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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azepanes
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Accession:CHEBI:46986 term browser browse the term



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3-(3-ethyl-1-methyl-3-azepanyl)phenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Meptazinol results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
5-(N,N-hexamethylene)amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of DDIT3 mRNA CTD PMID:19302589 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSP90B1 mRNA CTD PMID:19302589 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSPA5 mRNA CTD PMID:19302589 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PPP1R15A mRNA CTD PMID:19302589 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PTGS2 mRNA CTD PMID:19302589 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions ISO 5-(N,N-hexamethylene)amiloride results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form CTD PMID:25447644 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
molinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO molinate inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]; molinate metabolite binds to and results in decreased activity of ALDH2 protein; molinate metabolite inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde] CTD PMID:20954713 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Lhb luteinizing hormone subunit beta affects secretion EXP molinate affects the secretion of LHB protein CTD PMID:15601673 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO molinate results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO molinate results in increased activity of and results in increased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          nitrogen atom 18778
            nitrogen molecular entity 18778
              organonitrogen compound 18555
                organonitrogen heterocyclic compound 17670
                  azepanes 11
                    1-azepan-1-yl-2-phenyl-2-(4-thioxo-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-yl)ethanone adduct 0
                    3-(3-ethyl-1-methyl-3-azepanyl)phenol 1
                    5-(N,N-hexamethylene)amiloride 6
                    7-(1-azepanyl)-2-oxoheptanal oxime 0
                    Cetiedil 0
                    N-[(1S)-3-methyl-1-(\{(4S)-3-oxo-1-[(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl\}carbamoyl)butyl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide 0
                    N-[(1S)-3-methyl-1-\{[(4S)-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-yl]carbamoyl\}butyl]-1-benzofuran-2-carboxamide 0
                    N-[(3R,4R)-4-\{[(4-\{[5-(3,3-dimethylpiperidin-1-yl)-2-fluoro-6-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                    N-[(3R,4R)-4-\{[(4-\{[5-(3,3-dimethylpiperidin-1-yl)-2-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                    N-[(3R,4R)-4-\{[(4-\{[5-(4,4-dimethylpiperidin-1-yl)-2-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                    N-\{(3R,4R)-4-[(\{4-[(2-hydroxy-5-piperidin-1-ylphenyl)carbonyl]phenyl\}carbonyl)amino]azepan-3-yl\}isonicotinamide 0
                    azepane 0
                    buzepide 0
                    ethoheptazine 0
                    molinate 4
                    trimethidinium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organic heteromonocyclic compound 17116
                                    azepanes 11
                                      1-azepan-1-yl-2-phenyl-2-(4-thioxo-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-yl)ethanone adduct 0
                                      3-(3-ethyl-1-methyl-3-azepanyl)phenol 1
                                      5-(N,N-hexamethylene)amiloride 6
                                      7-(1-azepanyl)-2-oxoheptanal oxime 0
                                      Cetiedil 0
                                      N-[(1S)-3-methyl-1-(\{(4S)-3-oxo-1-[(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl\}carbamoyl)butyl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide 0
                                      N-[(1S)-3-methyl-1-\{[(4S)-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-yl]carbamoyl\}butyl]-1-benzofuran-2-carboxamide 0
                                      N-[(3R,4R)-4-\{[(4-\{[5-(3,3-dimethylpiperidin-1-yl)-2-fluoro-6-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                                      N-[(3R,4R)-4-\{[(4-\{[5-(3,3-dimethylpiperidin-1-yl)-2-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                                      N-[(3R,4R)-4-\{[(4-\{[5-(4,4-dimethylpiperidin-1-yl)-2-hydroxyphenyl]carbonyl\}phenyl)carbonyl]amino\}azepan-3-yl]isonicotinamide 0
                                      N-\{(3R,4R)-4-[(\{4-[(2-hydroxy-5-piperidin-1-ylphenyl)carbonyl]phenyl\}carbonyl)amino]azepan-3-yl\}isonicotinamide 0
                                      azepane 0
                                      buzepide 0
                                      ethoheptazine 0
                                      molinate 4
                                      trimethidinium 0
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