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G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO |
nonivamide results in increased expression of ATF3 mRNA [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA |
CTD |
PMID:17332266 |
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NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
[nonivamide binds to and results in increased activity of CCND1 protein] which results in decreased expression of CCND1 mRNA nonivamide results in decreased expression of CCND1 mRNA |
CTD |
PMID:17332266 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Ccng2 |
cyclin G2 |
multiple interactions increases expression |
ISO |
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA nonivamide results in increased expression of CCNG2 mRNA |
CTD |
PMID:17332266 |
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NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
nonivamide results in increased expression of CXCL2 mRNA |
CTD |
PMID:22155782 |
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NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
nonivamide results in increased expression of CXCL1 mRNA |
CTD |
PMID:22155782 |
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NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
decreases response to substance multiple interactions affects expression increases expression |
ISO |
DDIT3 protein results in decreased susceptibility to nonivamide [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA nonivamide affects the expression of DDIT3 mRNA nonivamide results in increased expression of DDIT3 mRNA; nonivamide results in increased expression of DDIT3 protein |
CTD |
PMID:17332266 PMID:21343315 PMID:21949157 |
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NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases phosphorylation decreases response to substance |
ISO |
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide] nonivamide results in increased phosphorylation of EIF2A protein |
CTD |
PMID:17332266 |
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NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions increases expression |
ISO |
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA nonivamide results in increased expression of GADD45A mRNA |
CTD |
PMID:17332266 |
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NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA nonivamide results in increased expression of HSPA5 mRNA |
CTD |
PMID:17332266 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
nonivamide results in increased expression of IGF1 protein |
CTD |
PMID:17307377 |
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NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
nonivamide results in increased expression of IL6 mRNA |
CTD |
PMID:22155782 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions increases response to substance increases activity |
ISO |
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; nonivamide binds to and results in increased activity of TRPV1 protein TRPV1 protein results in increased susceptibility to nonivamide nonivamide results in increased activity of TRPV1 protein |
CTD |
PMID:17332266 PMID:21343315 PMID:22155782 |
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NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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