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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzoxazole
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Accession:CHEBI:46700 term browser browse the term
Definition:Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton.
Synonyms:related_synonym: benzoxazoles


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2-benzoxazolinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO benzoxazolone results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
6-Hydroxychlorzoxazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation
increases chemical synthesis
multiple interactions
increases abundance		 ISO
EXP		 CYP2E1 protein results in increased hydroxylation of 6-hydroxychlorzoxazone
CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone
[CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [Dextran Sulfate results in decreased activity of CYP2E1 protein] which results in decreased chemical synthesis of 6-hydroxychlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone
CYP2E1 protein results in increased abundance of 6-hydroxychlorzoxazone		 CTD PMID:12401345 PMID:15155557 PMID:19900514 PMID:21915887 PMID:23669205 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [stearic acid results in increased chemical synthesis of 6-hydroxychlorzoxazone] CTD PMID:26739624 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
benoxaprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases response to substance ISO ALB protein results in decreased susceptibility to benoxaprofen CTD PMID:6699424 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity EXP benoxaprofen results in decreased activity of ALOX12 protein CTD PMID:3928952 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity		 ISO
EXP		 [benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:2724698 PMID:2849922 PMID:3020588 PMID:3928952 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity		 EXP
ISO		 benoxaprofen results in increased expression of CYP1A1 protein
benoxaprofen results in decreased activity of CYP1A1 protein		 CTD PMID:2069584 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP benoxaprofen results in increased expression of CYP1A2 protein CTD PMID:2069584 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO benoxaprofen results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP benoxaprofen results in increased expression of CYP4A1 protein CTD PMID:2069584 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP benoxaprofen results in increased expression of EHHADH protein CTD PMID:2069584 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Gusb glucuronidase, beta increases secretion ISO benoxaprofen results in increased secretion of GUSB protein CTD PMID:6737371 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:6430271 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects response to substance ISO UGT1A3 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects response to substance ISO UGT1A9 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance
increases glucuronidation		 ISO UGT2B7 affects the susceptibility to benoxaprofen
UGT2B7 protein alternative form results in increased glucuronidation of benoxaprofen		 CTD PMID:8423545 PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
chlorzoxazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] CTD PMID:15728263 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing EXP CYP1A1 protein affects the metabolism of Chlorzoxazone CTD PMID:15231049 PMID:15879494 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases hydroxylation		 ISO
EXP		 CYP1A2 protein affects the metabolism of Chlorzoxazone
CYP1A2 protein results in increased hydroxylation of Chlorzoxazone		 CTD PMID:11911841 PMID:14586387 PMID:15879494 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Chlorzoxazone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects metabolic processing EXP CYP2B1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing EXP CYP2C6V1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects hydroxylation
increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
increases oxidation		 ISO
EXP		 CYP2E1 protein affects the hydroxylation of Chlorzoxazone
CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein results in increased hydroxylation of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
CYP2E1 mRNA results in increased metabolism of Chlorzoxazone; CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein affects the metabolism of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CYP2E1 protein results in increased oxidation of Chlorzoxazone
[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine; [CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]; phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]		 CTD PMID:7747284 PMID:8558417 PMID:8858968 PMID:9817075 PMID:9825833 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation
affects metabolic processing		 EXP CYP3A23-3A1 protein results in increased hydroxylation of Chlorzoxazone
CYP3A23-3A1 protein affects the metabolism of Chlorzoxazone		 CTD PMID:11911841 PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing EXP CYP3A9 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone] CTD PMID:26739624 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases activity ISO Chlorzoxazone results in increased activity of KCNN4 protein CTD PMID:14985237 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing ISO NAT2 protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
iloperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO iloperidone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
decreases expression		 ISO iloperidone results in decreased activity of CYP3A4 protein
iloperidone results in decreased expression of CYP3A4 mRNA		 CTD PMID:32941854 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
paliperidone palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
multiple interactions
increases export
increases transport
affects response to substance
decreases activity		 ISO
EXP		 ABCB1 gene polymorphism affects the abundance of Paliperidone Palmitate; ABCB1 protein affects the abundance of Paliperidone Palmitate
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]
ABCB1A protein results in increased transport of Paliperidone Palmitate
ABCB1A protein affects the susceptibility to Paliperidone Palmitate
Paliperidone Palmitate results in decreased activity of ABCB1 protein
Paliperidone Palmitate inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased transport of Paliperidone Palmitate		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17541883 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Paliperidone Palmitate CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Paliperidone Palmitate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Paliperidone Palmitate results in increased expression of BDNF mRNA CTD PMID:21220416 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects abundance ISO CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate; CYP2D6 protein affects the abundance of Paliperidone Palmitate CTD PMID:10639689 PMID:15089809 PMID:17541883 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding		 ISO
EXP		 Paliperidone Palmitate binds to and results in decreased activity of DRD2 protein
Paliperidone Palmitate binds to DRD2 protein		 CTD PMID:19713555 PMID:22437487 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 EXP Paliperidone Palmitate results in increased expression of FADS2 mRNA
[Paliperidone Palmitate results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding
multiple interactions		 ISO
EXP		 Paliperidone Palmitate binds to HTR2A protein
Paliperidone Palmitate binds to and results in decreased activity of HTR2A protein		 CTD PMID:7520908 PMID:19713555 PMID:22437487 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Paliperidone Palmitate results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Paliperidone Palmitate results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 increases expression ISO Paliperidone Palmitate results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Paliperidone Palmitate results in decreased activity of KCNH2 protein CTD PMID:21394035 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Prl prolactin increases expression ISO Paliperidone Palmitate results in increased expression of PRL protein CTD PMID:17460786 PMID:19825908 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
phosalone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity		 ISO [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] results in decreased activity of ABCB1 protein; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone results in decreased activity of ABCB1 protein]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [phosalone results in decreased activity of ABCB1 protein]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [Endosulfan results in decreased activity of ABCB1 protein]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole results in decreased activity of ABCB1 protein]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [phosalone results in decreased activity of ABCB1 protein] CTD PMID:21783720 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO phosalone metabolite results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [phosalone results in increased activity of AR protein]; phosalone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:15064155 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO phosalone binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions
increases activity		 EXP Ellagic Acid inhibits the reaction [phosalone results in increased activity of GAL protein] CTD PMID:27965107 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL1B protein] CTD PMID:27965107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL6 protein] CTD PMID:27965107 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
multiple interactions		 EXP phosalone results in increased expression of MAPK14 protein
Ellagic Acid inhibits the reaction [phosalone results in increased expression of MAPK14 protein]		 CTD PMID:27965107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phosalone binds to and results in increased activity of NR1I2 protein
[Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased activity of NR1I2 protein; phosalone binds to and results in increased activity of NR1I2 protein		 CTD PMID:21115097 PMID:25028461 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO phosalone results in increased activity of NR1I3 protein CTD PMID:20143881 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO phosalone binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO phosalone results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 protein]
phosalone results in increased expression of RB1 mRNA; phosalone results in increased expression of RB1 protein		 CTD PMID:27965107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of RELA protein] CTD PMID:27965107 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Si sucrase-isomaltase decreases activity EXP phosalone results in decreased activity of SI protein CTD PMID:92405 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity
multiple interactions		 EXP phosalone results in decreased activity of TERT protein
Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]		 CTD PMID:27965107 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of TNF protein] CTD PMID:27965107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 EXP phosalone results in increased expression of TP53 mRNA; phosalone results in increased expression of TP53 protein
Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 protein]		 CTD PMID:27965107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
multiple interactions
increases export
increases transport
decreases activity
affects response to substance
increases response to substance		 ISO
EXP		 ABCB1 gene polymorphism affects the abundance of Risperidone; ABCB1 protein affects the abundance of Risperidone
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]
ABCB1A protein results in increased transport of Risperidone
Risperidone results in decreased activity of ABCB1 protein
ABCB1A protein affects the susceptibility to Risperidone
ABCB1 protein results in increased transport of Risperidone
Risperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased susceptibility to Risperidone
ABCB1 gene polymorphism affects the susceptibility to Risperidone; ABCB1 protein affects the susceptibility to Risperidone		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17054409 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Risperidone CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] CTD PMID:18834354 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions		 EXP
ISO		 Risperidone results in decreased expression of BDNF mRNA
BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]		 CTD PMID:12393228 PMID:17442543 PMID:19997080 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Calm2 calmodulin 2 increases expression EXP Risperidone results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Risperidone results in decreased expression of CAMK2A protein CTD PMID:19289156 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP Risperidone results in decreased expression of CAMK4 protein CTD PMID:19289156 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Risperidone results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Risperidone results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Risperidone results in increased expression of CEBPA mRNA; Risperidone results in increased expression of CEBPA protein		 CTD PMID:20564506 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects response to substance ISO CHRM4 affects the susceptibility to Risperidone CTD PMID:21269601 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Risperidone results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein] CTD PMID:16144542 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
increases response to substance
affects response to substance
decreases hydroxylation
decreases metabolic processing
affects abundance
multiple interactions		 ISO CYP2D6 gene polymorphism affects the metabolism of Risperidone; CYP2D6 protein affects the metabolism of Risperidone
CYP2D6 protein results in increased metabolism of Risperidone
CYP2D6 protein results in increased susceptibility to Risperidone
CYP2D6 gene polymorphism affects the susceptibility to Risperidone; CYP2D6 protein polymorphism affects the susceptibility to Risperidone
CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone
CYP2D6 gene polymorphism results in decreased metabolism of Risperidone
CYP2D6 gene polymorphism affects the abundance of Risperidone; CYP2D6 protein affects the abundance of Risperidone
CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone; CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone		 CTD PMID:10639689 PMID:15089809 PMID:15260906 PMID:15565299 PMID:15669884 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects response to substance		 ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
CYP3A4 gene polymorphism affects the susceptibility to Risperidone; CYP3A4 protein affects the susceptibility to Risperidone		 CTD PMID:19395426 PMID:21402137 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects abundance
increases metabolic processing		 ISO CYP3A5 gene polymorphism affects the abundance of Risperidone; CYP3A5 protein affects the abundance of Risperidone
CYP3A5 protein results in increased metabolism of Risperidone		 CTD PMID:18708991 PMID:20332423 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases response to substance
affects response to substance		 ISO
EXP		 Risperidone binds to and results in decreased activity of DRD2 protein
Risperidone binds to DRD2 protein
[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]
DRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to Risperidone
DRD2 gene polymorphism affects the susceptibility to Risperidone		 CTD PMID:1380082 PMID:7520908 PMID:8804920 PMID:10831489 PMID:12191584 More... NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 gene SNP results in increased susceptibility to Risperidone; DRD3 protein results in increased susceptibility to Risperidone CTD PMID:19506579 PMID:19997080 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein] CTD PMID:16144542 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G Egr1 early growth response 1 decreases expression EXP Risperidone results in decreased expression of EGR1 protein CTD PMID:17028028 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 decreases expression
multiple interactions		 EXP
ISO		 Risperidone results in decreased expression of EGR2 protein
Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR2 protein]]		 CTD PMID:17028028 PMID:32980479 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases phosphorylation EXP Risperidone results in increased phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Risperidone results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 EXP Risperidone results in increased expression of FADS2 mRNA
[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA] CTD PMID:20564506 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP
ISO		 Risperidone promotes the reaction [Rotenone results in increased expression of FOS mRNA]
Dronabinol inhibits the reaction [Risperidone results in increased expression of FOS protein]; Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]]
Risperidone results in increased expression of FOS mRNA		 CTD PMID:11516571 PMID:17442543 PMID:28272498 PMID:32980479 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Risperidone affects the expression of FSHB protein CTD PMID:18838228 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions		 EXP Risperidone results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]		 CTD PMID:16144542 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein] CTD PMID:16144542 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Risperidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Risperidone results in increased expression of HOMER1 mRNA CTD PMID:20147574 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases response to substance
multiple interactions		 EXP HTR1A protein results in increased susceptibility to Risperidone
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]		 CTD PMID:17530476 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
affects response to substance		 ISO
EXP		 HTR2A gene SNP results in increased susceptibility to Risperidone; HTR2A protein results in increased susceptibility to Risperidone
Risperidone binds to HTR2A protein
Risperidone binds to and results in decreased activity of HTR2A protein; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; Risperidone binds to and results in decreased activity of HTR2A protein
HTR2A protein affects the susceptibility to Risperidone		 CTD PMID:7520908 PMID:11927170 PMID:12191584 PMID:16314884 PMID:16948927 More... NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects response to substance
multiple interactions
increases response to substance		 ISO HTR2C gene polymorphism affects the susceptibility to Risperidone; HTR2C protein affects the susceptibility to Risperidone
HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
HTR2C protein results in increased susceptibility to Risperidone		 CTD PMID:19142101 PMID:19997080 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions ISO HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein] CTD PMID:19997080 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO 2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Risperidone binds to and results in decreased activity of HTR7 protein; SB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Inha inhibin subunit alpha multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Inhbb inhibin subunit beta B multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Ins2 insulin 2 increases expression ISO Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA] CTD PMID:20564506 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Maoa monoamine oxidase A affects response to substance
increases response to substance		 ISO MAOA gene polymorphism affects the susceptibility to Risperidone
MAOA protein results in increased susceptibility to Risperidone		 CTD PMID:22544010 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B increases expression EXP Risperidone results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Risperidone results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Risperidone results in decreased expression of NGFR mRNA CTD PMID:12111809 PMID:16513140 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:21402137 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nrg1 neuregulin 1 increases expression EXP Risperidone results in increased expression of NRG1 protein CTD PMID:26961615 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO Risperidone results in increased expression of PPARG mRNA; Risperidone results in increased expression of PPARG protein
Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]		 CTD PMID:20564506 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
decreases expression		 EXP [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Risperidone results in decreased expression of PPP3CA mRNA; Risperidone results in decreased expression of PPP3CA protein		 CTD PMID:16033416 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression		 ISO
EXP		 [Risperidone co-treated with Clozapine] results in increased expression of PRL protein; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]; BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]		 CTD PMID:1380082 PMID:9696519 PMID:9989566 PMID:10084644 PMID:11048906 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP Risperidone results in increased expression of RGS2 mRNA CTD PMID:11516571 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G S100b S100 calcium binding protein B increases secretion EXP Risperidone results in increased secretion of S100B protein CTD PMID:18421423 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Risperidone results in increased expression of SLC17A6 mRNA; Risperidone results in increased expression of SLC17A6 protein CTD PMID:18155072 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to Risperidone CTD PMID:15823421 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP Risperidone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Risperidone results in increased expression of SOD1 mRNA		 CTD PMID:12111809 PMID:12752374 PMID:16564057 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Risperidone results in increased expression of SREBF1 mRNA; Risperidone results in increased expression of SREBF1 protein		 CTD PMID:20564506 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Risperidone inhibits the reaction [Rotenone results in decreased expression of STAT3 mRNA] CTD PMID:17442543 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP Risperidone results in increased expression of TH protein CTD PMID:17028028 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
suvorexant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] CTD PMID:33609567 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression ISO suvorexant results in increased expression of GRIN2A protein CTD PMID:33609567 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] CTD PMID:33609567 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] CTD PMID:33609567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
tafamidis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin multiple interactions ISO tafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]; tafamidis results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein] CTD PMID:25595224 PMID:27093678 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
zonisamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 multiple interactions ISO zonisamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO zonisamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO zonisamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP DRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]; DRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid] CTD PMID:19482038 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein] CTD PMID:18693129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:19199078 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ifng interferon gamma decreases expression ISO zonisamide results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity		 ISO zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
zonisamide results in decreased activity of MAOB protein		 CTD PMID:19948168 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP zonisamide results in increased expression of NOS2 mRNA CTD PMID:12429386 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP zonisamide results in increased expression of SLC1A1 protein CTD PMID:12941455 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions		 ISO Zonisamide results in increased expression of TH mRNA; Zonisamide results in increased expression of TH protein
zonisamide results in increased expression of TH protein
[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein; zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]		 CTD PMID:19199078 PMID:19948168 PMID:20196486 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Zoxazolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases response to substance ISO ABCB6 gene mutant form results in increased susceptibility to Zoxazolamine CTD PMID:25623066 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Ahr aryl hydrocarbon receptor affects response to substance ISO AHR protein affects the susceptibility to Zoxazolamine CTD PMID:2856069 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor multiple interactions
decreases response to substance		 ISO GHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Zoxazolamine]
GHRHR gene mutant form results in decreased susceptibility to Zoxazolamine		 CTD PMID:17521389 NCBI chr 4:84,498,159...84,532,847
Ensembl chr 4:84,500,212...84,532,776 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases activity ISO Zoxazolamine results in increased activity of KCNN4 protein CTD PMID:14985237 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Med1 mediator complex subunit 1 increases response to substance ISO MED1 gene mutant form results in increased susceptibility to Zoxazolamine CTD PMID:16109766 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
affects response to substance		 ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the reaction [NR1I3 affects the susceptibility to Zoxazolamine]; GHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Zoxazolamine]; nonylphenol affects the reaction [NR1I3 affects the susceptibility to Zoxazolamine]; NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased susceptibility to Zoxazolamine]
NR1I3 protein results in increased susceptibility to Zoxazolamine
NR1I3 affects the susceptibility to Zoxazolamine; NR1I3 protein affects the susceptibility to Zoxazolamine		 CTD PMID:17483497 PMID:17521389 PMID:19041682 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          nitrogen atom 18922
            nitrogen molecular entity 18922
              organonitrogen compound 18757
                organonitrogen heterocyclic compound 18027
                  benzoxazole 121
                    (1,3-benzoxazol-2-ylthio)formic acid hexyl ester 0
                    1,3-benzoxazoles + 49
                    1-(1,3-benzoxazol-2-yl)-N-[(4-ethylphenyl)methyl]-3-piperidinecarboxamide 0
                    2-(1,3-Benzoxazol-2-ylsulfanyl)acetonitrile 0
                    2-(1,3-benzoxazol-2-yl)-3-(4-hydroxy-2-methylanilino)-2-propenenitrile 0
                    2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone 0
                    2-(1,3-benzoxazol-2-ylthio)-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone 0
                    2-(1,3-benzoxazol-2-ylthio)-N-(2-methoxyphenyl)acetamide 0
                    2-(1,3-benzoxazol-2-ylthio)-N-(4-phenyl-2-thiazolyl)acetamide 0
                    2-(1,3-benzoxazol-2-ylthio)-N-(6-bromo-1,3-benzothiazol-2-yl)acetamide 0
                    2-(1,3-benzoxazol-2-ylthio)propanoic acid 0
                    2-(2-phenylethyl)-1,3-benzoxazol-5-amine 0
                    2-(4-chlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamide 0
                    2-(5-chloro-1,3-benzoxazol-2-yl)-3-[(5-chloro-2-pyridinyl)amino]-2-propenal 0
                    2-Hydroxy-6,7-dimethoxybenzoxazole 0
                    2-[(2-nitrophenyl)methylthio]-1,3-benzoxazole 0
                    2-[(3-bromo-5,7-dimethyl-2-imidazo[1,2-a]pyrimidinyl)methylthio]-1,3-benzoxazole 0
                    2-[(3S)-1-(2-Thienylmethyl)-3-pyrrolidinyl]-1,3-benzoxazole 0
                    2-[(4-nitrophenyl)methylthio]-1,3-benzoxazole 0
                    2-[2-oxo-6-(1-pyrrolidinylsulfonyl)-1,3-benzoxazol-3-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 0
                    2-[2-oxo-6-(1-pyrrolidinylsulfonyl)-1,3-benzoxazol-3-yl]-N-(1-phenylethyl)acetamide 0
                    2-[[[2-(1,3-benzoxazol-2-ylthio)-1-oxoethyl]hydrazinylidene]methyl]benzoic acid 0
                    2-benzoxazolinone 1
                    2-chloro-N-(3-ethyl-2-oxo-1,3-benzoxazol-6-yl)acetamide 0
                    2-mercapto-1,3-benzoxazole 0
                    3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one 0
                    3-(2-oxo-1,3-benzoxazol-3-yl)-N-phenylpropanamide 0
                    3-(4-methylphenyl)sulfonyl-1,3-benzoxazol-2-one 0
                    3-[(2-propoxyphenyl)methyl]-1,3-benzoxazol-2-one 0
                    3-[(4-methylanilino)methyl]-1,3-benzoxazol-2-one 0
                    3-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(1-piperidinylsulfonyl)-1,3-benzoxazol-2-one 0
                    3-[2-(2-ethyl-1-piperidinyl)-2-oxoethyl]-1,3-benzoxazol-2-one 0
                    3-ethyl-2-[(3,5,5-trimethyl-1-cyclohex-2-enylidene)methyl]-1,3-benzoxazol-3-ium 0
                    3-methyl-1,3-benzoxazole-2-thione 0
                    4-Acetyl-2(3H)-benzoxazolone 0
                    4-Chloro-6,7-dimethoxy-2-benzoxazolinone 0
                    4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]benzoic acid methyl ester 0
                    4-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]benzoic acid ethyl ester 0
                    4-[oxo-[2-(3-phenylpropyl)-1,3-benzoxazol-5-yl]methyl]-1-piperazinecarboxylic acid ethyl ester 0
                    4-oxo-3-pyrimido[2,1-b][1,3]benzoxazolecarboxylic acid ethyl ester 0
                    5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine 0
                    5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid 0
                    5-bromo-N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]-2-furancarboxamide 0
                    5-methyl-3-(2-morpholino-2-oxoethyl)-1,3-benzoxazol-2(3H)-one 0
                    5-methyl-N-(4,5,6-trimethyl-2-pyrimidinyl)-1,3-benzoxazol-2-amine 0
                    6-(1,3-benzoxazol-2-yl)-1,3-benzothiazol-2-amine 0
                    6-(2-chloro-1-oxoethyl)-3H-1,3-benzoxazol-2-one 0
                    6-Amino-benzoxazole 0
                    6-Hydroxychlorzoxazone 2
                    6-Methyl-2,3-dihydro-1,3-benzoxazole-2-thione 0
                    6-methylbenzoxazole 0
                    Coixol 0
                    N'-(1,3-benzoxazol-2-yl)benzohydrazide 0
                    N,N-diethyl-2-[(4-fluorophenyl)methylthio]-1,3-benzoxazole-5-sulfonamide 0
                    N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)butanamide 0
                    N-(3-fluoro-4-methylphenyl)-3-methyl-2-oxo-1,3-benzoxazole-6-sulfonamide 0
                    N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide 0
                    N-[2-(5-bromo-3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide 0
                    N-[3-(2-phenylethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]-1,3-benzoxazol-2-amine 0
                    N-[[2-(difluoromethoxy)phenyl]methylideneamino]-1,3-benzoxazol-2-amine 0
                    N-[amino-[(5-methyl-1,3-benzoxazol-2-yl)imino]methyl]acetamide 0
                    N-[amino-[(5-methyl-1,3-benzoxazol-2-yl)imino]methyl]cyclopropanecarboxamide 0
                    Nakijinol B 0
                    Zoxazolamine 6
                    benzisoxazole + 75
                    cincreasin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organic heteropolycyclic compound 18297
                                    organic heterobicyclic compound 17247
                                      benzoxazole 121
                                        (1,3-benzoxazol-2-ylthio)formic acid hexyl ester 0
                                        1,3-benzoxazoles + 49
                                        1-(1,3-benzoxazol-2-yl)-N-[(4-ethylphenyl)methyl]-3-piperidinecarboxamide 0
                                        2-(1,3-Benzoxazol-2-ylsulfanyl)acetonitrile 0
                                        2-(1,3-benzoxazol-2-yl)-3-(4-hydroxy-2-methylanilino)-2-propenenitrile 0
                                        2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone 0
                                        2-(1,3-benzoxazol-2-ylthio)-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone 0
                                        2-(1,3-benzoxazol-2-ylthio)-N-(2-methoxyphenyl)acetamide 0
                                        2-(1,3-benzoxazol-2-ylthio)-N-(4-phenyl-2-thiazolyl)acetamide 0
                                        2-(1,3-benzoxazol-2-ylthio)-N-(6-bromo-1,3-benzothiazol-2-yl)acetamide 0
                                        2-(1,3-benzoxazol-2-ylthio)propanoic acid 0
                                        2-(2-phenylethyl)-1,3-benzoxazol-5-amine 0
                                        2-(4-chlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamide 0
                                        2-(5-chloro-1,3-benzoxazol-2-yl)-3-[(5-chloro-2-pyridinyl)amino]-2-propenal 0
                                        2-Hydroxy-6,7-dimethoxybenzoxazole 0
                                        2-[(2-nitrophenyl)methylthio]-1,3-benzoxazole 0
                                        2-[(3-bromo-5,7-dimethyl-2-imidazo[1,2-a]pyrimidinyl)methylthio]-1,3-benzoxazole 0
                                        2-[(3S)-1-(2-Thienylmethyl)-3-pyrrolidinyl]-1,3-benzoxazole 0
                                        2-[(4-nitrophenyl)methylthio]-1,3-benzoxazole 0
                                        2-[2-oxo-6-(1-pyrrolidinylsulfonyl)-1,3-benzoxazol-3-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 0
                                        2-[2-oxo-6-(1-pyrrolidinylsulfonyl)-1,3-benzoxazol-3-yl]-N-(1-phenylethyl)acetamide 0
                                        2-[[[2-(1,3-benzoxazol-2-ylthio)-1-oxoethyl]hydrazinylidene]methyl]benzoic acid 0
                                        2-benzoxazolinone 1
                                        2-chloro-N-(3-ethyl-2-oxo-1,3-benzoxazol-6-yl)acetamide 0
                                        2-mercapto-1,3-benzoxazole 0
                                        3-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-one 0
                                        3-(2-oxo-1,3-benzoxazol-3-yl)-N-phenylpropanamide 0
                                        3-(4-methylphenyl)sulfonyl-1,3-benzoxazol-2-one 0
                                        3-[(2-propoxyphenyl)methyl]-1,3-benzoxazol-2-one 0
                                        3-[(4-methylanilino)methyl]-1,3-benzoxazol-2-one 0
                                        3-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(1-piperidinylsulfonyl)-1,3-benzoxazol-2-one 0
                                        3-[2-(2-ethyl-1-piperidinyl)-2-oxoethyl]-1,3-benzoxazol-2-one 0
                                        3-ethyl-2-[(3,5,5-trimethyl-1-cyclohex-2-enylidene)methyl]-1,3-benzoxazol-3-ium 0
                                        3-methyl-1,3-benzoxazole-2-thione 0
                                        4-Acetyl-2(3H)-benzoxazolone 0
                                        4-Chloro-6,7-dimethoxy-2-benzoxazolinone 0
                                        4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]benzoic acid methyl ester 0
                                        4-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]benzoic acid ethyl ester 0
                                        4-[oxo-[2-(3-phenylpropyl)-1,3-benzoxazol-5-yl]methyl]-1-piperazinecarboxylic acid ethyl ester 0
                                        4-oxo-3-pyrimido[2,1-b][1,3]benzoxazolecarboxylic acid ethyl ester 0
                                        5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine 0
                                        5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid 0
                                        5-bromo-N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]-2-furancarboxamide 0
                                        5-methyl-3-(2-morpholino-2-oxoethyl)-1,3-benzoxazol-2(3H)-one 0
                                        5-methyl-N-(4,5,6-trimethyl-2-pyrimidinyl)-1,3-benzoxazol-2-amine 0
                                        6-(1,3-benzoxazol-2-yl)-1,3-benzothiazol-2-amine 0
                                        6-(2-chloro-1-oxoethyl)-3H-1,3-benzoxazol-2-one 0
                                        6-Amino-benzoxazole 0
                                        6-Hydroxychlorzoxazone 2
                                        6-Methyl-2,3-dihydro-1,3-benzoxazole-2-thione 0
                                        6-methylbenzoxazole 0
                                        Coixol 0
                                        N'-(1,3-benzoxazol-2-yl)benzohydrazide 0
                                        N,N-diethyl-2-[(4-fluorophenyl)methylthio]-1,3-benzoxazole-5-sulfonamide 0
                                        N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)butanamide 0
                                        N-(3-fluoro-4-methylphenyl)-3-methyl-2-oxo-1,3-benzoxazole-6-sulfonamide 0
                                        N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide 0
                                        N-[2-(5-bromo-3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide 0
                                        N-[3-(2-phenylethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]-1,3-benzoxazol-2-amine 0
                                        N-[[2-(difluoromethoxy)phenyl]methylideneamino]-1,3-benzoxazol-2-amine 0
                                        N-[amino-[(5-methyl-1,3-benzoxazol-2-yl)imino]methyl]acetamide 0
                                        N-[amino-[(5-methyl-1,3-benzoxazol-2-yl)imino]methyl]cyclopropanecarboxamide 0
                                        Nakijinol B 0
                                        Zoxazolamine 6
                                        benzisoxazole + 75
                                        cincreasin 0
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