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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1'-acetoxychavicol acetate
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Accession:CHEBI:469 term browser browse the term
Definition:An acetate ester that is chavicol acetate substituted by an acetoxy group at position 1'.
Synonyms:exact_synonym: (1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate
 related_synonym: (alphaS)-4-(Acetyloxy)-alpha-ethenylbenzenemethanol;   Formula=C13H14O4;   InChI=1S/C13H14O4/c1-4-13(17-10(3)15)11-5-7-12(8-6-11)16-9(2)14/h4-8,13H,1H2,2-3H3/t13-/m0/s1;   InChIKey=JAMQIUWGGBSIKZ-ZDUSSCGKSA-N;   SMILES=CC(=O)O[C@@H](C=C)c1ccc(OC(C)=O)cc1
 xref: CAS:52946-22-2;   KEGG:C10426;   KNApSAcK:C00002711
 xref_mesh: MESH:C047948
 xref: PMID:15899834;   PMID:24480522;   PMID:25301089;   Reaxys:2376729


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1'-acetoxychavicol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:15905586 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15905586 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] CTD PMID:15905586 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15905586 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15905586 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15905586 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15905586 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15905586 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15905586 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO 1'-acetoxychavicol acetate analog results in decreased activity of GSR protein
1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]
CTD PMID:20230805 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15905586 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein] CTD PMID:15905586 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of RELA protein] CTD PMID:15905586 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein] CTD PMID:15905586 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1'-acetoxychavicol acetate results in increased phosphorylation of MAPK1 protein
[1'-acetoxychavicol acetate co-treated with Butyric Acid] results in increased phosphorylation of MAPK1 protein
CTD PMID:24480522 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [1'-acetoxychavicol acetate co-treated with Butyric Acid] results in increased phosphorylation of MAPK3 protein
1'-acetoxychavicol acetate results in increased phosphorylation of MAPK3 protein
CTD PMID:24480522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15905586 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:15905586 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [Doxorubicin results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15905586 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:15905586 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15905586 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15905586 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO 1'-acetoxychavicol acetate inhibits the reaction [Doxorubicin results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein affects the localization of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
1'-acetoxychavicol acetate results in decreased activity of RELA protein
CTD PMID:15905586 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein affects the localization of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of CHUK protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MYC protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRADD protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; 1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15905586 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein] CTD PMID:15905586 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [1'-acetoxychavicol acetate co-treated with Butyric Acid] results in increased phosphorylation of TP53 protein CTD PMID:24480522 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRADD protein] CTD PMID:15905586 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein] CTD PMID:15905586 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein] CTD PMID:15905586 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of VEGFA protein] CTD PMID:15905586 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15905586 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        inhibitor 18584
          NF-kappaB inhibitor 2257
            1'-acetoxychavicol acetate 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            acetate ester 3875
                                              1'-acetoxychavicol acetate 31
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