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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diether
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Accession:CHEBI:46786 term browser browse the term
Definition:A polyether in which the number of ether linkages is 2.
Synonyms:related_synonym: diethers


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diclofop-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein CTD PMID:25419412 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding ISO dichlorfop-methyl binds to ALB protein CTD PMID:32278049 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cat catalase increases activity EXP dichlorfop-methyl results in increased activity of CAT protein CTD PMID:11275354 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO dichlorfop-methyl binds to and results in increased activity of PPARA protein CTD PMID:17084873 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
diethylene glycol monoethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase increases activity EXP carbitol results in increased activity of GPT protein CTD PMID:25959454 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
ethylene glycol bis(2-aminoethyl)tetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP [Egtazic Acid co-treated with Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone] inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species] CTD PMID:18854758 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:21544200 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein] CTD PMID:30266318 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G C5 complement C5 multiple interactions ISO [Egtazic Acid co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein; [Egtazic Acid co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein CTD PMID:10777245 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Egtazic Acid promotes the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
CTD PMID:19837105, PMID:20020783, PMID:21544200, PMID:29111403 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cck cholecystokinin multiple interactions ISO Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of CCL5 protein] CTD PMID:21245013 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cfl1 cofilin 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in decreased phosphorylation of and results in increased activity of CFL1 protein]; Egtazic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of and results in increased activity of CFL1 protein] CTD PMID:17303079 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP
ISO
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]
CTD PMID:27554787, PMID:28731686 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions ISO [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]; [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] CTD PMID:18435905 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO Egtazic Acid results in decreased phosphorylation of CREB1 protein CTD PMID:21443188 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]] CTD PMID:21443188 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP Egtazic Acid inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] CTD PMID:16187300 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of CXCL10 protein] CTD PMID:21245013 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA] CTD PMID:28731686 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Egtazic Acid inhibits the reaction [Amiodarone results in increased expression of DDIT3]
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]
CTD PMID:21292685, PMID:29111403 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of EGR1 protein] CTD PMID:29149324 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21544200 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of FOS protein] CTD PMID:29149324 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased secretion of FSHB protein] CTD PMID:28731686 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gcg glucagon multiple interactions ISO Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gnal G protein subunit alpha L multiple interactions ISO Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein]; Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to azelaic acid]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to citronellal]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol] CTD PMID:15598656 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO Egtazic Acid inhibits the reaction [[GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to citronellal]; Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to Isoproterenol] CTD PMID:15598656 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18357586, PMID:21443188 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Egtazic Acid results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Egtazic Acid results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA] CTD PMID:16173059 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of JUN protein] CTD PMID:29149324 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Egtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of KIF5A protein]; Egtazic Acid inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24239783, PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased secretion of LHB protein] CTD PMID:28731686 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions EXP Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Thapsigargin results in increased activity of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased localization of MAPK1 protein modified form]
CTD PMID:11914123, PMID:11981161, PMID:19576918, PMID:21245013, PMID:21544200, PMID:29149324 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:21544200 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Thapsigargin results in increased activity of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased localization of MAPK3 protein modified form]
CTD PMID:11914123, PMID:11981161, PMID:19576918, PMID:21245013, PMID:21544200, PMID:29149324 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]
CTD PMID:11981161, PMID:15254339, PMID:21544200 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]
CTD PMID:11981161, PMID:15254339, PMID:21544200 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] CTD PMID:21245013 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein] CTD PMID:21544200 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nefl neurofilament light multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] CTD PMID:21443188 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
ISO Egtazic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of NOS1 protein alternative form]
Egtazic Acid results in decreased expression of NOS1 protein alternative form
CTD PMID:16791854 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Egtazic Acid results in decreased expression of NOS3; Egtazic Acid results in decreased expression of NOS3 mRNA CTD PMID:19837105, PMID:20020783 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]
[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:21544200, PMID:29111403 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19576918 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pla2g1b phospholipase A2 group IB decreases activity ISO Egtazic Acid results in decreased activity of PLA2G1B protein CTD PMID:15528384 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO
EXP
Egtazic Acid results in decreased activity of PON1 protein
[Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon
[Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon
CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions EXP [Egtazic Acid co-treated with Calcium deficiency] results in increased expression of PPP1R15A mRNA CTD PMID:9878749 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Egtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] CTD PMID:20172950 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:29149324 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein] CTD PMID:21544200 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
Egtazic Acid inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:14516795, PMID:21544200 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Srr serine racemase multiple interactions ISO
EXP
[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein CTD PMID:24012499 NCBI chr10:61,756,138...61,772,327
Ensembl chr10:61,756,138...61,772,293
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of STAR mRNA]; Egtazic Acid inhibits the reaction [Quercetin results in increased expression of STAR mRNA]
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
CTD PMID:17332522, PMID:27554787, PMID:28731686 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Egtazic Acid inhibits the reaction [TNF protein results in increased transport of Chlorides]; Egtazic Acid inhibits the reaction [TNF protein results in increased transport of Potassium] CTD PMID:10783394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of TNFSF10 mRNA] CTD PMID:22200406 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Egtazic Acid inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; Egtazic Acid inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Vim vimentin multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
pentamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Pentamidine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO Pentamidine results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pentamidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atm ATM serine/threonine kinase affects localization
decreases activity
ISO Pentamidine affects the localization of ATM protein modified form
Pentamidine results in decreased activity of ATM protein
CTD PMID:20144237 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Pentamidine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Pentamidine results in increased expression of DEPP1 mRNA CTD PMID:15342952 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pentamidine results in decreased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G H2ax H2A.X variant histone affects localization ISO Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hpn hepsin increases expression ISO Pentamidine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:15588918, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein
Pentamidine results in decreased expression of IL10 protein
CTD PMID:15588918 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Pentamidine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:15588918, PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Pentamidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions
decreases activity
ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
Pentamidine results in decreased activity of KAT5 protein
CTD PMID:20144237 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pentamidine results in decreased activity of KCNH2 protein
CTD PMID:15340016, PMID:15711590, PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lss lanosterol synthase decreases expression ISO Pentamidine results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases activity ISO Pentamidine results in decreased activity of MRE11 protein CTD PMID:20144237 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Nbn nibrin affects localization ISO Pentamidine affects the localization of NBN protein CTD PMID:20144237 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Pentamidine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Pentamidine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Pentamidine results in increased expression of NUPR1 mRNA CTD PMID:15342952 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Pentamidine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Pentamidine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Pentamidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] CTD PMID:20144237 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Pentamidine results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          oxygen atom 19361
            oxygen molecular entity 19361
              organooxygen compound 18816
                ether 16076
                  polyether 244
                    diether 105
                      (2-ethoxyethoxy)acetic acid 0
                      1,2-dimethoxyethane 0
                      1-butoxy-1-ethoxyethane 0
                      1-ethoxy-1-pentoxyethane 0
                      2-(2-methoxyethoxy)ethanol 0
                      2-[2-(2-methoxyethoxy)ethoxy]-1,3-dioxolane 0
                      2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid + 4
                      3',4'-difluoro-N-\{4'-fluoro-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-yl\}-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-carboxamide 0
                      N,N-bis(2-methoxyethyl)-2-(4-methylphenyl)quinazolin-4-amine 0
                      bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether 0
                      cadiyenol 0
                      cenicriviroc 0
                      diethylene glycol monoethyl ether 1
                      dimethoxymethane 0
                      ethylene glycol bis(2-aminoethyl)tetraacetic acid 69
                      glymidine 0
                      isotalatizidine 0
                      methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + 4
                      pentamidine 31
                      senbusine A 0
                      squaric acid dibutyl ester 0
                      tilorone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  ether 16076
                                    polyether 244
                                      diether 105
                                        (2-ethoxyethoxy)acetic acid 0
                                        1,2-dimethoxyethane 0
                                        1-butoxy-1-ethoxyethane 0
                                        1-ethoxy-1-pentoxyethane 0
                                        2-(2-methoxyethoxy)ethanol 0
                                        2-[2-(2-methoxyethoxy)ethoxy]-1,3-dioxolane 0
                                        2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid + 4
                                        3',4'-difluoro-N-\{4'-fluoro-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-yl\}-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-carboxamide 0
                                        N,N-bis(2-methoxyethyl)-2-(4-methylphenyl)quinazolin-4-amine 0
                                        bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether 0
                                        cadiyenol 0
                                        cenicriviroc 0
                                        diethylene glycol monoethyl ether 1
                                        dimethoxymethane 0
                                        ethylene glycol bis(2-aminoethyl)tetraacetic acid 69
                                        glymidine 0
                                        isotalatizidine 0
                                        methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + 4
                                        pentamidine 31
                                        senbusine A 0
                                        squaric acid dibutyl ester 0
                                        tilorone 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.