53 protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]

PMID:14993511 PMID:15113391 PMID:15987750 PMID:16152783 PMID:17035936

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

transthyretin

increases expression

Puromycin Aminonucleoside results in increased expression of TTR protein

NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833

G

uncoupling protein 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of UCP3 protein

NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085

G

versican

decreases expression

Puromycin Aminonucleoside results in decreased expression of VCAN mRNA; Puromycin Aminonucleoside results in decreased expression of VCAN protein

NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303

G

vinculin

affects localization
increases expression

Puromycin Aminonucleoside affects the localization of VCL protein
Puromycin Aminonucleoside results in increased expression of VCL mRNA; Puromycin Aminonucleoside results in increased expression of VCL protein

NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363

G

vascular endothelial growth factor A

affects expression
increases expression

Puromycin Aminonucleoside affects the expression of VEGFA mRNA
Puromycin Aminonucleoside results in increased expression of VEGFA protein

PMID:11744811 PMID:14752241

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

vimentin

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

WT1 interacting protein

affects localization

Puromycin Aminonucleoside affects the localization of WTIP protein

NCBI chr19:34,481,758...34,512,304
Ensembl chr19:34,481,758...34,512,304

G

X-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of XCL1 mRNA

NCBI chr 1:168,576,605...168,582,069
Ensembl chr 1:168,576,605...168,582,069

G

xanthine dehydrogenase

increases activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of XDH
[Tungsten co-treated with Puromycin Aminonucleoside] results in decreased activity of XDH protein

PMID:7583048 PMID:11041286

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

3'-phospho-5'-adenylyl sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

[NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

purinergic receptor P2Y1

decreases activity

Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein

NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439

G

sulfotransferase family 1A member 1

multiple interactions
increases sulfation

2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]
SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate

PMID:11425650 PMID:16601080 PMID:20545351

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

sulfotransferase family 1A member 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:28,591,943...28,597,050
Ensembl chr16:28,591,943...28,597,050

G

sulfotransferase family 1A member 3

increases sulfation

SULT1A3 protein results in increased sulfation of Phosphoadenosine Phosphosulfate

NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310

G

sulfotransferase family 2A member 1

multiple interactions

[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]

NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315

3-iodobenzyl-5'-N-methylcarboxamidoadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A3 receptor

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein

PMID:12672554 PMID:15452191 PMID:19966059

NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633

G

AKT serine/threonine kinase 1

multiple interactions

Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

baculoviral IAP repeat containing 3

decreases expression
decreases response to substance

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

baculoviral IAP repeat containing 5

decreases response to substance

BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

interleukin 12A

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019

G

interleukin 12B

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

NLR family apoptosis inhibitory protein

decreases expression
decreases response to substance

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA
NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,166...71,025,339

G

natriuretic peptide A

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:15452191 PMID:19966059

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

regulator of G protein signaling 2

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

solute carrier family 9 member A1

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]

NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981

5'-S-methyl-5'-thioadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

RGD

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

adenosine A2b receptor

multiple interactions

5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts]

RGD

NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

C-C motif chemokine ligand 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin D1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

collagen type I alpha 1 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A1 mRNA
5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

CTD
RGD

PMID:15983038 PMID:21209952

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A2 mRNA

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
increases abundance

Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]

NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477

G

interferon gamma

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA]
5'-methylthioadenosine results in decreased secretion of IFNG protein

PMID:17080400 PMID:31712395

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interferon lambda 1

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA]

NCBI chr19:39,296,407...39,298,673
Ensembl chr19:39,296,407...39,298,673

G

interferon lambda 2

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL2 mRNA]

NCBI chr19:39,268,396...39,270,188
Ensembl chr19:39,268,396...39,270,188

G

interleukin 1 beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA]
5'-methylthioadenosine results in decreased secretion of IL2 protein

PMID:17080400 PMID:31712395

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 33

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA]

NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983

G

interleukin 6

multiple interactions
decreases expression

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver

CTD
RGD

PMID:17080400 PMID:21209952

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 7

multiple interactions

IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr 8:78,675,044...78,805,463
Ensembl chr 8:78,675,743...78,805,523

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622

G

lymphotoxin beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA]

NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522

G

MDM4 regulator of p53

multiple interactions

5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form

NCBI chr 1:204,516,406...204,558,120
Ensembl chr 1:204,516,379...204,558,120

G

marker of proliferation Ki-67

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver

RGD

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

matrix metallopeptidase 13

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver

RGD

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

mechanistic target of rapamycin kinase

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

nitric oxide synthase 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver

RGD

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

ribosomal protein S6

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein

NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236

G

transforming growth factor beta 1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

tenascin C

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver

RGD

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

multiple interactions

5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts]

RGD

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

increases expression

5'-methylthioadenosine results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

5-fluorocytidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytidine deaminase

increases metabolic processing

CDA protein results in increased metabolism of 5-fluorocytidine

NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903

5-fluorouridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 5

increases export

ABCC5 protein results in increased export of 5-fluorouridine

NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939

G

superoxide dismutase 1

affects binding

5-fluorouridine binds to SOD1 protein; 5-fluorouridine binds to SOD1 protein mutant form

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

5-iodotubercidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 1B

decreases phosphorylation

5-iodotubercidin results in decreased phosphorylation of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

CDC like kinase 1

decreases activity

5-iodotubercidin results in decreased activity of CLK1 protein

NCBI chr 2:200,853,009...200,864,658
Ensembl chr 2:200,853,009...200,864,691

G

CDC like kinase 2

decreases activity

5-iodotubercidin results in decreased activity of CLK2 protein

NCBI chr 1:155,262,868...155,273,504
Ensembl chr 1:155,262,868...155,278,491

G

CDC like kinase 3

decreases activity

5-iodotubercidin results in decreased activity of CLK3 protein

NCBI chr15:74,608,372...74,630,201
Ensembl chr15:74,598,500...74,645,414

G

CDC like kinase 4

decreases activity

5-iodotubercidin results in decreased activity of CLK4 protein

NCBI chr 5:178,602,664...178,627,050
Ensembl chr 5:178,602,664...178,630,615

G

dual specificity tyrosine phosphorylation regulated kinase 1A

decreases activity

5-iodotubercidin results in decreased activity of DYRK1A protein

NCBI chr21:37,365,573...37,526,358
Ensembl chr21:37,365,573...37,526,358

G

dual specificity tyrosine phosphorylation regulated kinase 1B

decreases activity

5-iodotubercidin results in decreased activity of DYRK1B protein

NCBI chr19:39,825,350...39,834,162
Ensembl chr19:39,825,350...39,834,201

G

dual specificity tyrosine phosphorylation regulated kinase 2

decreases activity

5-iodotubercidin results in decreased activity of DYRK2 protein

NCBI chr12:67,648,745...67,665,406
Ensembl chr12:67,648,338...67,665,406

G

dual specificity tyrosine phosphorylation regulated kinase 3

decreases activity

5-iodotubercidin results in decreased activity of DYRK3 protein

NCBI chr 1:206,635,536...206,655,158
Ensembl chr 1:206,635,536...206,684,419

G

dual specificity tyrosine phosphorylation regulated kinase 4

decreases activity

5-iodotubercidin results in decreased activity of DYRK4 protein

NCBI chr12:4,562,208...4,613,875
Ensembl chr12:4,562,208...4,615,302

G

insulin

increases secretion
affects secretion

5-iodotubercidin results in increased secretion of INS protein
5-iodotubercidin affects the secretion of INS protein

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

matrix metallopeptidase 3

increases expression

5-iodotubercidin results in increased expression of MMP3 mRNA

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

neurofilament medium chain

increases expression

5-iodotubercidin results in increased expression of NEFM mRNA

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

G

olfactomedin 4

decreases expression

5-iodotubercidin results in decreased expression of OLFM4 mRNA

NCBI chr13:53,028,813...53,052,057
Ensembl chr13:53,028,813...53,052,057

G

regenerating family member 1 beta

decreases expression

5-iodotubercidin results in decreased expression of REG1B mRNA

NCBI chr 2:79,085,023...79,087,993
Ensembl chr 2:79,085,023...79,088,019

G

regenerating family member 3 alpha

decreases expression

5-iodotubercidin results in decreased expression of REG3A mRNA

NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753

G

solute carrier family 2 member 2

increases expression

5-iodotubercidin results in increased expression of SLC2A2 mRNA

NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743

6-methylthioinosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 29 member 1 (Augustine blood group)

affects transport

SLC29A1 mRNA affects the transport of Methylthioinosine

NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142

8-chloro-2'-deoxyguanosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 5

decreases expression

8-chloro-2'-deoxyguanosine results in decreased expression of CCL5 mRNA

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

interleukin 18

increases expression

8-chloro-2'-deoxyguanosine results in increased expression of IL18 mRNA

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

increases secretion
increases expression

8-chloro-2'-deoxyguanosine results in increased secretion of IL1B protein
8-chloro-2'-deoxyguanosine results in increased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

8-hydroxy-2'-deoxyguanosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

increases abundance

AGT protein modified form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

apurinic/apyrimidinic endodeoxyribonuclease 1

affects abundance

APEX1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

BRCA1 DNA repair associated

multiple interactions

[BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245

G

cytochrome P450 family 2 subfamily D member 6

multiple interactions

[Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

DNA methyltransferase 1

affects abundance
decreases activity

DNMT1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine results in decreased activity of DNMT1 protein

PMID:19896490 PMID:33052562

NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286

G

DNA methyltransferase 3 beta

affects abundance

DNMT3B gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359

G

glutaredoxin

affects abundance

GLRX gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726

G

HRas proto-oncogene, GTPase

multiple interactions
increases abundance

PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine]

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

8-oxoguanine DNA glycosylase

multiple interactions
increases cleavage

thymidine glycol inhibits the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine]; thymidine glycol promotes the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine]

NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219

G

cytochrome p450 oxidoreductase

multiple interactions

[Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855

G

peroxiredoxin 1

multiple interactions

PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine]

NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

thioredoxin reductase 1

affects abundance

TXNRD1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thioredoxin reductase 2

affects abundance

TXNRD2 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine

NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820

acetoacetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid 17-beta dehydrogenase 2

affects binding

acetoacetyl CoA binds to HSD17B2 protein

NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534

acetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP citrate lyase

increases abundance
affects abundance

ACLY protein results in increased abundance of Acetyl Coenzyme A
ACLY protein affects the abundance of Acetyl Coenzyme A

PMID:28077572 PMID:36933457

NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542

G

amyloid beta precursor protein

affects localization
increases secretion
multiple interactions

APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

PMID:16122837 PMID:22906069

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

carnitine O-acetyltransferase

decreases activity

Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein

NCBI chr 9:129,094,794...129,110,793
Ensembl chr 9:129,094,142...129,111,189

G

ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

interleukin 1 beta

multiple interactions

IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

lysine acetyltransferase 2B

affects binding

Acetyl Coenzyme A binds to KAT2B protein

NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404

G

meteorin like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A]

NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122

G

N-acetyltransferase 1

multiple interactions
affects binding

[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein

PMID:20545351 PMID:22835378

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

sulfotransferase family 1A member 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:28,591,943...28,597,050
Ensembl chr16:28,591,943...28,597,050

acryloyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 2:190,189,735...190,319,826
Ensembl chr 2:190,189,735...190,344,193

adenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

decreases metabolic processing
increases metabolic processing

ADA alternative form results in decreased metabolism of Adenosine
ADA protein results in increased metabolism of Adenosine

NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252

G

adenosine A1 receptor

multiple interactions
affects binding

Adenosine analog binds to and affects the activity of ADORA1 protein; Adenosine analog binds to and results in decreased activity of ADORA1 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]
[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine; Adenosine analog binds to and results in increased activity of ADORA1 protein
Adenosine binds to ADORA1 protein

PMID:10649980 PMID:11520205 PMID:18404447 PMID:20571079 PMID:20932874

NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405

G

adenosine A2a receptor

multiple interactions
affects binding

Adenosine analog binds to and results in decreased activity of ADORA2A protein; Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]
Adenosine binds to ADORA2A protein

PMID:18404447 PMID:20067761

NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357

G

adenosine A2b receptor

affects response to substance

ADORA2B protein affects the susceptibility to Adenosine

NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746

G

adenosine A3 receptor

multiple interactions
increases expression
affects binding

Adenosine analog binds to and affects the activity of ADORA3 protein; Adenosine analog binds to and results in decreased activity of ADORA3 protein; Adenosine analog binds to and results in increased activity of ADORA3 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]
Adenosine results in increased expression of ADORA3 mRNA
Adenosine binds to ADORA3 protein

PMID:11520205 PMID:18404447 PMID:20067761 PMID:20571079

NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633

G

alkaline phosphatase, intestinal

multiple interactions

Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein]

NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753

G

adenosine monophosphate deaminase 2

multiple interactions

[tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine

NCBI chr 1:109,619,837...109,632,055
Ensembl chr 1:109,616,104...109,632,051

G

BCL2 associated X, apoptosis regulator

increases localization
multiple interactions

Adenosine results in increased localization of BAX protein
Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 like 1

decreases expression
multiple interactions

Adenosine results in decreased expression of BCL2L1 mRNA; Adenosine results in decreased expression of BCL2L1 protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

baculoviral IAP repeat containing 2

decreases expression

Adenosine results in decreased expression of BIRC2 mRNA; Adenosine results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

decreases expression

Adenosine results in decreased expression of BIRC3 mRNA

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

bone morphogenetic protein 2

increases expression

Adenosine results in increased expression of BMP2 mRNA

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

bone morphogenetic protein 4

increases expression
multiple interactions

Adenosine results in increased expression of BMP4 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]

NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761

G

bone morphogenetic protein receptor type 1A

increases expression

Adenosine results in increased expression of BMPR1A mRNA

NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,755,786...86,932,825

G

caspase 3

multiple interactions
increases activity

Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein]

PMID:11570579 PMID:16469385 PMID:17303086 PMID:20063052

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity
multiple interactions

Adenosine results in increased activity of CASP8 protein
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]

PMID:16469385 PMID:17303086

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity
multiple interactions

Adenosine results in increased activity of CASP9 protein
Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein]

PMID:11570579 PMID:16469385

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cyclin D1

increases expression

Adenosine results in increased expression of CCND1 mRNA

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

CD14 molecule

increases expression

Adenosine results in increased expression of CD14 mRNA

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

G

CASP8 and FADD like apoptosis regulator

decreases expression
multiple interactions

Adenosine results in decreased expression of CFLAR mRNA; Adenosine results in decreased expression of CFLAR mRNA alternative form; Adenosine results in decreased expression of CFLAR protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

CF transmembrane conductance regulator

increases activity
multiple interactions

Adenosine results in increased activity of CFTR protein
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

G

cAMP responsive element binding protein 1

increases expression
multiple interactions

Adenosine results in increased expression of CREB1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

catenin beta 1

increases expression

Adenosine results in increased expression of CTNNB1 mRNA

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

C-X-C motif chemokine ligand 8

multiple interactions

[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of CXCL8 mRNA

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

diablo IAP-binding mitochondrial protein

increases expression
multiple interactions

Adenosine results in increased expression of DIABLO mRNA; Adenosine results in increased expression of DIABLO protein
Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

Adenosine results in increased expression of DKK1 mRNA

NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042

G

dipeptidyl peptidase 4

decreases expression
multiple interactions

Adenosine results in decreased expression of DPP4 mRNA; Adenosine results in decreased expression of DPP4 protein
[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein

NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394

G

epidermal growth factor

increases expression
multiple interactions

Adenosine results in increased expression of EGF mRNA
Adenosine results in increased expression of and results in increased secretion of EGF protein

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

estrogen receptor 1

increases expression

Adenosine results in increased expression of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

increases expression

Adenosine results in increased expression of ESR2 protein

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

Fas associated via death domain

decreases expression
multiple interactions

Adenosine results in decreased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas ligand

increases expression
multiple interactions

Adenosine results in increased expression of FASLG protein
[Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA

PMID:11992407 PMID:16419169

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fibroblast growth factor 6

multiple interactions

Adenosine results in increased expression of and results in increased secretion of FGF6 protein

NCBI chr12:4,434,142...4,445,815
Ensembl chr12:4,428,155...4,445,815

G

follicle stimulating hormone subunit beta

increases expression

Adenosine results in increased expression of FSHB protein

NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261

G

frizzled class receptor 3

increases expression

Adenosine results in increased expression of FZD3 mRNA

NCBI chr 8:28,494,212...28,574,258
Ensembl chr 8:28,494,205...28,574,267

G

frizzled class receptor 5

increases expression

Adenosine results in increased expression of FZD5 mRNA

NCBI chr 2:207,762,598...207,769,906
Ensembl chr 2:207,762,598...207,769,906

G

glial cell derived neurotrophic factor

increases secretion

Adenosine results in increased secretion of GDNF protein

NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041

G

glycogen synthase kinase 3 beta

increases phosphorylation
increases expression

Adenosine results in increased phosphorylation of GSK3B protein
Adenosine results in increased expression of GSK3B mRNA

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

granzyme B

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA

NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267

G

H2A.X variant histone

multiple interactions

Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

hypoxia inducible factor 1 subunit alpha

increases expression

Adenosine results in increased expression of HIF1A mRNA

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
increases abundance

Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine]

NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477

G

interferon gamma

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

insulin like growth factor 1

affects expression
multiple interactions

Adenosine affects the expression of IGF1 mRNA
Adenosine results in increased expression of and results in increased secretion of IGF1 protein

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 2

multiple interactions

Adenosine results in increased expression of and results in increased secretion of IGF2 protein

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

interleukin 10

multiple interactions
increases expression

Adenosine promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Adenosine results in increased expression of IL10 mRNA; Adenosine results in increased expression of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 12B

decreases expression
multiple interactions

Adenosine results in decreased expression of IL12B protein
Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 1 beta

multiple interactions

Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 1 receptor type 1

multiple interactions

Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]

NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874

G

interleukin 2

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

lymphoid enhancer binding factor 1

increases expression

Adenosine results in increased expression of LEF1 mRNA

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

lymphocyte antigen 96

increases expression

Adenosine results in increased expression of LY96 mRNA

NCBI chr 8:73,991,392...74,099,857
Ensembl chr 8:73,991,392...74,029,079

G

mitogen-activated protein kinase kinase 1

increases phosphorylation

Adenosine results in increased phosphorylation of MAP2K1 protein

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 2

increases phosphorylation

Adenosine results in increased phosphorylation of MAP2K2 protein

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation

[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

decreases phosphorylation
multiple interactions

Adenosine results in decreased phosphorylation of MAPK3 protein
[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

marker of proliferation Ki-67

affects expression

Adenosine affects the expression of MKI67 mRNA

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

mechanistic target of rapamycin kinase

increases phosphorylation

Adenosine results in increased phosphorylation of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression
multiple interactions

Adenosine results in decreased expression of MYC protein
Adenosine results in increased expression of MYC mRNA
Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein]; Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein]

PMID:9808420 PMID:34070360

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

NFKB inhibitor alpha

multiple interactions

[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 2

decreases stability
multiple interactions

Adenosine results in decreased stability of NOS2 mRNA
Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

5'-nucleotidase ecto

multiple interactions

[alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]

NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791

G

placental growth factor

increases secretion

Adenosine results in increased secretion of PGF protein

NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626

G

PPARG coactivator 1 alpha

increases expression

Adenosine results in increased expression of PPARGC1A mRNA

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

perforin 1

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA

NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759

G

prostaglandin D2 receptor

multiple interactions

[Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine

NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

renin

decreases secretion

Adenosine results in decreased secretion of REN protein

NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324

G

receptor interacting serine/threonine kinase 1

multiple interactions

[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein

NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187

G

ribosomal protein S6 kinase B1

increases phosphorylation

Adenosine results in increased phosphorylation of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

solute carrier family 28 member 1

affects transport
multiple interactions

SLC28A1 protein affects the transport of Adenosine
Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]

NCBI chr15:84,884,662...84,975,649
Ensembl chr15:84,884,654...84,945,798

G

solute carrier family 28 member 2

increases transport

SLC28A2 protein results in increased transport of Adenosine

NCBI chr15:45,252,234...45,277,846
Ensembl chr15:45,252,234...45,277,846

G

solute carrier family 29 member 1 (Augustine blood group)

multiple interactions
increases uptake
affects abundance

4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; [4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]; [SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine; Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
SLC29A1 protein alternative form results in increased uptake of Adenosine; SLC29A1 protein results in increased uptake of Adenosine
Cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; draflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ticagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]
Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
SLC29A1 affects the abundance of Adenosine

PMID:9353301 PMID:9396714 PMID:11179696 PMID:21283641 PMID:21872611 More...

NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142

G

solute carrier family 29 member 2

increases uptake

SLC29A2 protein results in increased uptake of Adenosine

NCBI chr11:66,362,521...66,372,446
Ensembl chr11:66,362,521...66,372,214

G

solute carrier family 29 member 3

affects transport

SLC29A3 protein affects the transport of Adenosine

NCBI chr10:71,319,259...71,381,423
Ensembl chr10:71,319,259...71,381,423

G

solute carrier family 5 member 5

increases expression

Adenosine results in increased expression of SLC5A5 mRNA; Adenosine results in increased expression of SLC5A5 protein

NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174

G

transforming growth factor alpha

increases secretion

Adenosine results in increased secretion of TGFA protein

NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193

G

transforming growth factor beta 1

increases expression

Adenosine results in increased expression of TGFB1 mRNA; Adenosine results in increased expression of TGFB1 protein

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

increases expression
multiple interactions

Adenosine results in increased expression of TGFB2 mRNA
Adenosine results in increased expression of and results in increased secretion of TGFB2 protein

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

toll like receptor 4

increases expression
affects localization
multiple interactions

Adenosine results in increased expression of TLR4 mRNA
Adenosine affects the localization of TLR4 protein
Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein]

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions
decreases expression

5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
Adenosine results in decreased expression of TNF protein

PMID:11023991 PMID:21538184 PMID:24224954

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF alpha induced protein 3

multiple interactions

[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein

NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314

G

TNF superfamily member 10

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728

G

uridine phosphorylase 1

increases metabolic processing

UPP1 protein results in increased metabolism of Adenosine

NCBI chr 7:48,088,704...48,108,736
Ensembl chr 7:48,088,628...48,108,736

G

vascular endothelial growth factor A

multiple interactions
increases expression
increases secretion

Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Adenosine results in increased expression of and results in increased secretion of VEGFA protein
Adenosine results in increased expression of VEGFA mRNA
Adenosine results in increased secretion of VEGFA protein

PMID:20067761 PMID:34070360

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

adenosine 3',5'-bismonophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

sulfotransferase family 1A member 1

multiple interactions

Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

sulfotransferase family 1E member 1

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; Estradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]

NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145

G

sulfotransferase family 2A member 1

affects binding
multiple interactions

adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein
Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]

NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315

adenosine 5'-(hexahydrogen pentaphosphate)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nudix hydrolase 10

multiple interactions

[NUDT10 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate

NCBI chr X:51,332,231...51,337,525
Ensembl chr X:51,332,231...51,337,525

G

nudix hydrolase 11

multiple interactions

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate

NCBI chr X:51,490,011...51,496,592
Ensembl chr X:51,490,011...51,496,592

adenosine 5'-[gamma-thio]triphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD80 molecule

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein

NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614

G

CD86 molecule

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

C-X-C motif chemokine ligand 8

multiple interactions

[adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

interleukin 10

decreases expression

adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 12B

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 1 beta

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

purinergic receptor P2X 7

affects response to substance

P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate)

NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032

G

purinergic receptor P2Y11

multiple interactions

[adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein; adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein

NCBI chr19:10,111,693...10,115,372
Ensembl chr19:10,111,693...10,115,372

G

prostaglandin D2 receptor

multiple interactions

adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]

NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724

G

transient receptor potential cation channel subfamily V member 1

increases activity
multiple interactions

adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein
Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]

NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411

adenosine 5'-monophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

multiple interactions

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]

NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543

G

aldehyde dehydrogenase 1 family member A1

multiple interactions

[4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein

NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442

G

ERCC excision repair 6, chromatin remodeling factor

increases abundance

ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

G

H2A.X variant histone

multiple interactions

Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

potassium inwardly rectifying channel subfamily J member 11

multiple interactions

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]

NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331

G

nudix hydrolase 10

multiple interactions

[NUDT10 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT10 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate

NCBI chr X:51,332,231...51,337,525
Ensembl chr X:51,332,231...51,337,525

G

nudix hydrolase 11

multiple interactions

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate

NCBI chr X:51,490,011...51,496,592
Ensembl chr X:51,490,011...51,496,592

G

PPARG coactivator 1 alpha

increases expression

Adenosine Monophosphate results in increased expression of PPARGC1A mRNA

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728

G

tumor protein p73

affects abundance

TP73 protein affects the abundance of Adenosine Monophosphate

NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201

ADP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions
affects binding

estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; Vanadates promotes the reaction [Adenosine Diphosphate binds to ABCC1 protein]
Adenosine Diphosphate binds to ABCC1 protein; Adenosine Diphosphate binds to ABCC1 protein mutant form

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

aryl hydrocarbon receptor

multiple interactions

Adenosine Diphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

adenylate kinase 1

increases abundance

AK1 protein results in increased abundance of Adenosine Diphosphate

NCBI chr 9:127,866,480...127,879,621
Ensembl chr 9:127,866,486...127,877,675

G

albumin

decreases secretion
multiple interactions

Adenosine Diphosphate results in decreased secretion of ALB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

AXL receptor tyrosine kinase

decreases response to substance

AXL protein results in decreased susceptibility to Adenosine Diphosphate

NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766

G

catalase

multiple interactions

CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

CD40 ligand

increases expression
multiple interactions

Adenosine Diphosphate results in increased expression of CD40LG protein
clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]

PMID:11297035 PMID:17043144

NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390

G

CF transmembrane conductance regulator

multiple interactions

Adenosine Diphosphate binds to and results in decreased activity of CFTR protein; P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein]

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

G

cysteine and histidine rich domain containing 1

multiple interactions

Adenosine Diphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Diphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]

NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077

G

cytochrome P450 family 2 subfamily C member 19

multiple interactions

CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid]

PMID:16772608 PMID:18004210 PMID:18394438

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

deoxythymidylate kinase

multiple interactions

DTYMK protein binds to [N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine co-treated with Adenosine Diphosphate]

NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944

G

dual specificity phosphatase 1

multiple interactions

Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP1 protein]]

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

G

dual specificity phosphatase 6

multiple interactions

Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP6 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP6 protein]]

NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501

G

EPH receptor A4

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein
Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]

NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
decreases activity

Adenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein]
Adenosine Diphosphate results in decreased activity of ERN1 protein

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

coagulation factor II, thrombin

increases abundance
multiple interactions

F2 protein results in increased abundance of Adenosine Diphosphate
Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

fibrinogen alpha chain

multiple interactions
increases secretion

Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein]

NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742

G

fibrinogen beta chain

decreases secretion
multiple interactions

Adenosine Diphosphate results in decreased secretion of FGB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]

NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807

G

fibrinogen gamma chain

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of FGG protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]

NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]

NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374

G

growth arrest specific 6

increases response to substance

GAS6 protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076

G

H2A.X variant histone

multiple interactions

Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

HRas proto-oncogene, GTPase

multiple interactions

Adenosine Diphosphate binds to and affects the folding of HRAS protein

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

isocitrate dehydrogenase (NADP(+)) 2

increases abundance
multiple interactions

IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate]

NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477

G

interleukin 6

increases expression
multiple interactions

Adenosine Diphosphate results in increased expression of IL6 protein
MRS 2211 inhibits the reaction [Adenosine Diphosphate results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha 2

multiple interactions

ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]

NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779

G

integrin subunit alpha 2b

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649

G

integrin subunit beta 1 binding protein 2

multiple interactions

Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr X:71,301,750...71,305,371
Ensembl chr X:71,301,750...71,305,371

G

integrin subunit beta 3

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein
Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]]

PMID:15034929 PMID:32941855

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein
Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK3 protein]]

PMID:15034929 PMID:32941855

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

MER proto-oncogene, tyrosine kinase

increases response to substance

MERTK protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561

G

nitric oxide synthase 2

multiple interactions

NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

5'-nucleotidase ecto

decreases activity

Adenosine Diphosphate analog results in decreased activity of NT5E protein

NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791

G

purinergic receptor P2Y12

affects response to substance
increases response to substance
multiple interactions

P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate; P2RY12 protein affects the susceptibility to Adenosine Diphosphate
P2RY12 protein results in increased susceptibility to Adenosine Diphosphate
Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]
P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]

PMID:11196645 PMID:11413167 PMID:18404433 PMID:23849096

NCBI chr 3:151,336,843...151,384,753
Ensembl chr 3:151,336,843...151,384,753

G

platelet derived growth factor subunit B

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of PDGFB protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]

NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982

G

platelet factor 4

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of PF4 protein
silidianin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; Silybin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]

PMID:19428933 PMID:29439388

NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027

G

phosphofructokinase, muscle

multiple interactions

Adenosine Diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein]

NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404

G

phosphoglycolate phosphatase

decreases phosphorylation

PGP protein results in decreased phosphorylation of Adenosine Diphosphate

NCBI chr16:2,211,593...2,214,840
Ensembl chr16:2,211,593...2,214,840

G

pro-platelet basic protein

increases secretion

Adenosine Diphosphate results in increased secretion of PPBP protein

NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190

G

protein phosphatase 5 catalytic subunit

multiple interactions

Adenosine Diphosphate binds to and affects the folding of PPP5C protein

NCBI chr19:46,347,087...46,390,975
Ensembl chr19:46,347,087...46,392,981

G

protein tyrosine phosphatase non-receptor type 1

increases glutathionylation
multiple interactions

Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein
CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]

NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241

G

selectin P

multiple interactions
increases expression

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]; P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; Quercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein]

PMID:9740346 PMID:18394438 PMID:18404433 PMID:23249183

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

G

sirtuin 3

decreases abundance

SIRT3 protein results in decreased abundance of Adenosine Diphosphate

NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931

G

transaldolase 1

increases abundance

TALDO1 gene mutant form results in increased abundance of Adenosine Diphosphate

NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012

G

thrombospondin 1

increases secretion

Adenosine Diphosphate results in increased secretion of THBS1 protein

NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]

NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728

G

TYRO3 protein tyrosine kinase

increases response to substance

TYRO3 protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr15:41,559,212...41,583,589
Ensembl chr15:41,557,675...41,583,589

G

vasodilator stimulated phosphoprotein

multiple interactions
increases phosphorylation

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of VASP protein]

NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,989

ADP-D-ribose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADP-ribosylarginine hydrolase

increases hydrolysis

ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite

NCBI chr 3:119,579,492...119,589,945
Ensembl chr 3:119,579,268...119,589,945

G

ADP-ribosylserine hydrolase

increases hydrolysis
multiple interactions

ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]

NCBI chr 1:36,088,892...36,093,932
Ensembl chr 1:36,088,892...36,093,932

G

nitric oxide synthase 1

multiple interactions

NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose]

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

G

transient receptor potential cation channel subfamily M member 2

multiple interactions
increases activity

Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]; Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; Glutathione inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]

PMID:18204483 PMID:20878536 PMID:21900507 PMID:22750002 PMID:33309544 More...

NCBI chr21:44,353,621...44,442,644
Ensembl chr21:44,350,163...44,443,081

AMP-PNP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

Adenylyl Imidodiphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

CF transmembrane conductance regulator

affects activity

Adenylyl Imidodiphosphate affects the activity of CFTR protein

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

G

casein kinase 2 alpha 1

affects binding

Adenylyl Imidodiphosphate binds to CSNK2A1 protein

NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835

G

prostaglandin D2 receptor

multiple interactions

Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]

NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724

arachidonoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisome proliferator activated receptor alpha

multiple interactions

arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

ATP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

multiple interactions

Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,867,289...68,955,392

G

ATP binding cassette subfamily B member 1

multiple interactions
affects binding
increases hydrolysis

[Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCB1 protein
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate

PMID:2900677 PMID:14978246 PMID:18829547 PMID:18955043 PMID:22233293 More...

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

multiple interactions

Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions
affects activity
increases hydrolysis
affects binding

[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCC1 protein

PMID:10856430 PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 More...

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

multiple interactions
affects activity
affects metabolic processing

Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat]
Adenosine Triphosphate affects the activity of ABCC2 protein
[Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the metabolism of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine]

PMID:9067317 PMID:9794919 PMID:20060011 PMID:22027652 PMID:24039982 More...

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

multiple interactions

Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine]

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily C member 4 (PEL blood group)

multiple interactions
affects activity
increases hydrolysis

[Adenosine Triphosphate affects the activity of ABCC4 protein] which results in increased transport of Acetaminophen metabolite; ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]

PMID:14978246 PMID:16156793 PMID:32472168

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

ATP binding cassette subfamily C member 6

affects binding

Adenosine Triphosphate binds to ABCC6 protein

NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522

G

ATP binding cassette subfamily C member 8

multiple interactions

Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]

NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894

G

ATP binding cassette subfamily C member 9

multiple interactions

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]

PMID:11390963 PMID:28842488

NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543

G

ATP binding cassette subfamily G member 2 (JR blood group)

increases hydrolysis
multiple interactions

ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]

PMID:18829547 PMID:32003934

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions
increases chemical synthesis

[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]
ABL1 protein mutant form results in increased chemical synthesis of Adenosine Triphosphate

PMID:19366808 PMID:33070465

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acyl-CoA synthetase long chain family member 5

multiple interactions

[ACSL5 protein affects the susceptibility to Palmitic Acid] which affects the abundance of Adenosine Triphosphate

NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379

G

actin alpha 2, smooth muscle

multiple interactions

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ACTA2 mRNA]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ACTA2 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

adenylate cyclase activating polypeptide 1

increases secretion

ADCYAP1 protein results in increased secretion of Adenosine Triphosphate

NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172

G

angiotensin II receptor type 1

multiple interactions
decreases expression

Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]; CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]; Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A protein]

NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008

G

aryl hydrocarbon receptor

multiple interactions

Adenosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

AKT serine/threonine kinase 1

decreases activity
multiple interactions

Adenosine Triphosphate results in decreased activity of AKT1 protein
Alcohols inhibits the reaction [Adenosine Triphosphate results in decreased activity of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

aldehyde dehydrogenase 5 family member A1

increases abundance

ALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate

NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207

G

ALK receptor tyrosine kinase

affects binding
multiple interactions

ALK protein binds to Adenosine Triphosphate
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]

NCBI chr 2:29,192,774...29,921,586
Ensembl chr 2:29,192,774...29,921,586

G

alkaline phosphatase, biomineralization associated

increases response to substance
multiple interactions

ALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]

NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410

G

annexin A1

multiple interactions

[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]

NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393

G

amyloid beta precursor protein

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of APP protein modified form
Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]; Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; Rotenone inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

arrestin beta 2

multiple interactions

Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]

NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499

G

acid sensing ion channel subunit 1

multiple interactions

[Acids binds to and affects the activity of ASIC1 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611

G

acid sensing ion channel subunit 2

multiple interactions

[Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964

G

acid sensing ion channel subunit 3

multiple interactions

[Acids binds to and affects the activity of ASIC3 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756

G

ATPase copper transporting alpha

multiple interactions

[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein

NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395

G

ATPase copper transporting beta

multiple interactions
increases phosphorylation

[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein
Adenosine Triphosphate results in increased phosphorylation of ATP7B protein

PMID:19405516 PMID:20964302

NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125

G

ATPase phospholipid transporting 8B1

increases hydrolysis

ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphate

NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315

G

arginine vasopressin

multiple interactions
increases secretion

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein]

NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724

G

BCL2 apoptosis regulator

multiple interactions

[Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCR activator of RhoGEF and GTPase

multiple interactions

[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]

NCBI chr22:23,180,509...23,318,037
Ensembl chr22:23,179,704...23,318,037

G

baculoviral IAP repeat containing 5

increases abundance

BIRC5 protein results in increased abundance of Adenosine Triphosphate

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

calcineurin binding protein 1

multiple interactions

CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]

NCBI chr22:24,011,304...24,178,628
Ensembl chr22:24,011,192...24,178,628

G

calcitonin related polypeptide alpha

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CALCA protein
Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]

NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354

G

caspase 1

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CASP1 mRNA; Adenosine Triphosphate results in increased activity of CASP1 protein
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein; Acetylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; dapansutrile inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; fraxinellone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form]; neoisoliquiritin affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of CASP1 protein modified form; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein]; dapansutrile inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of CASP1 protein modified form]; Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA]

PMID:18604214 PMID:19130485 PMID:21832250 PMID:23430110 PMID:24149798 More...

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

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caspase 3

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of CASP3
Adenosine Triphosphate inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]

PMID:19448140 PMID:24732427

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

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caspase 4

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein]
Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]

PMID:24149798 PMID:25288807

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

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catalase

increases expression

Adenosine Triphosphate results in increased expression of CAT mRNA

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

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C-C motif chemokine ligand 3

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CCL3 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein]

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

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CF transmembrane conductance regulator

multiple interactions

3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]]; [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Adenosine Triphosphate binds to and results in increased activity of CFTR protein; Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]

PMID:14710196 PMID:15623556 PMID:17178710 PMID:20675434

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

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cysteine and histidine rich domain containing 1

multiple interactions

Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]
Adenosine Triphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]

NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077

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collagen type I alpha 1 chain

multiple interactions

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COL1A1 mRNA]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COL1A1 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

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catechol-O-methyltransferase

multiple interactions

[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975

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carnitine palmitoyltransferase 2

multiple interactions

[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]

NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197

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CRK like proto-oncogene, adaptor protein

multiple interactions

[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]

NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747

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colony stimulating factor 2

multiple interactions

[CSF2 protein affects the susceptibility to stearic acid] which affects the abundance of Adenosine Triphosphate

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

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casein kinase 2 alpha 1

multiple interactions
affects binding

silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]

NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835

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casein kinase 2 beta

multiple interactions
affects binding

silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]

NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343

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cystatin B

multiple interactions

Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]

NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330

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cathepsin B

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CTSB protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein]

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

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C-X-C motif chemokine ligand 2

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CXCL2 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein]

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

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dystrophin

increases secretion
multiple interactions

DMD gene mutant form results in increased secretion of Adenosine Triphosphate
Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate]

NCBI chr X:31,119,222...33,339,388
Ensembl chr X:31,097,677...33,339,609

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dual specificity phosphatase 1

multiple interactions

Adenosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP1 protein]]

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

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dual specificity phosphatase 6

multiple interactions

Adenosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP6 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP6 protein]]

NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501

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epidermal growth factor receptor

multiple interactions
increases phosphorylation

sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

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early growth response 1

multiple interactions
increases expression

Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

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ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]

NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453

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ectonucleotide pyrophosphatase/phosphodiesterase 7

decreases activity

Adenosine Triphosphate results in decreased activity of ENPP7 protein

NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,730,943...79,742,219

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ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate
nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate]

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

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coagulation factor II, thrombin

multiple interactions
increases transport
increases abundance
increases secretion

2,4,3',5'-tetramethoxystilbene inhibits the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; [RWJ-56110 co-treated with 2,4,3',5'-tetramethoxystilbene] inhibits the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]; Resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]
STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate]

PMID:2030746 PMID:15342215 PMID:30696774 PMID:35288162

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

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family with sequence similarity 66 member C

increases abundance
multiple interactions

FAM66C mRNA results in increased abundance of Adenosine Triphosphate
[[FAM66C mRNA binds to and results in decreased expression of MIR23 mRNA] which results in increased expression of KCND2 protein] which results in increased abundance of Adenosine Triphosphate

NCBI chr12:8,180,209...8,201,000
Ensembl chr12:8,180,207...8,216,151

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fatty acid synthase

multiple interactions
decreases abundance

FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; Protein Kinase Inhibitors inhibits the reaction [FASN protein results in decreased abundance of Adenosine Triphosphate]

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

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fructose-bisphosphatase 1

multiple interactions

[Enzyme Inhibitors results in decreased activity of FBP1 protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249

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F-box protein 3

multiple interactions

FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]

NCBI chr11:33,740,944...33,774,520
Ensembl chr11:33,740,939...33,774,543

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Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of FOS mRNA
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
[Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; Glucose affects the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]

PMID:10723097 PMID:19463813 PMID:27466191

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

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fascin actin-bundling protein 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]

NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655

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glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]

NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374

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growth hormone 1

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of GH1 protein
NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]

NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839

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gap junction protein alpha 1

increases export

GJA1 protein mutant form results in increased export of Adenosine Triphosphate; GJA1 protein results in increased export of Adenosine Triphosphate

NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727

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gasdermin D

multiple interactions

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]

PMID:33851234 PMID:34212273 PMID:34217685 PMID:35962723 PMID:36577999 More...

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

G

glutathione S-transferase pi 1

multiple interactions

[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

H2A.X variant histone

multiple interactions

Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; U 0126 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

HCK proto-oncogene, Src family tyrosine kinase

multiple interactions
affects binding

[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]

NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein]

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

hexokinase 1

multiple interactions

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein]

NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884

G

hexokinase 2

multiple interactions

[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of HK2 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of HK2 protein

NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359

G

high mobility group box 1

affects chemical synthesis
multiple interactions

HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein; Adenosine Triphosphate promotes the reaction [fullerene C60 results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein]

PMID:21641551 PMID:31504961 PMID:34405489

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

heme oxygenase 1

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein]

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family B (small) member 1

affects chemical synthesis

HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Neomycin inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; resveratrol inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

intercellular adhesion molecule 1

multiple interactions

Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon gamma

multiple interactions

Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 12B

multiple interactions

Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 18

multiple interactions
increases secretion

[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
Adenosine Triphosphate results in increased secretion of IL18 protein
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein]; prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA]

PMID:17404311 PMID:24149798 PMID:26431797 PMID:27311643 PMID:29378952 More...

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 alpha

multiple interactions

(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

multiple interactions
increases secretion
decreases abundance

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein; Enzyme Inhibitors inhibits the reaction [IL1B protein results in decreased abundance of Adenosine Triphosphate]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]
Adenosine Triphosphate results in increased secretion of IL1B protein
(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased secretion of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; dapansutrile inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and affects the cleavage of IL1B protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; dapansutrile inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; L 709049 inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; neoisoliquiritin affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]

PMID:10365824 PMID:14623498 PMID:17404311 PMID:18604214 PMID:19130485 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

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interleukin 6

multiple interactions
increases expression

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein]; NF157 compound inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; resveratrol inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]
[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL6 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL6 mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]; MRS 2211 inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]

PMID:17707769 PMID:24793913 PMID:24849676 PMID:25348860 PMID:26104857 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

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insulin

multiple interactions

[ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; INS protein inhibits the reaction [Acetaminophen results in decreased abundance of Adenosine Triphosphate]; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]

PMID:17965850 PMID:26739624

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

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INS-IGF2 readthrough

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of INS1 protein
Adenosine Triphosphate inhibits the reaction [Glucose results in increased secretion of INS1 protein]
[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]

PMID:10535451 PMID:10780946 PMID:16366736 PMID:22221676

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

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interferon regulatory factor 2

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IRF2 mRNA; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IRF2 mRNA]

NCBI chr 4:184,387,729...184,474,550
Ensembl chr 4:184,385,702...184,474,558

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integrin subunit beta 1 binding protein 2

multiple interactions

Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]]
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr X:71,301,750...71,305,371
Ensembl chr X:71,301,750...71,305,371

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Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

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potassium voltage-gated channel subfamily D member 2

increases abundance
multiple interactions

KCND2 protein results in increased abundance of Adenosine Triphosphate
[[FAM66C mRNA binds to and results in decreased expression of MIR23 mRNA] which results in increased expression of KCND2 protein] which results in increased abundance of Adenosine Triphosphate; [[MIR23B mRNA binds to KCND2 3' UTR] which results in decreased expression of KCND2 protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337

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potassium voltage-gated channel subfamily H member 2

decreases activity

Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

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potassium inwardly rectifying channel subfamily J member 11

multiple interactions
decreases response to substance

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
KCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate

PMID:11390963 PMID:28842488

NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331

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potassium inwardly rectifying channel subfamily J member 15

increases activity

Adenosine Triphosphate results in increased activity of KCNJ15 protein

NCBI chr21:38,229,926...38,307,357
Ensembl chr21:38,155,549...38,307,357

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potassium inwardly rectifying channel subfamily J member 8

multiple interactions
decreases response to substance

Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
KCNJ8 protein mutant form results in decreased susceptibility to Adenosine Triphosphate

NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600

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ketohexokinase

multiple interactions

KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]

NCBI chr 2:27,086,772...27,100,762
Ensembl chr 2:27,086,772...27,100,762

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kinesin family member 5A

multiple interactions
increases hydrolysis

Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]; Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]

PMID:24239783 PMID:28122263

NCBI chr12:57,550,044...57,586,633
Ensembl chr12:57,546,026...57,586,633

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leptin

multiple interactions

[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

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lipase E, hormone sensitive type

increases activity

Adenosine Triphosphate results in increased activity of LIPE protein

NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388

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lipoprotein lipase

affects response to substance

LPL protein affects the susceptibility to Adenosine Triphosphate

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

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mitogen-activated protein kinase kinase 1

affects binding

Adenosine Triphosphate binds to MAP2K1 protein

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

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mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein]

PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

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mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK3 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK3 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK3 protein]]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein]

PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

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