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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:solvent
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Accession:CHEBI:46787 term browser browse the term
Definition:A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
Synonyms:related_synonym: Loesungsmittel;   solvant;   solvents
 xref: Wikipedia:Solvent


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions
EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
9-cis-retinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of 9-cis-retinal CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985
JBrowse link
benzyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Benzyl Alcohol CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export EXP ABCC1 protein affects the export of calcein AM CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP Clofibrate results in increased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain increases expression EXP Clofibrate results in increased expression of ACADVL protein CTD PMID:19952500 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990
JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Clofibrate results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767
JBrowse link
G ASL argininosuccinate lyase increases expression EXP Clofibrate results in increased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424
JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Clofibrate results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 increases expression EXP Clofibrate results in increased expression of CPS1 protein CTD PMID:19952500 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697
JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP Clofibrate results in increased expression of CPT2 mRNA CTD PMID:19952500 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Clofibrate results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Clofibrate results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350
JBrowse link
G CYP2B6 cytochrome P450 2B11 decreases expression EXP Clofibrate results in decreased expression of CYP2B6 mRNA CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
G CYP2C18 cytochrome P450 2C21 decreases expression EXP Clofibrate results in decreased expression of CYP2C18 mRNA CTD PMID:19952500 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Clofibrate results in increased expression of CYP2E1 protein CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases expression EXP Clofibrate results in decreased expression of CYP3A12 mRNA CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 decreases expression EXP Clofibrate results in decreased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 increases expression EXP Clofibrate results in increased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,663,337...13,676,350
Ensembl chr15:13,604,130...13,676,344
JBrowse link
G DLST dihydrolipoamide S-succinyltransferase increases expression EXP Clofibrate results in increased expression of DLST protein CTD PMID:19952500 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 increases expression EXP Clofibrate results in increased expression of ECHS1 protein CTD PMID:19952500 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167
JBrowse link
G GDI1 GDP dissociation inhibitor 1 increases expression EXP Clofibrate results in increased expression of GDI1 protein CTD PMID:19952500 NCBI chr  X:122,141,633...122,146,724
Ensembl chr  X:122,141,566...122,146,824
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Clofibrate results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Clofibrate results in decreased expression of GSTK1 mRNA CTD PMID:19952500 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Clofibrate results in decreased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase increases expression EXP Clofibrate results in increased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clofibrate results in increased expression of HSPD1 protein CTD PMID:19952500 NCBI chr37:7,010,421...7,025,912 JBrowse link
G KRT1 keratin 1 increases expression EXP Clofibrate results in increased expression of KRT1 protein CTD PMID:19952500 NCBI chr27:2,422,150...2,427,160 JBrowse link
G KRT18 keratin 18 decreases expression EXP Clofibrate results in decreased expression of KRT18 protein CTD PMID:19952500 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368
JBrowse link
G LOC100855679 serine--pyruvate aminotransferase, mitochondrial decreases expression EXP Clofibrate results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G LOC474938 glutathione S-transferase A2 decreases expression EXP Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC479912 glutathione S-transferase Mu 1 decreases expression EXP Clofibrate results in decreased expression of GSTM1 mRNA; Clofibrate results in decreased expression of GSTM5 mRNA CTD PMID:19952500 NCBI chr 6:42,201,697...42,207,886 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Clofibrate results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
JBrowse link
G PC pyruvate carboxylase increases expression EXP Clofibrate results in increased expression of PC protein CTD PMID:19952500 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669
JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression EXP Clofibrate results in increased expression of PCK2 protein CTD PMID:19952500 NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865
JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Clofibrate results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Clofibrate results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 decreases expression EXP Clofibrate results in decreased expression of SHMT1 protein CTD PMID:19952500 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Clofibrate results in decreased expression of UGP2 protein CTD PMID:19952500 NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452
JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP Clofibrate results in increased expression of UQCRC1 protein CTD PMID:19952500 NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110
JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Clofibrate results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141
JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
delta-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase decreases activity
multiple interactions
EXP delta-hexachlorocyclohexane results in decreased activity of CDIPT protein
[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate
CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:89824, PMID:3627083 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:3627083, PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity
EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Isoflurophate results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Eplerenone binds to and results in decreased activity of AR protein CTD PMID:23242577 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
gamma-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions
affects activity
EXP [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Nitroglycerin results in decreased activity of REN protein CTD PMID:8640982 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
paraoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Paraoxon results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
pentane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of 2,3-pentanedione CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of phenylglyoxylic acid CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G SLC6A9 solute carrier family 6 member 9 multiple interactions
affects localization
EXP Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]
Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein
CTD PMID:19473961 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933
JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
phosphatidylinositol 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link
toluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
affects metabolic processing
EXP Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Troleandomycin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions
increases activity
EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
multiple interactions
affects response to substance
EXP ABCB1 protein results in increased export of Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]
CTD PMID:24975508, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity
EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP VX results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 221
    role 221
      chemical role 159
        solvent 69
          (trifluoromethyl)benzene + 1
          1-bromopropane 0
          2-(2-methoxyethoxy)ethanol 0
          2-methoxyethanol + 0
          aprotic solvent + 0
          benzyl alcohol + 1
          carbon dioxide 0
          chlorobenzene 0
          cyclohexanol + 0
          decalin + 0
          diglyme 0
          dimethyl carbonate 0
          drying control chemical additive 0
          ethylene glycol + 0
          formamide + 0
          formic acid + 4
          glycerol + 3
          isophorone + 0
          non-polar solvent + 3
          oleic acid + 0
          perfluorodecalin 0
          perfluorotributylamine 0
          phosphoric acid + 9
          polar solvent + 64
          thiodiglycol 0
          triacetin 0
          triglyme 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.