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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzoxadiazole
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Accession:CHEBI:46829 term browser browse the term
Synonyms:related_synonym: benzoxadiazoles



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Isradipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Isradipine results in decreased activity of ABCB11 protein
Isradipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Isradipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]; omega-conotoxin-MVIIC promotes the reaction [Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:11179973 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO Isradipine inhibits the reaction [CACNA1F protein results in increased transport of Barium] CTD PMID:14744918 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO Isradipine results in increased expression of CYP1A1 mRNA
Isradipine results in decreased activity of CYP1A1 protein
CTD PMID:27732883 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Isradipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Isradipine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Isradipine results in increased expression of CYP2B6 mRNA; Isradipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Isradipine results in decreased activity of CYP2C9 protein CTD PMID:27732883 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
affects metabolic processing
ISO Isradipine results in increased expression of CYP3A4 mRNA
Isradipine results in increased expression of and results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Isradipine
CTD PMID:15286053 PMID:27732883 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fgf2 fibroblast growth factor 2 increases secretion ISO Isradipine results in increased secretion of FGF2 protein CTD PMID:15257873 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Isradipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Penk proenkephalin multiple interactions EXP Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA] CTD PMID:18947822 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Ren renin increases activity ISO Isradipine results in increased activity of REN protein CTD PMID:2550243 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    chemical entity 19902
      atom 19902
        nonmetal atom 19838
          nitrogen atom 18998
            nitrogen molecular entity 18998
              organonitrogen compound 18841
                organonitrogen heterocyclic compound 18179
                  benzoxadiazole 17
                    1-(2,1,3-benzoxadiazol-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone 0
                    1-oleoyl-2-\{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phospho-L-serine 0
                    2,1,3-Benzoxadiazole 0
                    202-791 0
                    4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester 0
                    4-Methyl-2,1,3-benzoxadiazole 0
                    4-[(4-phenethyl-1,4-diazepan-1-yl)sulfonyl]-2,1,3-benzoxadiazole 0
                    4-chloro-7-nitrobenzofurazan 0
                    7-benzylamino-4-nitrobenz-2-oxa-1,3-diazole 0
                    7-chloro-5-(4-morpholinyl)-2,1,3-benzoxadiazol-4-amine 0
                    7-nitrobenzoxadiazole-6-aminohexanoic acid 0
                    C-12 NBD-dihydro-ceramide 0
                    HCK-123 dye 0
                    Isradipine 17
                    N-[2-(2-oxo-1-imidazolidinyl)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide 0
                    N5,N5-dimethyl-2,1,3-benzoxadiazole-4,5-diamine 0
                    O-(7-amino-1,3-dihydro-2,1,3-benzoxadiazol-4-yl)-L-tyrosine 0
                    PN-204-144 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19852
                    p-block element atom 19852
                      carbon group element atom 19797
                        carbon atom 19792
                          organic molecular entity 19792
                            organic molecule 19746
                              organic cyclic compound 19551
                                organic heterocyclic compound 18894
                                  organic heteropolycyclic compound 18324
                                    organic heterobicyclic compound 17270
                                      benzoxadiazole 17
                                        1-(2,1,3-benzoxadiazol-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone 0
                                        1-oleoyl-2-\{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phospho-L-serine 0
                                        2,1,3-Benzoxadiazole 0
                                        202-791 0
                                        4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester 0
                                        4-Methyl-2,1,3-benzoxadiazole 0
                                        4-[(4-phenethyl-1,4-diazepan-1-yl)sulfonyl]-2,1,3-benzoxadiazole 0
                                        4-chloro-7-nitrobenzofurazan 0
                                        7-benzylamino-4-nitrobenz-2-oxa-1,3-diazole 0
                                        7-chloro-5-(4-morpholinyl)-2,1,3-benzoxadiazol-4-amine 0
                                        7-nitrobenzoxadiazole-6-aminohexanoic acid 0
                                        C-12 NBD-dihydro-ceramide 0
                                        HCK-123 dye 0
                                        Isradipine 17
                                        N-[2-(2-oxo-1-imidazolidinyl)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide 0
                                        N5,N5-dimethyl-2,1,3-benzoxadiazole-4,5-diamine 0
                                        O-(7-amino-1,3-dihydro-2,1,3-benzoxadiazol-4-yl)-L-tyrosine 0
                                        PN-204-144 0
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