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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxadiazole
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Accession:CHEBI:46685 term browser browse the term
Synonyms:related_synonym: oxadiazoles


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1,3,4-oxadiazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity EXP 1,3,4-oxadiazole analog results in decreased activity of CYP17A1 protein CTD PMID:25993309 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
azilsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in increased expression of BAX protein CTD PMID:29408668 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in decreased expression of BCL2L1 protein CTD PMID:29408668 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in increased expression of CASP9 protein CTD PMID:29408668 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
GR 127935 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP GR 127935 inhibits the reaction [eletriptan results in decreased expression of CALCA mRNA]; GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA] CTD PMID:14715155 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP GR 127935 binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP [[volinanserin binds to and results in decreased activity of HTR2A protein] which co-treated with GR 127935] results in decreased susceptibility to Methamphetamine; GR 127935 binds to and results in decreased activity of HTR2A protein CTD PMID:9109356, PMID:11751031 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
GSK690693 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; GSK690693 results in decreased expression of and results in increased phosphorylation of AKT1 protein
GSK690693 results in decreased phosphorylation of AKT1 protein
CTD PMID:30871965, PMID:31445927, PMID:31962201 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein] CTD PMID:30871965 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein] CTD PMID:30871965 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:22532600 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO GSK690693 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO GSK690693 results in decreased expression of and results in decreased phosphorylation of GSK3B protein CTD PMID:31962201 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK1 protein] CTD PMID:31962201 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO GSK690693 results in increased phosphorylation of MAPK3 protein
dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK3 protein]
CTD PMID:31962201 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein CTD PMID:31962201 NCBI chr 5:150,032,999...150,060,769
Ensembl chr 5:150,032,999...150,060,765
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein CTD PMID:31962201 NCBI chr 3:159,305,345...159,310,668
Ensembl chr 3:159,305,345...159,310,668
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein] CTD PMID:30871965 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO GSK690693 results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
decreases phosphorylation
ISO [sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein
CTD PMID:22532600 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      atom 19788
        nonmetal atom 19662
          nitrogen atom 18561
            nitrogen molecular entity 18561
              organonitrogen compound 18331
                organonitrogen heterocyclic compound 17477
                  oxadiazole 23
                    1,2,4-oxadiazole + 7
                    1,2,5-oxadiazole + 15
                    1,3,4-oxadiazoles + 1
                    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester 0
                    1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-1-butanone 0
                    1-ethyl-4-[[methyl-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]amino]methyl]-2-pyrrolidinone 0
                    2,5-dichloro-N-methyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide 0
                    2-(2-methoxyphenyl)-N-[4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide 0
                    2-(4-methoxyphenyl)-N-[4-[5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide 0
                    2-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzamide 0
                    2-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    3-(2-chlorophenyl)-N-cyclohexyl-5-methyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-4-isoxazolecarboxamide 0
                    3-(2-methoxy-6-methyl-3-pyridinyl)-5-(2-methoxyphenyl)-1,2,4-oxadiazole 0
                    3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester 0
                    3-(4-Chlorophenyl)-5-(4,5-dihydro-1H-imidazol-2-ylsulfanylmethyl)-1,2,4-oxadiazole 0
                    3-(4-bromophenyl)-5-(3,5-dimethoxyphenyl)-1,2,4-oxadiazole 0
                    3-(4-methoxyphenyl)-5-(2-phenylethyl)-1,2,4-oxadiazole 0
                    3-(4-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole 0
                    3-(5-bromo-2-furanyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole 0
                    3-[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-pyridinyl)propanamide 0
                    3-[3-(4-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-ethylpropanamide 0
                    3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methylphenyl)propanamide 0
                    3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide 0
                    3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-cyclopropylpropanamide 0
                    3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-ethylpropanamide 0
                    3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-methylpropanamide 0
                    3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    3-phenyl-5-[[[4-phenyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole 0
                    3-phenyl-5-thioxo-2,5-dihydro-1,2,3-oxadiazol-3-ium 0
                    4-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-[5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid 0
                    4-morpholinyl-[4-[3-[4-(4-morpholinylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone 0
                    5-(2,3-dihydrobenzofuran-5-yl)-3-(4-fluorophenyl)-1,2,4-oxadiazole 0
                    5-(2-chloro-4-fluorophenyl)-3-(2-pyrazinyl)-1,2,4-oxadiazole 0
                    5-(2-ethoxyphenyl)-3-(2-methoxy-6-methyl-3-pyridinyl)-1,2,4-oxadiazole 0
                    5-(3,4-diethoxyphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                    5-(3,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole 0
                    5-(3,5-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole 0
                    5-(3-chloro-4-methylphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                    5-(5-bromo-2-chlorophenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                    5-(6-chloro-3-pyridinyl)-3-(3-methoxyphenyl)-1,2,4-oxadiazole 0
                    5-[(4-methyl-1-piperidinyl)methyl]-3-phenyl-1,2,4-oxadiazole 0
                    5-[(4-methylphenoxy)methyl]-3-phenyl-1,2,4-oxadiazole 0
                    5-[4-phenyl-5-(trifluoromethyl)-2-thiophenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 0
                    5-[[(1-cyclohexyl-5-tetrazolyl)thio]methyl]-3-phenyl-1,2,4-oxadiazole 0
                    5-chloro-2-methoxy-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-ylbenzamide 0
                    AZD1979 + 0
                    AZD1979 oxetane hydrolysis product 0
                    N,2-dimethyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-3-furancarboxamide 0
                    N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine 0
                    N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-(4-chlorophenyl)-4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinecarboxamide 0
                    N-(5-chloro-2,4-dimethoxyphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,3,5-trimethylphenoxy)acetamide 0
                    N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-thiophenecarboxamide 0
                    N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-[4-[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]phenyl]-2-(4-methoxyphenyl)acetamide 0
                    N-ethyl-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(phenylmethyl)propanamide 0
                    N-ethyl-3-[3-(4-propan-2-ylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-ethyl-N-(2-ethylphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-methyl-3-[3-(4-propan-2-ylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                    N-tert-butyl-2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]benzamide 0
                    [2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(1-pyrrolidinyl)methanone 0
                    butalamine 0
                    imolamine 0
                    opicapone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic heterocyclic compound 18422
                                  organic heteromonocyclic compound 16461
                                    oxadiazole 23
                                      1,2,4-oxadiazole + 7
                                      1,2,5-oxadiazole + 15
                                      1,3,4-oxadiazoles + 1
                                      1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester 0
                                      1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-1-butanone 0
                                      1-ethyl-4-[[methyl-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]amino]methyl]-2-pyrrolidinone 0
                                      2,5-dichloro-N-methyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide 0
                                      2-(2-methoxyphenyl)-N-[4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide 0
                                      2-(4-methoxyphenyl)-N-[4-[5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide 0
                                      2-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzamide 0
                                      2-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      3-(2-chlorophenyl)-N-cyclohexyl-5-methyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-4-isoxazolecarboxamide 0
                                      3-(2-methoxy-6-methyl-3-pyridinyl)-5-(2-methoxyphenyl)-1,2,4-oxadiazole 0
                                      3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester 0
                                      3-(4-Chlorophenyl)-5-(4,5-dihydro-1H-imidazol-2-ylsulfanylmethyl)-1,2,4-oxadiazole 0
                                      3-(4-bromophenyl)-5-(3,5-dimethoxyphenyl)-1,2,4-oxadiazole 0
                                      3-(4-methoxyphenyl)-5-(2-phenylethyl)-1,2,4-oxadiazole 0
                                      3-(4-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole 0
                                      3-(5-bromo-2-furanyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole 0
                                      3-[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-pyridinyl)propanamide 0
                                      3-[3-(4-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-ethylpropanamide 0
                                      3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methylphenyl)propanamide 0
                                      3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide 0
                                      3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-cyclopropylpropanamide 0
                                      3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-ethylpropanamide 0
                                      3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-methylpropanamide 0
                                      3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      3-phenyl-5-[[[4-phenyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole 0
                                      3-phenyl-5-thioxo-2,5-dihydro-1,2,3-oxadiazol-3-ium 0
                                      4-[5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-[5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid 0
                                      4-morpholinyl-[4-[3-[4-(4-morpholinylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone 0
                                      5-(2,3-dihydrobenzofuran-5-yl)-3-(4-fluorophenyl)-1,2,4-oxadiazole 0
                                      5-(2-chloro-4-fluorophenyl)-3-(2-pyrazinyl)-1,2,4-oxadiazole 0
                                      5-(2-ethoxyphenyl)-3-(2-methoxy-6-methyl-3-pyridinyl)-1,2,4-oxadiazole 0
                                      5-(3,4-diethoxyphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                                      5-(3,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole 0
                                      5-(3,5-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole 0
                                      5-(3-chloro-4-methylphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                                      5-(5-bromo-2-chlorophenyl)-3-pyridin-4-yl-1,2,4-oxadiazole 0
                                      5-(6-chloro-3-pyridinyl)-3-(3-methoxyphenyl)-1,2,4-oxadiazole 0
                                      5-[(4-methyl-1-piperidinyl)methyl]-3-phenyl-1,2,4-oxadiazole 0
                                      5-[(4-methylphenoxy)methyl]-3-phenyl-1,2,4-oxadiazole 0
                                      5-[4-phenyl-5-(trifluoromethyl)-2-thiophenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 0
                                      5-[[(1-cyclohexyl-5-tetrazolyl)thio]methyl]-3-phenyl-1,2,4-oxadiazole 0
                                      5-chloro-2-methoxy-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-ylbenzamide 0
                                      AZD1979 + 0
                                      AZD1979 oxetane hydrolysis product 0
                                      N,2-dimethyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-3-furancarboxamide 0
                                      N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine 0
                                      N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-(4-chlorophenyl)-4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinecarboxamide 0
                                      N-(5-chloro-2,4-dimethoxyphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,3,5-trimethylphenoxy)acetamide 0
                                      N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-thiophenecarboxamide 0
                                      N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-[4-[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]phenyl]-2-(4-methoxyphenyl)acetamide 0
                                      N-ethyl-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(phenylmethyl)propanamide 0
                                      N-ethyl-3-[3-(4-propan-2-ylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-ethyl-N-(2-ethylphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-methyl-3-[3-(4-propan-2-ylphenyl)-1,2,4-oxadiazol-5-yl]propanamide 0
                                      N-tert-butyl-2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]benzamide 0
                                      [2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(1-pyrrolidinyl)methanone 0
                                      butalamine 0
                                      imolamine 0
                                      opicapone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.