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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indolyl carboxylate ester
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Accession:CHEBI:46939 term browser browse the term
Synonyms:related_synonym: indolyl carboxylate esters


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GR 113808 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
affects binding
ISO
EXP
GR 113808 binds to and results in decreased activity of HTR4 protein
GR 113808 binds to HTR4 protein
CTD PMID:11020291, PMID:12736770, PMID:15236628 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698
JBrowse link
LM-1685 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in decreased expression of AKT1 protein modified form] CTD PMID:15867384 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased cleavage of CASP3 protein] CTD PMID:15867384 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in decreased expression of CCND1 protein] CTD PMID:15867384 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased activity of MAPK1 protein] CTD PMID:15867384 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased activity of MAPK3 protein] CTD PMID:15867384 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased cleavage of PARP1 protein] CTD PMID:15867384 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] CTD PMID:23285267 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP tropisetron results in increased expression of HMOX1 protein
SB 203580 inhibits the reaction [tropisetron results in increased expression of HMOX1 protein]
CTD PMID:23285267 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:24374478 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
tropisetron results in decreased expression of IL6 protein
CTD PMID:23285267 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:23285267, PMID:25837923 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of TNF protein]; tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:23285267, PMID:24374478 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        inorganic group 19148
          oxo group 18391
            organic oxo compound 18391
              carbonyl compound 18391
                carboxylic ester 14077
                  indolyl carboxylate ester 18
                    1H-indole-3-carboxylate ester + 0
                    4-(indol-3-yl)butanoyl-beta-D-glucose 0
                    4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylic acid propan-2-yl ester 0
                    GR 113808 1
                    LM-1685 6
                    acremoauxin A 0
                    indoleacetic acid ester conjugate + 0
                    methyl (6-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetate 0
                    tropisetron 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzopyrrole 9340
                                        indoles 9194
                                          indolyl carboxylate ester 18
                                            1H-indole-3-carboxylate ester + 0
                                            4-(indol-3-yl)butanoyl-beta-D-glucose 0
                                            4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylic acid propan-2-yl ester 0
                                            GR 113808 1
                                            LM-1685 6
                                            acremoauxin A 0
                                            indoleacetic acid ester conjugate + 0
                                            methyl (6-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetate 0
                                            tropisetron 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.