CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (R)-pantothenic acid
Accession: CHEBI:46905
browse the term
Definition: A pantothenic acid having R-configuration.
Synonyms: exact_synonym: 3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoic acid
related_synonym: (R)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine; D(+)-N-(2,4-dihydroxy-3,3-dimethylbutyryl)-beta-alanine; D-pantothenic acid; Formula=C9H17NO5; InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)/t7-/m0/s1; InChIKey=GHOKWGTUZJEAQD-ZETCQYMHSA-N; N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanine; PANTOTHENOIC ACID; Pantothenic acid; SMILES=CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O; chick antidermatitis factor; vitamin B5
alt_id: CHEBI:18701; CHEBI:44679
xref: Beilstein:1727064; CAS:79-83-4; DrugBank:DB01783; Drug_Central:2055; HMDB:HMDB0000210; KEGG:C00864; KEGG:D07413; KNApSAcK:C00001550
xref_mesh: MESH:D010205
xref: MetaCyc:PANTOTHENATE; PDBeChem:PAU; PMID:12664639; PMID:14675432; PMID:15065769; PMID:15912738; PMID:16042590; PMID:17023940; PMID:17439666; PMID:17913047; PMID:19959891; PMID:22052867; PMID:22468352; PMID:5352084; Reaxys:1727064; Wikipedia:Pantothenic_Acid
cyclic_relationship: is_conjugate_acid_of CHEBI:29032
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Atoh8
atonal bHLH transcription factor 8
increases expression
ISO
Pantothenic Acid results in increased expression of ATOH8 mRNA
CTD
PMID:19397697
NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]
CTD
PMID:24709313
NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
Pantothenic Acid results in increased expression of CYP1B1 mRNA
CTD
PMID:19397697
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Fam43a
family with sequence similarity 43, member A
increases expression
ISO
Pantothenic Acid results in increased expression of FAM43A mRNA
CTD
PMID:19397697
NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984
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Fut7
fucosyltransferase 7
decreases expression
ISO
Pantothenic Acid results in decreased expression of FUT7 mRNA
CTD
PMID:19397697
NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648
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Hmox1
heme oxygenase 1
increases expression
ISO
Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein
CTD
PMID:19397697
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hspb7
heat shock protein family B (small) member 7
increases expression
ISO
Pantothenic Acid results in increased expression of HSPB7 mRNA
CTD
PMID:19397697
NCBI chr 5:159,968,077...159,971,563
Ensembl chr 5:159,967,839...159,971,562
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Id1
inhibitor of DNA binding 1, HLH protein
increases expression
ISO
Pantothenic Acid results in increased expression of ID1 mRNA
CTD
PMID:19397697
NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
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Id3
inhibitor of DNA binding 3, HLH protein
increases expression
ISO
Pantothenic Acid results in increased expression of ID3 mRNA
CTD
PMID:19397697
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
increases abundance multiple interactions
ISO
IDH2 protein mutant form results in increased abundance of Pantothenic Acid Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]
CTD
PMID:27469509
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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Il6
interleukin 6
increases expression
ISO
Pantothenic Acid results in increased expression of IL6 mRNA
CTD
PMID:19397697
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Lepr
leptin receptor
affects abundance
ISO
LEPR affects the abundance of Pantothenic Acid
CTD
PMID:20567778
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Marchf2
membrane associated ring-CH-type finger 2
increases expression
ISO
Pantothenic Acid results in increased expression of MARCHF2 mRNA
CTD
PMID:19397697
NCBI chr 7:18,559,301...18,585,351
Ensembl chr 7:18,559,205...18,585,313
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Mtres1
mitochondrial transcription rescue factor 1
increases expression
ISO
Pantothenic Acid results in increased expression of MTRES1 mRNA
CTD
PMID:19397697
NCBI chr20:48,276,101...48,294,975
Ensembl chr20:48,275,762...48,294,948
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Myb
MYB proto-oncogene, transcription factor
multiple interactions
ISO
Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]
CTD
PMID:16112698
NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
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Mycn
MYCN proto-oncogene, bHLH transcription factor
increases expression
ISO
Pantothenic Acid results in increased expression of MYCN mRNA
CTD
PMID:19397697
NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
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Nhlrc1
NHL repeat containing E3 ubiquitin protein ligase 1
increases expression
ISO
Pantothenic Acid results in increased expression of NHLRC1 mRNA
CTD
PMID:19397697
NCBI chr17:18,059,382...18,060,572
Ensembl chr17:18,059,382...18,060,572
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
[Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA
CTD
PMID:20505214
NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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Nrep
neuronal regeneration related protein
increases expression
ISO
Pantothenic Acid results in increased expression of NREP mRNA
CTD
PMID:19397697
NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein]
CTD
PMID:16112698
NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
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Pou3f4
POU class 3 homeobox 4
increases expression
ISO
Pantothenic Acid results in increased expression of POU3F4 mRNA
CTD
PMID:19397697
NCBI chr X:82,143,789...82,145,066
Ensembl chr X:82,143,789...82,145,066
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Ptprcap
protein tyrosine phosphatase, receptor type, C-associated protein
increases expression
ISO
Pantothenic Acid results in increased expression of PTPRCAP mRNA
CTD
PMID:19397697
NCBI chr 1:219,403,970...219,406,129
Ensembl chr 1:219,403,970...219,406,128
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Slc51b
solute carrier family 51 subunit beta
increases expression
ISO
Pantothenic Acid results in increased expression of SLC51B mRNA
CTD
PMID:19397697
NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
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Slc5a6
solute carrier family 5 member 6
increases transport multiple interactions
EXP ISO
SLC5A6 results in increased transport of Pantothenic Acid Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid] Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD
PMID:9516450 PMID:10329687
NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
Pantothenic Acid results in decreased expression of SOX2 mRNA
CTD
PMID:19397697
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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Tmem18
transmembrane protein 18
increases expression
ISO
Pantothenic Acid results in increased expression of TMEM18 mRNA
CTD
PMID:19397697
NCBI chr 6:49,529,228...49,534,960
Ensembl chr 6:49,529,228...49,536,648
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Zfp575
zinc finger protein 575
decreases expression
ISO
Pantothenic Acid results in decreased expression of ZNF575 mRNA
CTD
PMID:19397697
NCBI chr 1:81,447,987...81,450,156
Ensembl chr 1:81,447,987...81,450,094
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