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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dofetilide
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Accession:CHEBI:4681 term browser browse the term
Definition:A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug.
Synonyms:exact_synonym: N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
 related_synonym: Formula=C19H27N3O5S2;   InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3;   InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N;   SMILES=CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1;   Tikosyn;   beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;   dofetilida;   dofetilidum
 xref: CAS:115256-11-6;   DrugBank:DB00204;   Drug_Central:942;   KEGG:C07751;   KEGG:D00647;   LINCS:LSM-5925
 xref_mesh: MESH:C063533
 xref: PMID:11326815;   PMID:25620152;   PMID:25626340;   Patent:EP245997;   Patent:US4959366;   Reaxys:3572833;   Wikipedia:Dofetilide


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dofetilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1B FKBP prolyl isomerase 1B multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] CTD PMID:20723002 NCBI chr 2:24,033,206...24,063,681
Ensembl chr 2:24,049,701...24,063,681 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects binding		 EXP [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein; Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]; dofetilide binds to and results in decreased activity of KCNH2 protein; dofetilide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium affects the reaction [dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]]; Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium promotes the reaction [dofetilide binds to KCNH2 protein] CTD PMID:9395068 PMID:10828461 PMID:15272206 PMID:15821840 PMID:15961988 More... NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein] CTD PMID:20723002 NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905 		JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein] CTD PMID:20723002 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            cardiovascular drug 8765
              anti-arrhythmia drug 1505
                dofetilide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              oxoacid 22975
                                chalcogen oxoacid 14506
                                  sulfur oxoacid 14255
                                    sulfonic acid 11958
                                      sulfonic acid derivative 11958
                                        sulfonamide 5298
                                          dofetilide 4
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