CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | polyether |
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Accession: | CHEBI:46774
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browse the term
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Definition: | Any ether that contains more than one ether linkage. |
Synonyms: | related_synonym: | polyethers |
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Ache |
acetylcholinesterase |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein] |
CTD |
PMID:31077737 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein |
CTD |
PMID:31077737 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cat |
catalase |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein] |
CTD |
PMID:31077737 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:31077737 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Il10 |
interleukin 10 |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] |
CTD |
PMID:31077737 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein] |
CTD |
PMID:31077737 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein] |
CTD |
PMID:31077737 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] |
CTD |
PMID:31077737 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
multiple interactions |
ISO |
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein |
CTD |
PMID:31077737 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] |
CTD |
PMID:31077737 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein] |
CTD |
PMID:31077737 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases activity |
ISO |
glaucine results in increased activity of ABCB1 protein |
CTD |
PMID:23273999 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abca8 |
ATP binding cassette subfamily A member 8 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport decreases expression decreases activity increases activity affects response to substance multiple interactions increases expression |
ISO EXP |
ABCB1 protein results in increased transport of Verapamil Verapamil results in decreased expression of ABCB1A mRNA Verapamil results in decreased activity of ABCB1 protein; Verapamil results in decreased activity of ABCB1A protein Verapamil results in increased activity of ABCB1 protein ABCB1A protein affects the susceptibility to Verapamil [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride] [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein]; Verapamil promotes the reaction [Vanadates results in decreased activity of ABCB1A protein] Verapamil results in increased expression of ABCB1 mRNA Verapamil analog results in increased activity of ABCB1 protein mutant form; Verapamil results in increased activity of ABCB1 protein Verapamil results in decreased expression of ABCB1 protein [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] results in decreased activity of ABCB1 protein; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] results in decreased activity of ABCB1 protein; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Cyclosporine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Demecolcine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]; Verapamil binds to and affects the activity of ABCB1 protein; Verapamil binds to and results in decreased activity of ABCB1 protein; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased abundance of Quercetin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of cyazofamid]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Verapamil inhibits the reaction [Acetaminophen results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [tangeretin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Verapamil promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [kaempferol results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Verapamil promotes the reaction [propiconazole results in decreased activity of ABCB1 protein]; Verapamil promotes the reaction [Quercetin results in increased activity of ABCB1 protein]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] |
CTD |
PMID:2900677 PMID:7083125 PMID:7476894 PMID:8917702 PMID:10527640 PMID:10571255 PMID:10636889 PMID:10997946 PMID:11027628 PMID:11836167 PMID:11895100 PMID:11920757 PMID:12202523 PMID:12387747 PMID:12670938 PMID:12708479 PMID:12711602 PMID:15112361 PMID:15276086 PMID:15451006 PMID:15502009 PMID:15627040 PMID:15640379 PMID:15725475 PMID:15861398 PMID:16033948 PMID:16049968 PMID:16121039 PMID:16442095 PMID:16904803 PMID:16930294 PMID:16959878 PMID:17134887 PMID:17526808 PMID:17947497 PMID:17973928 PMID:18408562 PMID:18673531 PMID:19070657 PMID:19505989 PMID:19528478 PMID:19944135 PMID:20457140 PMID:21783720 PMID:22079615 PMID:22233293 PMID:23200901 PMID:23273999 PMID:23976943 PMID:24321342 PMID:24380838 PMID:24446304 PMID:25058526 PMID:25268938 PMID:25625052 PMID:26995013 PMID:28587984 PMID:28597291 PMID:28669723 PMID:29079042 PMID:29174985 PMID:29625142 PMID:30102254 PMID:30391378 PMID:31348918 PMID:31756430 PMID:32003934 PMID:32497533 PMID:33321149 PMID:34217736 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b |
ATP-binding cassette, subfamily B (MDR/TAP), member 1B |
decreases activity affects response to substance |
EXP ISO |
Verapamil results in decreased activity of ABCB1B protein ABCB1B protein affects the susceptibility to Verapamil |
CTD |
PMID:12202523 PMID:15502009 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity decreases expression |
EXP ISO |
Verapamil results in decreased activity of ABCB4 protein Verapamil results in decreased expression of ABCB4 mRNA |
CTD |
PMID:12202523 PMID:28437613 PMID:28552422 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc1 |
ATP binding cassette subfamily C member 1 |
affects activity multiple interactions decreases activity |
ISO |
Verapamil affects the activity of ABCC1 protein Verapamil inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione] Verapamil results in decreased activity of ABCC1 protein Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide] |
CTD |
PMID:7954421 PMID:9334814 PMID:10856430 PMID:11278867 PMID:12485947 PMID:15044619 PMID:15451006 PMID:15498506 PMID:16101123 PMID:16636798 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCC2 protein affects the export of 5-carboxyfluorescein diacetate] |
CTD |
PMID:16636798 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCC3 protein affects the export of 5-carboxyfluorescein diacetate] |
CTD |
PMID:16636798 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc6 |
ATP binding cassette subfamily C member 6 |
decreases activity |
ISO |
Verapamil results in decreased activity of ABCC6 protein |
CTD |
PMID:14667841 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of ACTA2 protein] |
CTD |
PMID:17223571 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adra1a |
adrenoceptor alpha 1A |
multiple interactions affects binding |
ISO |
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate] Verapamil binds to ADRA1A protein |
CTD |
PMID:9570190 |
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NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra1b |
adrenoceptor alpha 1B |
multiple interactions affects binding |
ISO |
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate] Verapamil binds to ADRA1B protein |
CTD |
PMID:9570190 |
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NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Adra1d |
adrenoceptor alpha 1D |
multiple interactions affects binding |
ISO |
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate] Verapamil binds to ADRA1D protein |
CTD |
PMID:9570190 |
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NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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Adrb1 |
adrenoceptor beta 1 |
affects response to substance |
ISO |
ADRB1 protein polymorphism affects the susceptibility to Verapamil |
CTD |
PMID:22192668 |
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NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Thioacetamide results in decreased expression of AKT1 mRNA] |
CTD |
PMID:30526075 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aqp1 |
aquaporin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [cobaltous chloride results in increased expression of AQP1 protein] |
CTD |
PMID:22415096 |
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NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Verapamil results in increased expression of BAX protein [Verapamil co-treated with Temozolomide] results in increased expression of BAX mRNA; Temozolomide promotes the reaction [Verapamil results in increased expression of BAX protein] |
CTD |
PMID:30003979 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 mRNA; [Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 protein; [Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein Verapamil results in decreased expression of BCL2 mRNA; Verapamil results in decreased expression of BCL2 protein |
CTD |
PMID:24373880 PMID:30003979 |
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NCBI chr13:22,689,783...22,853,920
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Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
multiple interactions increases response to substance decreases expression |
EXP ISO |
Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CACNA1C gene polymorphism results in increased susceptibility to Verapamil Verapamil results in decreased expression of CACNA1C mRNA; Verapamil results in decreased expression of CACNA1C protein |
CTD |
PMID:19791473 PMID:20031608 PMID:27095094 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacna1f |
calcium voltage-gated channel subunit alpha1 F |
multiple interactions |
ISO |
Verapamil inhibits the reaction [CACNA1F protein results in increased transport of Barium] |
CTD |
PMID:14744918 |
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NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413
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Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
multiple interactions decreases expression |
EXP |
Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein] Verapamil results in decreased expression of CACNA1H mRNA; Verapamil results in decreased expression of CACNA1H protein |
CTD |
PMID:19791473 |
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NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
ISO |
Verapamil inhibits the reaction [[Ionomycin co-treated with Lipopolysaccharides] results in increased expression of CALCA protein]; Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] |
CTD |
PMID:20682585 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:11073891 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] |
CTD |
PMID:11073891 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Casp1 |
caspase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] |
CTD |
PMID:28633109 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp12 |
caspase 12 |
multiple interactions |
ISO |
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:19631781 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3 |
caspase 3 |
multiple interactions increases expression |
EXP ISO |
Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] [Doxorubicin co-treated with Verapamil] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein] Verapamil results in increased expression of CASP3 mRNA |
CTD |
PMID:14527821 PMID:15861398 PMID:18358092 PMID:19631781 PMID:19815060 PMID:19927300 PMID:24373880 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7 |
caspase 7 |
multiple interactions |
ISO |
[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein] |
CTD |
PMID:15861398 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8 |
caspase 8 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:24373880 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:24373880 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cd44 |
CD44 molecule (Indian blood group) |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein] |
CTD |
PMID:9929743 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] |
CTD |
PMID:34217686 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Ciita |
class II, major histocompatibility complex, transactivator |
affects expression |
ISO |
Verapamil affects the expression of CIITA mRNA |
CTD |
PMID:25811541 |
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NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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G |
Clu |
clusterin |
affects expression |
ISO |
Verapamil affects the expression of CLU protein |
CTD |
PMID:12388792 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:27095094 PMID:34217686 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein] |
CTD |
PMID:34217686 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Csrp3 |
cysteine and glycine rich protein 3 |
decreases localization |
EXP |
Verapamil results in decreased localization of CSRP3 protein |
CTD |
PMID:19376126 |
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NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1A2 protein |
CTD |
PMID:18420780 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Cyclosporine results in increased expression of CYP2C11 protein] |
CTD |
PMID:28899749 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity multiple interactions |
ISO |
Verapamil results in decreased activity of CYP2C8 protein Verapamil results in decreased activity of CYP2C29 protein torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein] |
CTD |
PMID:15304522 PMID:18420780 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2D22 protein; Verapamil results in decreased activity of CYP2D6 protein |
CTD |
PMID:18420780 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a18 |
cytochrome P450, family 3, subfamily a, polypeptide 18 |
decreases expression |
EXP |
Verapamil results in decreased expression of CYP3A18 mRNA |
CTD |
PMID:17973928 |
|
NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity affects metabolic processing |
ISO |
[Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] Verapamil results in decreased activity of CYP3A4 protein |
CTD |
PMID:15286053 PMID:15689501 PMID:15692829 PMID:15860655 PMID:16013069 PMID:19299527 PMID:21915887 PMID:25455453 More...
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
decreases expression decreases activity |
EXP ISO |
Verapamil results in decreased expression of CYP3A9 mRNA Verapamil results in decreased activity of CYP3A5 protein |
CTD |
PMID:15689501 PMID:17973928 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased expression of DDIT3 protein |
CTD |
PMID:24373880 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnm1l |
dynamin 1-like |
multiple interactions increases phosphorylation |
ISO |
Verapamil inhibits the reaction [bisphenol A affects the localization of DNM1L protein] Verapamil results in increased phosphorylation of DNM1L protein |
CTD |
PMID:31830493 PMID:34023961 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SCH 23390 binds to DRD1 protein] |
CTD |
PMID:9533112 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Raclopride binds to DRD2 protein] |
CTD |
PMID:9533112 |
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NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] |
CTD |
PMID:28942281 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] |
CTD |
PMID:34217686 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Verapamil results in increased expression of FOS mRNA |
CTD |
PMID:12730611 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] |
CTD |
PMID:27095094 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gal |
galanin and GMAP prepropeptide |
affects expression |
ISO |
Verapamil affects the expression of GAL protein |
CTD |
PMID:12388792 |
|
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Gap43 |
growth associated protein 43 |
affects expression |
ISO |
Verapamil affects the expression of GAP43 protein |
CTD |
PMID:12388792 |
|
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gc |
GC, vitamin D binding protein |
affects expression |
EXP |
Verapamil affects the expression of GC protein |
CTD |
PMID:23533533 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] Verapamil results in increased expression of GFAP mRNA |
CTD |
PMID:21863293 PMID:21879721 PMID:22954530 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Thioacetamide results in increased expression of GPT protein] |
CTD |
PMID:30526075 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsn |
gelsolin |
affects expression |
EXP |
Verapamil affects the expression of GSN protein |
CTD |
PMID:23533533 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions |
ISO |
Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] |
CTD |
PMID:27095094 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO EXP |
Verapamil results in increased expression of HMOX1 protein Verapamil inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:21525764 PMID:30526075 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Iapp |
islet amyloid polypeptide |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Glucose results in increased expression of IAPP mRNA] |
CTD |
PMID:9142872 |
|
NCBI chr 4:175,237,013...175,244,373
Ensembl chr 4:175,237,115...175,242,920
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] |
CTD |
PMID:15613243 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:20682585 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Kcna10 |
potassium voltage-gated channel subfamily A member 10 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [KCNA10 protein results in increased transport of Potassium] |
CTD |
PMID:10836990 |
|
NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575
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G |
Kcna3 |
potassium voltage-gated channel subfamily A member 3 |
decreases activity multiple interactions |
ISO |
Verapamil results in decreased activity of KCNA3 protein [Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium |
CTD |
PMID:21362439 |
|
NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138
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G |
Kcnd3 |
potassium voltage-gated channel subfamily D member 3 |
decreases activity |
ISO |
Verapamil results in decreased activity of KCND3 protein |
CTD |
PMID:11181069 |
|
NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
[Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:15671647 PMID:19583963 PMID:21158687 PMID:21362439 PMID:24052561 PMID:30561737 More...
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnmb1 |
potassium calcium-activated channel subfamily M regulatory beta subunit 1 |
affects response to substance |
ISO |
KCNMB1 gene SNP affects the susceptibility to Verapamil |
CTD |
PMID:17700361 |
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NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
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G |
Lif |
LIF, interleukin 6 family cytokine |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:11073891 |
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NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15456914 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15456914 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein] |
CTD |
PMID:15936777 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] |
CTD |
PMID:27095094 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Verapamil promotes the reaction [Paraquat results in increased activity of MPO protein] |
CTD |
PMID:17015168 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mybpc3 |
myosin binding protein C3 |
affects response to substance |
ISO |
MYBPC3 protein affects the susceptibility to Verapamil |
CTD |
PMID:23896226 |
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NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions decreases expression |
ISO |
Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]] |
CTD |
PMID:19596060 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myl2 |
myosin light chain 2 |
multiple interactions decreases expression |
ISO |
[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA; Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]] Verapamil results in decreased expression of MYL2 mRNA |
CTD |
PMID:19596060 |
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NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
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G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] |
CTD |
PMID:21863293 PMID:21879721 |
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NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nefm |
neurofilament medium chain |
multiple interactions |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 PMID:21879721 |
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NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions |
ISO EXP |
Verapamil affects the localization of NFE2L2 protein Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:21525764 PMID:30526075 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nppa |
natriuretic peptide A |
multiple interactions increases expression affects secretion |
ISO |
[Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein Verapamil results in increased expression of NPPA protein Verapamil affects the secretion of NPPA protein |
CTD |
PMID:1457087 PMID:11996326 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
ISO |
Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] |
CTD |
PMID:28942281 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr0b1 |
nuclear receptor subfamily 0, group B, member 1 |
multiple interactions decreases expression |
ISO |
Verapamil promotes the reaction [Cyclic AMP results in decreased expression of NR0B1 mRNA] Verapamil results in decreased expression of NR0B1 mRNA |
CTD |
PMID:19822634 |
|
NCBI chr X:50,756,886...50,761,014
Ensembl chr X:50,756,886...50,761,011
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions |
ISO |
Verapamil results in increased activity of NR1I2 protein [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Verapamil promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein] |
CTD |
PMID:12871829 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [PARP1 gene mutant form results in decreased uptake of Doxorubicin] [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein] |
CTD |
PMID:15861398 PMID:24373880 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pf4 |
platelet factor 4 |
decreases expression |
ISO |
Verapamil results in decreased expression of PF4 protein |
CTD |
PMID:2962587 |
|
NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
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G |
Polr1h |
RNA polymerase I subunit H |
multiple interactions |
ISO |
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [POLR1H protein results in increased secretion of Doxorubicin] |
CTD |
PMID:14726695 |
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NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854
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G |
Ppbp |
pro-platelet basic protein |
decreases expression |
ISO |
Verapamil results in decreased expression of PPBP protein |
CTD |
PMID:2962587 |
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NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppp3cb |
protein phosphatase 3 catalytic subunit beta |
multiple interactions |
ISO |
Verapamil inhibits the reaction [bisphenol F results in increased expression of PPP3CB protein] |
CTD |
PMID:34023961 |
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NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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G |
Prl |
prolactin |
increases secretion increases expression multiple interactions |
ISO |
Verapamil results in increased secretion of PRL protein Verapamil results in increased expression of PRL protein Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] |
CTD |
PMID:7851873 PMID:8845563 PMID:8977754 PMID:20595935 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ret |
ret proto-oncogene |
affects expression |
ISO |
Verapamil affects the expression of RET protein |
CTD |
PMID:12388792 |
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NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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G |
Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] |
CTD |
PMID:27095094 |
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NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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G |
Slc19a3 |
solute carrier family 19 member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] |
CTD |
PMID:26528626 |
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NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 PMID:25466967 PMID:25862123 PMID:27450509 PMID:27989701 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO EXP |
Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of mepiquat] |
CTD |
PMID:21599003 PMID:33639197 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] |
CTD |
PMID:21641380 PMID:21697722 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
decreases activity |
ISO |
Verapamil results in decreased activity of SLC22A5 protein |
CTD |
PMID:15486076 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions decreases activity |
ISO |
Verapamil inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium] Verapamil results in decreased activity of SLC47A1 protein |
CTD |
PMID:22419765 PMID:27450509 PMID:27989701 PMID:31364238 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions decreases activity |
ISO |
Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] Verapamil results in decreased activity of SLC47A2 protein |
CTD |
PMID:22419765 PMID:27989701 PMID:28629854 PMID:31364238 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] |
CTD |
PMID:24947867 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:34217686 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD1 protein]] |
CTD |
PMID:17015168 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD2 protein]] |
CTD |
PMID:17015168 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR protein] |
CTD |
PMID:19822634 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein] |
CTD |
PMID:19299911 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein] Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:17223571 PMID:34217686 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
affects expression multiple interactions |
ISO EXP |
Verapamil affects the expression of TIMP1 protein Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] |
CTD |
PMID:12388792 PMID:27095094 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Verapamil inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein] Verapamil affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Verapamil inhibits the reaction [Particulate Matter results in increased secretion of TNF protein] |
CTD |
PMID:15613243 PMID:17092623 PMID:17129690 PMID:17369293 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trh |
thyrotropin releasing hormone |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] |
CTD |
PMID:7851873 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein] |
CTD |
PMID:7851873 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Vim |
vimentin |
multiple interactions |
EXP ISO |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:21863293 PMID:21879721 PMID:34217686 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions |
ISO |
ABCB1 protein results in increased transport of benzoylaconine [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine |
CTD |
PMID:23200901 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine |
CTD |
PMID:23200901 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases transport |
ISO |
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine ABCB1 protein results in increased transport of benzoylhypaconine |
CTD |
PMID:23200901 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine |
CTD |
PMID:23200901 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of benzoylhypaconine |
CTD |
PMID:23200901 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions |
ISO |
ABCB1 protein results in increased transport of benzoylmesaconine [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine |
CTD |
PMID:23200901 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine |
CTD |
PMID:23200901 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
copanlisib results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:31445927 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Fas |
Fas cell surface death receptor |
affects response to substance |
ISO |
copanlisib affects the susceptibility to FAS protein |
CTD |
PMID:31445927 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Tnf |
tumor necrosis factor |
increases response to substance |
ISO |
copanlisib results in increased susceptibility to TNF protein |
CTD |
PMID:31445927 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
deguelin results in increased expression of ABCC4 mRNA |
CTD |
PMID:33512557 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
decreases expression |
ISO |
deguelin results in decreased expression of ABCC5 mRNA |
CTD |
PMID:33512557 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcf1 |
ATP binding cassette subfamily F member 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ABCF1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
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G |
Adam12 |
ADAM metallopeptidase domain 12 |
decreases expression |
ISO |
deguelin results in decreased expression of ADAM12 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667
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G |
Adam8 |
ADAM metallopeptidase domain 8 |
decreases expression |
ISO |
deguelin results in decreased expression of ADAM8 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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G |
Adm |
adrenomedullin |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA] |
CTD |
PMID:22745725 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Ado |
2-aminoethanethiol dioxygenase |
increases expression |
ISO |
deguelin results in increased expression of ADO mRNA |
CTD |
PMID:33512557 |
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NCBI chr20:21,044,815...21,045,983
Ensembl chr20:21,044,555...21,049,235
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
deguelin results in increased expression of AEN mRNA |
CTD |
PMID:33512557 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
deguelin results in increased expression of and affects the localization of AIFM1 protein |
CTD |
PMID:26592500 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akap8l |
A-kinase anchoring protein 8 like |
increases expression |
ISO |
deguelin results in increased expression of AKAP8L mRNA |
CTD |
PMID:33512557 |
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NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
decreases expression |
ISO |
deguelin results in decreased expression of AKR1B1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases expression |
ISO |
deguelin results in increased expression of AKR1C3 mRNA |
CTD |
PMID:33512557 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
decreases expression |
ISO |
deguelin results in decreased expression of AKR7A2 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases expression affects phosphorylation increases phosphorylation multiple interactions decreases phosphorylation |
ISO |
deguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 mRNA; deguelin results in decreased expression of AKT1 protein deguelin affects the phosphorylation of AKT1 protein deguelin results in increased phosphorylation of AKT1 protein deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein] deguelin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:16288123 PMID:17015749 PMID:18593368 PMID:19139008 PMID:19336726 PMID:19901985 PMID:25322282 PMID:29512685 PMID:33512557 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
decreases expression |
ISO |
deguelin results in decreased expression of ALDH7A1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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G |
Aldh8a1 |
aldehyde dehydrogenase 8 family, member A1 |
decreases expression |
ISO |
deguelin results in decreased expression of ALDH8A1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
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G |
Amdhd2 |
amidohydrolase domain containing 2 |
decreases expression |
ISO |
deguelin results in decreased expression of AMDHD2 mRNA |
CTD |
PMID:33512557 |
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NCBI chr10:13,187,579...13,196,148
Ensembl chr10:13,187,578...13,196,095
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G |
Amer1 |
APC membrane recruitment protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of AMER1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr X:60,300,595...60,316,480
Ensembl chr X:60,295,751...60,316,440
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
ISO |
deguelin results in decreased expression of ANGPTL2 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl4 |
angiopoietin-like 4 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA] |
CTD |
PMID:22745725 |
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NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Anln |
anillin, actin binding protein |
increases expression |
ISO |
deguelin results in increased expression of ANLN mRNA |
CTD |
PMID:33512557 |
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NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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G |
Ano10 |
anoctamin 10 |
decreases expression |
ISO |
deguelin results in decreased expression of ANO10 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 8:121,841,664...121,960,739
Ensembl chr 8:121,841,665...121,962,670
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G |
Anxa7 |
annexin A7 |
increases expression |
ISO |
deguelin results in increased expression of ANXA7 mRNA |
CTD |
PMID:33512557 |
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NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385
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G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
decreases expression |
ISO |
deguelin results in decreased expression of AP2M1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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G |
Ap3m1 |
adaptor related protein complex 3 subunit mu 1 |
decreases expression |
ISO |
deguelin results in decreased expression of AP3M1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844
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G |
Aplp1 |
amyloid beta precursor like protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of APLP1 mRNA |
CTD |
PMID:33512557 |
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NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
deguelin results in decreased expression of and affects the localization of AR protein |
CTD |
PMID:27255535 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap8 |
Rho GTPase activating protein 8 |
increases expression |
ISO |
deguelin results in increased expression of ARHGAP8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:115,842,223...115,902,094
Ensembl chr 7:115,850,654...115,902,093
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G |
Arhgap9 |
Rho GTPase activating protein 9 |
increases expression |
ISO |
deguelin results in increased expression of ARHGAP9 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524
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G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
increases expression |
ISO |
deguelin results in increased expression of ARHGEF2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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G |
Arid4a |
AT-rich interaction domain 4A |
decreases expression |
ISO |
deguelin results in decreased expression of ARID4A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:89,522,463...89,593,868
Ensembl chr 6:89,522,442...89,593,510
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G |
Arih2 |
ariadne RBR E3 ubiquitin protein ligase 2 |
increases expression |
ISO |
deguelin results in increased expression of ARIH2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:109,296,738...109,355,909
Ensembl chr 8:109,296,738...109,355,852
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G |
Arl1 |
ADP-ribosylation factor like GTPase 1 |
increases expression |
ISO |
deguelin results in increased expression of ARL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
increases expression |
ISO |
deguelin results in increased expression of ARNT mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Arrdc4 |
arrestin domain containing 4 |
decreases expression |
ISO |
deguelin results in decreased expression of ARRDC4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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G |
Arsg |
arylsulfatase G |
increases expression |
ISO |
deguelin results in increased expression of ARSG mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941
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G |
Ascc3 |
activating signal cointegrator 1 complex subunit 3 |
increases expression |
ISO |
deguelin results in increased expression of ASCC3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165
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G |
Ascl1 |
achaete-scute family bHLH transcription factor 1 |
increases expression |
ISO |
deguelin results in increased expression of ASCL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
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G |
Asf1b |
anti-silencing function 1B histone chaperone |
decreases expression |
ISO |
deguelin results in decreased expression of ASF1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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G |
Asgr1 |
asialoglycoprotein receptor 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ASGR1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
deguelin results in increased expression of ASNS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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|
G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
ISO |
deguelin results in increased expression of ASS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
deguelin results in increased expression of ATF4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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|
G |
Atf5 |
activating transcription factor 5 |
increases expression |
ISO |
deguelin results in increased expression of ATF5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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|
G |
Atg3 |
autophagy related 3 |
increases expression |
ISO |
deguelin results in increased expression of ATG3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
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|
G |
Atic |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
increases expression |
ISO |
deguelin results in increased expression of ATIC mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
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|
G |
Atm |
ATM serine/threonine kinase |
decreases expression |
ISO |
deguelin results in decreased expression of ATM mRNA |
CTD |
PMID:22227970 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atmin |
ATM interactor |
decreases expression |
ISO |
deguelin results in decreased expression of ATMIN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:44,996,506...45,013,606
Ensembl chr19:44,996,356...45,013,605
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|
G |
Atp11b |
ATPase phospholipid transporting 11B (putative) |
decreases expression |
ISO |
deguelin results in decreased expression of ATP11B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
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G |
Atp11c |
ATPase phospholipid transporting 11C |
decreases expression |
ISO |
deguelin results in decreased expression of ATP11C mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204
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|
G |
Atp6v0e1 |
ATPase H+ transporting V0 subunit e1 |
decreases expression |
ISO |
deguelin results in decreased expression of ATP6V0E1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434
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|
G |
Atp6v1b2 |
ATPase H+ transporting V1 subunit B2 |
decreases expression |
ISO |
deguelin results in decreased expression of ATP6V1B2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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|
G |
Atr |
ATR serine/threonine kinase |
decreases expression |
ISO |
deguelin results in decreased expression of ATR mRNA |
CTD |
PMID:22227970 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Atraid |
all-trans retinoic acid-induced differentiation factor |
increases expression |
ISO |
deguelin results in increased expression of ATRAID mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:25,315,236...25,319,804
|
|
G |
Aurka |
aurora kinase A |
increases expression |
ISO |
deguelin results in increased expression of AURKA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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|
G |
B2m |
beta-2 microglobulin |
increases expression |
ISO |
deguelin results in increased expression of B2M mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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|
G |
B3galt6 |
Beta-1,3-galactosyltransferase 6 |
decreases expression |
ISO |
deguelin results in decreased expression of B3GALT6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
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|
G |
B3gat1 |
beta-1,3-glucuronyltransferase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of B3GAT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395
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|
G |
Bag3 |
BAG cochaperone 3 |
increases expression |
ISO |
deguelin results in increased expression of BAG3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
deguelin results in increased expression of BAK1 protein |
CTD |
PMID:26592500 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
deguelin results in increased expression of BAX mRNA; deguelin results in increased expression of BAX protein |
CTD |
PMID:26592500 PMID:29512685 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
ISO |
deguelin results in increased expression of BCAT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
deguelin results in decreased expression of BCL2 mRNA; deguelin results in decreased expression of BCL2 protein deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] |
CTD |
PMID:19365708 PMID:22623043 PMID:26592500 PMID:29512685 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA] deguelin results in decreased expression of BCL2L1 mRNA; deguelin results in decreased expression of BCL2L1 protein |
CTD |
PMID:19365708 PMID:21472727 PMID:22623043 PMID:26592500 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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|
G |
Bcl2l11 |
Bcl2-like 11 |
decreases expression |
ISO |
deguelin results in decreased expression of BCL2L11 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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|
G |
Bcl2l13 |
Bcl2-like 13 |
decreases expression |
ISO |
deguelin results in decreased expression of BCL2L13 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985
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|
G |
Bcl2l2 |
Bcl2-like 2 |
decreases expression |
ISO |
deguelin results in decreased expression of BCL2L2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression |
ISO |
deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] deguelin results in increased expression of BDNF mRNA |
CTD |
PMID:17209049 PMID:33512557 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
deguelin results in decreased expression of BID mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions increases expression decreases expression |
ISO |
deguelin inhibits the reaction [docetaxel results in increased expression of BIRC5 protein]; deguelin inhibits the reaction [Doxorubicin results in increased expression of BIRC5 protein] deguelin results in increased expression of BIRC5 mRNA deguelin results in decreased expression of BIRC5 protein |
CTD |
PMID:17035597 PMID:18593368 PMID:21472727 PMID:33512557 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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|
G |
Bloc1s2 |
biogenesis of lysosomal organelles complex-1, subunit 2 |
increases expression |
ISO |
deguelin results in increased expression of BLOC1S2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
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|
G |
Bmf |
Bcl2 modifying factor |
decreases expression |
ISO |
deguelin results in decreased expression of BMF mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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|
G |
Bnip3l |
BCL2 interacting protein 3 like |
increases expression |
ISO |
deguelin results in increased expression of BNIP3L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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|
G |
Bphl |
biphenyl hydrolase like |
decreases expression |
ISO |
deguelin results in decreased expression of BPHL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288
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|
G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
deguelin results in decreased expression of BRCA1 mRNA |
CTD |
PMID:22227970 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brd2 |
bromodomain containing 2 |
increases expression |
ISO |
deguelin results in increased expression of BRD2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
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G |
Brd3 |
bromodomain containing 3 |
decreases expression |
ISO |
deguelin results in decreased expression of BRD3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577
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|
G |
Brms1l |
BRMS1 like transcriptional repressor |
decreases expression |
ISO |
deguelin results in decreased expression of BRMS1L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:73,266,673...73,300,631
Ensembl chr 6:73,266,691...73,300,631
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|
G |
Bsg |
basigin (Ok blood group) |
increases expression |
ISO |
deguelin results in increased expression of BSG mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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G |
Btg3 |
BTG anti-proliferation factor 3 |
increases expression |
ISO |
deguelin results in increased expression of BTG3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
decreases expression |
ISO |
deguelin results in decreased expression of BZW1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
C1s |
complement C1s |
decreases expression |
ISO |
deguelin results in decreased expression of C1S mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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|
G |
C2cd5 |
C2 calcium-dependent domain containing 5 |
decreases expression |
ISO |
deguelin results in decreased expression of C2CD5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558
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|
G |
Calcoco1 |
calcium binding and coiled coil domain 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CALCOCO1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
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|
G |
Calm1 |
calmodulin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CALM1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Calm3 |
calmodulin 3 |
decreases expression |
ISO |
deguelin results in decreased expression of CALM3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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G |
Calr |
calreticulin |
decreases expression |
ISO |
deguelin results in decreased expression of CALR mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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|
G |
Calu |
calumenin |
decreases expression |
ISO |
deguelin results in decreased expression of CALU mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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|
G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
decreases expression |
ISO |
deguelin results in decreased expression of CAMK2B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Cant1 |
calcium activated nucleotidase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CANT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109
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|
G |
Canx |
calnexin |
increases expression |
ISO |
deguelin results in increased expression of CANX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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|
G |
Capn1 |
calpain 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CAPN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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|
G |
Caps |
calcyphosine |
decreases expression |
ISO |
deguelin results in decreased expression of CAPS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647
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|
G |
Car9 |
carbonic anhydrase 9 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CARMIL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
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|
G |
Cars |
cysteinyl-tRNA synthetase |
increases expression |
ISO |
deguelin results in increased expression of CARS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
|
|
G |
Cask |
calcium/calmodulin dependent serine protein kinase |
increases expression |
ISO |
deguelin results in increased expression of CASK mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694
|
|
G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases activity |
ISO |
deguelin results in increased cleavage of CASP3 protein [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein deguelin results in increased activity of CASP3 protein |
CTD |
PMID:18593368 PMID:19336726 PMID:22623043 PMID:22986522 PMID:25242579 PMID:26592500 More...
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|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp6 |
caspase 6 |
multiple interactions |
ISO |
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein |
CTD |
PMID:25242579 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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|
G |
Casp7 |
caspase 7 |
increases expression |
ISO |
deguelin metabolite results in increased expression of CASP7 protein modified form; deguelin results in increased expression of CASP7 protein modified form |
CTD |
PMID:19139008 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein |
CTD |
PMID:25242579 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Cast |
calpastatin |
decreases expression |
ISO |
deguelin results in decreased expression of CAST mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
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|
G |
Cblb |
Cbl proto-oncogene B |
decreases expression |
ISO |
deguelin results in decreased expression of CBLB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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|
G |
Cbx4 |
chromobox 4 |
increases expression |
ISO |
deguelin results in increased expression of CBX4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
deguelin promotes the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] |
CTD |
PMID:28529457 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccl9 |
C-C motif chemokine ligand 9 |
decreases expression |
ISO |
deguelin results in decreased expression of CCL15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
|
|
G |
Ccna2 |
cyclin A2 |
increases expression |
ISO |
deguelin results in increased expression of CCNA2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
|
|
G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
deguelin results in increased expression of CCNB1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
|
|
G |
Ccnb2 |
cyclin B2 |
increases expression |
ISO |
deguelin results in increased expression of CCNB2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] |
CTD |
PMID:15960896 PMID:17015749 PMID:19861542 PMID:21472727 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
deguelin results in decreased expression of CCND3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
deguelin results in decreased expression of CCNE1 mRNA |
CTD |
PMID:29512685 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO |
deguelin results in decreased expression of CCNE2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
|
|
G |
Ccng1 |
cyclin G1 |
increases expression |
ISO |
deguelin results in increased expression of CCNG1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
|
|
G |
Ccnh |
cyclin H |
increases expression |
ISO |
deguelin results in increased expression of CCNH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819
|
|
G |
Cct6a |
chaperonin containing TCP1 subunit 6A |
increases expression |
ISO |
deguelin results in increased expression of CCT6A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
|
|
G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein |
CTD |
PMID:25242579 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
|
|
G |
Cd163 |
CD163 molecule |
multiple interactions |
EXP |
[deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA |
CTD |
PMID:22745725 |
|
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
|
|
G |
Cd19 |
CD19 molecule |
decreases expression |
ISO |
deguelin results in decreased expression of CD19 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
|
|
G |
Cd24 |
CD24 molecule |
decreases expression |
ISO |
deguelin results in decreased expression of CD24 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
|
|
G |
Cd44 |
CD44 molecule (Indian blood group) |
decreases expression |
ISO |
deguelin results in decreased expression of CD44 mRNA; deguelin results in decreased expression of CD44 protein |
CTD |
PMID:26884827 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
|
|
G |
Cdc45 |
cell division cycle 45 |
decreases expression |
ISO |
deguelin results in decreased expression of CDC45 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
|
|
G |
Cdc6 |
cell division cycle 6 |
decreases expression |
ISO |
deguelin results in decreased expression of CDC6 mRNA |
CTD |
PMID:34642769 |
|
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions affects localization increases expression |
ISO |
deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein] deguelin affects the localization of CDH1 protein deguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 protein |
CTD |
PMID:22986522 PMID:28509438 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cdh10 |
cadherin 10 |
decreases expression |
ISO |
deguelin results in decreased expression of CDH10 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:68,628,623...68,850,995
Ensembl chr 2:68,628,780...68,850,995
|
|
G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
deguelin results in decreased expression of CDH2 mRNA; deguelin results in decreased expression of CDH2 protein |
CTD |
PMID:22986522 PMID:33512557 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
|
|
G |
Cdh3 |
cadherin 3 |
increases expression |
ISO |
deguelin results in increased expression of CDH3 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
|
|
G |
Cdh7 |
cadherin 7 |
increases expression |
ISO |
deguelin results in increased expression of CDH7 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr13:26,672,058...26,821,571
Ensembl chr13:26,672,484...26,819,846
|
|
G |
Cdh9 |
cadherin 9 |
increases expression |
ISO |
deguelin results in increased expression of CDH9 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr 2:66,280,422...66,367,121
Ensembl chr 2:66,228,117...66,367,121
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
ISO |
deguelin results in increased expression of CDK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of CDK4 protein; deguelin results in decreased expression of CDK4 protein |
CTD |
PMID:19139008 PMID:19336726 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdk5 |
cyclin-dependent kinase 5 |
decreases expression |
ISO |
deguelin results in decreased expression of CDK5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
|
|
G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CDK5R1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
|
|
G |
Cdk6 |
cyclin-dependent kinase 6 |
increases expression |
ISO |
deguelin results in increased expression of CDK6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
ISO |
[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; deguelin metabolite results in decreased expression of CDKN1A protein; deguelin results in decreased expression of CDKN1A protein deguelin results in increased expression of CDKN1A mRNA |
CTD |
PMID:19139008 PMID:25242579 PMID:29512685 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
deguelin results in increased expression of CDKN1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
increases expression |
ISO |
deguelin results in increased expression of CDKN3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
|
|
G |
Cdt1 |
chromatin licensing and DNA replication factor 1 |
increases expression |
ISO |
deguelin results in increased expression of CDT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein |
CTD |
PMID:25242579 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression |
ISO |
deguelin results in increased expression of CEBPB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G |
Cel |
carboxyl ester lipase |
decreases expression |
ISO |
deguelin results in decreased expression of CEL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
|
|
G |
Cemip2 |
cell migration inducing hyaluronidase 2 |
decreases expression |
ISO |
deguelin results in decreased expression of CEMIP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
|
|
G |
Cenpf |
centromere protein F |
increases expression |
ISO |
deguelin results in increased expression of CENPF mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
|
|
G |
Cenpk |
centromere protein K |
decreases expression |
ISO |
deguelin results in decreased expression of CENPK mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:35,360,132...35,421,372
Ensembl chr 2:35,360,132...35,385,706
|
|
G |
Cenpu |
centromere protein U |
increases expression |
ISO |
deguelin results in increased expression of CENPU mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
|
|
G |
Cep55 |
centrosomal protein 55 |
increases expression |
ISO |
deguelin results in increased expression of CEP55 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394
|
|
G |
Cetn3 |
centrin 3 |
decreases expression |
ISO |
deguelin results in decreased expression of CETN3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:12,089,025...12,101,828
Ensembl chr 2:12,089,226...12,101,828
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] deguelin results in decreased expression of CFLAR mRNA |
CTD |
PMID:22623043 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
deguelin results in increased expression of CHAC1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
|
|
G |
Chek1 |
checkpoint kinase 1 |
increases expression |
ISO |
deguelin results in increased expression of CHEK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
|
|
G |
Chka |
choline kinase alpha |
increases expression |
ISO |
deguelin results in increased expression of CHKA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
|
|
G |
Chn1 |
chimerin 1 |
increases expression |
ISO |
deguelin results in increased expression of CHN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:58,509,822...58,676,774
Ensembl chr 3:58,510,536...58,676,490
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
decreases expression |
ISO |
deguelin results in decreased expression of CHRNA4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
|
|
G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
decreases expression |
ISO |
deguelin results in decreased expression of CHRNB2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases expression |
ISO |
deguelin results in increased expression of CHUK mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cisd1 |
CDGSH iron sulfur domain 1 |
increases expression |
ISO |
deguelin results in increased expression of CISD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924
|
|
G |
Cks1b |
CDC28 protein kinase regulatory subunit 1B |
increases expression |
ISO |
deguelin results in increased expression of CKS1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
|
|
G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
increases expression |
ISO |
deguelin results in increased expression of CKS2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:13,570,611...13,575,770
|
|
G |
Cldn2 |
claudin 2 |
increases expression |
ISO |
deguelin results in increased expression of CLDN2 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
|
|
G |
Cldn5 |
claudin 5 |
increases expression decreases expression |
ISO |
deguelin results in increased expression of CLDN5 mRNA deguelin results in decreased expression of CLDN5 mRNA |
CTD |
PMID:19861542 PMID:33512557 |
|
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
|
|
G |
Clic4 |
chloride intracellular channel 4 |
increases expression |
ISO |
deguelin results in increased expression of CLIC4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
|
|
G |
Clk1 |
CDC-like kinase 1 |
increases expression |
ISO |
deguelin results in increased expression of CLK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
|
|
G |
Clpx |
caseinolytic mitochondrial matrix peptidase chaperone subunit X |
increases expression |
ISO |
deguelin results in increased expression of CLPX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082
|
|
G |
Cltc |
clathrin heavy chain |
increases expression |
ISO |
deguelin results in increased expression of CLTC mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
|
|
G |
Cmss1 |
cms1 ribosomal small subunit homolog |
increases expression |
ISO |
deguelin results in increased expression of CMSS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624
|
|
G |
Cntn1 |
contactin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CNTN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
|
|
G |
Coa6 |
cytochrome c oxidase assembly factor 6 |
increases expression |
ISO |
deguelin results in increased expression of COA6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:54,395,682...54,398,918
Ensembl chr19:54,395,742...54,399,407
|
|
G |
Col4a2 |
collagen type IV alpha 2 chain |
increases expression |
ISO |
deguelin results in increased expression of COL4A2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
|
|
G |
Comt |
catechol-O-methyltransferase |
increases expression |
ISO |
deguelin results in increased expression of COMT mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
|
|
G |
Cops5 |
COP9 signalosome subunit 5 |
decreases expression |
ISO |
deguelin results in decreased expression of COPS5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
|
|
G |
Coro1a |
coronin 1A |
decreases expression |
ISO |
deguelin results in decreased expression of CORO1A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
|
|
G |
Cpne3 |
copine 3 |
decreases expression |
ISO |
deguelin results in decreased expression of CPNE3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:33,014,658...33,064,004
Ensembl chr 5:33,016,307...33,063,934
|
|
G |
Cramp1 |
cramped chromatin regulator homolog 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CRAMP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:13,983,781...14,032,409
Ensembl chr10:13,983,866...14,032,392
|
|
G |
Crebrf |
CREB3 regulatory factor |
increases expression |
ISO |
deguelin results in increased expression of CREBRF mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
|
|
G |
Crk |
CRK proto-oncogene, adaptor protein |
decreases expression |
ISO |
deguelin results in decreased expression of CRK mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
|
|
G |
Crkl |
CRK like proto-oncogene, adaptor protein |
increases expression |
ISO |
deguelin results in increased expression of CRKL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
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G |
Csnk1a1 |
casein kinase 1, alpha 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CSNK1A1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
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G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
increases expression |
ISO |
deguelin results in increased expression of CSRNP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
deguelin results in increased expression of CTH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Ctnnal1 |
catenin alpha-like 1 |
increases expression |
ISO |
deguelin results in increased expression of CTNNAL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression increases degradation |
ISO |
[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein] deguelin results in decreased expression of CTNNB1 mRNA; deguelin results in decreased expression of CTNNB1 protein |
CTD |
PMID:21472727 PMID:22986522 PMID:33512557 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctnnd1 |
catenin delta 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CTNND1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516
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G |
Ctps1 |
CTP synthase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CTPS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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G |
Ctsd |
cathepsin D |
increases expression |
ISO |
deguelin results in increased expression of CTSD mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctss |
cathepsin S |
decreases expression |
ISO |
deguelin results in decreased expression of CTSS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cttn |
cortactin |
decreases expression |
ISO |
deguelin results in decreased expression of CTTN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions decreases expression |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA] deguelin results in decreased expression of CXCR4 mRNA |
CTD |
PMID:22745725 PMID:33512557 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cycs |
cytochrome c, somatic |
decreases expression |
ISO |
deguelin results in decreased expression of CYCS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] |
CTD |
PMID:19961161 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
ISO |
deguelin results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
affects expression |
ISO |
deguelin affects the expression of CYP3A5 mRNA |
CTD |
PMID:34642769 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Daam1 |
dishevelled associated activator of morphogenesis 1 |
decreases expression |
ISO |
deguelin results in decreased expression of DAAM1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114
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G |
Daxx |
death-domain associated protein |
decreases expression |
ISO |
deguelin results in decreased expression of DAXX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Dbf4 |
DBF4 zinc finger |
increases expression |
ISO |
deguelin results in increased expression of DBF4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066
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G |
Dbndd2 |
dysbindin domain containing 2 |
decreases expression |
ISO |
deguelin results in decreased expression of DBNDD2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:153,193,213...153,220,651
Ensembl chr 3:153,191,090...153,220,651
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G |
Dctd |
dCMP deaminase |
increases expression |
ISO |
deguelin results in increased expression of DCTD mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:44,066,952...44,098,654
Ensembl chr16:44,055,128...44,098,446
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G |
Dcx |
doublecortin |
decreases expression |
ISO |
deguelin results in decreased expression of DCX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ddc |
dopa decarboxylase |
decreases expression |
ISO |
deguelin results in decreased expression of DDC mRNA |
CTD |
PMID:33512557 PMID:34642769 |
|
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
deguelin results in increased expression of DDIT3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dennd3 |
DENN domain containing 3 |
decreases expression |
ISO |
deguelin results in decreased expression of DENND3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592
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G |
Depdc1b |
DEP domain containing 1B |
increases expression |
ISO |
deguelin results in increased expression of DEPDC1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
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G |
Dffb |
DNA fragmentation factor subunit beta |
decreases expression |
ISO |
deguelin results in decreased expression of DFFB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhdds |
dehydrodolichyl diphosphate synthase subunit |
decreases expression |
ISO |
deguelin results in decreased expression of DHDDS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454
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G |
Dhrs7 |
dehydrogenase/reductase 7 |
increases expression |
ISO |
deguelin results in increased expression of DHRS7 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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G |
Dhx15 |
DEAH-box helicase 15 |
increases expression |
ISO |
deguelin results in increased expression of DHX15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:58,787,147...58,825,083
Ensembl chr14:58,787,127...58,825,088
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G |
Dkk2 |
dickkopf WNT signaling pathway inhibitor 2 |
decreases expression |
ISO |
deguelin results in decreased expression of DKK2 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
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G |
Dkk4 |
dickkopf WNT signaling pathway inhibitor 4 |
increases expression |
ISO |
deguelin results in increased expression of DKK4 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr16:69,402,989...69,406,580
Ensembl chr16:69,402,989...69,406,580
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
increases expression |
ISO |
deguelin results in increased expression of DLAT mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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G |
Dlgap5 |
DLG associated protein 5 |
increases expression |
ISO |
deguelin results in increased expression of DLGAP5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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G |
Dll4 |
delta like canonical Notch ligand 4 |
decreases expression |
ISO |
deguelin results in decreased expression of DLL4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
deguelin results in increased expression of DNAJB1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
deguelin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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|
G |
Dnajc15 |
DnaJ heat shock protein family (Hsp40) member C15 |
increases expression |
ISO |
deguelin results in increased expression of DNAJC15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
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G |
Dnm1 |
dynamin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of DNM1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538
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G |
Dnm1l |
dynamin 1-like |
increases expression |
ISO |
deguelin results in increased expression of DNM1L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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|
G |
Dpp10 |
dipeptidyl peptidase like 10 |
increases expression |
ISO |
deguelin results in increased expression of DPP10 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:34,584,420...36,269,619
Ensembl chr13:34,595,868...36,269,292
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G |
Drd2 |
dopamine receptor D2 |
decreases expression |
ISO |
deguelin results in decreased expression of DRD2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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G |
Dusp14 |
dual specificity phosphatase 14 |
increases expression |
ISO |
deguelin results in increased expression of DUSP14 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
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G |
Dusp3 |
dual specificity phosphatase 3 |
increases expression |
ISO |
deguelin results in increased expression of DUSP3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
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G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
ISO |
deguelin results in increased expression of DUSP4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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G |
Dyrk3 |
dual specificity tyrosine phosphorylation regulated kinase 3 |
decreases expression |
ISO |
deguelin results in decreased expression of DYRK3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:42,594,120...42,604,898
Ensembl chr13:42,594,121...42,604,778
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
deguelin results in decreased expression of E2F1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Ebf1 |
EBF transcription factor 1 |
decreases expression |
ISO |
deguelin results in decreased expression of EBF1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
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G |
Ebna1bp2 |
EBNA1 binding protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of EBNA1BP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267
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G |
Eea1 |
early endosome antigen 1 |
increases expression |
ISO |
deguelin results in increased expression of EEA1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
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G |
Eef1b2 |
eukaryotic translation elongation factor 1 beta 2 |
increases expression |
ISO |
deguelin results in increased expression of EEF1B2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:64,580,009...64,582,737
Ensembl chr 9:64,579,893...64,582,737
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G |
Egfr |
epidermal growth factor receptor |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of EGFR protein; deguelin results in decreased expression of EGFR protein |
CTD |
PMID:19139008 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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|
G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
increases expression |
ISO |
deguelin results in increased expression of EIF1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation |
ISO |
deguelin results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:25322282 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
increases expression |
ISO |
deguelin results in increased expression of EIF2S2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif4b |
eukaryotic translation initiation factor 4B |
increases expression |
ISO |
deguelin results in increased expression of EIF4B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:133,206,637...133,228,436
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|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases expression increases expression decreases phosphorylation |
ISO |
deguelin metabolite results in decreased expression of EIF4EBP1 protein modified form; deguelin results in decreased expression of EIF4EBP1 protein modified form deguelin results in increased expression of EIF4EBP1 mRNA deguelin results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:19139008 PMID:27255535 PMID:33512557 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Elavl1 |
ELAV like RNA binding protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ELAVL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
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|
G |
Elmod1 |
ELMO domain containing 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ELMOD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140
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|
G |
Elp1 |
elongator acetyltransferase complex subunit 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ELP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
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G |
Endog |
endonuclease G |
decreases expression |
ISO |
deguelin results in decreased expression of ENDOG mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Eno2 |
enolase 2 |
decreases secretion decreases expression |
ISO |
deguelin results in decreased secretion of ENO2 protein deguelin results in decreased expression of ENO2 mRNA |
CTD |
PMID:26884827 PMID:33512557 |
|
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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|
G |
Entpd1 |
ectonucleoside triphosphate diphosphohydrolase 1 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] |
CTD |
PMID:27899277 |
|
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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G |
Ep300 |
E1A binding protein p300 |
decreases expression |
ISO |
deguelin results in decreased expression of EP300 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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|
G |
Epas1 |
endothelial PAS domain protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of EPAS1 protein |
CTD |
PMID:19336726 |
|
NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
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|
G |
Ephb2 |
Eph receptor B2 |
decreases expression |
ISO |
deguelin results in decreased expression of EPHB2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
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|
G |
Eps15 |
epidermal growth factor receptor pathway substrate 15 |
increases expression |
ISO |
deguelin results in increased expression of EPS15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
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|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ERN1 protein |
CTD |
PMID:25322282 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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|
G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
increases expression |
ISO |
deguelin results in increased expression of ERO1A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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|
G |
Etf1 |
eukaryotic translation termination factor 1 |
increases expression |
ISO |
deguelin results in increased expression of ETF1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
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|
G |
Etnk1 |
ethanolamine kinase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ETNK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770
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|
G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
increases expression |
ISO |
deguelin results in increased expression of ETS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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|
G |
Etv1 |
ETS variant transcription factor 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ETV1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
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|
G |
Evl |
Enah/Vasp-like |
decreases expression |
ISO |
deguelin results in decreased expression of EVL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:127,473,119...127,594,342
Ensembl chr 6:127,474,543...127,594,344
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|
G |
Exosc4 |
exosome component 4 |
decreases expression |
ISO |
deguelin results in decreased expression of EXOSC4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
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|
G |
Exosc8 |
exosome component 8 |
increases expression |
ISO |
deguelin results in increased expression of EXOSC8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
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|
G |
Fam174a |
family with sequence similarity 174, member A |
decreases expression |
ISO |
deguelin results in decreased expression of FAM174A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:95,742,927...95,761,081
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|
G |
Fam72a |
family with sequence similarity 72, member A |
increases expression |
ISO |
deguelin results in increased expression of FAM72A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:42,968,409...42,978,976
Ensembl chr13:42,967,578...42,984,208
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|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
deguelin results in increased expression of FAS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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|
G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
deguelin results in decreased expression of FASN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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|
G |
Fastkd5 |
FAST kinase domains 5 |
decreases expression |
ISO |
deguelin results in decreased expression of FASTKD5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:117,830,227...117,847,737
Ensembl chr 3:117,830,083...117,847,820
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|
G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
ISO |
deguelin results in increased expression of FGF2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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|
G |
Fibin |
fin bud initiation factor homolog |
increases expression |
ISO |
deguelin results in increased expression of FIBIN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676
|
|
G |
Fig4 |
FIG4 phosphoinositide 5-phosphatase |
decreases expression |
ISO |
deguelin results in decreased expression of FIG4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:44,600,603...44,724,047
Ensembl chr20:44,600,603...44,723,844
|
|
G |
Fkbp14 |
FKBP prolyl isomerase 14 |
decreases expression |
ISO |
deguelin results in decreased expression of FKBP14 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528
|
|
G |
Fkbp4 |
FKBP prolyl isomerase 4 |
increases expression |
ISO |
deguelin results in increased expression of FKBP4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
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|
G |
Flna |
filamin A |
increases expression |
ISO |
deguelin results in increased expression of FLNA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] |
CTD |
PMID:9270009 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
deguelin results in increased expression of FOSL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
|
|
G |
Foxj3 |
forkhead box J3 |
increases expression |
ISO |
deguelin results in increased expression of FOXJ3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:133,140,344...133,228,489
Ensembl chr 5:133,140,884...133,228,489
|
|
G |
Foxo4 |
forkhead box O4 |
decreases expression |
ISO |
deguelin results in decreased expression of FOXO4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
|
|
G |
Frzb |
frizzled-related protein |
increases expression |
ISO |
deguelin results in increased expression of FRZB mRNA |
CTD |
PMID:19861542 |
|
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
|
|
G |
Fstl1 |
follistatin-like 1 |
decreases expression |
ISO |
deguelin results in decreased expression of FSTL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
|
|
G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
deguelin results in increased expression of FTH1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
|
|
G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
deguelin results in increased expression of FTL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
|
|
G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
deguelin results in decreased expression of FYN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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|
G |
Fzd10 |
frizzled class receptor 10 |
increases expression |
ISO |
deguelin results in increased expression of FZD10 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr12:28,098,371...28,101,566
Ensembl chr12:28,098,371...28,101,566
|
|
G |
Fzd4 |
frizzled class receptor 4 |
increases expression |
ISO |
deguelin results in increased expression of FZD4 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr 1:143,280,065...143,288,799
Ensembl chr 1:143,280,065...143,285,724
|
|
G |
Fzd8 |
frizzled class receptor 8 |
increases expression |
ISO |
deguelin results in increased expression of FZD8 mRNA |
CTD |
PMID:19861542 |
|
NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650
|
|
G |
G3bp2 |
G3BP stress granule assembly factor 2 |
decreases expression |
ISO |
deguelin results in decreased expression of G3BP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:15,932,356...16,020,555
Ensembl chr14:15,987,417...16,020,548
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases expression |
ISO |
deguelin results in decreased expression of G6PD mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gaa |
alpha glucosidase |
decreases expression |
ISO |
deguelin results in decreased expression of GAA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
|
|
G |
Gabpb1 |
GA binding protein transcription factor subunit beta 1 |
increases expression |
ISO |
deguelin results in increased expression of GABPB1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:113,879,972...113,924,744
Ensembl chr 3:113,879,973...113,923,696
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
deguelin results in increased expression of GADD45A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
|
|
G |
Gale |
UDP-galactose-4-epimerase |
decreases expression |
ISO |
deguelin results in decreased expression of GALE mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388
|
|
G |
Galnt3 |
polypeptide N-acetylgalactosaminyltransferase 3 |
decreases expression |
ISO |
deguelin results in decreased expression of GALNT3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
|
|
G |
Gap43 |
growth associated protein 43 |
decreases expression |
ISO |
deguelin results in decreased expression of GAP43 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
|
|
G |
Gata2 |
GATA binding protein 2 |
increases expression |
ISO |
deguelin results in increased expression of GATA2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
deguelin results in increased expression of GCLC mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
deguelin results in increased expression of GCLM mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
deguelin results in increased expression of GDF15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gins2 |
GINS complex subunit 2 |
decreases expression |
ISO |
deguelin results in decreased expression of GINS2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339
|
|
G |
Gins3 |
GINS complex subunit 3 |
decreases expression |
ISO |
deguelin results in decreased expression of GINS3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687
|
|
G |
Gldc |
glycine decarboxylase |
decreases expression |
ISO |
deguelin results in decreased expression of GLDC mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:227,883,247...227,962,119
Ensembl chr 1:227,883,249...227,962,097
|
|
G |
Gli3 |
GLI family zinc finger 3 |
decreases expression |
ISO |
deguelin results in decreased expression of GLI3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
|
|
G |
Glrx |
glutaredoxin |
decreases expression |
ISO |
deguelin results in decreased expression of GLRX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
|
|
G |
Gmip |
Gem-interacting protein |
decreases expression |
ISO |
deguelin results in decreased expression of GMIP mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027
|
|
G |
Gmpr2 |
guanosine monophosphate reductase 2 |
decreases expression |
ISO |
deguelin results in decreased expression of GMPR2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:29,165,421...29,175,933
Ensembl chr15:29,165,783...29,174,935
|
|
G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
ISO |
deguelin results in decreased expression of GNAI2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
|
|
G |
Gnpda1 |
glucosamine-6-phosphate deaminase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of GNPDA1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:30,165,435...30,177,462
Ensembl chr18:30,165,427...30,177,486
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression |
ISO |
deguelin results in increased expression of GOT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G |
Gpc1 |
glypican 1 |
decreases expression |
ISO |
deguelin results in decreased expression of GPC1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
|
|
G |
Grb10 |
growth factor receptor bound protein 10 |
increases expression |
ISO |
deguelin results in increased expression of GRB10 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806
|
|
G |
Grb14 |
growth factor receptor bound protein 14 |
increases expression |
ISO |
deguelin results in increased expression of GRB14 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
|
|
G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
decreases expression |
ISO |
deguelin results in decreased expression of GRIA2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
|
|
G |
Grin2d |
glutamate ionotropic receptor NMDA type subunit 2D |
decreases expression |
ISO |
deguelin results in decreased expression of GRIN2D mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
|
|
G |
Grm4 |
glutamate metabotropic receptor 4 |
decreases expression |
ISO |
deguelin results in decreased expression of GRM4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
|
|
G |
Grn |
granulin precursor |
decreases expression |
ISO |
deguelin results in decreased expression of GRN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation |
ISO |
deguelin results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:19336726 PMID:21472727 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO |
deguelin results in increased expression of GSR mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
ISO |
deguelin results in decreased expression of GSTM2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Gtf2e2 |
general transcription factor IIE subunit 2 |
increases expression |
ISO |
deguelin results in increased expression of GTF2E2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371
|
|
G |
Gtpbp8 |
GTP-binding protein 8 (putative) |
increases expression |
ISO |
deguelin results in increased expression of GTPBP8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635
|
|
G |
Gucy2c |
guanylate cyclase 2C |
decreases expression |
ISO |
deguelin results in decreased expression of GUCY2C mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092
|
|
G |
H1f0 |
H1.0 linker histone |
increases expression |
ISO |
deguelin results in increased expression of H1-0 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694
|
|
G |
H1f2 |
H1.2 linker histone, cluster member |
increases expression |
ISO |
deguelin results in increased expression of H1-2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:41,391,106...41,392,611
Ensembl chr17:41,388,477...41,392,635
|
|
G |
H2az2 |
H2A.Z variant histone 2 |
decreases expression |
ISO |
deguelin results in decreased expression of H2AZ2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:81,293,299...81,312,209
Ensembl chr14:81,293,299...81,312,144
|
|
G |
H2bc12 |
H2B clustered histone 12 |
increases expression |
ISO |
deguelin results in increased expression of H2BC12 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:42,485,746...42,486,126
|
|
G |
Hba-a3 |
hemoglobin alpha, adult chain 3 |
increases expression |
ISO |
deguelin results in increased expression of HBA2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481
|
|
G |
Hells |
helicase, lymphoid specific |
increases expression |
ISO |
deguelin results in increased expression of HELLS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
|
|
G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
ISO |
deguelin results in increased expression of HERPUD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
|
|
G |
Hes1 |
hes family bHLH transcription factor 1 |
increases expression |
ISO |
deguelin results in increased expression of HES1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G |
Hexa |
hexosaminidase subunit alpha |
decreases expression |
ISO |
deguelin results in decreased expression of HEXA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013
|
|
G |
Hexb |
hexosaminidase subunit beta |
increases expression |
ISO |
deguelin results in increased expression of HEXB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
|
|
G |
Hhip |
Hedgehog-interacting protein |
increases expression |
ISO |
deguelin results in increased expression of HHIP mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases degradation multiple interactions |
ISO |
deguelin results in increased degradation of HIF1A protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] |
CTD |
PMID:17764071 PMID:18575727 PMID:19139008 PMID:22745725 PMID:27899277 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hist1h2af |
histone cluster 1 H2A family member F |
increases expression |
ISO |
deguelin results in increased expression of H2AC8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
|
|
G |
Hist1h2ah |
histone cluster 1 H2A family member H |
increases expression |
ISO |
deguelin results in increased expression of H2AC11 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:41,384,521...41,385,018
|
|
G |
Hist1h2bd |
histone cluster 1 H2B family member D |
increases expression |
ISO |
deguelin results in increased expression of H2BC5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:42,792,887...42,793,268
|
|
G |
Hmga2 |
high mobility group AT-hook 2 |
increases expression |
ISO |
deguelin results in increased expression of HMGA2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
|
|
G |
Hmmr |
hyaluronan-mediated motility receptor |
increases expression |
ISO |
deguelin results in increased expression of HMMR mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
deguelin results in increased expression of HMOX1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnrnpm |
heterogeneous nuclear ribonucleoprotein M |
decreases expression |
ISO |
deguelin results in decreased expression of HNRNPM mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762
|
|
G |
Homer2 |
homer scaffold protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of HOMER2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772
|
|
G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases expression |
ISO |
deguelin results in increased expression of HPRT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
|
|
G |
Hsd17b11 |
hydroxysteroid (17-beta) dehydrogenase 11 |
increases expression |
ISO |
deguelin results in increased expression of HSD17B11 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161
|
|
G |
Hsd17b8 |
hydroxysteroid (17-beta) dehydrogenase 8 |
decreases expression |
ISO |
deguelin results in decreased expression of HSD17B8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742
|
|
G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
deguelin results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
|
|
G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
increases expression |
ISO |
deguelin results in increased expression of HSP90AB1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
|
|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
ISO |
deguelin results in increased expression of HSPA1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
|
|
G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
increases expression |
ISO |
deguelin results in increased expression of HSPA4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
|
|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression |
ISO |
deguelin results in increased expression of HSPA8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
|
|
G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
ISO |
deguelin results in increased expression of HSPB1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
increases expression |
ISO |
deguelin results in increased expression of HSPD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
|
|
G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
increases expression |
ISO |
deguelin results in increased expression of HSPE1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
|
|
G |
Hyou1 |
hypoxia up-regulated 1 |
increases expression |
ISO |
deguelin results in increased expression of HYOU1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:17015749 PMID:22745725 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Id1 |
inhibitor of DNA binding 1, HLH protein |
decreases expression |
ISO |
deguelin results in decreased expression of ID1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
|
|
G |
Idh3a |
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
increases expression |
ISO |
deguelin results in increased expression of IDH3A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
|
|
G |
Ifi44 |
interferon-induced protein 44 |
decreases expression |
ISO |
deguelin results in decreased expression of IFI44 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
|
|
G |
Ifi44l |
interferon-induced protein 44-like |
increases expression |
ISO |
deguelin results in increased expression of IFI44L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
|
|
G |
Ifitm2 |
interferon induced transmembrane protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of IFITM2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
|
|
G |
Ifitm3 |
interferon induced transmembrane protein 3 |
decreases expression |
ISO |
deguelin results in decreased expression of IFITM3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
EXP ISO |
deguelin inhibits the reaction [Perfadex results in increased expression of IFNG protein] [deguelin co-treated with OVAL protein] results in increased expression of IFNG protein |
CTD |
PMID:22745725 PMID:28529457 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
ISO |
deguelin results in increased expression of IFRD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
|
|
G |
Ifrd2 |
interferon-related developmental regulator 2 |
increases expression |
ISO |
deguelin results in increased expression of IFRD2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:108,260,969...108,266,191
Ensembl chr 8:108,260,969...108,266,194
|
|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA] |
CTD |
PMID:17764071 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Igf1r |
insulin-like growth factor 1 receptor |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of IGF1R protein; deguelin results in decreased expression of IGF1R mRNA; deguelin results in decreased expression of IGF1R protein |
CTD |
PMID:19139008 PMID:33512557 |
|
NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
|
|
G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of IGFBP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
|
|
G |
Ighmbp2 |
immunoglobulin mu DNA binding protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of IGHMBP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:200,506,641...200,529,293
Ensembl chr 1:200,506,338...200,529,514
|
|
G |
Ihh |
Indian hedgehog signaling molecule |
increases expression |
ISO |
deguelin results in increased expression of IHH mRNA |
CTD |
PMID:19861542 |
|
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
|
|
G |
Ikbip |
IKBKB interacting protein |
increases expression |
ISO |
deguelin results in increased expression of IKBIP mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:25,579,759...25,598,548
Ensembl chr 7:25,579,832...25,605,162
|
|
G |
Ikzf1 |
IKAROS family zinc finger 1 |
decreases expression |
ISO |
deguelin results in decreased expression of IKZF1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
deguelin inhibits the reaction [OVAL protein results in increased expression of IL13 protein] |
CTD |
PMID:28529457 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
EXP ISO |
deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA] deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 protein] |
CTD |
PMID:22745725 PMID:28529457 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
deguelin inhibits the reaction [OVAL protein results in increased expression of IL5 protein] |
CTD |
PMID:28529457 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
deguelin inhibits the reaction [Perfadex results in decreased expression of IL6 protein] |
CTD |
PMID:22745725 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ina |
internexin neuronal intermediate filament protein, alpha |
decreases expression |
ISO |
deguelin results in decreased expression of INA mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
|
|
G |
Ipo5 |
importin 5 |
increases expression |
ISO |
deguelin results in increased expression of IPO5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126
|
|
G |
Iqgap1 |
IQ motif containing GTPase activating protein 1 |
increases expression |
ISO |
deguelin results in increased expression of IQGAP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein |
CTD |
PMID:25242579 |
|
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Itpr2 |
inositol 1,4,5-trisphosphate receptor, type 2 |
decreases expression |
ISO |
deguelin results in decreased expression of ITPR2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
|
|
G |
Jmjd6 |
jumonji domain containing 6, arginine demethylase and lysine hydroxylase |
increases expression |
ISO |
deguelin results in increased expression of JMJD6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
ISO |
deguelin results in increased phosphorylation of JUN protein |
CTD |
PMID:25322282 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
deguelin results in decreased expression of JUNB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
|
|
G |
Kat6a |
lysine acetyltransferase 6A |
increases expression |
ISO |
deguelin results in increased expression of KAT6A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606
|
|
G |
Kcnj8 |
potassium inwardly-rectifying channel, subfamily J, member 8 |
increases expression |
ISO |
deguelin results in increased expression of KCNJ8 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
|
|
G |
Kcnk1 |
potassium two pore domain channel subfamily K member 1 |
decreases expression |
ISO |
deguelin results in decreased expression of KCNK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724
|
|
G |
Kctd9 |
potassium channel tetramerization domain containing 9 |
increases expression |
ISO |
deguelin results in increased expression of KCTD9 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:41,942,165...41,969,862
Ensembl chr15:41,942,381...41,969,862
|
|
G |
Kdm5b |
lysine demethylase 5B |
decreases expression |
ISO |
deguelin results in decreased expression of KDM5B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
|
|
G |
Kdr |
kinase insert domain receptor |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of KDR protein; deguelin results in decreased expression of KDR protein |
CTD |
PMID:19139008 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
ISO |
deguelin results in increased expression of KEAP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Khdrbs3 |
KH RNA binding domain containing, signal transduction associated 3 |
increases expression |
ISO |
deguelin results in increased expression of KHDRBS3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460
|
|
G |
Kif15 |
kinesin family member 15 |
increases expression |
ISO |
deguelin results in increased expression of KIF15 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750
|
|
G |
Kif20a |
kinesin family member 20A |
increases expression |
ISO |
deguelin results in increased expression of KIF20A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
|
|
G |
Kif23 |
kinesin family member 23 |
increases expression |
ISO |
deguelin results in increased expression of KIF23 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
|
|
G |
Kif2c |
kinesin family member 2C |
increases expression |
ISO |
deguelin results in increased expression of KIF2C mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
|
|
G |
Kif5c |
kinesin family member 5C |
decreases expression |
ISO |
deguelin results in decreased expression of KIF5C mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
|
|
G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
decreases expression |
ISO |
deguelin results in decreased expression of KIT mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
|
|
G |
Klhl24 |
kelch-like family member 24 |
increases expression |
ISO |
deguelin results in increased expression of KLHL24 mRNA |
CTD |
PMID:34642769 |
|
NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
|
|
G |
Knl1 |
kinetochore scaffold 1 |
increases expression |
ISO |
deguelin results in increased expression of KNL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
|
|
G |
Krt17 |
keratin 17 |
increases expression |
ISO |
deguelin results in increased expression of KRT17 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
|
|
G |
Krt18 |
keratin 18 |
increases expression multiple interactions |
ISO |
deguelin results in increased expression of KRT18 protein deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein] |
CTD |
PMID:22986522 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
|
|
G |
Ktn1 |
kinectin 1 |
increases expression |
ISO |
deguelin results in increased expression of KTN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578
|
|
G |
L1cam |
L1 cell adhesion molecule |
decreases expression |
ISO |
deguelin results in decreased expression of L1CAM mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857
|
|
G |
Lamc2 |
laminin subunit gamma 2 |
decreases expression |
ISO |
deguelin results in decreased expression of LAMC2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
|
|
G |
Lamp1 |
lysosomal-associated membrane protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of LAMP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
|
|
G |
Lef1 |
lymphoid enhancer binding factor 1 |
increases expression |
ISO |
deguelin results in increased expression of LEF1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
|
|
G |
Lgmn |
legumain |
decreases expression |
ISO |
deguelin results in decreased expression of LGMN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
|
|
G |
Lmod1 |
leiomodin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of LMOD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900
|
|
G |
LOC100125598 |
metallothionein 1a pseudogene |
increases expression |
ISO |
deguelin results in increased expression of MT1G mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
|
|
G |
LOC102549061 |
histone H2B type 1-N-like |
increases expression |
ISO |
deguelin results in increased expression of H2BC3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:41,380,058...41,380,685
|
|
G |
LOC102556347 |
carbonyl reductase [NADPH] 1-like |
decreases expression |
ISO |
deguelin results in decreased expression of CBR1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275
|
|
G |
LOC103690190 |
histone H2A type 1-E |
increases expression |
ISO |
deguelin results in increased expression of H2AC6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:42,707,863...42,708,420
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|
G |
LOC498265 |
similar to hypothetical protein FLJ10706 |
decreases expression |
ISO |
deguelin results in decreased expression of C1ORF112 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804
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G |
LOC684841 |
similar to CG31613-PA |
increases expression |
ISO |
deguelin results in increased expression of H3C10 mRNA |
CTD |
PMID:33512557 |
|
|
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G |
LOC686035 |
similar to heat shock 70kDa protein 6 (HSP70B) |
increases expression |
ISO |
deguelin results in increased expression of HSPA6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:83,271,340...83,275,267
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G |
Lox |
lysyl oxidase |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
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G |
Loxl1 |
lysyl oxidase-like 1 |
decreases expression |
ISO |
deguelin results in decreased expression of LOXL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356
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|
G |
Lpar2 |
lysophosphatidic acid receptor 2 |
decreases expression |
ISO |
deguelin results in decreased expression of LPAR2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:19,592,067...19,600,850
Ensembl chr16:19,595,655...19,599,998
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|
G |
Lrp4 |
LDL receptor related protein 4 |
increases expression |
ISO |
deguelin results in increased expression of LRP4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
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|
G |
Lsm2 |
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
increases expression |
ISO |
deguelin results in increased expression of LSM2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266
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G |
Lss |
lanosterol synthase |
decreases expression |
ISO |
deguelin results in decreased expression of LSS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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|
G |
Magi1 |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MAGI1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:126,205,667...126,811,354
Ensembl chr 4:126,206,816...126,811,691
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|
G |
Map1b |
microtubule-associated protein 1B |
decreases expression |
ISO |
deguelin results in decreased expression of MAP1B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
ISO |
deguelin results in increased expression of MAP1LC3B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of MAP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of MAP2K1 protein; deguelin results in decreased expression of MAP2K1 protein |
CTD |
PMID:19139008 PMID:19336726 |
|
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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|
G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
decreases expression |
ISO |
deguelin results in decreased expression of MAP2K2 protein |
CTD |
PMID:19336726 |
|
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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|
G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
decreases expression |
ISO |
deguelin results in decreased expression of MAP2K7 protein |
CTD |
PMID:25322282 |
|
NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
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G |
Map3k3 |
mitogen activated protein kinase kinase kinase 3 |
affects expression |
ISO |
deguelin affects the expression of MAP3K3 protein |
CTD |
PMID:25322282 |
|
NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
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|
G |
Map6 |
microtubule-associated protein 6 |
decreases expression |
ISO |
deguelin results in decreased expression of MAP6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:153,568,019...153,634,415
Ensembl chr 1:153,568,368...153,634,414
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
affects phosphorylation |
ISO |
deguelin affects the phosphorylation of MAPK1 protein |
CTD |
PMID:25322282 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk12 |
mitogen-activated protein kinase 12 |
decreases expression |
ISO |
deguelin results in decreased expression of MAPK12 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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|
G |
Mapk1ip1l |
mitogen-activated protein kinase 1 interacting protein 1-like |
increases expression |
ISO |
deguelin results in increased expression of MAPK1IP1L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:20,545,028...20,567,010
Ensembl chr15:20,545,059...20,569,674
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G |
Mapk3 |
mitogen activated protein kinase 3 |
affects phosphorylation decreases expression |
ISO |
deguelin affects the phosphorylation of MAPK3 protein deguelin results in decreased expression of MAPK3 mRNA |
CTD |
PMID:25322282 PMID:33512557 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapre3 |
microtubule-associated protein, RP/EB family, member 3 |
decreases expression |
ISO |
deguelin results in decreased expression of MAPRE3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881
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G |
Marcks |
myristoylated alanine rich protein kinase C substrate |
decreases expression |
ISO |
deguelin results in decreased expression of MARCKS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
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|
G |
Mat2a |
methionine adenosyltransferase 2A |
decreases expression |
ISO |
deguelin results in decreased expression of MAT2A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
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|
G |
Mbtps1 |
membrane-bound transcription factor peptidase, site 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MBTPS1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791
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|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
deguelin results in decreased expression of MCL1 protein |
CTD |
PMID:21472727 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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|
G |
Mcm3 |
minichromosome maintenance complex component 3 |
decreases expression |
ISO |
deguelin results in decreased expression of MCM3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
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G |
Mcoln1 |
mucolipin TRP cation channel 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MCOLN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252
|
|
G |
Mcur1 |
mitochondrial calcium uniporter regulator 1 |
increases expression |
ISO |
deguelin results in increased expression of MCUR1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:21,142,526...21,159,651
Ensembl chr17:21,141,602...21,159,651
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
ISO |
deguelin results in increased expression of MDM2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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|
G |
Me1 |
malic enzyme 1 |
increases expression |
ISO |
deguelin results in increased expression of ME1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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|
G |
Me2 |
malic enzyme 2 |
increases expression |
ISO |
deguelin results in increased expression of ME2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987
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|
G |
Metrn |
meteorin, glial cell differentiation regulator |
decreases expression |
ISO |
deguelin results in decreased expression of METRN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701
|
|
G |
Mfsd10 |
major facilitator superfamily domain containing 10 |
decreases expression |
ISO |
deguelin results in decreased expression of MFSD10 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:76,103,762...76,107,385
Ensembl chr14:76,103,815...76,107,377
|
|
G |
Mfsd14a |
major facilitator superfamily domain containing 14A |
increases expression |
ISO |
deguelin results in increased expression of MFSD14A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:204,579,174...204,611,600
Ensembl chr 2:204,579,174...204,659,319
|
|
G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases expression |
ISO |
deguelin results in decreased expression of MGMT mRNA |
CTD |
PMID:22227970 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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|
G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
deguelin results in decreased expression of MKI67 protein |
CTD |
PMID:22623043 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
|
|
G |
Mllt11 |
MLLT11, transcription factor 7 cofactor |
decreases expression |
ISO |
deguelin results in decreased expression of MLLT11 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
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|
G |
Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MMP1 protein |
CTD |
PMID:25322282 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
|
|
G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
deguelin results in decreased expression of MMP13 protein |
CTD |
PMID:25322282 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
deguelin results in decreased expression of and results in decreased activity of MMP2 protein deguelin results in decreased expression of MMP2 mRNA; deguelin results in decreased expression of MMP2 protein |
CTD |
PMID:25322282 PMID:26884827 PMID:33512557 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
deguelin results in decreased expression of MMP7 mRNA |
CTD |
PMID:25322282 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression decreases activity |
ISO |
deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] deguelin results in decreased expression of MMP9 mRNA; deguelin results in decreased expression of MMP9 protein deguelin results in decreased activity of MMP9 protein |
CTD |
PMID:17015749 PMID:25322282 PMID:26884827 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Mnd1 |
meiotic nuclear divisions 1 |
increases expression |
ISO |
deguelin results in increased expression of MND1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:169,433,538...169,496,081
Ensembl chr 2:169,433,540...169,496,096
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|
G |
Morn2 |
MORN repeat containing 2 |
decreases expression |
ISO |
deguelin results in decreased expression of MORN2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:14,718,799...14,725,281
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|
G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
EXP |
deguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA] |
CTD |
PMID:22745725 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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|
G |
Mrpl19 |
mitochondrial ribosomal protein L19 |
increases expression |
ISO |
deguelin results in increased expression of MRPL19 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053
|
|
G |
Mrpl58 |
mitochondrial ribosomal protein L58 |
increases expression |
ISO |
deguelin results in increased expression of MRPL58 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871
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|
G |
Mrps6 |
mitochondrial ribosomal protein S6 |
decreases expression |
ISO |
deguelin results in decreased expression of MRPS6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:31,295,358...31,348,483
Ensembl chr11:31,295,614...31,348,484
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|
G |
Msh6 |
mutS homolog 6 |
increases expression |
ISO |
deguelin results in increased expression of MSH6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
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G |
Msi2 |
musashi RNA-binding protein 2 |
decreases expression |
ISO |
deguelin results in decreased expression of MSI2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157
|
|
G |
Mt-nd6 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 |
decreases expression |
ISO |
deguelin results in decreased expression of ND6 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
|
|
G |
Mt2A |
metallothionein 2A |
increases expression |
ISO |
deguelin results in increased expression of MT2A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
|
|
G |
Mtf2 |
metal response element binding transcription factor 2 |
increases expression |
ISO |
deguelin results in increased expression of MTF2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524
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|
G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
increases expression |
ISO |
deguelin results in increased expression of MTHFD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
|
|
G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
increases expression |
ISO |
deguelin results in increased expression of MTHFD2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression decreases phosphorylation |
ISO |
deguelin metabolite results in decreased expression of MTOR protein; deguelin results in decreased expression of MTOR protein deguelin results in decreased phosphorylation of MTOR protein |
CTD |
PMID:19139008 PMID:27255535 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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|
G |
Muc1 |
mucin 1, cell surface associated |
decreases expression |
ISO |
deguelin results in decreased expression of MUC1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
|
|
G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
deguelin inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA] |
CTD |
PMID:28529457 |
|
NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G |
Mybl1 |
MYB proto-oncogene like 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MYBL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression decreases expression |
ISO |
[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein] deguelin results in increased expression of MYC mRNA deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein] |
CTD |
PMID:9270009 PMID:17015749 PMID:21472727 PMID:33512557 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Myl1 |
myosin, light chain 1 |
decreases expression |
ISO |
deguelin results in decreased expression of MYL1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
|
|
G |
Myl4 |
myosin, light chain 4 |
decreases expression |
ISO |
deguelin results in decreased expression of MYL4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363
|
|
G |
Nampt |
nicotinamide phosphoribosyltransferase |
increases expression |
ISO |
deguelin results in increased expression of NAMPT mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
|
|
G |
Nat1 |
N-acetyltransferase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NAT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
|
|
G |
Nav1 |
neuron navigator 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NAV1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449
|
|
G |
Ncan |
neurocan |
decreases expression |
ISO |
deguelin results in decreased expression of NCAN mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
|
|
G |
Ncaph |
non-SMC condensin I complex, subunit H |
increases expression |
ISO |
deguelin results in increased expression of NCAPH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
|
|
G |
Nck1 |
NCK adaptor protein 1 |
increases expression |
ISO |
deguelin results in increased expression of NCK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
|
|
G |
Ncoa3 |
nuclear receptor coactivator 3 |
decreases expression |
ISO |
deguelin results in decreased expression of NCOA3 mRNA; deguelin results in decreased expression of NCOA3 protein |
CTD |
PMID:19365708 |
|
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
|
|
G |
Ndrg1 |
N-myc downstream regulated 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NDRG1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
|
|
G |
Ndufv3 |
NADH:ubiquinone oxidoreductase subunit V3 |
increases expression |
ISO |
deguelin results in increased expression of NDUFV3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
|
|
G |
Nefh |
neurofilament heavy chain |
decreases expression |
ISO |
deguelin results in decreased expression of NEFH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
|
|
G |
Nefl |
neurofilament light chain |
decreases expression |
ISO |
deguelin results in decreased expression of NEFL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Neil3 |
nei-like DNA glycosylase 3 |
increases expression |
ISO |
deguelin results in increased expression of NEIL3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
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G |
Nek2 |
NIMA-related kinase 2 |
decreases expression increases expression |
ISO |
deguelin results in decreased expression of NEK2 mRNA; deguelin results in decreased expression of NEK2 protein deguelin results in increased expression of NEK2 mRNA |
CTD |
PMID:28509438 PMID:33512557 |
|
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
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G |
Neurod1 |
neuronal differentiation 1 |
increases expression |
ISO |
deguelin results in increased expression of NEUROD1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:64,360,222...64,363,526
Ensembl chr 3:64,359,395...64,363,649
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G |
Nfe2l1 |
NFE2 like bZIP transcription factor 1 |
increases expression |
ISO |
deguelin results in increased expression of NFE2L1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] deguelin inhibits the reaction [OVAL protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17015749 PMID:22623043 PMID:28529457 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nisch |
nischarin |
decreases expression |
ISO |
deguelin results in decreased expression of NISCH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668
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G |
Nolc1 |
nucleolar and coiled-body phosphoprotein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NOLC1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088
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G |
Nop58 |
NOP58 ribonucleoprotein |
increases expression |
ISO |
deguelin results in increased expression of NOP58 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
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|
G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
ISO |
deguelin results in decreased expression of NOS2 protein deguelin inhibits the reaction [OVAL protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:25322282 PMID:28529457 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Nos3 |
nitric oxide synthase 3 |
decreases expression increases expression |
ISO |
deguelin results in decreased expression of NOS3 protein deguelin results in increased expression of NOS3 mRNA |
CTD |
PMID:19336726 PMID:34642769 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch2 |
notch receptor 2 |
increases expression |
ISO |
deguelin results in increased expression of NOTCH2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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G |
Notch3 |
notch receptor 3 |
decreases expression |
ISO |
deguelin results in decreased expression of NOTCH3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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G |
Npdc1 |
neural proliferation, differentiation and control, 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NPDC1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:8,220,446...8,226,446
Ensembl chr 3:8,213,663...8,226,866
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G |
Npm1 |
nucleophosmin 1 |
decreases expression multiple interactions increases response to substance |
ISO |
[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein |
CTD |
PMID:25242579 |
|
NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
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G |
Nptx1 |
neuronal pentraxin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NPTX1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
deguelin results in increased expression of NQO1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr2f1 |
nuclear receptor subfamily 2, group F, member 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NR2F1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
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|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression |
ISO |
deguelin results in increased expression of NR3C1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
ISO |
deguelin results in decreased expression of NR4A2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NR5A1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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|
G |
Nras |
NRAS proto-oncogene, GTPase |
decreases expression |
ISO |
deguelin results in decreased expression of NRAS mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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G |
Nrcam |
neuronal cell adhesion molecule |
decreases expression |
ISO |
deguelin results in decreased expression of NRCAM mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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|
G |
Nrip1 |
nuclear receptor interacting protein 1 |
increases expression |
ISO |
deguelin results in increased expression of NRIP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Nrxn1 |
neurexin 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NRXN1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
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G |
Nsg1 |
neuronal vesicle trafficking associated 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NSG1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514
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G |
Nt5e |
5' nucleotidase, ecto |
multiple interactions |
ISO |
deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein] |
CTD |
PMID:27899277 |
|
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
Ntrk1 |
neurotrophic receptor tyrosine kinase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of NTRK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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G |
Nudcd3 |
NudC domain containing 3 |
decreases expression |
ISO |
deguelin results in decreased expression of NUDCD3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:80,975,417...81,059,183
Ensembl chr14:80,976,328...81,058,962
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G |
Nudt5 |
nudix hydrolase 5 |
decreases expression |
ISO |
deguelin results in decreased expression of NUDT5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr17:72,435,690...72,459,008
Ensembl chr17:72,435,697...72,459,001
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|
G |
Nudt9 |
nudix hydrolase 9 |
increases expression |
ISO |
deguelin results in increased expression of NUDT9 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142
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|
G |
Nuf2 |
NUF2 component of NDC80 kinetochore complex |
increases expression |
ISO |
deguelin results in increased expression of NUF2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
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G |
Nup85 |
nucleoporin 85 |
decreases expression |
ISO |
deguelin results in decreased expression of NUP85 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:100,806,482...100,825,029
Ensembl chr10:100,806,437...100,825,043
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|
G |
Nup88 |
nucleoporin 88 |
decreases expression |
ISO |
deguelin results in decreased expression of NUP88 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257
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G |
Nup98 |
nucleoporin 98 and 96 precursor |
decreases expression |
ISO |
deguelin results in decreased expression of NUP98 mRNA; deguelin results in decreased expression of NUP98 protein |
CTD |
PMID:17490514 |
|
NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
|
|
G |
Nvl |
nuclear VCP-like |
increases expression |
ISO |
deguelin results in increased expression of NVL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049
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|
G |
Oaz1 |
ornithine decarboxylase antizyme 1 |
increases expression |
ISO |
deguelin results in increased expression of OAZ1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310
|
|
G |
Odc1 |
ornithine decarboxylase 1 |
increases activity multiple interactions |
ISO |
deguelin results in increased activity of ODC1 protein deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]; deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA] |
CTD |
PMID:9270009 PMID:9834970 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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|
G |
Oip5 |
Opa interacting protein 5 |
increases expression |
ISO |
deguelin results in increased expression of OIP5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250
|
|
G |
Olfml2b |
olfactomedin-like 2B |
decreases expression |
ISO |
deguelin results in decreased expression of OLFML2B mRNA |
CTD |
PMID:33512557 |
|
NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607
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|
G |
Onecut1 |
one cut homeobox 1 |
decreases expression |
ISO |
deguelin results in decreased expression of ONECUT1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
|
|
G |
Orc3 |
origin recognition complex, subunit 3 |
decreases expression |
ISO |
deguelin results in decreased expression of ORC3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:49,123,758...49,181,552
Ensembl chr 5:49,126,955...49,181,633
|
|
G |
Oxa1l |
OXA1L, mitochondrial inner membrane protein |
increases expression |
ISO |
deguelin results in increased expression of OXA1L mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:27,813,688...27,821,319
Ensembl chr15:27,813,625...27,821,319
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|
G |
P2rx3 |
purinergic receptor P2X 3 |
decreases expression |
ISO |
deguelin results in decreased expression of P2RX3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
|
|
G |
Pafah1b1 |
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 |
increases expression |
ISO |
deguelin results in increased expression of PAFAH1B1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
|
|
G |
Pafah1b3 |
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 |
decreases expression |
ISO |
deguelin results in decreased expression of PAFAH1B3 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:80,881,263...80,883,789
Ensembl chr 1:80,881,309...80,883,893
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|
G |
Paip1 |
poly(A) binding protein interacting protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of PAIP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:51,523,142...51,550,241
Ensembl chr 2:51,522,921...51,550,241
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage increases expression |
ISO |
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] deguelin results in increased cleavage of PARP1 protein deguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified form |
CTD |
PMID:17015749 PMID:17035597 PMID:19139008 PMID:22986522 PMID:25242579 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Parp2 |
poly (ADP-ribose) polymerase 2 |
increases expression |
ISO |
deguelin results in increased expression of PARP2 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
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|
G |
Pbk |
PDZ binding kinase |
increases expression |
ISO |
deguelin results in increased expression of PBK mRNA |
CTD |
PMID:33512557 |
|
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
|
|
G |
Pcdha1 |
protocadherin alpha 1 |
decreases expression |
ISO |
deguelin results in decreased expression of PCDHA1 mRNA |
CTD |
PMID:33512557 |
|
Ensembl chr18:28,581,225...28,846,211
|
|
G |
Pcdha9 |
protocadherin alpha 9 |
decreases expression |
ISO |
deguelin results in decreased expression of PCDHA9 mRNA |
CTD |
PMID:33512557 |
|
|
|
G |
Pde1a |
phosphodiesterase 1A |
decreases expression |
ISO |
deguelin results in decreased expression of PDE1A mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
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|
G |
Pdgfb |
platelet derived growth factor subunit B |
decreases expression |
ISO |
deguelin results in decreased expression of PDGFB mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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|
G |
Pdhx |
pyruvate dehydrogenase complex, component X |
increases expression |
ISO |
deguelin results in increased expression of PDHX mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 3:89,372,472...89,396,759
Ensembl chr 3:89,371,497...89,431,773
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|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases expression |
ISO |
deguelin metabolite results in decreased expression of PDK1 protein; deguelin results in decreased expression of PDK1 protein |
CTD |
PMID:19139008 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
|
|
G |
Pebp1 |
phosphatidylethanolamine binding protein 1 |
decreases expression |
ISO |
deguelin results in decreased expression of PEBP1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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|
G |
Peg10 |
paternally expressed 10 |
decreases expression |
ISO |
deguelin results in decreased expression of PEG10 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 4:32,842,394...32,855,641
Ensembl chr 4:32,848,493...32,852,621
|
|
G |
Pfkfb4 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
decreases expression |
ISO |
deguelin results in decreased expression of PFKFB4 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
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|
G |
Pfkl |
phosphofructokinase, liver type |
decreases expression |
ISO |
deguelin results in decreased expression of PFKL mRNA |
CTD |
PMID:33512557 |
|
NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
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|
G |
Pfkp |
phosphofructokinase, platelet |
increases expression |
ISO |
deguelin results in increased expression of PFKP mRNA |
CTD |
PMID:34642769 |
|
NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
|
|
G |
Pga5 |
pepsinogen A5 |
increases expression |
ISO |
deguelin results in increased expression of PGA5 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 1:207,317,021...207,327,156
Ensembl chr 1:207,317,021...207,327,156
|
|
G |
Pgf |
placental growth factor |
decreases expression |
ISO |
deguelin results in decreased expression of PGF mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
|
|
G |
Pgk1 |
phosphoglycerate kinase 1 |
decreases expression |
ISO |
deguelin results in decreased expression of PGK1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
|
|
G |
Pgm1 |
phosphoglucomutase 1 |
increases expression |
ISO |
deguelin results in increased expression of PGM1 mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
|
|
G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression |
ISO |
deguelin results in increased expression of PHGDH mRNA |
CTD |
PMID:33512557 |
|
NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
|
|
G |
Phlda1 |
|