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Accession:CHEBI:4681 term browser browse the term
Definition:A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug.
Synonyms:exact_synonym: N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
 related_synonym: Formula=C19H27N3O5S2;   InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3;   InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N;   SMILES=CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1;   Tikosyn;   beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;   dofetilida;   dofetilidum
 xref: CAS:115256-11-6;   DrugBank:DB00204;   Drug_Central:942;   KEGG:C07751;   KEGG:D00647;   LINCS:LSM-5925
 xref_mesh: MESH:C063533
 xref: PMID:11326815;   PMID:25620152;   PMID:25626340;   Patent:EP245997;   Patent:US4959366;   Reaxys:3572833;   Wikipedia:Dofetilide

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dofetilide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fkbp1b FKBP prolyl isomerase 1B JBrowse link 6 29,975,863 29,987,252 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Ncf2 neutrophil cytosolic factor 2 JBrowse link 13 70,226,441 70,259,019 RGD:6480464
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      application 19363
        pharmaceutical 19233
          drug 19233
            cardiovascular drug 7615
              anti-arrhythmia drug 903
                dofetilide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      chalcogen 19356
                        oxygen atom 19319
                          oxygen molecular entity 19319
                            hydroxides 19063
                              oxoacid 18157
                                chalcogen oxoacid 11478
                                  sulfur oxoacid 11078
                                    sulfonic acid 7311
                                      sulfonic acid derivative 7311
                                        sulfonamide 3169
                                          dofetilide 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.