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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nonivamide
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Accession:CHEBI:46936 term browser browse the term
Definition:A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Synonyms:exact_synonym: N-(4-hydroxy-3-methoxybenzyl)nonanamide
 related_synonym: Formula=C17H27NO3;   Hydroxymethoxybenzyl pelargonamide;   InChI=1S/C17H27NO3/c1-3-4-5-6-7-8-9-17(20)18-13-14-10-11-15(19)16(12-14)21-2/h10-12,19H,3-9,13H2,1-2H3,(H,18,20);   InChIKey=RGOVYLWUIBMPGK-UHFFFAOYSA-N;   N-Nonanoyl vanillylamide;   N-Vanillylnonamide;   N-Vanillylpelargonamide;   Pelargonyl vanillylamide;   Pseudocapsaicin;   SMILES=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1;   Vanillyl-N-nonylamide
 xref: Beilstein:2144300;   CAS:2444-46-4
 xref_mesh: MESH:C040937
 xref: Reaxys:2144300;   Wikipedia:Nonivamide

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nonivamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression
multiple interactions		 ISO nonivamide results in increased expression of ATF3 mRNA
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA		 CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO [nonivamide binds to and results in increased activity of CCND1 protein] which results in decreased expression of CCND1 mRNA
nonivamide results in decreased expression of CCND1 mRNA		 CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccng2 cyclin G2 multiple interactions
increases expression		 ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA
nonivamide results in increased expression of CCNG2 mRNA		 CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO nonivamide results in increased expression of CXCL2 mRNA CTD PMID:22155782 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO nonivamide results in increased expression of CXCL1 mRNA CTD PMID:22155782 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases response to substance
multiple interactions
affects expression
increases expression		 ISO DDIT3 protein results in decreased susceptibility to nonivamide
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA
nonivamide affects the expression of DDIT3 mRNA
nonivamide results in increased expression of DDIT3 mRNA; nonivamide results in increased expression of DDIT3 protein		 CTD PMID:17332266 PMID:21343315 PMID:21949157 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation
decreases response to substance		 ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide]
nonivamide results in increased phosphorylation of EIF2A protein		 CTD PMID:17332266 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression		 ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA
nonivamide results in increased expression of GADD45A mRNA		 CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA
nonivamide results in increased expression of HSPA5 mRNA		 CTD PMID:17332266 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO nonivamide results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il6 interleukin 6 increases expression ISO nonivamide results in increased expression of IL6 mRNA CTD PMID:22155782 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases response to substance
increases activity		 ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; nonivamide binds to and results in increased activity of TRPV1 protein
TRPV1 protein results in increased susceptibility to nonivamide
nonivamide results in increased activity of TRPV1 protein		 CTD PMID:17332266 PMID:21343315 PMID:22155782 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biophysical role 12655
          lachrymator 62
            nonivamide 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                monocarboxylic acid amide 14583
                                                  fatty amide 771
                                                    capsaicinoid 494
                                                      nonivamide 12
paths to the root