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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indolyl carboxylate ester
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Accession:CHEBI:46939 term browser browse the term
Synonyms:related_synonym: indolyl carboxylate esters


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GR 113808 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
affects binding
ISO
EXP
GR 113808 binds to and results in decreased activity of HTR4 protein
GR 113808 binds to HTR4 protein
CTD PMID:11020291 PMID:12736770 PMID:15236628 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]] CTD PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:30611738 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]] CTD PMID:30611738 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
LM-1685 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in decreased expression of AKT1 protein modified form] CTD PMID:15867384 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased cleavage of CASP3 protein] CTD PMID:15867384 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in decreased expression of CCND1 protein] CTD PMID:15867384 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased activity of MAPK1 protein] CTD PMID:15867384 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased activity of MAPK3 protein] CTD PMID:15867384 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased cleavage of PARP1 protein] CTD PMID:15867384 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cst3 cystatin C multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] CTD PMID:23285267 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP tropisetron results in increased expression of HMOX1 protein
SB 203580 inhibits the reaction [tropisetron results in increased expression of HMOX1 protein]
CTD PMID:23285267 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:24374478 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
tropisetron results in decreased expression of IL6 protein
CTD PMID:23285267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA] CTD PMID:33387473 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA] CTD PMID:33387473 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:23285267 PMID:25837923 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:33387473 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of TNF protein]; tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:23285267 PMID:24374478 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:33387473 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        inorganic group 19265
          oxo group 18667
            organic oxo compound 18667
              carbonyl compound 18667
                carboxylic ester 15889
                  indolyl carboxylate ester 24
                    1H-indole-3-carboxylate ester + 0
                    4-(indol-3-yl)butanoyl-beta-D-glucose 0
                    4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylic acid propan-2-yl ester 0
                    GR 113808 5
                    LM-1685 6
                    acremoauxin A 0
                    indoleacetic acid ester conjugate + 0
                    methyl (6-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetate 0
                    tropisetron 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      benzopyrrole 9559
                                        indoles 9231
                                          indolyl carboxylate ester 24
                                            1H-indole-3-carboxylate ester + 0
                                            4-(indol-3-yl)butanoyl-beta-D-glucose 0
                                            4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylic acid propan-2-yl ester 0
                                            GR 113808 5
                                            LM-1685 6
                                            acremoauxin A 0
                                            indoleacetic acid ester conjugate + 0
                                            methyl (6-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetate 0
                                            tropisetron 16
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