Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorohydrocarbon
go back to main search page
Accession:CHEBI:46695 term browser browse the term
Definition:A compound derived from a hydrocarbon by replacing one or more hydrogen atoms with fluorine atoms.
Synonyms:related_synonym: FKW;   Fluorkohlenwasserstoffe;   HFC;   fluorohydrocarbons


show annotations for term's descendants           Sort by:
 
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to Flufenamic Acid CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions
ISO Flufenamic Acid results in decreased activity of AKR1C4 protein
Flufenamic Acid inhibits the reaction [AKR1C4 protein results in increased metabolism of Dihydrotestosterone]
CTD PMID:12604236 PMID:14672942 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity
ISO Flufenamic Acid inhibits the reaction [AKR1C2 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8573067 PMID:12604236 PMID:14672942 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects binding
multiple interactions
decreases activity
ISO Flufenamic Acid binds to AKR1C3 protein
Flufenamic Acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C3 protein
CTD PMID:12604236 PMID:14672942 PMID:14996743 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO Flufenamic Acid analog binds to and results in decreased activity of AR protein; Flufenamic Acid binds to and results in decreased activity of AR protein
Flufenamic Acid results in decreased expression of AR mRNA; Flufenamic Acid results in decreased expression of AR protein
CTD PMID:10537180 PMID:19645433 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 multiple interactions ISO Flufenamic Acid binds to and results in increased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAD protein] CTD PMID:27957685 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAK1 protein] CTD PMID:27957685 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Best1 bestrophin 1 decreases activity ISO Flufenamic Acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BID protein] CTD PMID:27957685 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:27957685 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Flufenamic Acid results in decreased activity of CFTR protein CTD PMID:15277574 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA CTD PMID:8404651 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Flufenamic Acid results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of FSHB mRNA CTD PMID:8404651 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:10866999 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
Flufenamic Acid results in increased expression of IL6 mRNA
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:15135310 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:204,117,941...204,129,494
Ensembl chr 1:204,114,572...204,125,925
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
JBrowse link
G Kiss1r KISS1 receptor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]; Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]
Flufenamic Acid results in increased expression of LDLR mRNA; Flufenamic Acid results in increased expression of LDLR protein
CTD PMID:10395027 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin multiple interactions ISO Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of LHB mRNA CTD PMID:8404651 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Flufenamic Acid results in increased expression of NOS2 mRNA
CTD PMID:10866999 PMID:15135310 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Panx1 Pannexin 1 decreases activity ISO Flufenamic Acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Flufenamic Acid binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid binds to and results in increased activity of PPARG protein CTD PMID:9013583 PMID:10866999 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of PTGS2 mRNA; Flufenamic Acid results in increased expression of PTGS2 protein
CTD PMID:10866999 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sell selectin L decreases expression ISO Flufenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc6a11 solute carrier family 6 member 11 multiple interactions ISO Flufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid] CTD PMID:15981712 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of TNF mRNA
CTD PMID:10866999 PMID:15135310 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity
ISO
EXP
[Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium
Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]
CTD PMID:11535132 PMID:14551041 PMID:21562303 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP
Flufenamic Acid results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
fluoxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aak1 AP2 associated kinase 1 decreases expression EXP Fluoxetine results in decreased expression of AAK1 mRNA CTD PMID:17033635 NCBI chr 4:119,300,128...119,451,834
Ensembl chr 4:119,295,257...119,450,969
JBrowse link
G Aanat aralkylamine N-acetyltransferase increases expression EXP Fluoxetine results in increased expression of AANAT mRNA CTD PMID:9951564 PMID:22291481 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Fluoxetine results in increased expression of ACACA mRNA CTD PMID:28677866 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:15312242 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression EXP Fluoxetine results in increased expression of ADAM10 mRNA CTD PMID:17033635 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 multiple interactions
increases expression
ISO ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]
Fluoxetine results in increased expression of ADARB1 mRNA; Fluoxetine results in increased expression of ADARB1 protein
CTD PMID:21320410 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
JBrowse link
G Adcy8 adenylate cyclase 8 decreases expression EXP Fluoxetine results in decreased expression of ADCY8 mRNA CTD PMID:17033635 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA CTD PMID:29107002 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Amelx amelogenin, X-linked decreases expression ISO Fluoxetine results in decreased expression of AMELX mRNA CTD PMID:21083617 NCBI chr  X:25,076,362...25,087,660
Ensembl chr  X:25,076,362...25,087,660
JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 increases expression EXP Fluoxetine results in increased expression of AMPD2 mRNA CTD PMID:20924750 NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271
JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Fluoxetine results in decreased expression of ANO3 mRNA CTD PMID:17033635 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A decreases expression EXP Fluoxetine results in decreased expression of ANP32A mRNA CTD PMID:17033635
G Anxa1 annexin A1 decreases expression EXP Fluoxetine results in decreased expression of ANXA1 mRNA CTD PMID:21852994 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa5 annexin A5 multiple interactions
affects expression
ISO
EXP
Fluoxetine promotes the reaction [Phosphatidylserines binds to ANXA5 protein]
Fluoxetine affects the expression of ANXA5 mRNA
CTD PMID:16076491 PMID:21852994 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Fluoxetine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 multiple interactions ISO Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2A2 protein] CTD PMID:31631060 NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 multiple interactions ISO Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2B1 protein] CTD PMID:31631060 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO
EXP
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO
EXP
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
CTD PMID:25766885 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression
increases expression
EXP Fluoxetine results in decreased expression of ARC mRNA
Fluoxetine results in increased expression of ARC mRNA
CTD PMID:15381288 PMID:17033635 PMID:18301726 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression EXP Fluoxetine results in increased expression of ARL4D mRNA CTD PMID:18301726 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases expression ISO Fluoxetine results in increased expression of ARNTL mRNA CTD PMID:15994025 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB1 mRNA] CTD PMID:19477151 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions
increases response to substance
ISO ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]; ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of MAPK3 protein]; Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB2 mRNA]
ARRB2 protein results in increased susceptibility to Fluoxetine
CTD PMID:19477151 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Fluoxetine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Fluoxetine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Fluoxetine results in increased expression of ATP2A2 mRNA CTD PMID:21852994 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Avp arginine vasopressin decreases expression EXP Fluoxetine results in decreased expression of AVP mRNA CTD PMID:17033635 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Fluoxetine results in increased expression of BAD mRNA CTD PMID:21497159 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 decreases expression EXP Fluoxetine results in decreased expression of BAIAP2 mRNA CTD PMID:17033635 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B decreases expression EXP Fluoxetine results in decreased expression of BCL11B mRNA CTD PMID:17033635 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
decreases expression
ISO
EXP
BCL2 protein results in decreased susceptibility to Fluoxetine
Fluoxetine results in decreased expression of BCL2 protein
Fluoxetine results in decreased expression of BCL2 mRNA
CTD PMID:16076491 PMID:19298536 PMID:21497159 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
affects expression
EXP Fluoxetine results in increased expression of BCL2L1 mRNA; Fluoxetine results in increased expression of BCL2L1 protein
Fluoxetine results in decreased expression of BCL2L1 protein
Fluoxetine affects the expression of BCL2L1 mRNA
CTD PMID:19298536 PMID:21740920 PMID:21852994 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance
increases expression
multiple interactions
decreases expression
affects expression
affects response to substance
increases response to substance
ISO
EXP
BDNF protein mutant form results in decreased susceptibility to Fluoxetine
Fluoxetine results in increased expression of BDNF mRNA; Fluoxetine results in increased expression of BDNF protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of BDNF protein]
Fluoxetine results in decreased expression of BDNF mRNA
Fluoxetine affects the expression of BDNF mRNA
Fluoxetine results in increased expression of BDNF mRNA; Fluoxetine results in increased expression of BDNF mRNA alternative form; Fluoxetine results in increased expression of BDNF protein
BDNF gene polymorphism affects the susceptibility to Fluoxetine
BDNF protein results in increased susceptibility to Fluoxetine
[Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA; [Fluoxetine co-treated with Ketanserin] results in increased expression of BDNF mRNA; Fluoxetine inhibits the reaction [Reserpine results in decreased expression of BDNF protein]
CTD PMID:8601816 PMID:12504921 PMID:15381288 PMID:15456934 PMID:15555640 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 increases expression ISO Fluoxetine results in increased expression of BECN1 protein CTD PMID:20503272 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like increases expression EXP Fluoxetine results in increased expression of BET1L mRNA CTD PMID:20924750 NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA] CTD PMID:21619414 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Brs3 bombesin receptor subtype 3 decreases expression EXP Fluoxetine results in decreased expression of BRS3 mRNA CTD PMID:21820738 NCBI chr  X:134,906,817...134,932,321
Ensembl chr  X:134,906,784...134,930,983
JBrowse link
G C1ql3 complement C1q like 3 decreases expression EXP Fluoxetine results in decreased expression of C1QL3 mRNA CTD PMID:17033635 NCBI chr17:76,121,832...76,128,327
Ensembl chr17:76,119,447...76,128,530
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G affects expression EXP Fluoxetine affects the expression of CACNA1G mRNA CTD PMID:21852994 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases expression EXP Fluoxetine results in decreased expression of CACNA1H mRNA CTD PMID:17033635 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression
multiple interactions
EXP Fluoxetine results in decreased expression of CAMK4 mRNA
Fluoxetine results in increased phosphorylation of and results in increased activity of CAMK4 protein
CTD PMID:15138445 PMID:17033635 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Fluoxetine results in decreased expression of CARTPT protein CTD PMID:21167239 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 increases expression EXP Fluoxetine results in increased expression of CASP1 mRNA CTD PMID:28677866 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
EXP
ISO
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CASP3 protein]; Fluoxetine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Fluoxetine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP3 protein]
Fluoxetine results in increased cleavage of CASP3 protein
CTD PMID:18371935 PMID:19135049 PMID:19298536 PMID:21619414 PMID:22700542 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluoxetine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Fluoxetine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Fluoxetine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Fluoxetine results in decreased activity of CAT protein
resveratrol inhibits the reaction [Fluoxetine results in decreased activity of CAT protein]
CTD PMID:26348076 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin decreases expression ISO
EXP
Fluoxetine results in decreased expression of CCK mRNA CTD PMID:17033635 PMID:17105902 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Fluoxetine results in decreased secretion of CCL2 protein CTD PMID:21083617 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Fluoxetine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:17477857 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression EXP Fluoxetine results in decreased expression of CCN3 mRNA CTD PMID:17033635 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fluoxetine results in decreased expression of CCNA2 mRNA; Fluoxetine results in decreased expression of CCNA2 protein CTD PMID:18371935 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Fluoxetine results in decreased expression of CCNB1 mRNA CTD PMID:21497159 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
increases expression
ISO
EXP
Fluoxetine results in decreased expression of CCND1 mRNA
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased expression of CCND1 mRNA]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased expression of CCND1 protein]
Fluoxetine results in increased expression of CCND1 mRNA; Fluoxetine results in increased expression of CCND1 protein
CTD PMID:18573488 PMID:18836303 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Fluoxetine results in decreased expression of CCND3 mRNA CTD PMID:21497159 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression
affects expression
multiple interactions
ISO Fluoxetine results in decreased expression of CCNE1 mRNA
Fluoxetine affects the expression of CCNE1 mRNA
[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein
CTD PMID:18371935 PMID:21497159 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fluoxetine results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd8a CD8a molecule increases expression ISO Fluoxetine results in increased expression of CD8A protein CTD PMID:21497159 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Fluoxetine results in decreased expression of CDK5 mRNA CTD PMID:17105902 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
affects expression
ISO [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1A protein
Fluoxetine results in increased expression of CDKN1A mRNA
Fluoxetine affects the expression of CDKN1A mRNA
CTD PMID:18371935 PMID:18836303 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
affects expression
multiple interactions
ISO Fluoxetine results in increased expression of CDKN1B mRNA
Fluoxetine affects the expression of CDKN1B mRNA
[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein
CTD PMID:18371935 PMID:21497159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Fluoxetine results in increased expression of CDKN2A mRNA CTD PMID:21497159 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Fluoxetine results in increased expression of CDKN2B mRNA CTD PMID:21497159 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdx1 caudal type homeo box 1 affects expression ISO Fluoxetine affects the expression of CDX1 mRNA CTD PMID:29893963 NCBI chr18:54,472,448...54,499,799
Ensembl chr18:54,473,444...54,490,814
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit decreases expression EXP Fluoxetine results in decreased expression of CHRNA5 mRNA CTD PMID:21820738 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit decreases expression EXP Fluoxetine results in decreased expression of CHRNB4 mRNA CTD PMID:21820738 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions
decreases expression
ISO [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1A protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein; Fluoxetine binds to and results in decreased activity of CKS1B protein
Fluoxetine results in decreased expression of CKS1B mRNA
CTD PMID:18371935 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Clock clock circadian regulator increases expression ISO Fluoxetine results in increased expression of CLOCK mRNA CTD PMID:15994025 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Cnksr2 connector enhancer of kinase suppressor of Ras 2 decreases expression EXP Fluoxetine results in decreased expression of CNKSR2 mRNA CTD PMID:17033635 NCBI chr  X:36,908,135...37,148,337
Ensembl chr  X:36,907,850...37,150,555
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of CNR1 mRNA; Fluoxetine results in decreased expression of and results in decreased phosphorylation of CNR1 protein
Fluoxetine results in decreased expression of CNR1 mRNA
CTD PMID:15936043 PMID:18722357 PMID:31339221 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of CREB1 mRNA
Fluoxetine results in decreased expression of CREB mRNA
Fluoxetine results in increased phosphorylation of CREB1 protein
Fluoxetine results in increased expression of CREB1 protein
ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]; Fluoxetine affects the reaction [sodium arsenate affects the expression of CREB1 protein]; Fluoxetine results in decreased phosphorylation of and results in decreased activity of CREB1 protein
[Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein; [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein; Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein; Fluoxetine results in increased phosphorylation of and results in increased localization of CREB1 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein]; staurosporine aglycone inhibits the reaction [Fluoxetine results in increased phosphorylation of CREB1 protein]
CTD PMID:8601816 PMID:14556240 PMID:15138445 PMID:16887358 PMID:18573488 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
ISO
EXP
Fluoxetine results in decreased expression of CRH mRNA
Fluoxetine results in increased expression of CRH mRNA
CTD PMID:1351783 PMID:9740405 PMID:20374287 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Fluoxetine results in increased expression of CRHR1 mRNA CTD PMID:9740405 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Cry1 cryptochrome circadian regulator 1 affects expression ISO Fluoxetine affects the expression of CRY1 mRNA CTD PMID:15994025 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression ISO Fluoxetine results in decreased expression of CRY2 mRNA CTD PMID:15994025 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP [9,10-Dimethyl-1,2-benzanthracene co-treated with Fluoxetine] affects the expression of CSF1R protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of CSF1R protein CTD PMID:31332895 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of CTNNB1 mRNA; Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CTNNB1 protein] CTD PMID:21619414 PMID:21627639 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:15312242 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Fluoxetine results in decreased secretion of CXCL10 protein CTD PMID:21083617 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Fluoxetine results in decreased expression of CYP11A1 mRNA
resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]
CTD PMID:26348076 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluoxetine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP Fluoxetine results in decreased expression of CYP26B1 mRNA CTD PMID:17033635 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Fluoxetine inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
increases metabolic processing
affects metabolic processing
EXP
ISO
Fluoxetine inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Fluoxetine results in decreased activity of CYP2C19 protein
Fluoxetine inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]
CYP2C19 gene polymorphism affects the metabolism of Fluoxetine; CYP2C19 protein affects the metabolism of Fluoxetine
CTD PMID:11453896 PMID:11752104 PMID:16236141 PMID:19858067 PMID:21915887 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Fluoxetine results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]
CTD PMID:15304522
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Fluoxetine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects abundance
decreases activity
increases metabolic processing
decreases methylation
multiple interactions
affects response to substance
decreases metabolic processing
affects metabolic processing
ISO CYP2D6 gene polymorphism affects the abundance of Fluoxetine; CYP2D6 protein affects the abundance of Fluoxetine
Fluoxetine results in decreased activity of CYP2D6 protein
CYP2D6 protein results in increased metabolism of Fluoxetine
CYP2D22 protein results in increased metabolism of Fluoxetine
CYP2D6 protein results in decreased methylation of Fluoxetine
[Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CYP2D6 protein affects the susceptibility to Fluoxetine
CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine
CYP2D6 gene polymorphism affects the metabolism of Fluoxetine; CYP2D6 protein affects the metabolism of Fluoxetine
CTD PMID:10583026 PMID:10755579 PMID:12173784 PMID:14639062 PMID:14716707 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP3A4 protein results in increased metabolism of Fluoxetine
Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine]
CTD PMID:11752104 PMID:12584149 PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Fluoxetine results in increased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Daglb diacylglycerol lipase, beta multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of DAGLB mRNA CTD PMID:31339221 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154
JBrowse link
G Dap death-associated protein increases expression EXP Fluoxetine results in increased expression of DAP mRNA CTD PMID:21852994 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
increases response to substance
ISO
EXP
DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin]
Fluoxetine results in increased expression of DBH mRNA
DBH protein results in increased susceptibility to Fluoxetine
CTD PMID:15148402 PMID:20626387 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression EXP Fluoxetine results in increased expression of DCLK1 mRNA CTD PMID:18301726 NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
JBrowse link
G Ddn dendrin decreases expression EXP Fluoxetine results in decreased expression of DDN mRNA CTD PMID:17033635 NCBI chr 7:129,953,317...129,957,299
Ensembl chr 7:129,953,318...129,957,341
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Fluoxetine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression EXP Fluoxetine results in increased expression of DGAT1 mRNA CTD PMID:28677866 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity
increases expression
multiple interactions
EXP Fluoxetine results in increased activity of DIO3 protein
Fluoxetine results in increased expression of DIO3 mRNA
SB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased activity of DIO3 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]
CTD PMID:15456934 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression EXP Fluoxetine results in decreased expression of DNAJA2 mRNA CTD PMID:21852994 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Fluoxetine results in increased expression of DNAJB9 mRNA CTD PMID:21852994 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
affects expression
EXP Fluoxetine results in decreased expression of DRD2 mRNA
Fluoxetine affects the expression of DRD2
CTD PMID:11981225 PMID:26475043 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression EXP Fluoxetine results in decreased expression of CPG21 mRNA CTD PMID:17033635 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression EXP Fluoxetine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases phosphorylation EXP Fluoxetine results in increased phosphorylation of EEF2 protein CTD PMID:16817885 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO Fluoxetine results in increased phosphorylation of EGFR protein
[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]
CTD PMID:18758753 PMID:19662385 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]
Fluoxetine results in increased expression of EGR1 mRNA
CTD PMID:19931852 PMID:21753012 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr3 early growth response 3 decreases expression EXP Fluoxetine results in decreased expression of EGR3 mRNA CTD PMID:17033635 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Egr4 early growth response 4 decreases expression EXP Fluoxetine results in decreased expression of EGR4 mRNA CTD PMID:17033635 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation EXP Fluoxetine results in increased phosphorylation of EIF4E protein CTD PMID:16817885 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Fluoxetine results in increased expression of ELOVL6 mRNA CTD PMID:28677866 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Enam enamelin decreases expression ISO Fluoxetine results in decreased expression of ENAM mRNA CTD PMID:21083617 NCBI chr14:19,556,729...19,581,433
Ensembl chr14:19,556,729...19,581,425
JBrowse link
G Ephx4 epoxide hydrolase 4 decreases expression EXP Fluoxetine results in decreased expression of EPHX4 mRNA CTD PMID:17033635 NCBI chr14:2,343,376...2,372,680
Ensembl chr14:2,340,248...2,373,022
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Fluoxetine results in increased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of FAAH mRNA CTD PMID:31339221 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Fluoxetine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Fluoxetine results in increased expression of FGF1 mRNA CTD PMID:17033635 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases expression EXP Fluoxetine results in decreased expression of FHL2 mRNA CTD PMID:21852994 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fmod fibromodulin decreases expression EXP Fluoxetine results in decreased expression of FMOD mRNA CTD PMID:17033635 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Fluoxetine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
affects expression
decreases expression
EXP
ISO
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; [Fluoxetine co-treated with Olanzapine] results in decreased expression of FOS protein; Fluoxetine inhibits the reaction [Fenfluramine results in increased expression of FOS protein]; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]; SB 206553 inhibits the reaction [Fluoxetine results in increased expression of FOS protein]
Fluoxetine results in increased expression of FOS mRNA; Fluoxetine results in increased expression of FOS protein
Fluoxetine affects the expression of FOS protein
Fluoxetine results in decreased expression of FOS mRNA
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOS protein]
CTD PMID:9452197 PMID:9740405 PMID:12527473 PMID:14556240 PMID:15609068 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Fluoxetine results in increased expression of FOSB mRNA; Fluoxetine results in increased expression of FOSB protein
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]
CTD PMID:18758753 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta decreases expression EXP Fluoxetine results in decreased expression of GABRD mRNA CTD PMID:17033635 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Fluoxetine results in increased expression of GAD1 mRNA CTD PMID:17033635 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression
decreases expression
EXP Fluoxetine results in increased expression of GAD2 protein
Fluoxetine results in decreased expression of GAD2 mRNA
CTD PMID:9526047 PMID:19359144 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gak cyclin G associated kinase decreases expression EXP Fluoxetine results in decreased expression of GAK mRNA CTD PMID:21852994 NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Fluoxetine results in increased expression of GAL mRNA CTD PMID:20816900 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP Fluoxetine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
EXP Fluoxetine results in increased expression of GDNF mRNA
U 0126 inhibits the reaction [Fluoxetine results in increased expression of GDNF mRNA]
CTD PMID:15456934 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Fluoxetine results in increased expression of GDPD3 mRNA CTD PMID:17175557 PMID:17567588 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Gfap glial fibrillary acidic protein increases response to substance
increases expression
ISO GFAP protein results in increased susceptibility to Fluoxetine
Fluoxetine results in increased expression of GFAP mRNA; Fluoxetine results in increased expression of GFAP protein
CTD PMID:20857517 PMID:22113448 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Fluoxetine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glo1 glyoxalase 1 increases response to substance ISO GLO1 protein results in increased susceptibility to Fluoxetine CTD PMID:22113448 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gna12 G protein subunit alpha 12 increases expression EXP Fluoxetine results in increased expression of GNA12 mRNA CTD PMID:1426031 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
EXP
ISO
Fluoxetine results in decreased expression of GNAI2 mRNA
Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of GNAI2 mRNA]
CTD PMID:19477151 PMID:21852994 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnaq G protein subunit alpha q increases expression EXP Fluoxetine results in increased expression of GNAQ mRNA CTD PMID:1426031 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression
EXP Fluoxetine results in increased expression of GNAS mRNA
Fluoxetine results in decreased expression of GNAS mRNA
CTD PMID:1426031 PMID:21852994 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb2 G protein subunit beta 2 decreases expression ISO Fluoxetine results in decreased expression of GNB2 mRNA CTD PMID:17105902 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019
JBrowse link
G Gpatch4 G patch domain containing 4 increases expression EXP Fluoxetine results in increased expression of GPATCH4 mRNA CTD PMID:17033635 NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 increases expression EXP Fluoxetine results in increased expression of GPD1 mRNA CTD PMID:17033635 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Fluoxetine results in increased expression of GPX3 mRNA CTD PMID:20924750 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gramd2b GRAM domain containing 2B increases expression EXP Fluoxetine results in increased expression of GRAMD3 mRNA CTD PMID:17033635 NCBI chr18:49,884,014...49,981,955
Ensembl chr18:49,884,014...49,981,953
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects expression
multiple interactions
affects phosphorylation
EXP
ISO
Fluoxetine affects the expression of GRIA1 protein
PPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]
CTD PMID:11880651 PMID:20417256 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression
multiple interactions
EXP Fluoxetine results in increased expression of GRIA2 protein
[Fluoxetine affects the susceptibility to Ethanol] which affects the expression of GRIA2 mRNA
CTD PMID:20417256 PMID:31339221 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of GRIA4 mRNA CTD PMID:31339221 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions
increases expression
ISO ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]
Fluoxetine results in increased expression of GRIK2 mRNA; Fluoxetine results in increased expression of GRIK2 protein
CTD PMID:21320410 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP Fluoxetine results in increased expression of GRIN2A protein CTD PMID:20417256 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grm3 glutamate metabotropic receptor 3 multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of GRM3 mRNA CTD PMID:31339221 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression EXP Fluoxetine results in increased expression of GSK3B protein CTD PMID:19359144 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 decreases expression EXP Fluoxetine results in decreased expression of HAPLN2 mRNA CTD PMID:17033635 NCBI chr 2:173,488,909...173,496,824
Ensembl chr 2:173,491,160...173,496,588
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of HDAC2 mRNA; Fluoxetine results in increased expression of HDAC2 protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of HDAC2 protein]
CTD PMID:16670375 PMID:24952232 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac5 histone deacetylase 5 increases response to substance ISO HDAC5 protein results in increased susceptibility to Fluoxetine CTD PMID:22113448 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP Fluoxetine results in increased expression of HES1 mRNA; Fluoxetine results in increased expression of HES1 protein CTD PMID:19801843 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hes5 hes family bHLH transcription factor 5 increases expression EXP Fluoxetine results in increased expression of HES5 mRNA; Fluoxetine results in increased expression of HES5 protein CTD PMID:17033635 PMID:19801843 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001
JBrowse link
G Hes7 hes family bHLH transcription factor 7 affects expression ISO Fluoxetine affects the expression of HES7 mRNA CTD PMID:29893963 NCBI chr10:53,824,124...53,828,350
Ensembl chr10:53,825,574...53,828,097
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fluoxetine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression EXP Fluoxetine results in decreased expression of HOMER1 mRNA CTD PMID:17033635 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hoxc6 homeo box C6 affects expression ISO Fluoxetine affects the expression of HOXC6 mRNA CTD PMID:29893963 NCBI chr 7:134,138,017...134,148,899 JBrowse link
G Hpcal1 hippocalcin-like 1 increases expression EXP Fluoxetine results in increased expression of HPCAL1 mRNA CTD PMID:20924750 NCBI chr 6:40,478,182...40,584,721
Ensembl chr 6:40,478,208...40,584,687
JBrowse link
G Hpn hepsin increases expression ISO Fluoxetine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hpx hemopexin decreases expression EXP Fluoxetine results in decreased expression of HPX mRNA CTD PMID:21852994 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression EXP Fluoxetine results in increased expression of HSPB8 mRNA CTD PMID:20924750 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects expression
decreases expression
increases response to substance
affects response to substance
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]
Fluoxetine affects the expression of HTR1A
Fluoxetine results in decreased expression of HTR1A mRNA
HTR1A gene polymorphism results in increased susceptibility to Fluoxetine; HTR1A protein results in increased susceptibility to Fluoxetine
HTR1A promoter polymorphism affects the susceptibility to Fluoxetine
Fluoxetine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Fluoxetine]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]
Fluoxetine results in increased expression of HTR1A mRNA
CTD PMID:10665824 PMID:11106871 PMID:15885359 PMID:16302021 PMID:16458487 More... NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B decreases expression
increases expression
EXP Fluoxetine results in decreased expression of HTR1B mRNA
Fluoxetine results in increased expression of HTR1B mRNA
CTD PMID:8914125 PMID:10665824 PMID:10861803 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance
affects expression
decreases activity
increases expression
ISO
EXP
HTR2A protein affects the susceptibility to Fluoxetine
Fluoxetine affects the expression of HTR2A
Fluoxetine results in decreased activity of HTR2A protein
Fluoxetine results in increased expression of HTR2A mRNA
CTD PMID:10773209 PMID:19445393 PMID:20464512 PMID:21083617 PMID:26475043 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B increases expression
increases activity
multiple interactions
ISO Fluoxetine results in increased expression of HTR2B mRNA
Fluoxetine results in increased activity of HTR2B protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein; [Fluoxetine results in increased expression of and results in increased activity of HTR2B protein] which results in increased metabolism of Glycogen; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Fluoxetine binds to and results in increased activity of HTR2B protein; Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]; Fluoxetine results in increased expression of and results in increased activity of HTR2B protein; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:11930908 PMID:18758753 PMID:19662385 PMID:21083617 PMID:21320410 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
increases expression
ISO
EXP
Fluoxetine binds to HTR2C protein
[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Fluoxetine binds to and results in increased activity of HTR2C protein
[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine binds to and results in decreased activity of HTR2C protein; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]
Fluoxetine results in increased expression of HTR2C mRNA; Fluoxetine results in increased expression of HTR2C mRNA alternative form
CTD PMID:9050900 PMID:15659601 PMID:18083778 PMID:19662385 PMID:21083617 More... NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Icam5 intercellular adhesion molecule 5 decreases expression EXP Fluoxetine results in decreased expression of ICAM5 mRNA CTD PMID:17033635 NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588
JBrowse link
G Ifng interferon gamma increases expression ISO Fluoxetine results in increased expression of IFNG mRNA CTD PMID:21497159 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression EXP Fluoxetine results in decreased expression of IGF2 mRNA CTD PMID:17033635 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression EXP Fluoxetine results in decreased expression of IGFBP2 mRNA CTD PMID:17033635 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Fluoxetine results in decreased expression of IL1B mRNA CTD PMID:21966942 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Fluoxetine results in increased expression of IL6 mRNA
CTD PMID:16413968 PMID:21575647 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Fluoxetine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Fluoxetine results in increased expression of INSIG1 mRNA CTD PMID:21852994 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:21575647 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itpka inositol-trisphosphate 3-kinase A decreases expression EXP Fluoxetine results in decreased expression of ITPKA mRNA CTD PMID:17033635 NCBI chr 3:106,726,036...106,734,601
Ensembl chr 3:106,726,036...106,734,600
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression EXP Fluoxetine results in increased expression of JAG1 mRNA; Fluoxetine results in increased expression of JAG1 protein CTD PMID:19801843 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Fluoxetine results in decreased expression of JUN mRNA CTD PMID:17105902 PMID:18836303 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity ISO Fluoxetine results in decreased activity of KCNA3 protein CTD PMID:17638537 NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression EXP Fluoxetine results in increased expression of KCNA5 mRNA; Fluoxetine results in increased expression of KCNA5 protein CTD PMID:19298536 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcna6 potassium voltage-gated channel subfamily A member 6 decreases expression EXP Fluoxetine results in decreased expression of KCNA6 mRNA CTD PMID:17033635 NCBI chr 4:159,542,941...159,576,189
Ensembl chr 4:159,542,615...159,576,189
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects response to substance
affects localization
ISO Fluoxetine binds to and results in decreased activity of KCNH2 protein; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluoxetine results in decreased activity of KCNH2 protein
KCNH2 protein affects the susceptibility to Fluoxetine
Fluoxetine affects the localization of KCNH2 protein
CTD PMID:11805215 PMID:15272206 PMID:16967046 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ5 protein] results in increased transport of Potassium]; Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:12684268 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of KCNJ4 mRNA] CTD PMID:21886566 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ5 protein] results in increased transport of Potassium] CTD PMID:12684268 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNJ6 protein results in increased transport of Potassium] CTD PMID:12684268 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 decreases activity
affects response to substance
multiple interactions
increases expression
ISO Fluoxetine results in decreased activity of KCNK10 protein
KCNK10 mRNA affects the susceptibility to Fluoxetine
[KCNK2 mRNA co-treated with KCNK10 mRNA] affects the susceptibility to Fluoxetine
Fluoxetine results in increased expression of KCNK10 mRNA
CTD PMID:23022515 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions
decreases activity
affects response to substance
decreases expression
decreases response to substance
EXP
ISO
Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 mRNA]; Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 protein]
[KCNK2 mRNA co-treated with KCNK10 mRNA] affects the susceptibility to Fluoxetine
Fluoxetine results in decreased activity of KCNK2 protein
KCNK2 mRNA affects the susceptibility to Fluoxetine
Fluoxetine results in decreased expression of KCNK2 mRNA
Fluoxetine results in decreased susceptibility to KCNK2 protein
Fluoxetine results in decreased expression of KCNK2 mRNA; Fluoxetine results in decreased expression of KCNK2 protein
CTD PMID:21069514 PMID:23022515 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 decreases expression EXP Fluoxetine results in decreased expression of KCNV1 mRNA CTD PMID:17033635 NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression EXP Fluoxetine results in increased expression of KLF10 mRNA CTD PMID:18301726 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fluoxetine results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G L1cam L1 cell adhesion molecule multiple interactions
increases expression
EXP Ondansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein] CTD PMID:16900104 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Lmna lamin A/C decreases expression EXP Fluoxetine results in decreased expression of LMNA mRNA CTD PMID:21852994 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression EXP Fluoxetine results in increased expression of LRG1 mRNA CTD PMID:17033635 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
JBrowse link
G Lss lanosterol synthase increases expression ISO Fluoxetine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Map1b microtubule-associated protein 1B increases expression EXP Fluoxetine results in increased expression of MAP1B mRNA CTD PMID:17033635 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]
Fluoxetine results in increased phosphorylation of MAPK1 protein
Fluoxetine results in increased expression of MAPK1 protein
Fluoxetine results in decreased phosphorylation of MAPK1 protein
Fluoxetine results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein; Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:15138445 PMID:15456934 PMID:16413968 PMID:18573488 PMID:18758753 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Fluoxetine results in increased phosphorylation of MAPK14 protein CTD PMID:16413968 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]
Fluoxetine results in increased phosphorylation of MAPK3 protein
Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Fluoxetine results in decreased phosphorylation of MAPK3 protein
CTD PMID:15138445 PMID:15456934 PMID:16413968 PMID:18573488 PMID:18758753 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP Fluoxetine results in decreased expression of MAPK8 mRNA CTD PMID:20924750 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 increases expression EXP Fluoxetine results in increased expression of MBD1 mRNA; Fluoxetine results in increased expression of MBD1 protein CTD PMID:16670375 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression EXP Fluoxetine results in decreased expression of MC4R mRNA; Fluoxetine results in decreased expression of MC4R protein CTD PMID:18359080 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mecp2 methyl CpG binding protein 2 increases expression EXP Fluoxetine results in increased expression of MECP2 mRNA; Fluoxetine results in increased expression of MECP2 mRNA alternative form; Fluoxetine results in increased expression of MECP2 protein CTD PMID:16670375 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Meox1 mesenchyme homeobox 1 affects expression ISO Fluoxetine affects the expression of MEOX1 mRNA CTD PMID:29893963 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mif macrophage migration inhibitory factor affects response to substance EXP MIF affects the susceptibility to Fluoxetine CTD PMID:20177408 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mixl1 Mix paired-like homeobox 1 affects expression ISO Fluoxetine affects the expression of MIXL1 mRNA CTD PMID:29893963 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
G Mmp20 matrix metallopeptidase 20 decreases expression ISO Fluoxetine results in decreased expression of MMP20 mRNA CTD PMID:21083617 NCBI chr 8:4,789,415...4,830,035
Ensembl chr 8:4,789,415...4,830,035
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
ISO
EXP
Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein
Fluoxetine results in decreased activity of MMP9 protein
CTD PMID:15312242 PMID:21966942 PMID:31332895 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein CTD PMID:21753012 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases phosphorylation ISO Fluoxetine results in decreased phosphorylation of MYC protein CTD PMID:18836303 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanog Nanog homeobox affects expression ISO Fluoxetine affects the expression of NANOG mRNA CTD PMID:29893963 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of NAPEPLD mRNA CTD PMID:31339221 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Fluoxetine results in increased expression of NCAM1 mRNA CTD PMID:21852994 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Neurod2 neuronal differentiation 2 decreases expression EXP Fluoxetine results in decreased expression of NEUROD2 mRNA CTD PMID:17033635 NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986
JBrowse link
G Nf1 neurofibromin 1 decreases expression ISO Fluoxetine results in decreased expression of NF1 mRNA CTD PMID:17105902 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
Fluoxetine results in increased expression of NFKBIA mRNA
CTD PMID:17033635 PMID:21575647 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngfr nerve growth factor receptor increases response to substance ISO NGFR protein results in increased susceptibility to Fluoxetine CTD PMID:19621217 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nodal nodal growth differentiation factor affects expression ISO Fluoxetine affects the expression of NODAL mRNA CTD PMID:29893963 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO Fluoxetine analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Fluoxetine analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Fluoxetine results in increased expression of NOS2 mRNA
CTD PMID:16413968 PMID:21467642 PMID:21575647 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 increases expression EXP Fluoxetine results in increased expression of NOTCH1 mRNA; Fluoxetine results in increased expression of NOTCH1 protein CTD PMID:19801843 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Npas2 neuronal PAS domain protein 2 affects expression ISO Fluoxetine affects the expression of NPAS2 mRNA CTD PMID:15994025 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
JBrowse link
G Nptx2 neuronal pentraxin 2 increases expression EXP Fluoxetine results in increased expression of NPTX2 mRNA CTD PMID:18301726 NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
JBrowse link
G Npy neuropeptide Y increases expression
decreases secretion
affects expression
decreases expression
ISO
EXP
Fluoxetine results in increased expression of NPY mRNA
Fluoxetine results in decreased secretion of NPY mRNA; Fluoxetine results in decreased secretion of NPY protein
Fluoxetine affects the expression of NPY mRNA
Fluoxetine results in decreased expression of NPY mRNA
CTD PMID:8737424 PMID:9729278 PMID:16042082 PMID:20816900 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects expression EXP Fluoxetine affects the expression of NPY1R mRNA CTD PMID:9729278 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Fluoxetine results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects expression
decreases expression
increases expression
affects response to substance
ISO
EXP
Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]
Fluoxetine affects the expression of NR3C1 protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of NR3C1 protein]; Fluoxetine promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Fluoxetine promotes the reaction [Hydrocortisone results in increased activity of NR3C1 protein]
Fluoxetine results in decreased expression of NR3C1 mRNA
Fluoxetine results in increased expression of NR3C1 mRNA; Fluoxetine results in increased expression of NR3C1 protein
NR3C1 protein affects the susceptibility to Fluoxetine
CTD PMID:10929085 PMID:11226678 PMID:11406320 PMID:12393271 PMID:12871829 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression
increases expression
multiple interactions
EXP Fluoxetine results in decreased expression of NR3C2 mRNA
Fluoxetine results in increased expression of NR3C2 mRNA; Fluoxetine results in increased expression of NR3C2 protein
Fluoxetine affects the reaction [Dexamethasone binds to NR3C2 protein]
CTD PMID:1351783 PMID:10929085 PMID:11406320 PMID:12393271 PMID:21281618 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Fluoxetine results in decreased expression of NR4A2 mRNA CTD PMID:20857517 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression EXP Fluoxetine results in decreased expression of NR4A3 mRNA CTD PMID:17033635 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Nrgn neurogranin decreases expression EXP Fluoxetine results in decreased expression of NRGN mRNA CTD PMID:17033635 NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516
JBrowse link
G Nrn1 neuritin 1 increases expression EXP Fluoxetine results in increased expression of NRN1 mRNA CTD PMID:18301726 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
increases phosphorylation
EXP
ISO
Fluoxetine results in increased expression of NTRK2 mRNA; Fluoxetine results in increased expression of NTRK2 mRNA alternative form
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]
Fluoxetine results in increased phosphorylation of NTRK2 protein
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2A2 protein]; Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2B1 protein]; Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Fluoxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein
CTD PMID:8601816 PMID:15456934 PMID:21666748 PMID:22396798 PMID:31631060 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nucb1 nucleobindin 1 affects expression EXP Fluoxetine affects the expression of NUCB1 mRNA CTD PMID:21852994 NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Fluoxetine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Olig2 oligodendrocyte transcription factor 2 increases expression ISO Fluoxetine results in increased expression of OLIG2 mRNA CTD PMID:20857517 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 mRNA]; Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 protein]
Fluoxetine results in increased expression of OPRM1 protein
CTD PMID:16484055 PMID:21886566 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Otx2 orthodenticle homeobox 2 affects expression ISO Fluoxetine affects the expression of OTX2 mRNA CTD PMID:29893963 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases expression EXP Fluoxetine results in decreased expression of OXT mRNA CTD PMID:17033635 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression
EXP Fluoxetine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]
Fluoxetine results in increased expression of OXTR protein
CTD PMID:15380831 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Fluoxetine results in increased expression of P4HB mRNA CTD PMID:21852994 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression EXP Fluoxetine results in increased expression of PAQR8 mRNA CTD PMID:17033635 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340
JBrowse link
G Pax3 paired box 3 affects expression ISO Fluoxetine affects the expression of PAX3 mRNA CTD PMID:29893963 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pde4a phosphodiesterase 4A increases expression EXP Fluoxetine results in increased expression of PDE4A mRNA CTD PMID:12504921 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
affects expression
increases expression
EXP Fluoxetine results in decreased expression of PDE4B protein
Fluoxetine affects the expression of PDE4B mRNA
Fluoxetine results in increased expression of PDE4B mRNA
CTD PMID:12504921 PMID:20222156 PMID:22291481 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde4d phosphodiesterase 4D affects expression EXP Fluoxetine affects the expression of PDE4D mRNA alternative form CTD PMID:12504921 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pde8b phosphodiesterase 8B increases expression EXP Fluoxetine results in increased expression of PDE8B mRNA CTD PMID:22291481 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Pdyn prodynorphin affects expression
decreases expression
EXP Fluoxetine affects the expression of PDYN protein
Fluoxetine results in decreased expression of PDYN mRNA
CTD PMID:14997015 PMID:15936043 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin decreases expression EXP Fluoxetine results in decreased expression of PENK mRNA CTD PMID:9526047 PMID:15936043 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 decreases expression ISO Fluoxetine results in decreased expression of PER1 mRNA CTD PMID:15994025 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 affects expression ISO Fluoxetine affects the expression of PER2 mRNA CTD PMID:15994025 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions
increases expression
ISO [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]
Fluoxetine results in increased expression of PLA2G4A mRNA; Fluoxetine results in increased expression of PLA2G4A protein
CTD PMID:19662385 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Fluoxetine results in decreased expression of PLCB1 mRNA; Fluoxetine results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Fluoxetine results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
JBrowse link
G Plec plectin decreases expression EXP Fluoxetine results in decreased expression of PLEC mRNA CTD PMID:21852994 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
JBrowse link
G Pmch pro-melanin-concentrating hormone decreases expression EXP Fluoxetine results in decreased expression of PMCH mRNA CTD PMID:17033635 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
JBrowse link
G Pomc proopiomelanocortin increases expression
decreases expression
EXP Fluoxetine results in increased expression of POMC mRNA; Fluoxetine results in increased expression of POMC protein
Fluoxetine results in decreased expression of POMC mRNA
CTD PMID:15936043 PMID:16042082 PMID:18359080 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pou5f1 POU class 5 homeobox 1 affects expression ISO Fluoxetine affects the expression of POU5F1 mRNA CTD PMID:29893963 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Fluoxetine affects the susceptibility to Ethanol] which affects the expression of PPARA mRNA CTD PMID:31339221 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein] CTD PMID:25766885 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects phosphorylation
increases response to substance
multiple interactions
increases expression
ISO Fluoxetine affects the phosphorylation of PPP1R1B protein
PPP1R1B protein results in increased susceptibility to Fluoxetine
PPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]
Fluoxetine results in increased expression of PPP1R1B mRNA; Fluoxetine results in increased expression of PPP1R1B protein
CTD PMID:11880651 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Prkcg protein kinase C, gamma decreases expression EXP Fluoxetine results in decreased expression of PRKCG mRNA CTD PMID:17033635 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein] CTD PMID:21619414 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO
EXP
[olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
Fluoxetine results in increased expression of PRL protein
CTD PMID:313977 PMID:9098464 PMID:16848655 PMID:19896213 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prss23 serine protease 23 decreases expression EXP Fluoxetine results in decreased expression of PRSS23 mRNA CTD PMID:17033635 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 affects expression EXP Fluoxetine affects the expression of PSMA3 mRNA CTD PMID:21852994 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression EXP Fluoxetine results in decreased expression of PSMB4 mRNA CTD PMID:21852994 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746
JBrowse link
G Pter phosphotriesterase related decreases expression EXP Fluoxetine results in decreased expression of PTER mRNA CTD PMID:17033635 NCBI chr17:76,058,388...76,119,633
Ensembl chr17:76,058,503...76,119,627
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression ISO Fluoxetine results in decreased expression of PTGDS mRNA CTD PMID:17105902 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Fluoxetine results in decreased expression of PTGS2 mRNA; Fluoxetine results in decreased expression of PTGS2 protein CTD PMID:17033635 PMID:21554931 PMID:21966942 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases expression EXP Fluoxetine results in decreased expression of PTK2B mRNA CTD PMID:17033635 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Qrfpr pyroglutamylated RFamide peptide receptor decreases expression EXP Fluoxetine results in decreased expression of QRFPR mRNA CTD PMID:21820738 NCBI chr 2:119,053,511...119,096,792
Ensembl chr 2:119,053,511...119,096,792
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Fluoxetine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Fluoxetine results in increased activity of RELA protein
CTD PMID:16413968 PMID:21575647 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin increases expression EXP Fluoxetine results in increased expression of RELN mRNA CTD PMID:19359144 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression EXP Fluoxetine results in increased expression of RGS3 mRNA CTD PMID:21852994 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Rprml reprimo-like decreases expression EXP Fluoxetine results in decreased expression of RPRML mRNA CTD PMID:17033635 NCBI chr10:88,560,248...88,561,252
Ensembl chr10:88,560,248...88,561,252
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Fluoxetine affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G S100b S100 calcium binding protein B increases response to substance
increases expression
ISO
EXP
S100B protein results in increased susceptibility to Fluoxetine
Fluoxetine results in increased expression of S100B protein
Fluoxetine results in increased expression of S100B mRNA; Fluoxetine results in increased expression of S100B protein
CTD PMID:12960766 PMID:20857517 PMID:22113448 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Samd4a sterile alpha motif domain containing 4A decreases expression EXP Fluoxetine results in decreased expression of SAMD4A mRNA CTD PMID:17033635 NCBI chr15:20,135,994...20,352,131
Ensembl chr15:20,134,377...20,348,380
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Fluoxetine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Fluoxetine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Fluoxetine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression EXP Fluoxetine results in increased expression of SGK1 mRNA CTD PMID:17033635 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc13a4 solute carrier family 13 member 4 decreases expression EXP Fluoxetine results in decreased expression of SLC13A4 mRNA CTD PMID:17033635 NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression
decreases expression
ISO
EXP
Fluoxetine results in increased expression of SLC17A7 mRNA; Fluoxetine results in increased expression of SLC17A7 protein
Fluoxetine results in decreased expression of SLC17A7 mRNA
CTD PMID:16111724 PMID:17033635 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluoxetine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Fluoxetine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc30a3 solute carrier family 30 member 3 decreases expression EXP Fluoxetine results in decreased expression of SLC30A3 mRNA CTD PMID:17033635 NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720
JBrowse link
G Slc32a1 solute carrier family 32 member 1 decreases expression EXP Fluoxetine results in decreased expression of SLC32A1 protein CTD PMID:20707986 NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA CTD PMID:29107002 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Fluoxetine inhibits the reaction [SLC6A2 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A2 protein results in increased import of Fluorescent Dyes] CTD PMID:28506818 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects expression
affects response to substance
ISO
EXP
SLC6A3 mutant form affects the reaction [Fluoxetine affects the abundance of Dopamine]
Fluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]; Fluoxetine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Fluoxetine affects the expression of SLC6A3
SLC6A3 protein affects the susceptibility to Fluoxetine
CTD PMID:11797063 PMID:14691264 PMID:26475043 PMID:28506818 PMID:31009648 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance
decreases activity
decreases response to substance
affects expression
multiple interactions
decreases expression
increases response to substance
decreases localization
increases expression
ISO
EXP
SLC6A4 affects the susceptibility to Fluoxetine; SLC6A4 protein affects the susceptibility to Fluoxetine
Fluoxetine results in decreased activity of SLC6A4 protein
SLC6A4 gene polymorphism results in decreased susceptibility to Fluoxetine
Fluoxetine affects the expression of SLC6A4 protein
Fluoxetine binds to and results in decreased activity of SLC6A4 protein; Fluoxetine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]
Fluoxetine results in decreased expression of SLC6A4 mRNA; Fluoxetine results in decreased expression of SLC6A4 protein
SLC6A4 gene polymorphism results in increased susceptibility to Fluoxetine; SLC6A4 protein results in increased susceptibility to Fluoxetine
Fluoxetine results in decreased localization of SLC6A4 protein
[Estradiol co-treated with Fluoxetine] results in increased expression of SLC6A4 mRNA; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Org 34850 promotes the reaction [Fluoxetine results in decreased expression of SLC6A4 protein]
Fluoxetine results in increased expression of SLC6A4 mRNA
CTD PMID:8914125 PMID:14573314 PMID:14604448 PMID:15936043 PMID:16272152 More... NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Fluoxetine results in increased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Smad1 SMAD family member 1 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]; Fluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein] CTD PMID:21619414 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
decreases activity
increases response to substance
ISO [Fluoxetine results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Fluoxetine results in decreased expression of and results in decreased activity of SMPD1 protein
Fluoxetine results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Fluoxetine
CTD PMID:23770692 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 increases expression EXP Fluoxetine results in increased expression of SND1 mRNA CTD PMID:21852994 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
JBrowse link
G Sox2 SRY-box transcription factor 2 affects expression ISO Fluoxetine affects the expression of SOX2 mRNA CTD PMID:29893963 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sp5 Sp5 transcription factor affects expression ISO Fluoxetine affects the expression of SP5 mRNA CTD PMID:29893963 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 affects expression ISO Fluoxetine affects the expression of SPRY2 mRNA CTD PMID:29893963 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Sqle squalene epoxidase decreases expression EXP Fluoxetine results in decreased expression of SQLE mRNA CTD PMID:21852994 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Fluoxetine results in decreased expression of SQSTM1 mRNA CTD PMID:17105902 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 affects expression EXP Fluoxetine affects the expression of SRSF5 mRNA CTD PMID:21852994 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP resveratrol inhibits the reaction [Fluoxetine results in decreased expression of STAR mRNA] CTD PMID:26348076 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP Fluoxetine results in increased expression of STC1 mRNA CTD PMID:17033635 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP Fluoxetine results in increased expression of STXBP1 mRNA CTD PMID:21852994 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Syn1 synapsin I increases expression EXP Fluoxetine results in increased expression of SYN1 mRNA CTD PMID:16887358 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Syp synaptophysin increases expression
decreases expression
EXP
ISO
Fluoxetine results in increased expression of SYP mRNA
Fluoxetine results in decreased expression of SYP mRNA
CTD PMID:17950272 PMID:20857517 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tagln transgelin decreases expression ISO Fluoxetine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tbx6 T-box transcription factor 6 affects expression ISO Fluoxetine affects the expression of TBX6 mRNA CTD PMID:29893963 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
JBrowse link
G Tbxt T-box transcription factor T affects expression ISO Fluoxetine affects the expression of T mRNA CTD PMID:29893963 NCBI chr 1:52,298,099...52,309,813
Ensembl chr 1:52,298,099...52,305,864
JBrowse link
G Th tyrosine hydroxylase decreases expression
affects expression
increases expression
ISO
EXP
Fluoxetine results in decreased expression of TH mRNA
Fluoxetine affects the expression of TH
Fluoxetine results in increased expression of TH mRNA
CTD PMID:1351783 PMID:15936043 PMID:20374287 PMID:20626387 PMID:20857517 More... NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of TIMP1 protein CTD PMID:31332895 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmc4 transmembrane channel-like 4 decreases expression EXP Fluoxetine results in decreased expression of TMC4 mRNA CTD PMID:17033635 NCBI chr 1:65,539,788...65,551,677
Ensembl chr 1:65,539,721...65,551,677
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases activity
ISO
EXP
Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Fluoxetine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [Reserpine results in increased expression of TNF protein]; Fluoxetine promotes the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
Fluoxetine results in increased expression of TNF mRNA
Fluoxetine results in decreased activity of TNF protein
Fluoxetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
CTD PMID:16413968 PMID:17477857 PMID:21497159 PMID:21575647 PMID:30529211 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA] CTD PMID:15312242 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Fluoxetine results in increased expression of TRP53 mRNA
Fluoxetine results in increased expression of TP53 mRNA
CTD PMID:18836303 PMID:21497159 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO
EXP
Fluoxetine results in increased expression of TPH1 mRNA CTD PMID:15631896 PMID:21083617 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Tph2 tryptophan hydroxylase 2 increases expression
decreases expression
increases response to substance
affects expression
affects response to substance
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of TPH2 mRNA
Fluoxetine results in decreased expression of TPH2 mRNA
TPH2 results in increased susceptibility to Fluoxetine
Fluoxetine affects the expression of TPH2 mRNA
TPH2 protein affects the susceptibility to Fluoxetine
[Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA
CTD PMID:11901216 PMID:16982082 PMID:17321503 PMID:17950541 PMID:20374287 More... NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Tpm1 tropomyosin 1 decreases expression EXP Fluoxetine results in decreased expression of TPM1 mRNA CTD PMID:21852994 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression EXP Fluoxetine results in increased expression of TSHB mRNA CTD PMID:17033635 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tssk2 testis-specific serine kinase 2 decreases expression EXP Fluoxetine results in decreased expression of TSSK2 mRNA CTD PMID:17033635 NCBI chr11:83,086,578...83,087,933 JBrowse link
G Ttr transthyretin increases expression ISO Fluoxetine results in increased expression of TTR mRNA CTD PMID:17105902 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Fluoxetine results in decreased expression of TUBB3 mRNA CTD PMID:20857517 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO
EXP
Fluoxetine results in increased expression of VEGFA mRNA
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of VEGFA protein
CTD PMID:21301813 PMID:31332895 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Fluoxetine results in increased expression of VGF mRNA CTD PMID:21301813 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP
ISO
Fluoxetine results in increased expression of VLDLR protein
Fluoxetine results in increased expression of VLDLR mRNA
CTD PMID:19359144 PMID:24356939 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein decreases expression EXP Fluoxetine results in decreased expression of WFS1 mRNA CTD PMID:17033635 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Fluoxetine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
G Wnt3a Wnt family member 3A increases phosphorylation
affects expression
EXP
ISO
Fluoxetine results in increased phosphorylation of WNT3A protein
Fluoxetine affects the expression of WNT3A mRNA
CTD PMID:21048974 PMID:29893963 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Fluoxetine results in increased expression of XIAP mRNA CTD PMID:17033635 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpo1 exportin 1 decreases expression
increases expression
EXP Fluoxetine results in decreased expression of XPO1 mRNA
Fluoxetine results in increased expression of XPO1 mRNA
CTD PMID:21852994 NCBI chr14:97,233,263...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon affects expression EXP Fluoxetine affects the expression of YWHAE mRNA CTD PMID:21852994 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta affects expression EXP Fluoxetine affects the expression of YWHAH mRNA CTD PMID:21852994 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression EXP Fluoxetine results in increased expression of YWHAZ mRNA; Fluoxetine results in increased expression of YWHAZ protein CTD PMID:15631896 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
fluvoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Fluvoxamine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fluvoxamine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Fluvoxamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Avp arginine vasopressin increases expression ISO Fluvoxamine results in increased expression of AVP protein CTD PMID:11195401 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluvoxamine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance
ISO
EXP
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite; CYP1A2 protein binds to and affects the metabolism of Fluvoxamine; Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine
CYP1A2 protein results in increased susceptibility to Fluvoxamine
CTD PMID:9029748 PMID:11763009 PMID:15545309 PMID:15845683 PMID:15905806 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein CTD PMID:15967061 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene SNP affects the susceptibility to Fluvoxamine CTD PMID:12607287 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of ICAM1 mRNA]
CTD PMID:27803785 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; Fluvoxamine binds to and results in decreased activity of KCNH2 protein; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluvoxamine results in decreased activity of KCNH2 protein
CTD PMID:20071423 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Fluvoxamine results in increased expression of NOS2 mRNA
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]
CTD PMID:12429386 PMID:27803785 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein CTD PMID:15967061 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
CTD PMID:27803785 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance
ISO Fluvoxamine results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Fluvoxamine
CTD PMID:19875396 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of VCAM1 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]
CTD PMID:27803785 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        polyatomic entity 19740
          heteroatomic molecular entity 19682
            halide 18142
              organohalogen compound 17920
                halohydrocarbon 14049
                  fluorohydrocarbon 380
                    (trifluoromethyl)benzene + 380
                    1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexadecane 0
                    1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctadec-7-ene + 0
                    bis(perfluorobutyl)ethene + 0
                    fluoromethane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    fluorohydrocarbon 380
                                      (trifluoromethyl)benzene + 380
                                      1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexadecane 0
                                      1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctadec-7-ene + 0
                                      bis(perfluorobutyl)ethene + 0
                                      fluoromethane 0
paths to the root