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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dobutamine
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Accession:CHEBI:4670 term browser browse the term
Definition:A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Synonyms:exact_synonym: 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
 related_synonym: (+-)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol;   3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine;   4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol;   DL-dobutamine;   Formula=C18H23NO3;   InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3;   InChIKey=JRWZLRBJNMZMFE-UHFFFAOYSA-N;   SMILES=CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1;   dobutamina;   dobutaminum;   rac-dobutamine;   racemic-dobutamine
 alt_id: CHEBI:184505;   CHEBI:554519
 xref: Beilstein:2946389;   CAS:34368-04-2;   DrugBank:DB00841;   Drug_Central:937;   HMDB:HMDB0014979;   KEGG:C06967;   KEGG:D03879;   LINCS:LSM-1807
 xref_mesh: MESH:D004280
 xref: PMID:11280019;   PMID:11950781;   PMID:18323735;   PMID:22537238;   Patent:DE2317710;   Patent:US3987200;   Reaxys:2946389;   Wikipedia:Dobutamine


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dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,145,890...68,231,615
JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,391,064...7,421,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 916
    role 875
      biological role 875
        molecular messenger 222
          monoamine molecular messenger 7
            catecholamine 3
              dobutamine 3
                (R)-dobutamine 0
                (S)-dobutamine 0
                dobutamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 916
    subatomic particle 901
      composite particle 901
        hadron 901
          baryon 901
            nucleon 901
              atomic nucleus 901
                atom 901
                  main group element atom 870
                    main group molecular entity 868
                      s-block molecular entity 755
                        hydrogen molecular entity 742
                          hydrides 358
                            inorganic hydride 250
                              pnictogen hydride 246
                                nitrogen hydride 246
                                  azane 239
                                    ammonia 239
                                      organic amino compound 239
                                        aralkylamino compound 16
                                          monoamine 7
                                            monoamine molecular messenger 7
                                              catecholamine 3
                                                dobutamine 3
                                                  (R)-dobutamine 0
                                                  (S)-dobutamine 0
                                                  dobutamine hydrochloride 0
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